JP7314115B2 - ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞 - Google Patents

ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞 Download PDF

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JP7314115B2
JP7314115B2 JP2020503358A JP2020503358A JP7314115B2 JP 7314115 B2 JP7314115 B2 JP 7314115B2 JP 2020503358 A JP2020503358 A JP 2020503358A JP 2020503358 A JP2020503358 A JP 2020503358A JP 7314115 B2 JP7314115 B2 JP 7314115B2
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JP2020512019A (ja
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ジュリアン スミス
フィリップ ドゥシャトー
ミュリエル デリアン
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セレクティス ソシエテ アノニム
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/365—Lactones
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/001111—Immunoglobulin superfamily
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61P35/00—Antineoplastic agents
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/28—Expressing multiple CARs, TCRs or antigens
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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JP2020503358A 2017-03-31 2018-03-30 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞 Active JP7314115B2 (ja)

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DKPA201770239 2017-03-31
DKPA201770239 2017-03-31
DKPA201770240 2017-03-31
DKPA201770240 2017-03-31
DKPA201770542 2017-06-30
DKPA201770542 2017-06-30
PCT/EP2017/076800 WO2018073393A2 (en) 2016-10-19 2017-10-19 Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
EPPCT/EP2017/076800 2017-10-19
PCT/EP2018/058367 WO2018178377A1 (en) 2017-03-31 2018-03-30 Universal anti-cd22 chimeric antigen receptor engineered immune cells

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JP2023114120A Active JP7634045B2 (ja) 2017-03-31 2023-07-12 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

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US (4) US11690873B2 (enExample)
EP (3) EP3592379B1 (enExample)
JP (2) JP7314115B2 (enExample)
KR (1) KR102726269B1 (enExample)
CN (1) CN110869046B (enExample)
AU (2) AU2018246377B2 (enExample)
BR (1) BR112019020203A2 (enExample)
CA (1) CA3058268A1 (enExample)
DK (1) DK3592379T3 (enExample)
ES (1) ES2979232T3 (enExample)
IL (1) IL269538B2 (enExample)
MX (1) MX2019011475A (enExample)
PT (1) PT3592379T (enExample)
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JP2023139070A (ja) * 2017-03-31 2023-10-03 セレクティス ソシエテ アノニム ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

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CN112888709B (zh) * 2018-03-30 2024-10-29 优瑞科生物技术公司 标靶cd22的构建体和其用途
CN112585276A (zh) * 2018-04-05 2021-03-30 朱诺治疗学股份有限公司 产生表达重组受体的细胞的方法和相关组合物
AU2019404302A1 (en) 2018-12-19 2021-08-05 The Trustees Of The University Of Pennsylvania Use of CD2/5/7 knock-out anti-CD2/5/7 chimeric antigen receptor t cells against t cell lymphomas and leukemias
BR112021021178A2 (pt) * 2019-04-26 2022-03-15 Allogene Therapeutics Inc Receptores de antígeno quimérico resistentes ao rituximabe e usos destes
WO2020236833A1 (en) * 2019-05-21 2020-11-26 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin compounds for enhancement of immunotherapy
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CN113527507A (zh) * 2020-04-16 2021-10-22 上海赛比曼生物科技有限公司 靶向cd22的嵌合抗原受体及其制法和应用
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CN111944850B (zh) * 2020-08-28 2023-03-31 澳门大学 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用
IL303269A (en) 2020-12-03 2023-07-01 Century Therapeutics Inc Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
TW202241935A (zh) 2020-12-18 2022-11-01 美商世紀治療股份有限公司 具有可調適受體專一性之嵌合抗原受體系統
EP4294831A1 (en) * 2021-02-16 2023-12-27 The United States of America, as represented by the Secretary, Department of Health and Human Services Hla class i-restricted t cell receptors against cd22
KR102829757B1 (ko) * 2021-11-17 2025-07-09 (주)이노베이션바이오 인간화된 cd22에 특이적인 항체 및 이를 이용한 키메라 항원 수용체
EP4452319A1 (en) * 2021-12-22 2024-10-30 Flagship Pioneering Innovations VI, LLC Compositions and methods for delivery of therapeutic agents to acceptor cells
JP2026502616A (ja) * 2023-01-19 2026-01-23 ウーハン チャオチー バイオテクノロジー カンパニー リミテッド Ｃａｒ分子、それを含む細胞若しくはエクソソーム、及びそれらの使用
WO2025049961A1 (en) * 2023-09-01 2025-03-06 Cargo Therapeutics, Inc. Anti-cd22 chimeric antigen receptor (car) therapies
WO2025212803A2 (en) * 2024-04-03 2025-10-09 Umoja Biopharma, Inc. Lentiviral delivery of anti-cd22 chimeric antigen receptors
CN119775433B (zh) * 2024-12-09 2025-11-28 吉林大学第一医院 一种细胞膜表达的il-15融合蛋白及其在细胞治疗中的应用

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JP2016502512A (ja) 2012-10-24 2016-01-28 アメリカ合衆国 Ｍ９７１キメラ抗原受容体
WO2016120218A1 (en) 2015-01-26 2016-08-04 Cellectis ANTI-CLL1 SPECIFIC SINGLE-CHAIN CHIMERIC ANTIGEN RECEPTORS (scCARS) FOR CANCER IMMUNOTHERAPY
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