KR102726269B1 - 범용 항-cd22 키메라 항원 수용체 조작된 면역 세포 - Google Patents

범용 항-cd22 키메라 항원 수용체 조작된 면역 세포 Download PDF

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KR102726269B1
KR102726269B1 KR1020197032371A KR20197032371A KR102726269B1 KR 102726269 B1 KR102726269 B1 KR 102726269B1 KR 1020197032371 A KR1020197032371 A KR 1020197032371A KR 20197032371 A KR20197032371 A KR 20197032371A KR 102726269 B1 KR102726269 B1 KR 102726269B1
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car
cell
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gene
cancer
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KR20200015467A (ko
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줄리앤 스미스
필립 두차타우
뮤리엘 데린
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셀렉티스 에스.에이.
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
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    • A61K39/001102Receptors, cell surface antigens or cell surface determinants
    • A61K39/001111Immunoglobulin superfamily
    • A61K39/001113CD22, BL-CAM, siglec-2 or sialic acid- binding Ig-related lectin 2
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    • A61K40/31Chimeric antigen receptors [CAR]
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    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C12N5/0634Cells from the blood or the immune system
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KR1020197032371A 2017-03-31 2018-03-30 범용 항-cd22 키메라 항원 수용체 조작된 면역 세포 Active KR102726269B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DKPA201770239 2017-03-31
DKPA201770240 2017-03-31
DKPA201770240 2017-03-31
DKPA201770239 2017-03-31
DKPA201770542 2017-06-30
DKPA201770542 2017-06-30
PCT/EP2017/076800 WO2018073393A2 (en) 2016-10-19 2017-10-19 Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
EPPCT/EP2017/076800 2017-10-19
PCT/EP2018/058367 WO2018178377A1 (en) 2017-03-31 2018-03-30 Universal anti-cd22 chimeric antigen receptor engineered immune cells

Publications (2)

Publication Number Publication Date
KR20200015467A KR20200015467A (ko) 2020-02-12
KR102726269B1 true KR102726269B1 (ko) 2024-11-05

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US (4) US11944643B2 (enExample)
EP (3) EP3592379B1 (enExample)
JP (2) JP7314115B2 (enExample)
KR (1) KR102726269B1 (enExample)
CN (1) CN110869046B (enExample)
AU (2) AU2018246377B2 (enExample)
BR (1) BR112019020203A2 (enExample)
CA (1) CA3058268A1 (enExample)
DK (1) DK3592379T3 (enExample)
ES (1) ES2979232T3 (enExample)
IL (1) IL269538B2 (enExample)
MX (1) MX2019011475A (enExample)
PT (1) PT3592379T (enExample)
WO (2) WO2018178377A1 (enExample)

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EP3592379B1 (en) * 2017-03-31 2024-04-24 Cellectis SA Universal anti-cd22 chimeric antigen receptor engineered immune cells
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JP7414226B2 (ja) * 2018-03-30 2024-01-16 エウレカ セラピューティクス インコーポレイテッド Cd22を標的とする構築物及びその使用
MA52656A (fr) * 2018-04-05 2021-02-17 Editas Medicine Inc Procédés de production de cellules exprimant un récepteur recombinant et compositions associées
CN113454117B (zh) 2018-12-19 2025-07-04 宾夕法尼亚大学董事会 Cd2/5/7敲除抗-cd2/5/7嵌合抗原受体t细胞针对t细胞淋巴瘤和白血病的用途
WO2020219848A1 (en) * 2019-04-26 2020-10-29 Allogene Therapeutics, Inc. Rituximab-resistant chimeric antigen receptors and uses thereof
AU2020277375A1 (en) * 2019-05-21 2022-01-27 The Board Of Trustees Of The Leland Stanford Junior University Bryostatin compounds for enhancement of immunotherapy
EP4127188A4 (en) * 2020-03-31 2024-08-21 Walking Fish Therapeutics MODIFIED B CELLS AND METHODS OF USE THEREOF
CN113527507A (zh) * 2020-04-16 2021-10-22 上海赛比曼生物科技有限公司 靶向cd22的嵌合抗原受体及其制法和应用
GB202007842D0 (en) * 2020-05-26 2020-07-08 Quell Therapeutics Ltd Polypeptide useful in adoptive cell therapy
AU2021316677A1 (en) * 2020-07-31 2023-02-23 Cellectis S.A. Dual CAR-T cells
CN111944850B (zh) * 2020-08-28 2023-03-31 澳门大学 表达抗cd22嵌合抗原受体和pd-l1阻断蛋白的细胞的制备方法、表达载体及应用
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021392032A1 (en) 2020-12-03 2023-06-22 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
US20240239864A1 (en) * 2021-02-16 2024-07-18 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Hla class i-restricted t cell receptors against cd22
KR102829757B1 (ko) * 2021-11-17 2025-07-09 (주)이노베이션바이오 인간화된 cd22에 특이적인 항체 및 이를 이용한 키메라 항원 수용체
US20250059569A1 (en) * 2021-12-22 2025-02-20 Flagship Pioneering Innovations Vi, Llc Compositions and methods for delivery of therapeutic agents to acceptor cells
WO2024153036A1 (zh) * 2023-01-19 2024-07-25 武汉昭智生物技术有限公司 一种car分子、包含其的细胞或外泌体及它们的应用
WO2025049961A1 (en) * 2023-09-01 2025-03-06 Cargo Therapeutics, Inc. Anti-cd22 chimeric antigen receptor (car) therapies
CN119775433B (zh) * 2024-12-09 2025-11-28 吉林大学第一医院 一种细胞膜表达的il-15融合蛋白及其在细胞治疗中的应用

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