JP7511469B2 - 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 - Google Patents
組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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| JP2024209675A JP2025023189A (ja) | 2017-09-27 | 2024-12-02 | 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 |
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| JP2023007311A Active JP7598960B2 (ja) | 2017-09-27 | 2023-01-20 | 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 |
| JP2024209675A Pending JP2025023189A (ja) | 2017-09-27 | 2024-12-02 | 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 |
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| JP2024209675A Pending JP2025023189A (ja) | 2017-09-27 | 2024-12-02 | 組換えエクトヌクレオチドピロホスファターゼ／ホスホジエステラーゼ（ｎｐｐ１）を使用して心血管機能を改善し、心血管疾患を処置するための方法。 |
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| US12134790B2 (en) | 2017-09-27 | 2024-11-05 | Inozyme Pharma, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (NPP1) |
| CA3180119A1 (en) * | 2020-05-27 | 2021-12-02 | Frank RUTSCH | Compositions and methods for inhibiting vascular smooth muscle cell proliferation |
| KR20230048480A (ko) * | 2020-05-27 | 2023-04-11 | 이노자임 파마, 인코포레이티드 | 말초 동맥 질환을 치료하기 위한 조성물 및 방법 |
| EP4162036A1 (en) | 2020-06-09 | 2023-04-12 | Inozyme Pharma, Inc. | Soluble enpp1 or enpp3 proteins and uses thereof |
| MX2024003506A (es) * | 2021-09-24 | 2024-04-23 | Inozyme Pharma Inc | Formulaciones de polipéptidos enpp1 liofilizados y usos de estas. |
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| WO2016100803A2 (en) | 2014-12-19 | 2016-06-23 | Alexion Pharmaceuticals, Inc. | Methods of treating tissue calcification |
| WO2016187408A1 (en) | 2015-05-19 | 2016-11-24 | Yale University | Compositions for treating pathological calcification conditions, and methods using same |
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| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
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| US20020164782A1 (en) | 1999-02-10 | 2002-11-07 | Gregory Richard J. | Adenovirus vectors for gene therapy |
| JPH04292169A (ja) | 1991-03-19 | 1992-10-16 | Sekisui Chem Co Ltd | ハイブリッド型人工膵臓 |
| US5418618A (en) | 1992-03-09 | 1995-05-23 | Mita Industrial Co., Ltd. | Tone processing method for forming a halftone image |
| US5804413A (en) | 1992-07-31 | 1998-09-08 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Herpes simplex virus strains for gene transfer |
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| GB9415319D0 (en) | 1994-07-29 | 1994-09-21 | Medical Res Council | HSV viral vector |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US6825396B2 (en) | 1996-06-12 | 2004-11-30 | Board Of Trustees Operating Michigan State University | Methods for tissue specific synthesis of protein in eggs of transgenic hens |
| CA2280957A1 (en) | 1997-02-14 | 1998-08-20 | Leslie Orgel | Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents |
| US6156303A (en) | 1997-06-11 | 2000-12-05 | University Of Washington | Adeno-associated virus (AAV) isolates and AAV vectors derived therefrom |
| EP1002119A1 (en) | 1997-07-31 | 2000-05-24 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Targeted hsv vectors |
| US20040019923A1 (en) | 1997-10-16 | 2004-01-29 | Ivarie Robert D. | Exogenous proteins expressed in avians and their eggs |
| US5932465A (en) | 1997-10-16 | 1999-08-03 | Icos Corporation | Phosphodiesterase 8A |
| AU752946B2 (en) | 1997-10-16 | 2002-10-03 | Avigenics, Inc. | Vectors comprising a magnum-specific promoter for avian transgenesis |
| PT1032662E (pt) | 1997-11-07 | 2006-07-31 | Trillium Therapeutics Inc | Metodos e composicoes para imunomodulacao. |
| US6894022B1 (en) | 1998-08-27 | 2005-05-17 | Eidgenossische Technische Hochschule Zurich | Growth factor modified protein matrices for tissue engineering |
| US6272859B1 (en) | 1998-10-02 | 2001-08-14 | Caterpillar Inc. | Device for controlling a variable geometry turbocharger |
| US6043056A (en) | 1998-11-06 | 2000-03-28 | Incyte Pharmaceuticals, Inc. | Cell surface glycoproteins |
| HK1044468A1 (zh) | 1998-12-03 | 2002-10-25 | 海斯塔泰克有限责任公司 | 治療哮喘和炎症的小肽和方法 |
| US6596535B1 (en) | 1999-08-09 | 2003-07-22 | Targeted Genetics Corporation | Metabolically activated recombinant viral vectors and methods for the preparation and use |
| JP3983449B2 (ja) | 1999-10-15 | 2007-09-26 | 株式会社リコー | パルス幅変調回路、光書き込み装置及び画像形成装置 |
| US7608681B2 (en) | 1999-12-24 | 2009-10-27 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| ATE447622T1 (de) | 2000-02-23 | 2009-11-15 | Pxe Internat Inc | Methoden und zusammensetzungen zur diagnose und behandlung von pseudoxanthoma elasticum und ähnlichen zuständen |
| JP2001274989A (ja) | 2000-03-27 | 2001-10-05 | Ricoh Co Ltd | 画像処理装置及び画像処理方法並びにプリンタ出力装置 |
| DE20121960U1 (de) | 2000-04-06 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Metastase assoziierten Krankheiten |
| US20040030167A1 (en) | 2000-08-08 | 2004-02-12 | Hiroaki Takayama | 3-Methyl-20-epi-vitamin d derivatives |
| US6521645B2 (en) | 2000-11-20 | 2003-02-18 | The University Of Kansas Medical Center | Methods for the treatment and prevention of urinary stone disease |
| EP1355919B1 (en) | 2000-12-12 | 2010-11-24 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US20020108132A1 (en) | 2001-02-02 | 2002-08-08 | Avigenics Inc. | Production of a monoclonal antibody by a transgenic chicken |
| US7211395B2 (en) | 2001-03-09 | 2007-05-01 | Dyax Corp. | Serum albumin binding moieties |
| WO2002092020A2 (en) | 2001-03-23 | 2002-11-21 | The Burnham Institute | Compositions and methods for modulating bone mineral deposition |
| US7888372B2 (en) | 2001-03-23 | 2011-02-15 | National Institutes Of Health (Nih) | Compositions and methods for modulating bone mineral deposition |
| US20030191073A1 (en) | 2001-11-07 | 2003-10-09 | Challita-Eid Pia M. | Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer |
| AU2002324700A1 (en) | 2001-08-14 | 2003-03-03 | Bayer Ag | Nucleic acid and amino acid sequences involved in pain |
| WO2003025146A2 (en) | 2001-09-18 | 2003-03-27 | Avigenics, Inc. | Production of a transgenic avian by cytoplasmic injection |
| EP1537140B1 (en) | 2001-11-07 | 2013-01-02 | Agensys, Inc. | Nucleic acid and corresponding protein entitled 161p2f10b useful in treatment and detection of cancer |
| US7335761B2 (en) | 2001-11-30 | 2008-02-26 | Avigenics, Inc. | Avian gene expression controlling regions |
| US7294507B2 (en) | 2001-11-30 | 2007-11-13 | Avigenics, Inc. | Ovomucoid promoters and methods of use |
| US6875588B2 (en) | 2001-11-30 | 2005-04-05 | Avigenics, Inc. | Ovomucoid promoter and methods of use |
| US7858297B2 (en) | 2001-12-18 | 2010-12-28 | Centre National De La Recherche Scientifique Cnrs | Chemokine-binding protein and methods of use |
| WO2003072593A2 (en) | 2002-02-21 | 2003-09-04 | University Of Virginia Patent Foundation | Bone targeting peptides |
| AU2003210806A1 (en) | 2002-03-05 | 2003-09-22 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| US20040071705A1 (en) | 2002-06-21 | 2004-04-15 | Dyax Corporation | Serum protein-associated target-specific ligands and identification method therefor |
| US20040224893A1 (en) | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| US20050090001A1 (en) | 2003-10-07 | 2005-04-28 | Parker Stephen H. | Cell lines and methods for producing proteins |
| CN102816241B (zh) | 2004-02-09 | 2015-07-22 | 人类基因科学公司 | 清蛋白融合蛋白 |
| PL1759001T3 (pl) | 2004-04-21 | 2011-09-30 | Alexion Pharma Inc | Koniugaty dostarczane do kości i sposób ich zastosowania do nakierowywania białek do kości |
| US9055984B2 (en) | 2004-04-21 | 2015-06-16 | DePuy Synthes Products, Inc. | Sternal reconstruction system |
| US20050287284A1 (en) | 2004-06-28 | 2005-12-29 | Shukla Triveni P | Processed meats comprising dietary fiber gel |
| US20090142347A1 (en) | 2004-09-29 | 2009-06-04 | The Burnham Institute For Medical Research | Tissue-Nonspecific Alkaline Phosphatase (TNAP): a Therapeutic Target for Arterial Calcification |
| WO2006050211A2 (en) | 2004-10-28 | 2006-05-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain |
| EP1813671A4 (en) | 2004-11-19 | 2008-06-11 | Ono Pharmaceutical Co | SOLUBLE PROTEIN AND USE THEREOF |
| GB0426397D0 (en) | 2004-12-01 | 2005-01-05 | Health Prot Agency | Fusion proteins |
| JP4495210B2 (ja) | 2005-06-09 | 2010-06-30 | パナソニック株式会社 | 振幅誤差補償装置及び直交度誤差補償装置 |
| CA2610159C (en) | 2005-06-10 | 2015-03-31 | Altus Pharmaceuticals Inc. | Methods to reduce oxalate concentration by administration of oxalate oxidase crystals |
| EP1736553A1 (en) | 2005-06-17 | 2006-12-27 | Centre National De La Recherche Scientifique | ENPP1 (PC-1) gene haplotype associated with the risk of obesity and type 2 diabetes and their applications |
| US20090180989A1 (en) | 2005-10-05 | 2009-07-16 | Synageva Biopharma Corp. | Compositions and methods for delivering nucleotide sequences to vertebrates |
| US11039942B2 (en) | 2006-06-13 | 2021-06-22 | Sino Medical Sciences Technology Inc. | Drug eluting stent and method of use of the same for enabling restoration of functional endothelial cell layers |
| PT2046373E (pt) | 2006-08-02 | 2013-05-06 | Althea Technologies Inc | Oxalato descarboxilase cristalizada e métodos de utilização |
| US20100113339A1 (en) | 2006-09-08 | 2010-05-06 | Ablynx N. V. | Serum albumin binding proteins with long half-lives |
| WO2008065225A2 (es) | 2006-11-28 | 2008-06-05 | Proyecto De Biomedicina Cima, S.L. | Vector viral y sus aplicaciones |
| US20080273206A1 (en) | 2007-04-23 | 2008-11-06 | University Of South Carolina | Biomimetic Mineralization Method and System |
| DK2662448T3 (en) | 2007-05-11 | 2017-03-20 | Alexion Pharma Inc | Bone-targeted alkaline phosphatase, kits and methods for its use |
| EP2178556B1 (en) | 2007-06-18 | 2011-08-17 | Oregon Health & Science University | Protein c for use in maintaining hemostasis |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| GB0803352D0 (en) | 2008-02-22 | 2008-04-02 | Ntnu Technology Transfer As | Oligopeptidic compounds and uses thereof |
| AR071885A1 (es) | 2008-05-23 | 2010-07-21 | Wyeth Corp | Proteinas de union al receptor de interleuquina 21 |
| JP4888439B2 (ja) | 2008-05-30 | 2012-02-29 | ブラザー工業株式会社 | 画像読取装置および原稿サイズ決定プログラム |
| WO2011097456A2 (en) | 2010-02-05 | 2011-08-11 | The University Of North Carolina At Chapel Hill | Compositions and methods for enhanced parvovirus transduction |
| EP2545080B1 (en) | 2010-03-12 | 2017-05-10 | Alexion Pharmaceuticals, Inc. | Npp1 fusion proteins |
| EP2683742B1 (en) | 2011-03-11 | 2018-12-19 | Alexion Pharmaceuticals, Inc. | Npp1 fusion proteins |
| WO2012130567A1 (en) | 2011-03-29 | 2012-10-04 | Beta-Cell Nv | Method for encapsulated therapeutic products and uses thereof |
| WO2013074615A1 (en) | 2011-11-14 | 2013-05-23 | Yale University | Compositions and methods for modulating coagulation |
| AU2014204045B2 (en) | 2013-01-04 | 2018-10-18 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| PL2956163T3 (pl) | 2013-02-13 | 2025-04-14 | Yale University | Kompozycje do leczenia patologicznego zwapnienia i kostnienia |
| WO2014152940A1 (en) | 2013-03-14 | 2014-09-25 | Shire Human Genetic Therapies, Inc. | Mrna therapeutic compositions and use to treat diseases and disorders |
| CN114717206A (zh) | 2013-03-15 | 2022-07-08 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| ES2523016B1 (es) | 2013-05-20 | 2015-09-09 | 3P Biopharmaceuticals | Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| CA2924259C (en) | 2013-09-19 | 2021-12-21 | Universitatsspital Basel | Artificial vascular graft |
| AU2015219339B2 (en) | 2014-02-19 | 2020-03-05 | Bioasis Technologies Inc. | P97-IDS fusion proteins |
| GB2526339A (en) | 2014-05-21 | 2015-11-25 | Imp Innovations Ltd | Lentiviral vectors |
| US10973931B2 (en) | 2014-09-16 | 2021-04-13 | Universitat Autònoma De Barcelona | Adeno-associated viral vectors for the gene therapy of metabolic diseases |
| US10926006B2 (en) | 2015-02-26 | 2021-02-23 | Remodeless Cv Ltd | Drug eluting stent |
| TN2018000163A1 (en) | 2015-11-12 | 2019-10-04 | Res Inst Nationwide Childrens Hospital | Methods of treating muscular dystrophy |
| EP3377105A4 (en) * | 2015-11-20 | 2019-04-24 | Yale University | COMPOSITIONS FOR THE TREATMENT OF ECTOPIC CALIBRATION DISORDERS AND METHODS THEREWITH |
| WO2017191274A2 (en) | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP3471747A1 (en) * | 2016-06-16 | 2019-04-24 | Alexion Pharmaceuticals, Inc. | Methods of treating myointimal proliferation |
| US11390859B2 (en) | 2016-08-05 | 2022-07-19 | Yale University | Compositions and methods for stroke prevention in pediatric sickle cell anemia patients |
| IL268198B2 (en) | 2017-02-27 | 2024-10-01 | Shattuck Labs Inc | Tigit- and light-based chimeric proteins |
| US12134790B2 (en) | 2017-09-27 | 2024-11-05 | Inozyme Pharma, Inc. | Methods of improving cardiovascular function and treating cardiovascular disease using a recombinant ectonucleotide pyrophosphatase phosphodiesterase (NPP1) |
| JP2021523139A (ja) | 2018-05-08 | 2021-09-02 | イエール ユニバーシティ | 腎石症の進行を遅らせるための組成物および方法 |
-
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- 2018-09-26 US US16/648,388 patent/US12134790B2/en active Active
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- 2024-12-02 JP JP2024209675A patent/JP2025023189A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100803A2 (en) | 2014-12-19 | 2016-06-23 | Alexion Pharmaceuticals, Inc. | Methods of treating tissue calcification |
| WO2016187408A1 (en) | 2015-05-19 | 2016-11-24 | Yale University | Compositions for treating pathological calcification conditions, and methods using same |
Non-Patent Citations (1)
| Title |
|---|
| Nature Communications，2015年，Vol. 6, article number 10006，pp. 1-11 |
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| CA3096821A1 (en) | 2019-04-04 |
| WO2019067502A1 (en) | 2019-04-04 |
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| US20250019677A1 (en) | 2025-01-16 |
| EP3687565A1 (en) | 2020-08-05 |
| JP7598960B2 (ja) | 2024-12-12 |
| JP2023033610A (ja) | 2023-03-10 |
| JP2025023189A (ja) | 2025-02-14 |
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