JP7461078B2 - 溶液中の粒子の特徴付け - Google Patents

溶液中の粒子の特徴付け Download PDF

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JP7461078B2
JP7461078B2 JP2022525259A JP2022525259A JP7461078B2 JP 7461078 B2 JP7461078 B2 JP 7461078B2 JP 2022525259 A JP2022525259 A JP 2022525259A JP 2022525259 A JP2022525259 A JP 2022525259A JP 7461078 B2 JP7461078 B2 JP 7461078B2
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container
particles
sample
light
measurements
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JP2023500642A (ja
JP2023500642A5 (enExample
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バースケ，フィリップ
デリクス，ヨナタン
ハスリンガー，ロベルト
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ナノテンパー・テクノロジーズ・ゲーエムベーハー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
JP2022525259A 2019-11-08 2020-11-06 溶液中の粒子の特徴付け Active JP7461078B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910.1 2020-09-23
EP20197910 2020-09-23
PCT/EP2020/081370 WO2021089834A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (3)

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JP2023500642A JP2023500642A (ja) 2023-01-10
JP2023500642A5 JP2023500642A5 (enExample) 2023-01-24
JP7461078B2 true JP7461078B2 (ja) 2024-04-03

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JP2022525259A Active JP7461078B2 (ja) 2019-11-08 2020-11-06 溶液中の粒子の特徴付け
JP2022525257A Pending JP2023501942A (ja) 2019-11-08 2020-11-06 溶液中の粒子の特徴付け

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US (2) US12618848B2 (enExample)
EP (2) EP4055365B1 (enExample)
JP (2) JP7461078B2 (enExample)
KR (2) KR102891303B1 (enExample)
CN (2) CN114930151A (enExample)
AU (2) AU2020379227B2 (enExample)
CA (1) CA3153480A1 (enExample)
WO (2) WO2021089841A1 (enExample)

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JP7461078B2 (ja) * 2019-11-08 2024-04-03 ナノテンパー・テクノロジーズ・ゲーエムベーハー 溶液中の粒子の特徴付け
JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis
CN119757675B (zh) * 2024-12-27 2025-10-17 浙江大学 一种预测或评估mRNA-LNP液体制剂稳定性的方法及其应用

Citations (3)

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US20100136611A1 (en) 2007-02-02 2010-06-03 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
JP2018507387A (ja) 2014-12-12 2018-03-15 ナノテンパー・テクノロジーズ・ゲーエムベーハー 無封止でキャピラリをテンパリングする方法およびシステム
US20180313758A1 (en) 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

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Publication number Priority date Publication date Assignee Title
US20100136611A1 (en) 2007-02-02 2010-06-03 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
JP2018507387A (ja) 2014-12-12 2018-03-15 ナノテンパー・テクノロジーズ・ゲーエムベーハー 無封止でキャピラリをテンパリングする方法およびシステム
US20180313758A1 (en) 2017-05-01 2018-11-01 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample

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Publication number Publication date
WO2021089841A9 (en) 2022-06-30
US20220373557A1 (en) 2022-11-24
KR20220093215A (ko) 2022-07-05
CN114930152B (zh) 2026-04-03
JP2023500642A (ja) 2023-01-10
WO2021089834A1 (en) 2021-05-14
EP4055365C0 (en) 2026-01-21
AU2020379227B2 (en) 2025-11-06
US20220404284A1 (en) 2022-12-22
EP4055366C0 (en) 2026-02-18
CN114930151A (zh) 2022-08-19
EP4055366B1 (en) 2026-02-18
KR102891303B1 (ko) 2025-11-26
US12618848B2 (en) 2026-05-05
CA3153480A1 (en) 2021-05-14
AU2020379227A1 (en) 2022-04-21
CN114930152A (zh) 2022-08-19
WO2021089841A1 (en) 2021-05-14
KR20220092620A (ko) 2022-07-01
AU2020378640A1 (en) 2022-04-28
JP2023501942A (ja) 2023-01-20
EP4055366A1 (en) 2022-09-14
EP4055365A1 (en) 2022-09-14
EP4055365B1 (en) 2026-01-21

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