JP7486920B2 - アポリポタンパク質（ａ）発現の調節 - Google Patents

アポリポタンパク質（ａ）発現の調節 Download PDF

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JP7486920B2
JP7486920B2 JP2018519962A JP2018519962A JP7486920B2 JP 7486920 B2 JP7486920 B2 JP 7486920B2 JP 2018519962 A JP2018519962 A JP 2018519962A JP 2018519962 A JP2018519962 A JP 2018519962A JP 7486920 B2 JP7486920 B2 JP 7486920B2
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oligomeric compound
human
pharmaceutical composition
isis
certain embodiments
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JP2018531605A5 (OSRAM
JP2018531605A (ja
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バイニー，ニコラス・ジェイ
ギアリー，リチャード・エス
ワン，ヤンフェン
ユー，ツェンロン
グナワン，ルディ
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Ionis Pharmaceuticals Inc
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Ionis Pharmaceuticals Inc
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Priority to JP2021128986A priority Critical patent/JP2021185149A/ja
Priority to JP2023083529A priority patent/JP2023116477A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
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  • Obesity (AREA)
  • Diabetes (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018519962A 2015-11-06 2016-11-07 アポリポタンパク質（ａ）発現の調節 Active JP7486920B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021128986A JP2021185149A (ja) 2015-11-06 2021-08-05 アポリポタンパク質（ａ）発現の調節
JP2023083529A JP2023116477A (ja) 2015-11-06 2023-05-19 アポリポタンパク質（ａ）発現の調節

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US201562252392P 2015-11-06 2015-11-06
US62/252,392 2015-11-06
PCT/US2016/060816 WO2017079739A1 (en) 2015-11-06 2016-11-07 MODULATING APOLIPOPROTEIN (a) EXPRESSION

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JP2021128986A Division JP2021185149A (ja) 2015-11-06 2021-08-05 アポリポタンパク質（ａ）発現の調節
JP2023083529A Division JP2023116477A (ja) 2015-11-06 2023-05-19 アポリポタンパク質（ａ）発現の調節

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JP2018531605A JP2018531605A (ja) 2018-11-01
JP2018531605A5 JP2018531605A5 (OSRAM) 2019-12-19
JP7486920B2 true JP7486920B2 (ja) 2024-05-20

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JP2018519962A Active JP7486920B2 (ja) 2015-11-06 2016-11-07 アポリポタンパク質（ａ）発現の調節
JP2021128986A Pending JP2021185149A (ja) 2015-11-06 2021-08-05 アポリポタンパク質（ａ）発現の調節
JP2023083529A Pending JP2023116477A (ja) 2015-11-06 2023-05-19 アポリポタンパク質（ａ）発現の調節

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JP2023083529A Pending JP2023116477A (ja) 2015-11-06 2023-05-19 アポリポタンパク質（ａ）発現の調節

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US (3) US10557137B2 (OSRAM)
EP (1) EP3370708A4 (OSRAM)
JP (3) JP7486920B2 (OSRAM)
KR (2) KR20250078597A (OSRAM)
CN (2) CN108348478A (OSRAM)
AU (3) AU2016349625B2 (OSRAM)
BR (1) BR122023026882A2 (OSRAM)
CA (1) CA2999341A1 (OSRAM)
CL (1) CL2018001221A1 (OSRAM)
CO (1) CO2018002198A2 (OSRAM)
IL (3) IL257647B (OSRAM)
MX (2) MX2018005277A (OSRAM)
MY (1) MY203086A (OSRAM)
NZ (1) NZ740026A (OSRAM)
PE (2) PE20241347A1 (OSRAM)
WO (1) WO2017079739A1 (OSRAM)
ZA (1) ZA201801208B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013173789A2 (en) 2012-05-17 2013-11-21 Isis Pharmaceuticals, Inc. Antisense oligonucleotide compositions
PL2992098T3 (pl) 2013-05-01 2019-09-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji hbv i ttr
SMT202400375T1 (it) * 2015-11-06 2024-11-15 Ionis Pharmaceuticals Inc Composti antisenso coniugati per uso in terapia
KR20250078597A (ko) 2015-11-06 2025-06-02 아이오니스 파마수티컬즈, 인코포레이티드 아포리포프로테인 (a) 발현 조정
EP3877523A1 (en) 2018-11-09 2021-09-15 Novartis AG Method for reducing the risk of a cardiovascular event with conjugated antisense compounds targeting apo(a)
US20220404378A1 (en) * 2019-11-14 2022-12-22 The Regents Of The University Of California Methods and compositions for determining oxpl-associated diseases and disorders
US20230293646A1 (en) * 2022-03-21 2023-09-21 Crispr Therapeutics Ag Methods and compositions for treating lipoprotein-related diseases

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2014179625A1 (en) 2013-05-01 2014-11-06 Isis Pharmaceuticals, Inc. COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION

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「新医薬品の臨床評価に関する一般指針について」、平成４年６月２９日、薬新薬第四三号、厚生省薬務局新医薬品課長通知、［ｈｔｔｐｓ：／／ｗｗｗ．ｐｍｄａ．ｇｏ．ｊｐ／ｆｉｌｅｓ／０００２０６７３９．ｐｄｆ］
ＦＡＳＥＢ Ｊ．，２００７，Ｖｏｌ．２２，ｐｐ．６５９－６６１
Ｌａｎｃｅｔ，２０１５年 ７月，Ｖｏｌ．３８６，ｐｐ．１４７２－１４８３

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US20200362340A1 (en) 2020-11-19
JP2021185149A (ja) 2021-12-09
IL324328A (en) 2025-12-01
IL257647B (en) 2021-08-31
US11319536B2 (en) 2022-05-03
KR102811595B1 (ko) 2025-05-22
AU2016349625B2 (en) 2022-07-07
WO2017079739A1 (en) 2017-05-11
JP2023116477A (ja) 2023-08-22
MX2023014444A (es) 2023-12-15
AU2022204221A1 (en) 2022-07-07
EP3370708A4 (en) 2019-06-26
US12410430B2 (en) 2025-09-09
PE20181180A1 (es) 2018-07-20
JP2018531605A (ja) 2018-11-01
CA2999341A1 (en) 2017-05-11
NZ740026A (en) 2025-07-25
MY203086A (en) 2024-06-07
BR122023026882A2 (pt) 2024-01-23
BR112018003291A2 (pt) 2018-09-25
CN108348478A (zh) 2018-07-31
PE20241347A1 (es) 2024-07-03
US20190136233A1 (en) 2019-05-09
IL257647A (en) 2018-04-30
AU2024204501A1 (en) 2024-07-18
US10557137B2 (en) 2020-02-11
KR20250078597A (ko) 2025-06-02
CO2018002198A2 (es) 2018-05-10
MX2018005277A (es) 2018-08-01
US20240218361A1 (en) 2024-07-04
CL2018001221A1 (es) 2018-12-28
AU2016349625A1 (en) 2018-03-15
IL285132A (en) 2021-08-31
ZA201801208B (en) 2020-06-24
CN113952353A (zh) 2022-01-21
KR20180073606A (ko) 2018-07-02
EP3370708A1 (en) 2018-09-12

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