JP7309698B2 - 複数の微小試料を光学的に検査する方法および装置 - Google Patents

複数の微小試料を光学的に検査する方法および装置 Download PDF

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JP7309698B2
JP7309698B2 JP2020517785A JP2020517785A JP7309698B2 JP 7309698 B2 JP7309698 B2 JP 7309698B2 JP 2020517785 A JP2020517785 A JP 2020517785A JP 2020517785 A JP2020517785 A JP 2020517785A JP 7309698 B2 JP7309698 B2 JP 7309698B2
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samples
light
light sheet
channel
detection
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カルクブレナー、トーマス
ジーベンモルゲン、イェルク
オールト、トーマス
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Carl Zeiss Microscopy GmbH
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G01N15/147—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/082—Condensers for incident illumination only
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Multimedia (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Microscoopes, Condenser (AREA)
JP2020517785A 2017-09-29 2018-09-25 複数の微小試料を光学的に検査する方法および装置 Active JP7309698B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102017122718.0 2017-09-29
DE102017122718.0A DE102017122718A1 (de) 2017-09-29 2017-09-29 Verfahren und Vorrichtung zur optischen Untersuchung einer Vielzahl mikroskopischer Proben
PCT/EP2018/075949 WO2019063539A1 (de) 2017-09-29 2018-09-25 Verfahren und vorrichtung zur optischen untersuchung einer vielzahl mikroskopischer proben

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JP2020535421A JP2020535421A (ja) 2020-12-03
JP2020535421A5 JP2020535421A5 (https=) 2021-11-04
JP7309698B2 true JP7309698B2 (ja) 2023-07-18

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US (1) US11371927B2 (https=)
JP (1) JP7309698B2 (https=)
CN (1) CN111164485B (https=)
DE (1) DE102017122718A1 (https=)
WO (1) WO2019063539A1 (https=)

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WO2020150239A1 (en) * 2019-01-14 2020-07-23 University Of Washington Apparatuses, systems and methods for solid immersion meniscus lenses
DE102019207873B4 (de) * 2019-05-29 2021-10-14 Leica Microsystems Cms Gmbh Optischer Aufbau für ein Mikroskop und Mikroskop
WO2021041807A1 (en) * 2019-08-30 2021-03-04 The Regents Of The University Of California Systems and methods for image cytometry
DE102020200193A1 (de) * 2020-01-09 2021-07-15 Albert-Ludwigs-Universität Freiburg Anordnung zur optischen Vorkonditionierung einer optisch aktivierbaren biologischen Probe
GB202001372D0 (en) * 2020-01-31 2020-03-18 Res & Innovation Uk Bioprinters
GB2595520A (en) * 2020-05-29 2021-12-01 Oxford Nanoimaging Ltd A diagnostic device and method
CN116324622A (zh) * 2020-08-11 2023-06-23 加泰罗尼亚生物工程基础研究所 用于立体光刻三维打印的设备和方法
CN112834410B (zh) * 2021-01-04 2022-09-13 桂林电子科技大学 基于双芯光纤光操控的片状光显微成像方法及装置
DE102021104871A1 (de) 2021-03-01 2022-09-01 Carl Zeiss Microscopy Gmbh Verfahren und Vorrichtung zur lichtblattmikroskopischen Untersuchung einer Probe
EP4067866B1 (en) * 2021-04-01 2025-11-05 Leica Microsystems CMS GmbH Imaging system and method for imaging biological samples
WO2022268325A1 (en) 2021-06-24 2022-12-29 Leica Microsystems Cms Gmbh Calibration object for calibrating an imaging system
WO2023057349A1 (en) * 2021-10-05 2023-04-13 Leica Microsystems Cms Gmbh Imaging system and method
US20240410818A1 (en) 2021-10-05 2024-12-12 Leica Microsystems Cms Gmbh Sample carrier and method for imaging a sample
EP4594808A1 (en) * 2022-09-26 2025-08-06 Consiglio Nazionale Delle Ricerche System and method for multicolor light sheet microscopy
CN116841026B (zh) * 2023-06-13 2026-03-24 武汉精立电子技术有限公司 一种显微成像方法、设备及存储介质
DE102024205127A1 (de) * 2024-06-04 2025-12-04 Carl Zeiss Microscopy Gmbh Bildgebungsverfahren für lichtdurchlässige Proben, optische Anordnung und Mikroskop
FR3166207A1 (fr) * 2024-09-10 2026-03-13 Universite De Bourgogne Olfactomètre d’étude comportementale de spécimen animal et procédé d’étude comportementale associé
US20260091385A1 (en) * 2024-09-30 2026-04-02 Illumina, Inc. Apparatus and methods for sample loading

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Publication number Publication date
CN111164485A (zh) 2020-05-15
CN111164485B (zh) 2023-01-24
JP2020535421A (ja) 2020-12-03
DE102017122718A1 (de) 2019-04-04
WO2019063539A1 (de) 2019-04-04
US20200284715A1 (en) 2020-09-10
US11371927B2 (en) 2022-06-28

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