JP7519660B2 - 疾患を処置するための遺伝子改変された細胞、組織、および臓器 - Google Patents

疾患を処置するための遺伝子改変された細胞、組織、および臓器 Download PDF

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JP7519660B2
JP7519660B2 JP2018565376A JP2018565376A JP7519660B2 JP 7519660 B2 JP7519660 B2 JP 7519660B2 JP 2018565376 A JP2018565376 A JP 2018565376A JP 2018565376 A JP2018565376 A JP 2018565376A JP 7519660 B2 JP7519660 B2 JP 7519660B2
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JP2019517803A5 (enExample
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バーナード ジェイ. へリング,
クリストファー ブルラク,
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リージェンツ オブ ザ ユニバーシティ オブ ミネソタ
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JP2018565376A 2016-06-14 2017-06-14 疾患を処置するための遺伝子改変された細胞、組織、および臓器 Active JP7519660B2 (ja)

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JP2021212142A JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

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US201662350048P 2016-06-14 2016-06-14
US62/350,048 2016-06-14
PCT/US2017/037566 WO2017218714A1 (en) 2016-06-14 2017-06-14 Genetically modified cells, tissues, and organs for treating disease

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JP2022129299A Division JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器

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JP2019517803A JP2019517803A (ja) 2019-06-27
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JP2021212142A Pending JP2022031487A (ja) 2016-06-14 2021-12-27 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2022129299A Pending JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A Pending JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A Pending JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

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JP2022129299A Pending JP2022160703A (ja) 2016-06-14 2022-08-15 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2024154774A Pending JP2024178220A (ja) 2016-06-14 2024-09-09 疾患を処置するための遺伝子改変された細胞、組織、および臓器
JP2025015908A Pending JP2025076449A (ja) 2016-06-14 2025-02-03 疾患を処置するための遺伝子改変された細胞、組織、および臓器

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KR (2) KR20230110373A (enExample)
CN (2) CN109640645B (enExample)
AU (1) AU2017285224B2 (enExample)
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Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US10231817B2 (en) 2013-09-24 2019-03-19 Giner Life Sciences, Inc. System for gas treatment of a cell implant
CA2935960C (en) 2014-01-08 2023-01-10 Bart Lipkens Acoustophoresis device with dual acoustophoretic chamber
AU2015360502A1 (en) 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN110494543A (zh) 2016-10-19 2019-11-22 弗洛设计声能学公司 通过声学的亲和细胞提取
US11033666B2 (en) 2016-11-15 2021-06-15 Giner Life Sciences, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
WO2018204867A1 (en) 2017-05-04 2018-11-08 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
KR20220066413A (ko) 2017-12-14 2022-05-24 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
EP4417212A3 (en) 2018-10-19 2024-12-04 Regents Of The University Of Minnesota Transplant tolerance induction with carbodiimide treated tolerizing vaccine
EP3760718A1 (en) * 2019-07-04 2021-01-06 Medizinische Hochschule Hannover Tissue for use as allogeneic or xenogeneic transplant and method for its production
CN111264469B (zh) * 2020-02-27 2022-03-25 西安交通大学医学院第一附属医院 一种基因免疫诱导的甲状腺相关性眼病动物模型的构建方法及雷帕霉素类药物的应用
WO2022005463A1 (en) * 2020-06-30 2022-01-06 National Yang-Ming University A glia cell and neuron co-culture system and method
CN111500693B (zh) * 2020-07-02 2020-09-22 中南大学 检测巨噬细胞中rfx1表达水平的试剂在制备巨噬细胞分型检测制剂中的应用
EP4380627A1 (en) * 2021-08-06 2024-06-12 Rutgers, the State University of New Jersey Method for producing genetically modified cells
EP4384544A1 (en) * 2021-08-11 2024-06-19 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
CN114958768B (zh) * 2022-06-02 2023-03-24 健颐生物科技发展(山东)有限公司 Fgf10旁分泌通用型人成纤维细胞制剂的制备方法

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770201A (en) 1994-12-23 1998-06-23 Rijsuniversiteit Te Leiden HA-2 antigenic peptide
JP2000510709A (ja) 1997-02-21 2000-08-22 コミサリア ア レネルジィエ アトミック 少なくとも1種のhla―gイソ型をその表面で発現する真核細胞、およびその使用
US6156306A (en) 1994-08-17 2000-12-05 Albert Einstein College Of Medicine Of Yeshiva University Pancreatic β-cells for allogeneic transplantation without immunosuppression
JP2001518066A (ja) 1996-03-20 2001-10-09 ブリストル―マイヤーズ スクイッブ カンパニー Gp39/cd40およびctla4/cd28/b7経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物
JP2003509031A (ja) 1999-09-13 2003-03-11 ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生
US20050123525A1 (en) 2003-11-13 2005-06-09 Ulrich Martin Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants
WO2011019385A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
JP2012502074A (ja) 2008-09-30 2012-01-26 キュアバック ゲーエムベーハー 哺乳動物において免疫を賦活する応答を提供または増強するための複合化された(m)RNAと裸のmRNAとを含んでいる組成物、およびその使用
JP2012507995A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Hla−gポリペプチドおよびその医薬的使用
JP2012507994A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Hla−gタンパク質及びその薬学的使用
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア, インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
CN102911270A (zh) 2011-08-05 2013-02-06 浙江大学 一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
US20130177577A1 (en) 2010-07-12 2013-07-11 Dana-Farber Cancer Institute, Inc. Nlrc5 as a target to intervene mhc class 1-mediated immune responses
JP2013545469A (ja) 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞rna発現のための方法
JP2014509195A (ja) 2011-02-25 2014-04-17 リコンビネティクス・インコーポレイテッド 遺伝子改変動物、およびそれを作製する方法
JP2015529457A (ja) 2012-07-31 2015-10-08 バジル・エム・ハンタッシュBasil M. HANTASH Hlag改変された細胞および方法
JP2016514462A (ja) 2013-03-16 2016-05-23 ノバルティス アーゲー ヒト化抗cd19キメラ抗原受容体を使用するがんの処置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU723003C (en) * 1995-08-04 2004-01-29 General Hospital Corporation, The Transgenic swine and swine cells having human HLA genes
KR100417566B1 (ko) * 1999-11-19 2004-02-05 한국생명공학연구원 체세포 핵치환 복제수정란의 대량생산방법
WO2002070648A2 (en) * 2000-11-17 2002-09-12 Hematech, Llc Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
CA2438501C (en) * 2001-02-14 2014-09-16 Leo T. Furcht Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
WO2003054150A2 (en) * 2001-12-07 2003-07-03 The Ohio State University Research Foundation Apoptotic ebv-transformed lymphocytes, a therapeutic agent for post-transplant lymphoproliferative disorder
KR20090068646A (ko) * 2007-12-24 2009-06-29 (주)엠젠 Hla-g 유전자 및 daf 유전자를 발현하는 형질전환복제 돼지 및 그의 제조 방법
KR20100022684A (ko) * 2008-08-20 2010-03-03 (주)엠젠 세 개의 유전자를 발현하는 복합형질전환 복제 돼지 및 그의 제조 방법
CA2745376A1 (en) * 2008-12-01 2010-06-10 Lifespan Extension Llc Methods and compositions for altering health, wellbeing, and lifespan
US8734786B2 (en) * 2009-09-16 2014-05-27 Northwestern University Use of ECDI-fixed cell tolerance as a method for preventing allograft rejection
US20140045915A1 (en) * 2010-08-31 2014-02-13 The General Hospital Corporation Cancer-related biological materials in microvesicles
NZ759163A (en) * 2011-02-14 2023-03-31 Revivicor Inc Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
KR102135601B1 (ko) * 2012-03-29 2020-07-20 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 탈모 질환의 치료 방법
WO2013188358A1 (en) * 2012-06-12 2013-12-19 The General Hospital Corporation Miniature swine transgenic for one or more coagulation factors
US20140115728A1 (en) * 2012-10-24 2014-04-24 A. Joseph Tector Double knockout (gt/cmah-ko) pigs, organs and tissues
CN104046593A (zh) * 2013-03-14 2014-09-17 浙江大学 一种低免疫原性的人细胞及其制备方法
CA2928635C (en) * 2013-11-28 2022-06-21 Horizon Genomics Gmbh Somatic haploid human cell line
US20160060655A1 (en) * 2014-05-30 2016-03-03 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods to treat latent viral infections
SG10201911411YA (en) * 2014-06-26 2020-02-27 Regeneron Pharma Methods and compositions for targeted genetic modifications and methods of use
CN105586389A (zh) * 2014-10-21 2016-05-18 天津华大基因科技有限公司 试剂盒及其在检测遗传性骨病基因中的用途
BR112017008251B1 (pt) * 2014-10-22 2022-02-22 Indiana University Research And Technology Corporation Usos de um tecido de um porco transgênico que compreende um gene a(1,3) galactosiltransferase, cmah e ß4galnt2 interrompido e de um produto relacionado com a pele, e, métodos para preparação de um material de transplante para xenoenxerto, para produção de um composto de interesse e para produzir um reagente de cultura de células
AU2015360502A1 (en) * 2014-12-10 2017-06-29 Regents Of The University Of Minnesota Genetically modified cells, tissues, and organs for treating disease
CN104789592A (zh) * 2015-03-19 2015-07-22 中国食品药品检定研究院 一种制备α-1,3GT基因敲除的非人哺乳动物的方法及应用

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156306A (en) 1994-08-17 2000-12-05 Albert Einstein College Of Medicine Of Yeshiva University Pancreatic β-cells for allogeneic transplantation without immunosuppression
US5770201A (en) 1994-12-23 1998-06-23 Rijsuniversiteit Te Leiden HA-2 antigenic peptide
JP2001518066A (ja) 1996-03-20 2001-10-09 ブリストル―マイヤーズ スクイッブ カンパニー Gp39/cd40およびctla4/cd28/b7経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物
JP2000510709A (ja) 1997-02-21 2000-08-22 コミサリア ア レネルジィエ アトミック 少なくとも1種のhla―gイソ型をその表面で発現する真核細胞、およびその使用
JP2003509031A (ja) 1999-09-13 2003-03-11 ユニバシティ オブ マサチューセッツ、ア パブリック インスチチユーション オブ ハイアー エデュケイション オブ ザ コモンウエルス オブ マサチューセッツ、アズ リプリゼンテッド バイ イッツ アマースト キャンパス ドナー細胞又は分化細胞からの核を使用する豚のクローニング並びに多能性豚の産生
US20050123525A1 (en) 2003-11-13 2005-06-09 Ulrich Martin Composition and method for inducing immune tolerance towards cell, tissue and/or organ transplants
JP2012502074A (ja) 2008-09-30 2012-01-26 キュアバック ゲーエムベーハー 哺乳動物において免疫を賦活する応答を提供または増強するための複合化された(m)RNAと裸のmRNAとを含んでいる組成物、およびその使用
JP2012507995A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Hla−gポリペプチドおよびその医薬的使用
JP2012507994A (ja) 2008-11-07 2012-04-05 エイチエルエイ−ジー・テクノロジーズ Hla−gタンパク質及びその薬学的使用
WO2011019385A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
JP2013501528A (ja) 2009-08-14 2013-01-17 レビビコア, インコーポレイテッド 糖尿病の処置のためのマルチ・トランスジェニック・ブタ
US20130177577A1 (en) 2010-07-12 2013-07-11 Dana-Farber Cancer Institute, Inc. Nlrc5 as a target to intervene mhc class 1-mediated immune responses
JP2013545469A (ja) 2010-12-03 2013-12-26 ビオエンテッヒ・アクチェンゲゼルシャフト 細胞rna発現のための方法
JP2014509195A (ja) 2011-02-25 2014-04-17 リコンビネティクス・インコーポレイテッド 遺伝子改変動物、およびそれを作製する方法
CN102911270A (zh) 2011-08-05 2013-02-06 浙江大学 一种抑制移植器官慢性排斥反应的抗体的制备及纯化方法
JP2015529457A (ja) 2012-07-31 2015-10-08 バジル・エム・ハンタッシュBasil M. HANTASH Hlag改変された細胞および方法
JP2016514462A (ja) 2013-03-16 2016-05-23 ノバルティス アーゲー ヒト化抗cd19キメラ抗原受容体を使用するがんの処置

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
Am.J.Transplant.,2014,Vol.14,pp.2713-2722
J.Exp.Med.,2001,Vol.193,No.8,pp.975-980
J.Immunol.,2001,Vol.167,pp.6002-6008
Nat.Biotechnol.,2013,Vol.31,No.3,pp.227-229
Regen.Med.,2014,Vol.9,No.6,pp.775-784
Stem Cell Res.,2014,Vol.13,pp.342-354
Transplant Immunol.,2003,Vol.11,pp.147-153
Transplant Immunol.,2015,Vol.32,pp.109-115
Xenotransplantation,1999,Vol.6,pp.52-65
Xenotransplantation,2013,Vol.20,p.64

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