CN114930151A - 溶液中颗粒的特征化 - Google Patents

溶液中颗粒的特征化 Download PDF

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Publication number
CN114930151A
CN114930151A CN202080092388.6A CN202080092388A CN114930151A CN 114930151 A CN114930151 A CN 114930151A CN 202080092388 A CN202080092388 A CN 202080092388A CN 114930151 A CN114930151 A CN 114930151A
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CN
China
Prior art keywords
container
particles
light
sample
measurement
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Pending
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CN202080092388.6A
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English (en)
Chinese (zh)
Inventor
菲利普·巴斯克
乔纳森·德里克斯
罗伯特·哈斯林格
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Nortemp Technology Co ltd
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Nortemp Technology Co ltd
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Publication of CN114930151A publication Critical patent/CN114930151A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
CN202080092388.6A 2019-11-08 2020-11-06 溶液中颗粒的特征化 Pending CN114930151A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910.1 2020-09-23
EP20197910 2020-09-23
PCT/EP2020/081378 WO2021089841A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (1)

Publication Number Publication Date
CN114930151A true CN114930151A (zh) 2022-08-19

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CN202080092388.6A Pending CN114930151A (zh) 2019-11-08 2020-11-06 溶液中颗粒的特征化
CN202080092390.3A Active CN114930152B (zh) 2019-11-08 2020-11-06 溶液中颗粒的特征化

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Country Status (8)

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US (2) US12618848B2 (enExample)
EP (2) EP4055365B1 (enExample)
JP (2) JP7461078B2 (enExample)
KR (2) KR102891303B1 (enExample)
CN (2) CN114930151A (enExample)
AU (2) AU2020379227B2 (enExample)
CA (1) CA3153480A1 (enExample)
WO (2) WO2021089841A1 (enExample)

Cited By (3)

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CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
WO2026139031A1 (zh) * 2024-12-27 2026-07-02 浙江大学 一种预测或评估mRNA-LNP液体制剂稳定性的方法及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7461078B2 (ja) * 2019-11-08 2024-04-03 ナノテンパー・テクノロジーズ・ゲーエムベーハー 溶液中の粒子の特徴付け
JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis

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CN108139309A (zh) * 2015-10-01 2018-06-08 微量热技术有限公司 用于光学地测量颗粒的稳定性和聚集的系统和方法
CN108983252A (zh) * 2018-07-30 2018-12-11 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法

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EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
CN107782643A (zh) * 2017-09-27 2018-03-09 华中科技大学 一种高浓度颗粒群的光纤动态光散射检测方法
CN108983252A (zh) * 2018-07-30 2018-12-11 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
WO2026139031A1 (zh) * 2024-12-27 2026-07-02 浙江大学 一种预测或评估mRNA-LNP液体制剂稳定性的方法及其应用

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Publication number Publication date
WO2021089841A9 (en) 2022-06-30
US20220373557A1 (en) 2022-11-24
KR20220093215A (ko) 2022-07-05
CN114930152B (zh) 2026-04-03
JP7461078B2 (ja) 2024-04-03
JP2023500642A (ja) 2023-01-10
WO2021089834A1 (en) 2021-05-14
EP4055365C0 (en) 2026-01-21
AU2020379227B2 (en) 2025-11-06
US20220404284A1 (en) 2022-12-22
EP4055366C0 (en) 2026-02-18
EP4055366B1 (en) 2026-02-18
KR102891303B1 (ko) 2025-11-26
US12618848B2 (en) 2026-05-05
CA3153480A1 (en) 2021-05-14
AU2020379227A1 (en) 2022-04-21
CN114930152A (zh) 2022-08-19
WO2021089841A1 (en) 2021-05-14
KR20220092620A (ko) 2022-07-01
AU2020378640A1 (en) 2022-04-28
JP2023501942A (ja) 2023-01-20
EP4055366A1 (en) 2022-09-14
EP4055365A1 (en) 2022-09-14
EP4055365B1 (en) 2026-01-21

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Application publication date: 20220819