JP7373991B2 - 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 - Google Patents

免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 Download PDF

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JP7373991B2
JP7373991B2 JP2019522627A JP2019522627A JP7373991B2 JP 7373991 B2 JP7373991 B2 JP 7373991B2 JP 2019522627 A JP2019522627 A JP 2019522627A JP 2019522627 A JP2019522627 A JP 2019522627A JP 7373991 B2 JP7373991 B2 JP 7373991B2
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JP2019525957A5 (enExample
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エヌ． ウッディ，ジェームズ
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ビラクタ セラピューティクス，インク．
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2019522627A 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤 Active JP7373991B2 (ja)

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JP2022032796A JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

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US201662362959P 2016-07-15 2016-07-15
US62/362,959 2016-07-15
PCT/US2017/042199 WO2018013962A1 (en) 2016-07-15 2017-07-14 Histone deacetylase inhibitors for use in immunotherapy

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JP2019525957A JP2019525957A (ja) 2019-09-12
JP2019525957A5 JP2019525957A5 (enExample) 2020-08-06
JP7373991B2 true JP7373991B2 (ja) 2023-11-06

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JP2019522629A Active JP7158104B2 (ja) 2016-07-15 2017-07-14 Ｎｋ細胞ベースの療法で使用するためのｈｄａｃ阻害剤
JP2019522627A Active JP7373991B2 (ja) 2016-07-15 2017-07-14 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
JP2022032796A Pending JP2022088404A (ja) 2016-07-15 2022-03-03 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤

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US (3) US12427152B2 (enExample)
EP (4) EP4596053A3 (enExample)
JP (3) JP7158104B2 (enExample)
CN (2) CN109715173A (enExample)
GB (2) GB2567093A (enExample)
WO (2) WO2018013962A1 (enExample)

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IL266918B2 (en) 2016-12-07 2024-03-01 Agenus Inc Anti-ctla-4 antibodies and methods of use thereof
US20200368280A1 (en) * 2018-01-12 2020-11-26 Viracta Therapeutics, Inc. Epigenetic modifiers for use in cellular immunotherapy
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CN109306341B (zh) * 2018-09-12 2022-01-28 华东师范大学 Hdac11基因干扰的嵌合抗原受体t细胞及其应用
KR102533540B1 (ko) 2018-10-31 2023-05-17 난트퀘스트, 인크. Pd-l1 키메라 항원 수용체-발현 nk 세포에 의한 pd-l1-양성 악성종양의 제거(elimination of pd-l1-positive malignancies by pd-l1 chimeric antigen receptor-expressing nk cells)
PH12021552997A1 (en) 2019-05-31 2023-08-14 Viracta Subsidiary Inc Methods of treating virally associated cancers with histone deacetylase inhibitors
WO2021037128A1 (zh) * 2019-08-28 2021-03-04 深圳微芯生物科技股份有限公司 一种西达本胺药物组合物及其应用
JP2022552642A (ja) * 2019-10-07 2022-12-19 ヴィラクタ サブシディアリー，インク． 副作用が軽減されたｈｄａｃ治療の調剤
CN113302307B (zh) 2019-11-26 2024-04-05 南克维斯特公司 原代nk car构建体和方法
EP4069229A4 (en) 2019-12-05 2024-02-07 Viracta Subsidiary, Inc. Hdac inhibitor solid state forms
CN111358777A (zh) * 2020-02-24 2020-07-03 军事科学院军事医学研究院环境医学与作业医学研究所 一种提高外周血单个核细胞线粒体功能的方法和应用
IL302289A (en) * 2020-10-28 2023-06-01 Viracta Subsidiary Inc Hdac inhibitor solid state forms
CN113502265B (zh) * 2021-05-25 2024-05-28 昭泰英基生物医药（香港）有限公司 将t细胞重编程为类nk细胞的诱导剂及其应用
WO2023003972A1 (en) * 2021-07-21 2023-01-26 Viracta Subsidiary, Inc. Cancer treatment combinations
WO2023247770A1 (en) * 2022-06-23 2023-12-28 Eximmium Biotechnologies Gmbh Treatment or prevention of a medical condition associated with a herpes virus infection
WO2024254774A1 (zh) * 2023-06-14 2024-12-19 香港北恒生物科技有限公司 免疫细胞联合疗法

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