JP2020512019A5 - - Google Patents

Download PDF

Info

Publication number
JP2020512019A5
JP2020512019A5 JP2020503358A JP2020503358A JP2020512019A5 JP 2020512019 A5 JP2020512019 A5 JP 2020512019A5 JP 2020503358 A JP2020503358 A JP 2020503358A JP 2020503358 A JP2020503358 A JP 2020503358A JP 2020512019 A5 JP2020512019 A5 JP 2020512019A5
Authority
JP
Japan
Prior art keywords
car
gene
ucart
seq
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020503358A
Other languages
English (en)
Japanese (ja)
Other versions
JP7314115B2 (ja
JP2020512019A (ja
Filing date
Publication date
Priority claimed from PCT/EP2017/076800 external-priority patent/WO2018073393A2/en
Application filed filed Critical
Priority claimed from PCT/EP2018/058367 external-priority patent/WO2018178377A1/en
Publication of JP2020512019A publication Critical patent/JP2020512019A/ja
Publication of JP2020512019A5 publication Critical patent/JP2020512019A5/ja
Priority to JP2023114120A priority Critical patent/JP7634045B2/ja
Application granted granted Critical
Publication of JP7314115B2 publication Critical patent/JP7314115B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020503358A 2017-03-31 2018-03-30 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞 Active JP7314115B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023114120A JP7634045B2 (ja) 2017-03-31 2023-07-12 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA201770239 2017-03-31
DKPA201770240 2017-03-31
DKPA201770240 2017-03-31
DKPA201770239 2017-03-31
DKPA201770542 2017-06-30
DKPA201770542 2017-06-30
PCT/EP2017/076800 WO2018073393A2 (en) 2016-10-19 2017-10-19 Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
EPPCT/EP2017/076800 2017-10-19
PCT/EP2018/058367 WO2018178377A1 (en) 2017-03-31 2018-03-30 Universal anti-cd22 chimeric antigen receptor engineered immune cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023114120A Division JP7634045B2 (ja) 2017-03-31 2023-07-12 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

Publications (3)

Publication Number Publication Date
JP2020512019A JP2020512019A (ja) 2020-04-23
JP2020512019A5 true JP2020512019A5 (enExample) 2021-05-06
JP7314115B2 JP7314115B2 (ja) 2023-07-25

Family

ID=63674321

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020503358A Active JP7314115B2 (ja) 2017-03-31 2018-03-30 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞
JP2023114120A Active JP7634045B2 (ja) 2017-03-31 2023-07-12 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023114120A Active JP7634045B2 (ja) 2017-03-31 2023-07-12 ユニバーサル抗ｃｄ２２キメラ抗原受容体操作免疫細胞

Country Status (14)

Country Link
US (4) US11944643B2 (enExample)
EP (3) EP3592379B1 (enExample)
JP (2) JP7314115B2 (enExample)
KR (1) KR102726269B1 (enExample)
CN (1) CN110869046B (enExample)
AU (2) AU2018246377B2 (enExample)
BR (1) BR112019020203A2 (enExample)
CA (1) CA3058268A1 (enExample)
DK (1) DK3592379T3 (enExample)
ES (1) ES2979232T3 (enExample)
IL (1) IL269538B2 (enExample)
MX (1) MX2019011475A (enExample)
PT (1) PT3592379T (enExample)
WO (2) WO2018178377A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3020330A1 (en) * 2016-04-07 2017-10-12 Bluebird Bio, Inc. Chimeric antigen receptor t cell compositions
WO2018067382A1 (en) 2016-10-05 2018-04-12 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin compounds and methods of preparing the same
EP3592379B1 (en) * 2017-03-31 2024-04-24 Cellectis SA Universal anti-cd22 chimeric antigen receptor engineered immune cells
WO2019070541A1 (en) 2017-10-03 2019-04-11 Juno Therapeutics, Inc. HPV-SPECIFIC BINDING MOLECULES
JP7414226B2 (ja) * 2018-03-30 2024-01-16 エウレカ セラピューティクス インコーポレイテッド Ｃｄ２２を標的とする構築物及びその使用
MA52656A (fr) * 2018-04-05 2021-02-17 Editas Medicine Inc Procédés de production de cellules exprimant un récepteur recombinant et compositions associées
CN113454117B (zh) 2018-12-19 2025-07-04 宾夕法尼亚大学董事会 Cd2/5/7敲除抗-cd2/5/7嵌合抗原受体t细胞针对t细胞淋巴瘤和白血病的用途
WO2020219848A1 (en) * 2019-04-26 2020-10-29 Allogene Therapeutics, Inc. Rituximab-resistant chimeric antigen receptors and uses thereof
AU2020277375A1 (en) * 2019-05-21 2022-01-27 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin compounds for enhancement of immunotherapy
EP4127188A4 (en) * 2020-03-31 2024-08-21 Walking Fish Therapeutics MODIFIED B CELLS AND METHODS OF USE THEREOF
CN113527507A (zh) * 2020-04-16 2021-10-22 上海赛比曼生物科技有限公司 靶向cd22的嵌合抗原受体及其制法和应用
GB202007842D0 (en) * 2020-05-26 2020-07-08 Quell Therapeutics Ltd Polypeptide useful in adoptive cell therapy
AU2021316677A1 (en) * 2020-07-31 2023-02-23 Cellectis S.A. Dual CAR-T cells
CN111944850B (zh) * 2020-08-28 2023-03-31 澳门大学 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
US20240239864A1 (en) * 2021-02-16 2024-07-18 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class i-restricted t cell receptors against cd22
KR102829757B1 (ko) * 2021-11-17 2025-07-09 (주)이노베이션바이오 인간화된 cd22에 특이적인 항체 및 이를 이용한 키메라 항원 수용체
US20250059569A1 (en) * 2021-12-22 2025-02-20 Flagship Pioneering Innovations Vi, Llc Compositions and methods for delivery of therapeutic agents to acceptor cells
WO2024153036A1 (zh) * 2023-01-19 2024-07-25 武汉昭智生物技术有限公司 一种car分子、包含其的细胞或外泌体及它们的应用
WO2025049961A1 (en) * 2023-09-01 2025-03-06 Cargo Therapeutics, Inc. Anti-cd22 chimeric antigen receptor (car) therapies
CN119775433B (zh) * 2024-12-09 2025-11-28 吉林大学第一医院 一种细胞膜表达的il-15融合蛋白及其在细胞治疗中的应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901228A (fr) 1943-01-16 1945-07-20 Deutsche Edelstahlwerke Ag Système d'aimant à entrefer annulaire
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
AU2337997A (en) 1996-03-20 1997-10-10 Arizona Board Of Regents, The Method of treating cancer using c-26 modified bryostatin
DE69840439D1 (de) 1997-04-24 2009-02-26 Univ Washington Zielgerichtete genveraenderung mit parvoviralen vektoren
JP2003515601A (ja) 1999-11-30 2003-05-07 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ ブリオスタチンアナログ、合成方法および使用
DK1257632T3 (da) 2000-02-24 2008-01-28 Xcyte Therapies Inc Samtidig stimulering og opkoncentrering af celler
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
KR20090120480A (ko) 2007-02-09 2009-11-24 블랜체트 록펠러 뉴로사이언시즈 인스티튜트 허혈/뇌졸중-유도된 기억 장애 및 뇌 손상에 대한 브리오스타틴, 브리오로그 및 기타 관련된 물질의 치료학적 효과
WO2008102199A1 (en) 2007-02-20 2008-08-28 Cellectis Meganuclease variants cleaving a dna target sequence from the beta-2-microglobulin gene and uses thereof
TR201802772T4 (tr) * 2010-11-17 2018-03-21 Chugai Pharmaceutical Co Ltd Kan pıhtılaşma faktörü VIII in işlevi için alternatif işleve sahip multi-spesifik antijen bağlayıcı molekül.
EP2694091B1 (en) 2011-04-05 2019-03-13 Cellectis Method for the generation of compact tale-nucleases and uses thereof
US8790651B2 (en) * 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
WO2013059593A1 (en) 2011-10-20 2013-04-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd22 chimeric antigen receptors
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
WO2013126720A2 (en) 2012-02-22 2013-08-29 The Trustees Of The University Of Pennsylvania Compositions and methods for the assessment of target cancer cell resistance to car engineered t cell killing
GB201206559D0 (en) 2012-04-13 2012-05-30 Ucl Business Plc Polypeptide
CA3133545C (en) * 2012-05-25 2023-08-08 Cellectis Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
AU2013312838B2 (en) 2012-09-04 2018-11-29 Cellectis Multi-chain chimeric antigen receptor and uses thereof
ES2718903T3 (es) 2012-10-24 2019-07-05 Us Health Receptores de antígenos quiméricos M971
DK3004337T3 (da) 2013-05-29 2017-11-13 Cellectis Fremgangsmåde til konstruktion af T-celler til immunoterapi ved brug af RNA-guidet Cas nuklease-system
WO2015075195A1 (en) 2013-11-22 2015-05-28 Cellectis Method of engineering chemotherapy drug resistant t-cells for immunotherapy
AU2014368383B2 (en) 2013-12-20 2020-01-16 Cellectis Method of engineering multi-input signal sensitive T cell for immunotherapy
JP6673838B2 (ja) 2014-02-14 2020-04-01 セレクティスＣｅｌｌｅｃｔｉｓ 免疫細胞と病的細胞の両方に存在する抗原を標的とするように操作された、免疫療法のための細胞
ES2782125T3 (es) 2014-03-11 2020-09-10 Cellectis Método para generar linfocitos T compatibles para trasplante alogénico
ES2740903T3 (es) * 2014-03-19 2020-02-07 Cellectis Receptores antigénicos quiméricos específicos de CD123 para inmunoterapia del cáncer
EP3131927B8 (en) * 2014-04-14 2020-12-23 Cellectis Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
CA2973529A1 (en) * 2015-01-26 2016-08-04 Cellectis Cll1-specific multi-chain chimeric antigen receptor
AU2016214301B2 (en) * 2015-02-06 2022-05-19 Cellectis Primary hematopoietic cells genetically engineered by slow release of nucleic acids using nanoparticles
US10738116B2 (en) * 2015-03-19 2020-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dual specific anti-CD22-anti-CD19 chimeric antigen receptors
BR112017020750A2 (pt) * 2015-03-27 2018-06-26 Harvard College células t modificadas e métodos de produção e utilização das mesmas
WO2016201047A1 (en) 2015-06-09 2016-12-15 Editas Medicine, Inc. Crispr/cas-related methods and compositions for improving transplantation
WO2017069958A2 (en) 2015-10-09 2017-04-27 The Brigham And Women's Hospital, Inc. Modulation of novel immune checkpoint targets
CN105958210B (zh) 2016-05-06 2018-10-30 中国科学院国家天文台 Fast望远镜开孔式反射面单元及其开孔方法
CN105968210B (zh) 2016-05-13 2019-05-31 深圳生创精准医疗科技有限公司 靶向cd22的强杀伤性嵌合抗原受体t细胞及其在制备治疗肿瘤的药物中的用途
AU2017291851B2 (en) 2016-07-06 2022-10-13 Cellectis Sequential gene editing in primary immune cells
WO2018073394A1 (en) * 2016-10-19 2018-04-26 Cellectis Cell death inducing chimeric antigen receptors
WO2018073391A1 (en) * 2016-10-19 2018-04-26 Cellectis Targeted gene insertion for improved immune cells therapy
WO2018073393A2 (en) * 2016-10-19 2018-04-26 Cellectis Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
EP3592379B1 (en) * 2017-03-31 2024-04-24 Cellectis SA Universal anti-cd22 chimeric antigen receptor engineered immune cells
JP2020530277A (ja) * 2017-06-30 2020-10-22 セレクティスＣｅｌｌｅｃｔｉｓ 反復投与のための細胞免疫療法
US20230248825A1 (en) * 2020-07-24 2023-08-10 Cellectis S.A. T-cells expressing immune cell engagers in allogenic settings

Similar Documents

Publication Publication Date Title
JP2020512019A5 (enExample)
JP7157839B2 (ja) 癌治療のための免疫療法とサイトカイン制御療法との組み合わせ
JP7527049B2 (ja) Ｃａｒ発現ベクター及びｃａｒ発現ｔ細胞
JP2023139070A5 (enExample)
CN106536563B (zh) 嵌合抗原受体
JP2024105296A5 (enExample)
JP2019511222A5 (enExample)
CA3062433A1 (en) Bicistronic chimeric antigen receptors and their uses
CN104853765A (zh) 肿瘤特异性t细胞受体
JP2015527070A5 (enExample)
EP3746103A1 (en) Engineered proteins to enhance sensitivity of a cell to il-2
JP2021501567A (ja) Ｙ１８２ｔ突然変異を有するｔ細胞−抗原カプラおよびその方法ならびに使用
TW202102533A (zh) Ｔ細胞受體及其使用方法
CN117264043B (zh) 靶向kras g12v突变多肽的t细胞受体及其用途
JPWO2018026018A1 (ja) Ｔ細胞受容体の認識機構を用いたがん又は感染症の治療及び診断
WO2021223604A1 (zh) 一种t细胞抗原受体、其多聚体复合物及其制备方法和应用
JP2018518945A (ja) 可溶性キメラインターロイキン−１０受容体およびその療法使用
CN113195535A (zh) 用于连接表达car的免疫细胞与抗原呈递细胞的双特异性多肽及其用途
WO2023051361A1 (zh) 工程化免疫细胞及其用途
EP4269595A2 (en) Methods for selectively expanding cells expressing a tcr with a murine constant region
EP4502150A1 (en) Engineered immune cell with cd7 gene knock-out and use thereof
WO2023207390A1 (zh) 一种ciita基因被敲除的工程化免疫细胞及其用途
WO2018176034A1 (en) Modulators of notch signaling and methods of use thereof
CN114555815A (zh) T细胞受体及其使用方法
TWI881993B (zh) Ｔ細胞受體及其使用方法