JP7434151B2 - Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害 - Google Patents

Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害 Download PDF

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JP7434151B2
JP7434151B2 JP2020520550A JP2020520550A JP7434151B2 JP 7434151 B2 JP7434151 B2 JP 7434151B2 JP 2020520550 A JP2020520550 A JP 2020520550A JP 2020520550 A JP2020520550 A JP 2020520550A JP 7434151 B2 JP7434151 B2 JP 7434151B2
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hsd17b13
seq
protein
nucleic acid
pnpla3
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JP2020536560A (ja
JP2020536560A5 (https=
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シン、ユーロン
グロマダ、ジェスパー
チェン、シーピン
デューイ、フレデリック
ドスタル、ターニャ テスロヴィッチ
シュールマン、クラウディア
バラス、アリス
アブル－フスン、ノウラ
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020520550A 2017-10-11 2018-10-11 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害 Active JP7434151B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024017035A JP7770438B2 (ja) 2017-10-11 2024-02-07 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害
JP2025185345A JP2026016717A (ja) 2017-10-11 2025-11-04 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570985P 2017-10-11 2017-10-11
US62/570,985 2017-10-11
PCT/US2018/055377 WO2019075181A1 (en) 2017-10-11 2018-10-11 INHIBITION OF HSD17B13 IN THE TREATMENT OF HEPATIC DISEASE IN PATIENTS EXPRESSING PNPLA3 I148M VARIATION

Related Child Applications (1)

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JP2024017035A Division JP7770438B2 (ja) 2017-10-11 2024-02-07 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害

Publications (3)

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JP2020536560A JP2020536560A (ja) 2020-12-17
JP2020536560A5 JP2020536560A5 (https=) 2021-11-25
JP7434151B2 true JP7434151B2 (ja) 2024-02-20

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JP2020520550A Active JP7434151B2 (ja) 2017-10-11 2018-10-11 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害
JP2024017035A Active JP7770438B2 (ja) 2017-10-11 2024-02-07 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害
JP2025185345A Pending JP2026016717A (ja) 2017-10-11 2025-11-04 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害

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JP2024017035A Active JP7770438B2 (ja) 2017-10-11 2024-02-07 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害
JP2025185345A Pending JP2026016717A (ja) 2017-10-11 2025-11-04 Ｐｎｐｌａ３ ｉ１４８ｍの変異を発現している患者の肝疾患の治療におけるｈｓｄ１７ｂ１３の阻害

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US (4) US10961583B2 (https=)
EP (3) EP4685243A3 (https=)
JP (3) JP7434151B2 (https=)
KR (2) KR102694809B1 (https=)
CN (1) CN111183234A (https=)
AU (2) AU2018348195B2 (https=)
CA (1) CA3078883A1 (https=)
IL (2) IL273550B2 (https=)
MX (1) MX2020003561A (https=)
NZ (1) NZ763161A (https=)
RU (1) RU2020115526A (https=)
SG (1) SG11202003254SA (https=)
WO (1) WO2019075181A1 (https=)

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US11957687B2 (en) 2019-07-02 2024-04-16 Regeneron Pharmaceuticals, Inc. Modulators of HSD17B13 and methods of use thereof
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CN118103038A (zh) 2021-08-20 2024-05-28 英安塔制药有限公司 17β-羟基类固醇脱氢酶13型抑制剂及其使用方法
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KR20250075705A (ko) * 2022-10-07 2025-05-28 화이자 인코포레이티드 Hsd17b13 억제제 및/또는 분해제
WO2024173343A1 (en) 2023-02-14 2024-08-22 Regeneron Pharmaceuticals, Inc. Compounds targeting hydroxysteroid 17-beta dehydrogenase (hsd17b) and uses thereof
WO2025012422A1 (en) 2023-07-13 2025-01-16 Enyo Pharma L-arginine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
WO2025012425A1 (en) 2023-07-13 2025-01-16 Enyo Pharma Tromethamine salt of 4-chloro-5-[4-(2,6-dichlorophenyl)sulfonylpiperazin-1-yl]-1-benzofuran-2-carboxylic acid and various forms thereof
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