JP7305539B2 - 細胞療法に使用するための、免疫学的に識別できる細胞表面変異体 - Google Patents

細胞療法に使用するための、免疫学的に識別できる細胞表面変異体 Download PDF

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JP7305539B2
JP7305539B2 JP2019521099A JP2019521099A JP7305539B2 JP 7305539 B2 JP7305539 B2 JP 7305539B2 JP 2019521099 A JP2019521099 A JP 2019521099A JP 2019521099 A JP2019521099 A JP 2019521099A JP 7305539 B2 JP7305539 B2 JP 7305539B2
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cells
isoform
surface protein
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JP2019533450A (ja
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イェカー,ルーカス
コルネテ,マーラ
シュヴェーデ,ロレンツァ ボルドリ
シュヴェーデ,トルステン
レポレ,ロザルバ
マローネ,ロミーナ マッター
レッヒャー,マイク
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ウニベルシテート バーゼル
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JP2019521099A 2016-11-02 2017-10-30 細胞療法に使用するための、免疫学的に識別できる細胞表面変異体 Active JP7305539B2 (ja)

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JP2023105962A JP7676472B2 (ja) 2016-11-02 2023-06-28 細胞療法に使用するための、免疫学的に識別できる細胞表面変異体

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Application Number Priority Date Filing Date Title
EP16196858 2016-11-02
EP16196860.7 2016-11-02
EP16196860 2016-11-02
EP16196858.1 2016-11-02
EPPCT/EP2017/059799 2017-04-25
PCT/EP2017/059799 WO2017186718A1 (en) 2016-04-25 2017-04-25 Allele editing and applications thereof
EP17197820 2017-10-23
EP17197820.8 2017-10-23
PCT/EP2017/077826 WO2018083071A1 (en) 2016-11-02 2017-10-30 Immunologically discernible cell surface variants for use in cell therapy

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JP7305539B2 true JP7305539B2 (ja) 2023-07-10

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JP2023105962A Active JP7676472B2 (ja) 2016-11-02 2023-06-28 細胞療法に使用するための、免疫学的に識別できる細胞表面変異体

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US (1) US20190365806A1 (https=)
EP (2) EP4360639A3 (https=)
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KR (2) KR20190072639A (https=)
CN (1) CN110191948A (https=)
AU (1) AU2017355218B2 (https=)
BR (1) BR112019008975A2 (https=)
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS61907B1 (sr) 2015-04-06 2021-06-30 Subdomain Llc Polipeptidi koji sadrže de novo vezujući domen i njihova primena
AU2016337525B2 (en) 2015-10-16 2022-01-20 The Trustees Of Columbia University In The City Of New York Compositions and methods for inhibition of lineage specific antigens
US11499168B2 (en) 2016-04-25 2022-11-15 Universitat Basel Allele editing and applications thereof
CA3053534A1 (en) * 2017-02-17 2018-08-23 Purdue Research Foundation Targeted ligand-payload based drug delivery for cell therapy
RU2019130504A (ru) 2017-02-28 2021-03-30 Вор Байофарма, Инк. Композиции и способы ингибирования линиеспецифических белков
KR20250070609A (ko) 2017-11-14 2025-05-20 아르셀엑스, 인크. 다기능성 면역 세포 요법
US11464803B2 (en) 2017-11-14 2022-10-11 Arcellx, Inc. D-domain containing polypeptides and uses thereof
RS67119B1 (sr) 2017-11-14 2025-09-30 Arcellx Inc Polipeptidi koji obuhvataju d domen i njihove upotrebe
AU2019265019B2 (en) 2018-05-11 2025-11-06 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
KR20210045360A (ko) 2018-05-16 2021-04-26 신테고 코포레이션 가이드 rna 설계 및 사용을 위한 방법 및 시스템
US12281151B2 (en) 2018-06-29 2025-04-22 City Of Hope CD6 targeted chimeric antigen receptors for treatment of certain autoimmune disorders
WO2020043750A1 (en) * 2018-08-28 2020-03-05 Roche Innovation Center Copenhagen A/S Neoantigen engineering using splice modulating compounds
CA3110837A1 (en) 2018-08-28 2020-03-05 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof
EP3908372A1 (en) * 2019-01-13 2021-11-17 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Antibodies specific to human nectin-2
KR102689877B1 (ko) * 2019-11-28 2024-08-01 주식회사 센트릭스바이오 CD300c 항원 또는 그의 수용체에 특이적으로 결합하는 키메라 항원 수용체
WO2021138454A1 (en) * 2019-12-30 2021-07-08 City Of Hope Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers
KR102347797B1 (ko) * 2020-03-03 2022-01-07 한국과학기술원 대식세포 세포 표면 항원 및 이의 다양한 용도
EP4126243A4 (en) * 2020-03-27 2024-06-12 The Trustees of Indiana University Immunotherapeutic targets in multiple myeloma and methods for their identification
JP2024502820A (ja) * 2020-12-31 2024-01-23 ブイオーアール バイオファーマ インコーポレーテッド Cd34遺伝子改変のための組成物及び方法
WO2022150831A1 (en) * 2021-01-07 2022-07-14 Innovative Cellular Therapeutics Holdings, Ltd. Car cells and polyspecific binding molecules for treating solid tumor
CN112852875B (zh) * 2021-02-26 2022-10-21 福建省立医院 示踪肿瘤T淋巴细胞浸润的CD3e转基因小鼠模型的构建方法
CN113109575A (zh) * 2021-04-16 2021-07-13 浙江普罗亭健康科技有限公司 一种用于监测人体免疫状态的40抗体试剂盒及应用
CN113125733A (zh) * 2021-04-16 2021-07-16 浙江普罗亭健康科技有限公司 一种用于监测人体免疫状态的42抗体试剂盒及应用
CN113125755A (zh) * 2021-04-16 2021-07-16 浙江普罗亭健康科技有限公司 一种用于监测人体免疫状态的9抗体试剂盒及应用
CN113125718A (zh) * 2021-04-16 2021-07-16 浙江普罗亭健康科技有限公司 一种用于监测人体免疫状态的45抗体试剂盒及应用
CN113125754A (zh) * 2021-04-16 2021-07-16 浙江普罗亭健康科技有限公司 一种用于监测人体免疫状态的23抗体试剂盒及应用
AU2021447099A1 (en) * 2021-05-27 2023-02-16 Cas Lamvac (Guangzhou) Biomedical Technology Co., Ltd. Method and kit for analyzing phenotype and function of CD303
WO2023283585A2 (en) 2021-07-06 2023-01-12 Vor Biopharma Inc. Inhibitor oligonucleotides and methods of use thereof
AU2022324093A1 (en) 2021-08-02 2024-02-08 Vor Biopharma Inc. Compositions and methods for gene modification
JP2024530465A (ja) 2021-08-06 2024-08-21 ウニバズィテート バーゼル 細胞療法に使用するための識別可能な細胞表面タンパク質変異体
EP4448573A1 (en) 2021-12-16 2024-10-23 Universität Basel Discernible cell surface protein variants of cd117 for use in cell therapy
AU2022422572A1 (en) 2021-12-23 2024-06-06 Cimeio Therapeutics Ag Discernible cell surface protein variants of cd45 for use in cell therapy
CN114292830B (zh) * 2021-12-31 2024-05-03 复旦大学 蛋白SaCas9的抗原表位及其在基因编辑中的应用
WO2024015925A2 (en) * 2022-07-13 2024-01-18 Vor Biopharma Inc. Compositions and methods for artificial protospacer adjacent motif (pam) generation
WO2024073751A1 (en) 2022-09-29 2024-04-04 Vor Biopharma Inc. Methods and compositions for gene modification and enrichment
EP4611807A1 (en) * 2022-11-04 2025-09-10 The Board of Trustees of the Leland Stanford Junior University Rebalancing the immune system through depletion of myeloid-biased hematopoietic stem cells
CN117912552B (zh) * 2023-01-07 2025-03-28 杭州链康医学检验实验室有限公司 一种pdx模型单细胞转录组数据的分析方法、设备和介质
EP4688850A1 (en) 2023-04-03 2026-02-11 Universität Basel Discernible cell surface protein variants of cd33 for use in cell therapy
WO2025031965A1 (en) 2023-08-04 2025-02-13 Cimeio Therapeutics Ag Discernible cell surface protein variants of cd52 for use in cell therapy
WO2025132801A1 (en) 2023-12-19 2025-06-26 Cimeio Therapeutics Ag Discernible protein variants of bcl-2 for use in cell therapy
CN120738344A (zh) * 2025-08-26 2025-10-03 北京康美天鸿生物科技有限公司 检测地中海贫血基因突变的引物组及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502840A (ja) 2012-12-06 2016-02-01 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC Crisprに基づくゲノム修飾および制御
US20160144026A1 (en) 2014-11-26 2016-05-26 Miltenyi Biotec Gmbh Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
JP2016521709A (ja) 2013-06-05 2016-07-25 ベリカム ファーマシューティカルズ, インコーポレイテッド カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法
JP2018533625A (ja) 2015-11-04 2018-11-15 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 造血幹細胞における遺伝子編集のための方法および組成物
JP2019516399A (ja) 2016-04-25 2019-06-20 ウニベルシテート バーゼル アレル編集およびその応用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002070738A2 (en) * 2001-03-07 2002-09-12 Andre Schuh Diagnosis and treatment of blood disorders
EP1674479A1 (en) * 2004-12-22 2006-06-28 Memorial Sloan-Kettering Cancer Center Modulation of Fc Gamma receptors for optimizing immunotherapy
WO2007087453A2 (en) * 2006-01-27 2007-08-02 Cellerant Therapeutics, Inc. Compositions and methods for treating haematological proliferative disorders
WO2008067115A2 (en) * 2006-11-03 2008-06-05 The Board Of Trustees Of The Leland Stanford Junior University Selective immunodepletion of endogenous stem cell niche for engraftment
WO2009023816A1 (en) * 2007-08-15 2009-02-19 Emory University Methods of making monoclonal antibodies using fusion- peptide epitope adoptive transfer (f-peat) technology
CN102271711B (zh) * 2008-12-12 2014-06-18 国立大学法人东京大学 每种维持移植物抗肿瘤效应的免疫重建促进剂或感染预防剂
EP3666795A1 (en) * 2013-03-12 2020-06-17 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
CA2914213A1 (en) * 2013-06-17 2014-12-24 Alain Moreau A method of increasing gipcr signalization in the cells of a scoliotic subject
WO2016014837A1 (en) * 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Gene editing for hiv gene therapy
HK1256681A1 (zh) * 2015-04-06 2019-10-04 President And Fellows Of Harvard College 用於非清髓性预处理的组合物和方法
JP2019508037A (ja) * 2016-02-16 2019-03-28 イェール ユニバーシティーYale Universit 標的化遺伝子編集を増強するための組成物およびその使用方法
JP2019508051A (ja) * 2016-03-14 2019-03-28 エディタス・メディシン、インコーポレイテッド β異常ヘモグロビン症を治療するためのCRISPR/CAS関連方法および組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016502840A (ja) 2012-12-06 2016-02-01 シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニーSigma−Aldrich Co., LLC Crisprに基づくゲノム修飾および制御
JP2016521709A (ja) 2013-06-05 2016-07-25 ベリカム ファーマシューティカルズ, インコーポレイテッド カスパーゼポリペプチドを使用して部分的なアポトーシスを誘導するための方法
US20160144026A1 (en) 2014-11-26 2016-05-26 Miltenyi Biotec Gmbh Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
JP2018533625A (ja) 2015-11-04 2018-11-15 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 造血幹細胞における遺伝子編集のための方法および組成物
JP2019516399A (ja) 2016-04-25 2019-06-20 ウニベルシテート バーゼル アレル編集およびその応用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Blood, 2003, Vol.101, No.6, pp.2434-2439
Diabetes, 1992, Vol.41, pp.956-961
Journal of Leukocyte Biology, 2011, Vol.89, pp.291-300
Nat. Biotechnol., 2017.4, Vol.35, No.4, pp.371-376
Nature, 2016, Vol.533, pp.420-424, Methods, Extended Data
生物物理, 2014, Vol.54, No.5, pp.247-252

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