JP6993004B2 - 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 - Google Patents
二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 Download PDFInfo
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Description
本発明は、概して、二次元アモルファス炭素(2DAC)被膜及び物品、並びに幹細胞の成長及び分化方法に関する。
従来技術には、生物医学用途などの特定の目的を意図した被膜に好適な用途を開発し提供するための要望が存在する。
定義
用語の定義が一般的に使用される用語の意味から逸脱する場合、出願人は、特に示さない限り、以下に与える定義を使用するものとする。
本発明は、様々な改変及び別の形態が可能であるが、その特定の実施形態は、図面に例示として示されており、かつ、以下で詳細に説明する。しかし、本発明を開示された特定の形態に限定することを意図するものではなく、逆に、本発明は、本発明の精神及び範囲内にある全ての改変物、均等物及び代替物を包含するものとする。
例1
実施例の主題
本発明の2DACのプロセスパラメータとしては、次のものを挙げることができる:(i)プロセスガス:CH4(ii)チャンバー圧力:2.0E-2mbar;(iii)レーザーフルエンス:70mJ/cm2;(iv)成長時間:1分;(v)プラズマ出力:5W;(vi)基材:銅箔。
次の参考文献は上で参照されており、参照により本明細書において援用する。
1. Ferrari, A.C. et al. “Interpretation of Raman spectra of disordered and amorphous carbon.” Physical Review B 61, 14095-14107 (2000).
2. Robertson, J. “Ultrathin carbon coatings for magnetic storage technology.” Thin Solid Films 383, 81-88 (2001).
3. Hu, S. et al. “Proton transport through one-atom-thick crystals.” Nature 516, 227-230 (2014).
4. Das, S. et al. “Measurements of adhesion energy of graphene to metallic substrates.” Carbon 59, 121-129 (2013).
5. Schriver, M. et al. “Graphene as a Long-Term Metal Oxidation Barrier: Worse Than Nothing” ACS Nano 7, 5763-5768 (2013).
6. Wang, J. S. et al. “The mechanical performance of DLC films on steel substrates.” Thin Solid Films 325, 163-174 (1998).
7. Leng, Y. X. et al. “Mechanical properties and platelet adhesion behavior of diamond-like carbon films synthesized by pulsed vacuum arc plasma deposition.” Surface Science 531, 177-184 (2003).
8. Maguire, P. D. et al. “Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires.” Diamond and Related Materials 14, 1277-1288 (2005).
9. Marcon, et. al. “The head-disk interface roadmap to an areal density of 4 Tbit/in2.” Advances in Tribology 2013, 1-8 (2013).
10. Discher, D. E., Mooney, D. J. & Zandstra, P. W. “Growth Factors, Matrices, and Forces Combine and Control Stem Cells.” Science 324, 1673-1677 (2009).
11. Spradling, A., Drummond-Barbosa, D. & Kai, T. “Stem cells find their niche.” Nature 414, 98-104 (2001).
12. Murry, C. E. & Keller, G. “Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development.” Cell 132, 661-680 (2008).
13. Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. “Matrix Elasticity Directs Stem Cell Lineage Specification.” Cell 126, 677-689 (2006).
14. Dalby, M. J. et al. “The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder.” Nature Materials 6, 997-1003 (2007).
15. Trappmann, B. et al. “Extracellular-matrix tethering regulates stem-cell fate.” Nature Materials 11, 642-649 (2012).
16. Lee, H. et al. “Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.” Scientific Reports 6, 20708 (2016).
17. Choi, W. J. et al. ”Effects of substrate conductivity on cell morphogenesis and proliferation using tailored, atomic layer deposition-grown ZnO thin films.” Scientific Reports 5, 9974 (2015).
Claims (1)
- 二次元(2D)アモルファス炭素フィルムの形成方法であって、前記2Dアモルファス炭素フィルムが0.8以下の結晶化度(C)を有し、前記方法が、
前駆体ガスを光分解によって分解して少なくとも1種の分解種を生成し、及び
前記少なくとも1種の分解種から2Dアモルファス炭素フィルムを基材の表面上に形成すること
を含み、
前記前駆体ガスが前駆体として炭化水素を含む、前記方法。
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JP2021166403A JP7118474B2 (ja) | 2017-02-24 | 2021-10-08 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
JP2022117400A JP2022132618A (ja) | 2017-02-24 | 2022-07-22 | 二次元アモルファス炭素被膜並びに幹細胞の成長及び分化方法 |
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US201762463112P | 2017-02-24 | 2017-02-24 | |
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US201762546680P | 2017-08-17 | 2017-08-17 | |
US62/546,680 | 2017-08-17 | ||
PCT/SG2018/050082 WO2018156082A1 (en) | 2017-02-24 | 2018-02-23 | Two-dimensional amorphous carbon coating and methods of growing and differentiating stem cells |
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US10984830B2 (en) * | 2017-02-24 | 2021-04-20 | The National University Of Singapore | Two dimensional amorphous carbon as overcoat for heat assisted magnetic recording media |
WO2020027728A1 (en) * | 2018-07-30 | 2020-02-06 | National University Of Singapore | Proton conductive two-dimensional amorphous carbon film for gas membrane and fuel cell applications |
US11858812B2 (en) | 2019-05-23 | 2024-01-02 | National University Of Singapore | Monolithic and fractal carbon foams and methods of preparing and using same |
US11145875B2 (en) * | 2019-08-19 | 2021-10-12 | Robert Bosch Gmbh | Fuel cell electrode catalyst layer coating |
CN114402091A (zh) * | 2019-09-20 | 2022-04-26 | 新加坡国立大学 | 包括一层或多层单层无定形膜的电子器件及其形成方法 |
JP2022550107A (ja) * | 2019-09-30 | 2022-11-30 | ナショナル ユニバーシティー オブ シンガポール | 電極、電気化学セル及びその形成方法 |
US11670790B2 (en) | 2019-11-25 | 2023-06-06 | Robert Bosch Gmbh | Fuel cell membrane electrode assemblies |
US11631863B2 (en) | 2020-03-27 | 2023-04-18 | Robert Bosch Gmbh | Fuel cell catalyst material with defective, carbon-based coating |
KR102632873B1 (ko) | 2023-05-02 | 2024-02-06 | 호서대학교 산학협력단 | 세포 배양 성능이 향상된 세포 배양 용기 |
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JP2002143185A (ja) | 2000-11-13 | 2002-05-21 | Utec:Kk | 歯科用インプラント及びその製造方法 |
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CN110312679A (zh) | 2019-10-08 |
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