CA3153480A1 - Characterization of particles in solution - Google Patents

Characterization of particles in solution Download PDF

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Publication number
CA3153480A1
CA3153480A1 CA3153480A CA3153480A CA3153480A1 CA 3153480 A1 CA3153480 A1 CA 3153480A1 CA 3153480 A CA3153480 A CA 3153480A CA 3153480 A CA3153480 A CA 3153480A CA 3153480 A1 CA3153480 A1 CA 3153480A1
Authority
CA
Canada
Prior art keywords
vessel
particles
measurement
light
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3153480A
Other languages
English (en)
French (fr)
Inventor
Philipp Baaske
Jonathan Derix
Robert Haslinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NanoTemper Technologies GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA3153480A1 publication Critical patent/CA3153480A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0092—Monitoring flocculation or agglomeration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/019—Biological contaminants; Fouling
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0222—Investigating a scatter or diffraction pattern from dynamic light scattering, e.g. photon correlation spectroscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
CA3153480A 2019-11-08 2020-11-06 Characterization of particles in solution Pending CA3153480A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19208187 2019-11-08
EP19208187.5 2019-11-08
EP20197910.1 2020-09-23
EP20197910 2020-09-23
PCT/EP2020/081370 WO2021089834A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Publications (1)

Publication Number Publication Date
CA3153480A1 true CA3153480A1 (en) 2021-05-14

Family

ID=73040120

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3153480A Pending CA3153480A1 (en) 2019-11-08 2020-11-06 Characterization of particles in solution

Country Status (8)

Country Link
US (2) US12618848B2 (enExample)
EP (2) EP4055365B1 (enExample)
JP (2) JP7461078B2 (enExample)
KR (2) KR102891303B1 (enExample)
CN (2) CN114930151A (enExample)
AU (2) AU2020379227B2 (enExample)
CA (1) CA3153480A1 (enExample)
WO (2) WO2021089841A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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JP7461078B2 (ja) * 2019-11-08 2024-04-03 ナノテンパー・テクノロジーズ・ゲーエムベーハー 溶液中の粒子の特徴付け
JP7658575B2 (ja) 2021-09-09 2025-04-08 国立大学法人東京農工大学 生体試料中のミスフォールディングタンパク質検出方法
EP4328569A1 (en) * 2022-08-23 2024-02-28 NanoTemper Technologies GmbH Measuring high protein concentrations
CN116735436A (zh) * 2023-06-27 2023-09-12 沈阳农业大学 一种zeta电位快速测定土壤胶体临界聚沉浓度的方法
EP4654117A1 (en) * 2024-05-20 2025-11-26 Malvern Panalytical Limited Material characterisation trend analysis
CN119757675B (zh) * 2024-12-27 2025-10-17 浙江大学 一种预测或评估mRNA-LNP液体制剂稳定性的方法及其应用

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JPH05506928A (ja) * 1990-04-23 1993-10-07 ソリッド　ステイト　ファームズ　インコーポレイテッド 沈降式血液分析装置および方法
US5328822A (en) 1990-04-23 1994-07-12 Solid State Farms, Inc. Apparatus and method for sedimentation based blood analysis
US5973779A (en) 1996-03-29 1999-10-26 Ansari; Rafat R. Fiber-optic imaging probe
CA2288476C (en) * 1998-11-05 2010-10-12 Denwood F. Ross, Iii Missing lens detection system and method
AU2003247276A1 (en) * 2002-02-20 2003-09-09 Affinium Pharmaceuticals, Inc. Methods and apparatuses for characterizing stability of biological molecules
FR2856792B1 (fr) * 2003-06-27 2006-09-15 Commissariat Energie Atomique Procede et dispositif de dosage d'un echantillon biologique ou chimique
JP2007518991A (ja) * 2004-01-14 2007-07-12 ルミネックス・コーポレーション ダイナミックレンジを拡大する方法及びシステム
DE102004005878A1 (de) * 2004-02-05 2005-09-01 Rina-Netzwerk Rna Technologien Gmbh Verfahren zur Überwachung der Herstellung von Biomolekülkristallen
EP1856777A4 (en) * 2005-01-24 2009-04-29 Thorlabs Inc COMPACT MULTIMODE LASER WITH FAST WAVELENGTH PATTERN
EP2115424B1 (en) * 2007-02-02 2018-10-24 Canadian Blood Services Method of detecting bacterial contamination using dynamic light scattering
CN102713575A (zh) * 2010-01-15 2012-10-03 三井造船株式会社 荧光检测装置和荧光检测方法
DE102010005962B4 (de) * 2010-01-21 2012-01-26 Alv-Laser Vertriebsgesellschaft Mbh Verfahren zur Bestimmung der statischen und/oder dynamischen Lichtstreuung
DE102011055330B4 (de) * 2011-11-14 2024-10-31 Leica Microsystems Cms Gmbh Verfahren zum Messen der Lebensdauer eines angeregten Zustandes in einer Probe
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KR20170013768A (ko) * 2015-07-28 2017-02-07 울산과학기술원 라만 센서 및 라만 분석 방법
PT3150988T (pt) * 2015-10-01 2021-04-30 Nanotemper Tech Gmbh Sistema e processo para a medição ótica da estabilidade e da agregação de partículas
CA3000822A1 (en) 2015-10-01 2017-04-06 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
EP3159674A1 (en) * 2015-10-19 2017-04-26 European Molecular Biology Laboratory Measurement cell for saxs measurements and for dls measurements
US9554738B1 (en) * 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
US11709120B2 (en) * 2016-04-06 2023-07-25 Covidien Ag System for blood flow measurement with affixed laser speckle contrast analysis
KR101934926B1 (ko) * 2017-01-10 2019-01-03 충남대학교산학협력단 유동 유체 내의 나노입자 거동 예측 방법 및 장치
US10473591B2 (en) * 2017-05-01 2019-11-12 Wyatt Technology Corporation High throughput method and apparatus for measuring multiple optical properties of a liquid sample
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CN108983252B (zh) * 2018-07-30 2022-08-26 武汉舒博光电技术有限公司 双光束超分辨定位系统及方法
JP7461078B2 (ja) * 2019-11-08 2024-04-03 ナノテンパー・テクノロジーズ・ゲーエムベーハー 溶液中の粒子の特徴付け

Also Published As

Publication number Publication date
WO2021089841A9 (en) 2022-06-30
US20220373557A1 (en) 2022-11-24
KR20220093215A (ko) 2022-07-05
CN114930152B (zh) 2026-04-03
JP7461078B2 (ja) 2024-04-03
JP2023500642A (ja) 2023-01-10
WO2021089834A1 (en) 2021-05-14
EP4055365C0 (en) 2026-01-21
AU2020379227B2 (en) 2025-11-06
US20220404284A1 (en) 2022-12-22
EP4055366C0 (en) 2026-02-18
CN114930151A (zh) 2022-08-19
EP4055366B1 (en) 2026-02-18
KR102891303B1 (ko) 2025-11-26
US12618848B2 (en) 2026-05-05
AU2020379227A1 (en) 2022-04-21
CN114930152A (zh) 2022-08-19
WO2021089841A1 (en) 2021-05-14
KR20220092620A (ko) 2022-07-01
AU2020378640A1 (en) 2022-04-28
JP2023501942A (ja) 2023-01-20
EP4055366A1 (en) 2022-09-14
EP4055365A1 (en) 2022-09-14
EP4055365B1 (en) 2026-01-21

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