JP7501928B2 - 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 - Google Patents
二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 Download PDFInfo
- Publication number
- JP7501928B2 JP7501928B2 JP2022117400A JP2022117400A JP7501928B2 JP 7501928 B2 JP7501928 B2 JP 7501928B2 JP 2022117400 A JP2022117400 A JP 2022117400A JP 2022117400 A JP2022117400 A JP 2022117400A JP 7501928 B2 JP7501928 B2 JP 7501928B2
- Authority
- JP
- Japan
- Prior art keywords
- 2dac
- carbon
- amorphous carbon
- substrate
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229910003481 amorphous carbon Inorganic materials 0.000 title claims description 74
- 238000000576 coating method Methods 0.000 title claims description 64
- 238000000034 method Methods 0.000 title claims description 38
- 210000000130 stem cell Anatomy 0.000 title description 42
- 230000010261 cell growth Effects 0.000 title description 8
- 230000024245 cell differentiation Effects 0.000 title description 4
- 239000000758 substrate Substances 0.000 claims description 136
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 99
- 239000011248 coating agent Substances 0.000 claims description 54
- 229910052799 carbon Inorganic materials 0.000 claims description 44
- 239000007943 implant Substances 0.000 claims description 38
- 239000002243 precursor Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000000354 decomposition reaction Methods 0.000 claims description 4
- 229930195733 hydrocarbon Natural products 0.000 claims description 4
- 150000002430 hydrocarbons Chemical class 0.000 claims description 4
- 238000002834 transmittance Methods 0.000 claims description 3
- 239000004215 Carbon black (E152) Substances 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000010408 film Substances 0.000 description 104
- 229910021389 graphene Inorganic materials 0.000 description 35
- 230000012010 growth Effects 0.000 description 32
- 210000004027 cell Anatomy 0.000 description 27
- 239000010410 layer Substances 0.000 description 22
- 239000000463 material Substances 0.000 description 20
- 239000002131 composite material Substances 0.000 description 18
- 239000011521 glass Substances 0.000 description 18
- 239000003102 growth factor Substances 0.000 description 18
- 229910052751 metal Inorganic materials 0.000 description 18
- 239000002184 metal Substances 0.000 description 18
- 210000001519 tissue Anatomy 0.000 description 14
- 239000007789 gas Substances 0.000 description 12
- 230000008569 process Effects 0.000 description 12
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 10
- 238000001069 Raman spectroscopy Methods 0.000 description 10
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 9
- 125000004432 carbon atom Chemical group C* 0.000 description 9
- 230000004069 differentiation Effects 0.000 description 9
- 230000001965 increasing effect Effects 0.000 description 9
- 239000010936 titanium Substances 0.000 description 9
- 229910052719 titanium Inorganic materials 0.000 description 9
- 238000012546 transfer Methods 0.000 description 9
- 238000003917 TEM image Methods 0.000 description 8
- 239000010949 copper Substances 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 238000001237 Raman spectrum Methods 0.000 description 7
- 238000004833 X-ray photoelectron spectroscopy Methods 0.000 description 7
- 238000004630 atomic force microscopy Methods 0.000 description 7
- 238000005260 corrosion Methods 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 239000002356 single layer Substances 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- 208000007536 Thrombosis Diseases 0.000 description 6
- 230000007797 corrosion Effects 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- DHCLVCXQIBBOPH-UHFFFAOYSA-N Glycerol 2-phosphate Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000007547 defect Effects 0.000 description 5
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 5
- 125000004429 atom Chemical group 0.000 description 4
- 238000005452 bending Methods 0.000 description 4
- 210000000988 bone and bone Anatomy 0.000 description 4
- 238000004113 cell culture Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000002158 endotoxin Substances 0.000 description 4
- -1 for example Substances 0.000 description 4
- 229910021397 glassy carbon Inorganic materials 0.000 description 4
- 229920006008 lipopolysaccharide Polymers 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000010409 thin film Substances 0.000 description 4
- 229910052582 BN Inorganic materials 0.000 description 3
- 239000002194 amorphous carbon material Substances 0.000 description 3
- 230000000975 bioactive effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 230000004663 cell proliferation Effects 0.000 description 3
- 238000005229 chemical vapour deposition Methods 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 239000004053 dental implant Substances 0.000 description 3
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 3
- 229960003957 dexamethasone Drugs 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000010354 integration Effects 0.000 description 3
- 230000000399 orthopedic effect Effects 0.000 description 3
- 230000009818 osteogenic differentiation Effects 0.000 description 3
- 238000006303 photolysis reaction Methods 0.000 description 3
- 230000015843 photosynthesis, light reaction Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 241000894007 species Species 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000003575 carbonaceous material Substances 0.000 description 2
- 230000008614 cellular interaction Effects 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000011889 copper foil Substances 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000000151 deposition Methods 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 108010082117 matrigel Proteins 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000000691 measurement method Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 230000037257 muscle growth Effects 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000010899 nucleation Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000002188 osteogenic effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000006433 tumor necrosis factor production Effects 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 description 1
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 1
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical class C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 description 1
- 101100441252 Caenorhabditis elegans csp-2 gene Proteins 0.000 description 1
- 101100222092 Caenorhabditis elegans csp-3 gene Proteins 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229910001069 Ti alloy Inorganic materials 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000010065 bacterial adhesion Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- GHRQXJHBXKYCLZ-UHFFFAOYSA-L beta-glycerolphosphate Chemical compound [Na+].[Na+].CC(CO)OOP([O-])([O-])=O GHRQXJHBXKYCLZ-UHFFFAOYSA-L 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000003114 blood coagulation factor Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229910021387 carbon allotrope Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 239000002041 carbon nanotube Substances 0.000 description 1
- 229910021393 carbon nanotube Inorganic materials 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000000541 cathodic arc deposition Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000004700 cellular uptake Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000000788 chromium alloy Substances 0.000 description 1
- 229910052681 coesite Inorganic materials 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229910052906 cristobalite Inorganic materials 0.000 description 1
- 239000002178 crystalline material Substances 0.000 description 1
- 238000002447 crystallographic data Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229910003472 fullerene Inorganic materials 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 238000002173 high-resolution transmission electron microscopy Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- RHDUVDHGVHBHCL-UHFFFAOYSA-N niobium tantalum Chemical compound [Nb].[Ta] RHDUVDHGVHBHCL-UHFFFAOYSA-N 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229940054269 sodium pyruvate Drugs 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 239000004071 soot Substances 0.000 description 1
- 238000012306 spectroscopic technique Methods 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 229910052682 stishovite Inorganic materials 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B32/00—Carbon; Compounds thereof
- C01B32/05—Preparation or purification of carbon not covered by groups C01B32/15, C01B32/20, C01B32/25, C01B32/30
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/08—Carbon ; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/30—Inorganic materials
- A61L27/303—Carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C14/00—Coating by vacuum evaporation, by sputtering or by ion implantation of the coating forming material
- C23C14/0005—Separation of the coating from the substrate
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/01—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes on temporary substrates, e.g. substrates subsequently removed by etching
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
- C23C16/00—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes
- C23C16/22—Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the deposition of inorganic material, other than metallic material
- C23C16/26—Deposition of carbon only
- C23C16/27—Diamond only
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M4/00—Electrodes
- H01M4/86—Inert electrodes with catalytic activity, e.g. for fuel cells
- H01M4/8647—Inert electrodes with catalytic activity, e.g. for fuel cells consisting of more than one material, e.g. consisting of composites
- H01M4/8657—Inert electrodes with catalytic activity, e.g. for fuel cells consisting of more than one material, e.g. consisting of composites layered
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M4/00—Electrodes
- H01M4/86—Inert electrodes with catalytic activity, e.g. for fuel cells
- H01M4/88—Processes of manufacture
- H01M4/8803—Supports for the deposition of the catalytic active composition
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M4/00—Electrodes
- H01M4/86—Inert electrodes with catalytic activity, e.g. for fuel cells
- H01M4/98—Raney-type electrodes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/10—Fuel cells with solid electrolytes
- H01M8/1016—Fuel cells with solid electrolytes characterised by the electrolyte material
- H01M8/1018—Polymeric electrolyte materials
- H01M8/102—Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer
- H01M8/1023—Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon, e.g. polyarylenes, polystyrenes or polybutadiene-styrenes
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/10—Fuel cells with solid electrolytes
- H01M8/1016—Fuel cells with solid electrolytes characterised by the electrolyte material
- H01M8/1018—Polymeric electrolyte materials
- H01M8/1039—Polymeric electrolyte materials halogenated, e.g. sulfonated polyvinylidene fluorides
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/10—Fuel cells with solid electrolytes
- H01M8/1016—Fuel cells with solid electrolytes characterised by the electrolyte material
- H01M8/1018—Polymeric electrolyte materials
- H01M8/1041—Polymer electrolyte composites, mixtures or blends
- H01M8/1053—Polymer electrolyte composites, mixtures or blends consisting of layers of polymers with at least one layer being ionically conductive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/02—Amorphous compounds
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/04—Compounds with a limited amount of crystallinty, e.g. as indicated by a crystallinity index
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2002/00—Crystal-structural characteristics
- C01P2002/20—Two-dimensional structures
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/40—Electric properties
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01M—PROCESSES OR MEANS, e.g. BATTERIES, FOR THE DIRECT CONVERSION OF CHEMICAL ENERGY INTO ELECTRICAL ENERGY
- H01M8/00—Fuel cells; Manufacture thereof
- H01M8/10—Fuel cells with solid electrolytes
- H01M2008/1095—Fuel cells with polymeric electrolytes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/30—Hydrogen technology
- Y02E60/50—Fuel cells
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Electrochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Sustainable Energy (AREA)
- Metallurgy (AREA)
- Mechanical Engineering (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Composite Materials (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Carbon And Carbon Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Description
本発明は、概して、二次元アモルファス炭素(2DAC)被膜及び物品、並びに幹細胞の成長及び分化方法に関する。
従来技術には、生物医学用途などの特定の目的を意図した被膜に好適な用途を開発し提供するための要望が存在する。
定義
用語の定義が一般的に使用される用語の意味から逸脱する場合、出願人は、特に示さない限り、以下に与える定義を使用するものとする。
本発明は、様々な改変及び別の形態が可能であるが、その特定の実施形態は、図面に例示として示されており、かつ、以下で詳細に説明する。しかし、本発明を開示された特定の形態に限定することを意図するものではなく、逆に、本発明は、本発明の精神及び範囲内にある全ての改変物、均等物及び代替物を包含するものとする。
例1
実施例の主題
本発明の2DACのプロセスパラメータとしては、次のものを挙げることができる:(i)プロセスガス:CH4(ii)チャンバー圧力:2.0E-2mbar;(iii)レーザーフルエンス:70mJ/cm2;(iv)成長時間:1分;(v)プラズマ出力:5W;(vi)基材:銅箔。
次の参考文献は上で参照されており、参照により本明細書において援用する。
1. Ferrari, A.C. et al. “Interpretation of Raman spectra of disordered and amorphous carbon.” Physical Review B 61, 14095-14107 (2000).
2. Robertson, J. “Ultrathin carbon coatings for magnetic storage technology.” Thin Solid Films 383, 81-88 (2001).
3. Hu, S. et al. “Proton transport through one-atom-thick crystals.” Nature 516, 227-230 (2014).
4. Das, S. et al. “Measurements of adhesion energy of graphene to metallic substrates.” Carbon 59, 121-129 (2013).
5. Schriver, M. et al. “Graphene as a Long-Term Metal Oxidation Barrier: Worse Than Nothing” ACS Nano 7, 5763-5768 (2013).
6. Wang, J. S. et al. “The mechanical performance of DLC films on steel substrates.” Thin Solid Films 325, 163-174 (1998).
7. Leng, Y. X. et al. “Mechanical properties and platelet adhesion behavior of diamond-like carbon films synthesized by pulsed vacuum arc plasma deposition.” Surface Science 531, 177-184 (2003).
8. Maguire, P. D. et al. “Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires.” Diamond and Related Materials 14, 1277-1288 (2005).
9. Marcon, et. al. “The head-disk interface roadmap to an areal density of 4 Tbit/in2.” Advances in Tribology 2013, 1-8 (2013).
10. Discher, D. E., Mooney, D. J. & Zandstra, P. W. “Growth Factors, Matrices, and Forces Combine and Control Stem Cells.” Science 324, 1673-1677 (2009).
11. Spradling, A., Drummond-Barbosa, D. & Kai, T. “Stem cells find their niche.” Nature 414, 98-104 (2001).
12. Murry, C. E. & Keller, G. “Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development.” Cell 132, 661-680 (2008).
13. Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. “Matrix Elasticity Directs Stem Cell Lineage Specification.” Cell 126, 677-689 (2006).
14. Dalby, M. J. et al. “The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.” Nature Materials 6, 997-1003 (2007).
15. Trappmann, B. et al. “Extracellular-matrix tethering regulates stem-cell fate.” Nature Materials 11, 642-649 (2012).
16. Lee, H. et al. “Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.” Scientific Reports 6, 20708 (2016).
17. Choi, W. J. et al. ”Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films.” Scientific Reports 5, 9974 (2015).
Claims (16)
- 非六角形炭素環及び六角形炭素環からなる原子構造を有する二次元アモルファス炭素(2DAC)被膜であって、前記二次元アモルファス炭素(2DAC)被膜が<1の結晶化度(C)を有し、0.2以下のsp3/sp2結合比を有し、かつ、均質であり、ここで、前記結晶化度(C)=六角形炭素環の数:(六角形炭素環の数+非六角形炭素環の数)であり、前記2DAC被膜がインプラント被膜である、二次元アモルファス炭素(2DAC)被膜。
- 前記二次元アモルファス炭素(2DAC)被膜の前記結晶化度(C)が≦0.8である、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 前記二次元アモルファス炭素(2DAC)被膜が0.01~1000Ω・cmの抵抗率を有する、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 前記インプラント被膜がインプラントの表面上に配置され、かつ、約60°の水滴接触角を形成する、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 前記インプラント被膜が約200J/m2以上の接着エネルギーでインプラントに付着する、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 前記非六角形炭素環が炭素4員環、炭素5員環、炭素7員環、炭素8員環及び炭素9員環よりなる群から選択される1つの形態である、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 550nm~650nmの波長で98%以上の透過度を有する、請求項1に記載の二次元アモルファス炭素(2DAC)被膜。
- 非六角形炭素環及び六角形炭素環からなる原子構造を有する二次元(2D)アモルファス炭素被膜であって、前記2Dアモルファス炭素被膜が<1の結晶化度(C)を有し、0.2以下のsp3/sp2結合比を有し、かつ、均質であり、ここで、結晶化度(C)=六角形炭素環の数:(六角形炭素環の数+非六角形炭素環の数)である、2Dアモルファス炭素被膜。
- 物品であって、
基材と、
前記基材の表面上に配置された二次元(2D)アモルファス炭素フィルムであって、前記二次元(2D)アモルファス炭素フィルムが<1の結晶化度(C)を有し、0.2以下のsp3/sp2結合比を有し、かつ、均質であり、ここで、前記結晶化度(C)=六角形炭素環の数:(六角形炭素環の数+非六角形炭素環の数)である、2Dアモルファス炭素フィルムと
を備える物品。 - 前記2Dアモルファス炭素フィルムが配置される前記基材の前記表面と前記2Dアモルファス炭素フィルムとの接着エネルギーが≧200J/m2である、請求項9に記載の物品。
- 請求項9に記載の物品の形成方法であって、次の工程:
前駆体ガスを光分解によって分解して少なくとも1種の分解種を生成し;及び
前記基材の表面上の前記少なくとも1種の分解種から前記2Dアモルファス炭素フィルムを形成させること
を含み、前記前駆体ガスが前駆体として炭化水素を含む方法。 - 前記2Dアモルファス炭素フィルムを形成させる前に前記基材を≦500℃の温度に加熱することを含む、請求項11に記載の方法。
- 前記2Dアモルファス炭素フィルムが実質的に前記基材の表面全体にわたる連続フィルムとして形成される、請求項11に記載の方法。
- 前記2Dアモルファス炭素フィルムを前記基材の表面から分離して、自立型の2Dアモルファス炭素フィルムを得ることを含む、請求項11に記載の方法。
- 前記自立型の2Dアモルファス炭素フィルムを別の基材の表面に転写することを含む、請求項11に記載の方法。
- 前記2Dアモルファス炭素フィルムが、550nm~650nmの波長で98%以上の透過度を有する、請求項11に記載の方法。
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762463112P | 2017-02-24 | 2017-02-24 | |
US62/463,112 | 2017-02-24 | ||
US201762546680P | 2017-08-17 | 2017-08-17 | |
US62/546,680 | 2017-08-17 | ||
JP2019546155A JP6993004B2 (ja) | 2017-02-24 | 2018-02-23 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
JP2021166403A JP7118474B2 (ja) | 2017-02-24 | 2021-10-08 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2021166403A Division JP7118474B2 (ja) | 2017-02-24 | 2021-10-08 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2022132618A JP2022132618A (ja) | 2022-09-08 |
JP2022132618A5 JP2022132618A5 (ja) | 2023-04-27 |
JP7501928B2 true JP7501928B2 (ja) | 2024-06-18 |
Family
ID=63245625
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019546155A Active JP6993004B2 (ja) | 2017-02-24 | 2018-02-23 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
JP2021166403A Active JP7118474B2 (ja) | 2017-02-24 | 2021-10-08 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
JP2022117400A Active JP7501928B2 (ja) | 2017-02-24 | 2022-07-22 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019546155A Active JP6993004B2 (ja) | 2017-02-24 | 2018-02-23 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
JP2021166403A Active JP7118474B2 (ja) | 2017-02-24 | 2021-10-08 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
Country Status (7)
Country | Link |
---|---|
US (3) | US11192788B2 (ja) |
EP (1) | EP3585728A4 (ja) |
JP (3) | JP6993004B2 (ja) |
KR (1) | KR102593257B1 (ja) |
CN (1) | CN110312679B (ja) |
SG (1) | SG11201907148SA (ja) |
WO (1) | WO2018156082A1 (ja) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10984830B2 (en) * | 2017-02-24 | 2021-04-20 | The National University Of Singapore | Two dimensional amorphous carbon as overcoat for heat assisted magnetic recording media |
WO2020027728A1 (en) * | 2018-07-30 | 2020-02-06 | National University Of Singapore | Proton conductive two-dimensional amorphous carbon film for gas membrane and fuel cell applications |
US11858812B2 (en) | 2019-05-23 | 2024-01-02 | National University Of Singapore | Monolithic and fractal carbon foams and methods of preparing and using same |
US11145875B2 (en) * | 2019-08-19 | 2021-10-12 | Robert Bosch Gmbh | Fuel cell electrode catalyst layer coating |
WO2021054900A1 (en) * | 2019-09-20 | 2021-03-25 | National University Of Singapore | Electronic device including one or more monolayer amorphous films and method of forming the same |
JP2022550107A (ja) * | 2019-09-30 | 2022-11-30 | ナショナル ユニバーシティー オブ シンガポール | 電極、電気化学セル及びその形成方法 |
US11670790B2 (en) | 2019-11-25 | 2023-06-06 | Robert Bosch Gmbh | Fuel cell membrane electrode assemblies |
US11631863B2 (en) | 2020-03-27 | 2023-04-18 | Robert Bosch Gmbh | Fuel cell catalyst material with defective, carbon-based coating |
US12021245B2 (en) | 2022-08-24 | 2024-06-25 | Robert Bosch Gmbh | Fuel cell electrode catalyst protective layer forming method |
KR20240080842A (ko) | 2022-11-30 | 2024-06-07 | 주식회사 엘엠케이 | 세포 배양용 이질 매체를 갖는 세포 배양 기재 |
KR20240083995A (ko) | 2022-12-06 | 2024-06-13 | 주식회사 엘엠케이 | 다층 구조로 이루어진 세포 배양 기재 |
KR102632873B1 (ko) | 2023-05-02 | 2024-02-06 | 호서대학교 산학협력단 | 세포 배양 성능이 향상된 세포 배양 용기 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002143185A (ja) | 2000-11-13 | 2002-05-21 | Utec:Kk | 歯科用インプラント及びその製造方法 |
JP2005523050A (ja) | 2002-02-06 | 2005-08-04 | オーバス メディカル テクノロジーズ インク. | 内皮細胞の接着および分化を促進するコーティングを有する医療用デバイス |
JP2014004166A (ja) | 2012-06-25 | 2014-01-16 | Hiroshima Univ | インプラント、その製造方法及び骨代謝の制御方法 |
US20160111180A1 (en) | 2014-10-16 | 2016-04-21 | Samsung Electronics Co., Ltd. | Method of forming amorphous carbon monolayer and electronic device including amorphous carbon monolayer |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4725345A (en) | 1985-04-22 | 1988-02-16 | Kabushiki Kaisha Kenwood | Method for forming a hard carbon thin film on article and applications thereof |
US5266409A (en) | 1989-04-28 | 1993-11-30 | Digital Equipment Corporation | Hydrogenated carbon compositions |
US5045165A (en) | 1990-02-01 | 1991-09-03 | Komag, Inc. | Method for sputtering a hydrogen-doped carbon protective film on a magnetic disk |
US5637373A (en) | 1992-11-19 | 1997-06-10 | Semiconductor Energy Laboratory Co., Ltd. | Magnetic recording medium |
JPH0991686A (ja) | 1995-09-26 | 1997-04-04 | Kao Corp | 磁気記録媒体 |
US6780388B2 (en) | 2000-05-31 | 2004-08-24 | Showa Denko K.K. | Electrically conducting fine carbon composite powder, catalyst for polymer electrolyte fuel battery and fuel battery |
TW550672B (en) * | 2001-02-21 | 2003-09-01 | Semiconductor Energy Lab | Method and apparatus for film deposition |
JP2002312923A (ja) | 2001-04-12 | 2002-10-25 | Fujitsu Ltd | 磁気記録媒体 |
JP2004045144A (ja) * | 2002-07-10 | 2004-02-12 | Unitika Ltd | 生化学物質固定用アモルファスカーボン基板 |
JP5217243B2 (ja) * | 2006-05-22 | 2013-06-19 | 株式会社豊田中央研究所 | 非晶質炭素膜、非晶質炭素膜の形成方法、非晶質炭素膜を備えた導電性部材および燃料電池用セパレータ |
US8497050B2 (en) | 2008-07-29 | 2013-07-30 | GM Global Technology Operations LLC | Amorphous carbon coatings for fuel cell bipolar plates |
WO2011016855A1 (en) | 2009-08-04 | 2011-02-10 | Gentex Corporation | Cathodic materials for use in electrochemical sensors and associated devices and methods of manufacturing the same |
US9306099B2 (en) | 2009-12-01 | 2016-04-05 | Samsung Electronics Co., Ltd. | Material including graphene and an inorganic material and method of manufacturing the material |
US9305571B2 (en) | 2009-12-23 | 2016-04-05 | HGST Netherlands B.V. | Magnetic devices and magnetic media with graphene overcoat |
US8999604B2 (en) | 2009-12-25 | 2015-04-07 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Oriented amorphous carbon film and process for forming the same |
US8951401B2 (en) * | 2010-05-28 | 2015-02-10 | Toyota Boshoku Kabushiki Kaisha | Method for electrochemically depositing carbon film on a substrate |
CN102509694B (zh) * | 2011-10-25 | 2015-04-01 | 上海华力微电子有限公司 | 保留部分无定形碳层的方法 |
US20130214875A1 (en) | 2012-02-16 | 2013-08-22 | Elwha Llc | Graphene sheet and nanomechanical resonator |
US8941950B2 (en) | 2012-05-23 | 2015-01-27 | WD Media, LLC | Underlayers for heat assisted magnetic recording (HAMR) media |
JP2014170601A (ja) | 2013-03-01 | 2014-09-18 | Toshiba Corp | 磁気記録媒体、その製造方法、及びスタンパーの製造方法 |
US9363256B2 (en) | 2013-04-11 | 2016-06-07 | Mx Technologies, Inc. | User authentication in separate authentication channels |
US20150093684A1 (en) | 2013-09-30 | 2015-04-02 | Nissan North America, Inc. | Fuel cell membrane with crossover barrier |
EP3102538B1 (en) * | 2014-02-04 | 2020-10-07 | National University of Singapore | Method of pulsed laser-based large area graphene synthesis on metallic and crystalline substrates |
WO2015156736A1 (en) | 2014-04-07 | 2015-10-15 | National University Of Singapore | Graphene as a protective overcoat for magnetic media without the use of a nucleation layer |
GB201416527D0 (en) | 2014-09-18 | 2014-11-05 | Univ Manchester | Graphene membrane |
KR20170088961A (ko) | 2014-11-26 | 2017-08-02 | 윌리엄 마쉬 라이스 유니버시티 | 전자 장치용 레이저 유도 그래핀 하이브리드 물질 |
MY191207A (en) | 2015-07-29 | 2022-06-08 | Nat Univ Singapore | A method of protecting a magnetic layer of a magnetic recording medium |
US10984830B2 (en) | 2017-02-24 | 2021-04-20 | The National University Of Singapore | Two dimensional amorphous carbon as overcoat for heat assisted magnetic recording media |
JP2019010013A (ja) | 2017-06-29 | 2019-01-24 | 株式会社ニコン | 細胞選別用物品及び細胞選別方法 |
-
2018
- 2018-02-21 US US15/901,099 patent/US11192788B2/en active Active
- 2018-02-23 SG SG11201907148SA patent/SG11201907148SA/en unknown
- 2018-02-23 WO PCT/SG2018/050082 patent/WO2018156082A1/en unknown
- 2018-02-23 JP JP2019546155A patent/JP6993004B2/ja active Active
- 2018-02-23 CN CN201880013364.XA patent/CN110312679B/zh active Active
- 2018-02-23 EP EP18757600.4A patent/EP3585728A4/en active Pending
- 2018-02-23 KR KR1020197027503A patent/KR102593257B1/ko active IP Right Grant
- 2018-07-30 US US16/049,034 patent/US11114674B2/en active Active
-
2020
- 2020-09-24 US US17/030,480 patent/US20210017026A1/en active Pending
-
2021
- 2021-10-08 JP JP2021166403A patent/JP7118474B2/ja active Active
-
2022
- 2022-07-22 JP JP2022117400A patent/JP7501928B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002143185A (ja) | 2000-11-13 | 2002-05-21 | Utec:Kk | 歯科用インプラント及びその製造方法 |
JP2005523050A (ja) | 2002-02-06 | 2005-08-04 | オーバス メディカル テクノロジーズ インク. | 内皮細胞の接着および分化を促進するコーティングを有する医療用デバイス |
JP2014004166A (ja) | 2012-06-25 | 2014-01-16 | Hiroshima Univ | インプラント、その製造方法及び骨代謝の制御方法 |
US20160111180A1 (en) | 2014-10-16 | 2016-04-21 | Samsung Electronics Co., Ltd. | Method of forming amorphous carbon monolayer and electronic device including amorphous carbon monolayer |
Non-Patent Citations (2)
Title |
---|
J. APPL. POLYM. SCI.,2014年,Vol.131,Ariticle No.40427 |
PHYSICAL REVIEW LETTERS,2011年,Vol.106, Article No.105505,pp.1-4 |
Also Published As
Publication number | Publication date |
---|---|
JP2022001551A (ja) | 2022-01-06 |
US20180244524A1 (en) | 2018-08-30 |
KR20190122726A (ko) | 2019-10-30 |
KR102593257B1 (ko) | 2023-10-23 |
US20180337411A1 (en) | 2018-11-22 |
CN110312679B (zh) | 2024-08-09 |
JP2022132618A (ja) | 2022-09-08 |
JP7118474B2 (ja) | 2022-08-16 |
JP2020510590A (ja) | 2020-04-09 |
SG11201907148SA (en) | 2019-09-27 |
CN110312679A (zh) | 2019-10-08 |
EP3585728A4 (en) | 2020-12-23 |
WO2018156082A1 (en) | 2018-08-30 |
US11192788B2 (en) | 2021-12-07 |
US11114674B2 (en) | 2021-09-07 |
US20210017026A1 (en) | 2021-01-21 |
JP6993004B2 (ja) | 2022-02-03 |
EP3585728A1 (en) | 2020-01-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7501928B2 (ja) | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 | |
Aryaei et al. | The effect of graphene substrate on osteoblast cell adhesion and proliferation | |
Mitura et al. | Nanocrystalline diamond coatings | |
Li et al. | CVD growth of graphene on NiTi alloy for enhanced biological activity | |
Convertino et al. | Peripheral neuron survival and outgrowth on graphene | |
Lipski et al. | Nanoscale engineering of biomaterial surfaces | |
Tutak et al. | The chemical and physical characteristics of single-walled carbon nanotube film impact on osteoblastic cell response | |
Jo et al. | Hydroxyapatite precipitation on nanotubular films formed on Ti-6Al-4V alloy for biomedical applications | |
Švorčík et al. | Cytocompatibility of polymers grafted by activated carbon nano-particles | |
Ion et al. | Surface plasma functionalization influences macrophage behavior on carbon nanowalls | |
Shen et al. | Control of hydroxyapatite coating by self‐assembled monolayers on titanium and improvement of osteoblast adhesion | |
Chi et al. | Biomimetic hydroxyapatite grown on biomedical polymer coated with titanium dioxide interlayer to assist osteocompatible performance | |
Chen et al. | Behavior of cultured human umbilical vein endothelial cells on titanium oxide films fabricated by plasma immersion ion implantation and deposition | |
Cheng et al. | Effect of plasma energy on enhancing biocompatibility and hemocompatibility of diamond-like carbon film with various titanium concentrations | |
Wang et al. | Regulating the behavior of human gingival fibroblasts by sp2 domains in reduced graphene oxide | |
Ou et al. | Surface properties of nano–structural silicon–doped carbon films for biomedical applications | |
Wei et al. | Rapid fabrication, microstructure, and in vitro and in vivo investigations of a high-performance multilayer coating with external, flexible, and silicon-doped hydroxyapatite nanorods on titanium | |
Hsu et al. | Fabrication of biomolecules coated nanostructured oxide layer to facilitate cell adhesion and proliferation for improving osseointegration | |
WO2021007922A1 (zh) | 石墨烯人工耳蜗电极及其制作方法 | |
Xiao et al. | In situ fabrication of anatase thin films with high percentage of exposed {001} facets to improve biocompatibility with MC3T3-E1 cells | |
Chen et al. | Effect of Ar plasma etching of Ti–O film surfaces on biological behavior of endothelial cell | |
Ichikawa et al. | Gene expression of osteoblast-like cells on carbon-nanowall as scaffolds during incubation with electrical stimulation | |
Jamesh et al. | Graded metal carbon protein binding films prepared by hybrid cathodic arc—Glow discharge plasma assisted chemical vapor deposition | |
Chen et al. | Effect of tantalum content of titanium oxide film fabricated by magnetron sputtering on the behavior of cultured human umbilical vein endothelial cells (HUVEC) | |
RO133145A2 (ro) | Acoperiri compozite de grafene-sericină mediate prin polidopamină pe suporturi plane |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220822 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230419 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230912 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20231211 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240312 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20240509 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20240530 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 7501928 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |