JP7393206B2 - 腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法 - Google Patents

腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法 Download PDF

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JP7393206B2
JP7393206B2 JP2019553158A JP2019553158A JP7393206B2 JP 7393206 B2 JP7393206 B2 JP 7393206B2 JP 2019553158 A JP2019553158 A JP 2019553158A JP 2019553158 A JP2019553158 A JP 2019553158A JP 7393206 B2 JP7393206 B2 JP 7393206B2
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analytes
mobile phase
tryptophan
creatinine
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フォード、リサ
フリード、ティファニー、エイ.
ハウザー、ディアドリ、エム.
グッドマン、ケリー
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メタボロン,インコーポレイテッド
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    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
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    • G01N33/62Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving urea
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    • G01N33/66Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806Determination of free amino acids
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • HELECTRICITY
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    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/005Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with gas, e.g. by introducing gas or by accelerating ions with an electric field
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    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/14Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers
    • H01J49/145Ion sources; Ion guns using particle bombardment, e.g. ionisation chambers using chemical ionisation
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    • G01N2570/00Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
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    • G01N2800/347Renal failures; Glomerular diseases; Tubulointerstitial diseases, e.g. nephritic syndrome, glomerulonephritis; Renovascular diseases, e.g. renal artery occlusion, nephropathy
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  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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JP2019553158A 2016-12-19 2017-12-14 腎機能代謝産物の検出及び定量化のための質量分析アッセイ方法 Active JP7393206B2 (ja)

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Application Number Priority Date Filing Date Title
US201662435967P 2016-12-19 2016-12-19
US62/435,967 2016-12-19
US201762526043P 2017-06-28 2017-06-28
US62/526,043 2017-06-28
US201762558014P 2017-09-13 2017-09-13
US62/558,014 2017-09-13
PCT/US2017/066364 WO2018118630A1 (en) 2016-12-19 2017-12-14 Mass spectrometry assay method for detection and quantitation of kidney function metabolites

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CN113892029A (zh) * 2019-05-31 2022-01-04 梅塔博隆股份有限公司 用于检测代谢物的质谱分析方法
CN112946150B (zh) * 2019-11-26 2024-06-18 深圳华大临床检验中心 一种快速检测人体尿液中高香草酸、香草扁桃酸、5-羟基吲哚乙酸及肌酐的方法及试剂盒
CN111007173A (zh) * 2019-12-20 2020-04-14 辉源生物科技(上海)有限公司 吲哚胺2,3-二氧化酶抑制剂的筛选方法
WO2021232211A1 (zh) * 2020-05-19 2021-11-25 深圳市中医院 诊断肾病的标志物以及诊断方法
CN115917323A (zh) * 2020-05-19 2023-04-04 赛诺菲 使用干血样验证药物水平的方法
CN114518413B (zh) * 2020-11-18 2024-12-31 江苏天士力帝益药业有限公司 一种卡托普利原料药中脯氨酸的含量测定方法
CN114216984B (zh) * 2021-12-16 2023-10-13 川北医学院附属医院 一种骨质疏松症负离子诊断标志物及其检测方法
CN114414700A (zh) * 2022-01-27 2022-04-29 重庆迪纳利医药科技有限责任公司 一种同时测定生物样品中多种内源性糖醇含量的方法和系统

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CN110088615B (zh) 2023-08-22
JP2020502544A (ja) 2020-01-23
EP3555615B9 (en) 2025-03-19
EP3555615A1 (en) 2019-10-23
AU2017382744B2 (en) 2023-02-09
CA3045022C (en) 2024-01-16
CA3045022A1 (en) 2018-06-28
WO2018118630A1 (en) 2018-06-28
CN110088615A (zh) 2019-08-02
EP3555615A4 (en) 2020-11-04
EP3555615B1 (en) 2024-10-30
US20190346455A1 (en) 2019-11-14
ES3004083T3 (en) 2025-03-11
AU2017382744A1 (en) 2019-06-13
US11619636B2 (en) 2023-04-04

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