JP7386083B2 - Ｃｄ８０バリアント免疫調節タンパク質及びその使用 - Google Patents

Ｃｄ８０バリアント免疫調節タンパク質及びその使用 Download PDF

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JP7386083B2
JP7386083B2 JP2019551327A JP2019551327A JP7386083B2 JP 7386083 B2 JP7386083 B2 JP 7386083B2 JP 2019551327 A JP2019551327 A JP 2019551327A JP 2019551327 A JP2019551327 A JP 2019551327A JP 7386083 B2 JP7386083 B2 JP 7386083B2
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variant
polypeptide
amino acid
domain
seq
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JP2020511143A5 (https=
JP2020511143A (ja
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ライアン スワンソン
マイケル コルナッカー
マーク エフ． マウラー
ダン アルドーレル
ダニエル ウィリアム デモンテ
ヨセフ エル． カウペル
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アルパイン イミューン サイエンシズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2019551327A 2017-03-16 2018-03-13 Ｃｄ８０バリアント免疫調節タンパク質及びその使用 Active JP7386083B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022163426A JP7702928B2 (ja) 2017-03-16 2022-10-11 Ｃｄ８０バリアント免疫調節タンパク質及びその使用
JP2025009520A JP2025076434A (ja) 2017-03-16 2025-01-23 Ｃｄ８０バリアント免疫調節タンパク質及びその使用

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201762472569P 2017-03-16 2017-03-16
US201762472572P 2017-03-16 2017-03-16
US201762472558P 2017-03-16 2017-03-16
US201762472554P 2017-03-16 2017-03-16
US62/472,569 2017-03-16
US62/472,554 2017-03-16
US62/472,572 2017-03-16
US62/472,558 2017-03-16
US201762472573P 2017-03-17 2017-03-17
US62/472,573 2017-03-17
US201762475204P 2017-03-22 2017-03-22
US62/475,204 2017-03-22
US201762537939P 2017-07-27 2017-07-27
US62/537,939 2017-07-27
US201762574165P 2017-10-18 2017-10-18
US62/574,165 2017-10-18
US201762582266P 2017-11-06 2017-11-06
US62/582,266 2017-11-06
PCT/US2018/022270 WO2018170026A2 (en) 2017-03-16 2018-03-13 Cd80 variant immunomodulatory proteins and uses thereof

Related Child Applications (1)

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JP2022163426A Division JP7702928B2 (ja) 2017-03-16 2022-10-11 Ｃｄ８０バリアント免疫調節タンパク質及びその使用

Publications (3)

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JP2020511143A JP2020511143A (ja) 2020-04-16
JP2020511143A5 JP2020511143A5 (https=) 2021-04-30
JP7386083B2 true JP7386083B2 (ja) 2023-11-24

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JP2019551327A Active JP7386083B2 (ja) 2017-03-16 2018-03-13 Ｃｄ８０バリアント免疫調節タンパク質及びその使用
JP2022163426A Active JP7702928B2 (ja) 2017-03-16 2022-10-11 Ｃｄ８０バリアント免疫調節タンパク質及びその使用
JP2025009520A Pending JP2025076434A (ja) 2017-03-16 2025-01-23 Ｃｄ８０バリアント免疫調節タンパク質及びその使用

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JP2022163426A Active JP7702928B2 (ja) 2017-03-16 2022-10-11 Ｃｄ８０バリアント免疫調節タンパク質及びその使用
JP2025009520A Pending JP2025076434A (ja) 2017-03-16 2025-01-23 Ｃｄ８０バリアント免疫調節タンパク質及びその使用

Country Status (12)

Country Link
US (7) US11639375B2 (https=)
EP (1) EP3596114A2 (https=)
JP (3) JP7386083B2 (https=)
KR (2) KR102813967B1 (https=)
CN (1) CN110662758A (https=)
AU (2) AU2018235838B2 (https=)
BR (1) BR112019018747A2 (https=)
CA (1) CA3054068A1 (https=)
IL (2) IL319966A (https=)
MX (1) MX2019010887A (https=)
SG (1) SG11201907769XA (https=)
WO (1) WO2018170026A2 (https=)

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SG11201907769XA (en) 2017-03-16 2019-09-27 Alpine Immune Sciences Inc Cd80 variant immunomodulatory proteins and uses thereof
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ｃｔｌａ－４変異型免疫調節タンパク質およびそれらの使用
AU2019205273B2 (en) 2018-01-03 2024-04-04 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
WO2019241758A1 (en) 2018-06-15 2019-12-19 Alpine Immune Sciences, Inc. Pd-1 variant immunomodulatory proteins and uses thereof
EP3853247A2 (en) * 2018-09-19 2021-07-28 Alpine Immune Sciences, Inc. Methods and uses of variant cd80 fusion proteins and related constructs
CA3120868A1 (en) * 2018-11-30 2020-06-04 Alpine Immune Sciences, Inc. Cd86 variant immunomodulatory proteins and uses thereof
RU2706554C1 (ru) * 2018-12-13 2019-11-19 Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ Способ создания противоинфекционной иммунологической защиты к Salmonella typhimurium и Listeria monocytogenes с помощью трансгенеза Т-лимфоцитов
CN111423512B (zh) * 2019-01-10 2024-01-05 北京比洋生物技术有限公司 阻断血管内皮细胞生长且活化t细胞的多靶向融合蛋白和包含其的药物组合物
JP7535273B2 (ja) * 2019-04-26 2024-08-16 スアンズ バイオファーマシューティカル カンパニー，リミテッド Ｃｄ８０バリアントタンパク質とその使用
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