AU2018348195B2 - Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation - Google Patents

Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation Download PDF

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AU2018348195B2
AU2018348195B2 AU2018348195A AU2018348195A AU2018348195B2 AU 2018348195 B2 AU2018348195 B2 AU 2018348195B2 AU 2018348195 A AU2018348195 A AU 2018348195A AU 2018348195 A AU2018348195 A AU 2018348195A AU 2018348195 B2 AU2018348195 B2 AU 2018348195B2
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seq
hsd17b13
isoform
protein
missense
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AU2018348195A1 (en
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Noura ABUL-HUSN
Aris BARAS
Xiping CHENG
Frederick Dewey
Jesper Gromada
Claudia SCHURMANN
Tanya Teslovich Dostal
Yurong XIN
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Gastroenterology & Hepatology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2018348195A 2017-10-11 2018-10-11 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation Active AU2018348195B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025203267A AU2025203267A1 (en) 2017-10-11 2025-05-07 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762570985P 2017-10-11 2017-10-11
US62/570,985 2017-10-11
PCT/US2018/055377 WO2019075181A1 (en) 2017-10-11 2018-10-11 INHIBITION OF HSD17B13 IN THE TREATMENT OF HEPATIC DISEASE IN PATIENTS EXPRESSING PNPLA3 I148M VARIATION

Related Child Applications (1)

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AU2025203267A Division AU2025203267A1 (en) 2017-10-11 2025-05-07 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation

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AU2018348195A1 AU2018348195A1 (en) 2020-04-23
AU2018348195B2 true AU2018348195B2 (en) 2025-05-15

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AU2018348195A Active AU2018348195B2 (en) 2017-10-11 2018-10-11 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation
AU2025203267A Pending AU2025203267A1 (en) 2017-10-11 2025-05-07 Inhibition of HSD17B13 in the treatment of liver disease in patients expressing the PNPLA3 I148M variation

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Country Link
US (4) US10961583B2 (https=)
EP (3) EP4685243A3 (https=)
JP (3) JP7434151B2 (https=)
KR (2) KR102694809B1 (https=)
CN (1) CN111183234A (https=)
AU (2) AU2018348195B2 (https=)
CA (1) CA3078883A1 (https=)
IL (2) IL319615A (https=)
MX (1) MX2020003561A (https=)
NZ (1) NZ763161A (https=)
RU (1) RU2020115526A (https=)
SG (1) SG11202003254SA (https=)
WO (1) WO2019075181A1 (https=)

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