JP7386544B2 - テトラベナジン経皮送達デバイス - Google Patents

テトラベナジン経皮送達デバイス Download PDF

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Publication number
JP7386544B2
JP7386544B2 JP2020559388A JP2020559388A JP7386544B2 JP 7386544 B2 JP7386544 B2 JP 7386544B2 JP 2020559388 A JP2020559388 A JP 2020559388A JP 2020559388 A JP2020559388 A JP 2020559388A JP 7386544 B2 JP7386544 B2 JP 7386544B2
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Prior art keywords
adhesive composition
transdermal delivery
tetrabenazine
adhesive
delivery device
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JP2021522240A5 (OSRAM
JP2021522240A (ja
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スレシュ ボルサディア
カルパナ パテル
ホック エス． タン
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Shinkei Therapeutics Inc
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Shinkei Therapeutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020559388A 2018-04-25 2019-04-24 テトラベナジン経皮送達デバイス Active JP7386544B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862662456P 2018-04-25 2018-04-25
US62/662,456 2018-04-25
PCT/US2019/028900 WO2019209940A1 (en) 2018-04-25 2019-04-24 Tetrabenazine transdermal delivery device

Publications (3)

Publication Number Publication Date
JP2021522240A JP2021522240A (ja) 2021-08-30
JP2021522240A5 JP2021522240A5 (OSRAM) 2022-04-20
JP7386544B2 true JP7386544B2 (ja) 2023-11-27

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JP2020559388A Active JP7386544B2 (ja) 2018-04-25 2019-04-24 テトラベナジン経皮送達デバイス

Country Status (15)

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US (2) US12144899B2 (OSRAM)
EP (1) EP3784237B1 (OSRAM)
JP (1) JP7386544B2 (OSRAM)
KR (1) KR102952482B1 (OSRAM)
CN (1) CN112165942B (OSRAM)
AU (1) AU2019261403B2 (OSRAM)
BR (1) BR112020021700A2 (OSRAM)
CA (1) CA3097189A1 (OSRAM)
DK (1) DK3784237T3 (OSRAM)
ES (1) ES2968827T3 (OSRAM)
IL (1) IL278185B2 (OSRAM)
MX (1) MX2020011269A (OSRAM)
TW (1) TWI832854B (OSRAM)
WO (1) WO2019209940A1 (OSRAM)
ZA (1) ZA202006415B (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3784237T3 (da) 2018-04-25 2024-01-08 Shinkei Therapeutics Inc Indretning til transdermal levering af tetrabenazin
CN114828851A (zh) * 2019-10-22 2022-07-29 新凯治疗有限责任公司 丁苯那嗪经皮递送装置
EP4125902A4 (en) * 2020-03-30 2024-05-22 Shinkei Therapeutics, Inc. TRANSDERMAL ADMINISTRATION OF DEXTROMETHORPHAN
CN116036055A (zh) * 2023-03-16 2023-05-02 上海世领制药有限公司 一种含甲磺酸雷沙吉兰的透皮贴剂及其制备方法

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JP2001517493A (ja) 1997-09-26 2001-10-09 ノーヴェン ファーマシューティカルズ インコーポレイテッド 生体接着剤組成物及び活性薬剤の局所投与方法
US20060078604A1 (en) 2004-10-08 2006-04-13 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing
JP2012503010A (ja) 2008-09-18 2012-02-02 オースペックス・ファーマシューティカルズ・インコーポレイテッド 小胞モノアミン輸送体２のベンゾキノリン阻害剤
JP2013501810A (ja) 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物
JP2013528631A (ja) 2010-06-17 2013-07-11 エルテーエス ローマン テラピー−ジステーメ アーゲー メマンチンの経皮投与
JP2015515475A (ja) 2012-04-04 2015-05-28 イヴァックス・インターナショナル・ゲーエムベーハー 併用療法のための医薬組成物
JP2016520638A (ja) 2013-06-04 2016-07-14 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システム
WO2017003935A1 (en) 2015-06-27 2017-01-05 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system
JP2017514850A (ja) 2014-05-06 2017-06-08 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 多動性運動障害を処置するためのｖｍａｔ２インヒビター

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JP2001517493A (ja) 1997-09-26 2001-10-09 ノーヴェン ファーマシューティカルズ インコーポレイテッド 生体接着剤組成物及び活性薬剤の局所投与方法
US20060078604A1 (en) 2004-10-08 2006-04-13 Noven Pharmaceuticals, Inc. Transdermal drug delivery device including an occlusive backing
JP2012503010A (ja) 2008-09-18 2012-02-02 オースペックス・ファーマシューティカルズ・インコーポレイテッド 小胞モノアミン輸送体２のベンゾキノリン阻害剤
JP2013501810A (ja) 2009-08-12 2013-01-17 ヴァリーント インターナショナル（バルバドス）エスアールエル 医薬組成物
JP2013528631A (ja) 2010-06-17 2013-07-11 エルテーエス ローマン テラピー−ジステーメ アーゲー メマンチンの経皮投与
JP2015515475A (ja) 2012-04-04 2015-05-28 イヴァックス・インターナショナル・ゲーエムベーハー 併用療法のための医薬組成物
JP2016520638A (ja) 2013-06-04 2016-07-14 エルテーエス ローマン テラピー−ジステーメ アーゲー 経皮送達システム
JP2017514850A (ja) 2014-05-06 2017-06-08 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 多動性運動障害を処置するためのｖｍａｔ２インヒビター
WO2017003935A1 (en) 2015-06-27 2017-01-05 Shenox Pharmaceuticals, Llc Ketamine transdermal delivery system

Also Published As

Publication number Publication date
AU2019261403A1 (en) 2020-11-12
DK3784237T3 (da) 2024-01-08
US20250144045A1 (en) 2025-05-08
WO2019209940A1 (en) 2019-10-31
CN112165942A (zh) 2021-01-01
ZA202006415B (en) 2024-04-24
BR112020021700A2 (pt) 2021-01-26
MX2020011269A (es) 2020-12-11
CN112165942B (zh) 2024-04-12
KR102952482B1 (ko) 2026-04-13
AU2019261403B2 (en) 2025-05-15
TW202014187A (zh) 2020-04-16
US20210128490A1 (en) 2021-05-06
TWI832854B (zh) 2024-02-21
EP3784237A1 (en) 2021-03-03
EP3784237A4 (en) 2022-02-16
KR20210005623A (ko) 2021-01-14
ES2968827T3 (es) 2024-05-14
IL278185A (OSRAM) 2020-12-31
US12144899B2 (en) 2024-11-19
JP2021522240A (ja) 2021-08-30
CA3097189A1 (en) 2019-10-31
IL278185B2 (en) 2024-11-01
IL278185B1 (en) 2024-07-01
EP3784237B1 (en) 2023-11-01

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