JP7295098B2 - 新規抗ｃｄ１９抗体 - Google Patents

新規抗ｃｄ１９抗体 Download PDF

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JP7295098B2
JP7295098B2 JP2020516576A JP2020516576A JP7295098B2 JP 7295098 B2 JP7295098 B2 JP 7295098B2 JP 2020516576 A JP2020516576 A JP 2020516576A JP 2020516576 A JP2020516576 A JP 2020516576A JP 7295098 B2 JP7295098 B2 JP 7295098B2
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seq
antibody
antigen
variable region
chain variable
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JP2020534012A5 (OSRAM
JP2020534012A (ja
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リ，ジン
リウ，ジイン
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ウーシー バイオロジクス アイルランド リミテッド
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118546959A (zh) 2019-03-05 2024-08-27 恩卡尔塔公司 Cd19定向性嵌合抗原受体及其在免疫疗法中的用途
CN110003334B (zh) * 2019-04-12 2023-05-09 深圳普瑞金生物药业股份有限公司 多肽、cd19单域抗体及其制备方法、核苷酸序列及试剂盒
WO2021067598A1 (en) 2019-10-04 2021-04-08 Ultragenyx Pharmaceutical Inc. Methods for improved therapeutic use of recombinant aav
CN110845617B (zh) * 2019-12-05 2021-07-09 常州费洛斯药业科技有限公司 针对cd19的全人源抗体或抗体片段、嵌合抗原受体及应用
CN110922482B (zh) * 2019-12-25 2021-08-31 源道隆（苏州）医学科技有限公司 可结合cd19的多肽及其应用
KR20230005268A (ko) 2020-04-24 2023-01-09 밀레니엄 파머슈티컬스 인코퍼레이티드 항-cd19 항체 및 이의 용도
CN111840571B (zh) * 2020-08-03 2022-09-20 杭州皓阳生物技术有限公司 一种抗体药物偶联物及其用途
WO2022266075A1 (en) 2021-06-14 2022-12-22 Caribou Biosciences, Inc. Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain
EP4368640A4 (en) * 2021-07-09 2025-01-22 Hainan Simcere Zaiming Pharmaceutical Co., Ltd. Cd19 antibody and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528209A (ja) 2003-07-31 2007-10-11 イミューノメディクス、インコーポレイテッド 抗ｃｄ１９抗体
JP2013535192A (ja) 2010-07-19 2013-09-12 インターナショナル−ドラッグ−デヴェロップメント−バイオテック Ａｄｃｃおよびｃｄｃ機能ならびに改善されたグリコシル化プロファイルを有する抗ｃｄ１９抗体
JP2018535657A (ja) 2015-10-02 2018-12-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 高親和性を有する抗ヒトｃｄｃ１９抗体

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080260731A1 (en) * 2002-03-01 2008-10-23 Bernett Matthew J Optimized antibodies that target cd19
CN101233156B (zh) * 2005-06-20 2012-06-27 米德列斯公司 Cd19抗体及其用途
RS53263B (sr) * 2006-08-14 2014-08-29 Xencor Inc. Optimizovana antitela usmerena na cd19
KR101456728B1 (ko) * 2006-09-08 2014-10-31 메디뮨 엘엘씨 인간화 항-ｃｄ19 항체, 및 이것의 종양학, 이식 및 자가면역 질환의 치료에서의 용도
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
SI2211904T1 (sl) * 2007-10-19 2016-12-30 Seattle Genetics, Inc. CD19 vezavna sredstva in njihove uporabe
WO2010095031A2 (en) * 2009-02-23 2010-08-26 Glenmark Pharmaceuticals S.A. Humanized antibodies that bind to cd19 and their uses
EP2409993A1 (en) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC function with improved glycosylation profile
EP2524929A1 (en) * 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
JPWO2014065402A1 (ja) * 2012-10-26 2016-09-08 株式会社ペルセウスプロテオミクス 抗ヒトｃｄ４０モノクローナル抗体及びその利用
BR112015013444B1 (pt) 2012-12-13 2022-11-01 Immunomedics, Inc Uso de um imunoconjugado
US9758575B2 (en) * 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
CA3026858A1 (en) 2016-06-30 2018-01-04 F. Hoffmann-La Roche Ag Improved adoptive t-cell therapy
EP3802617A4 (en) * 2018-06-07 2022-04-27 Cullinan Oncology, Inc. MULTISPECIFIC BINDING PROTEINS AND METHODS OF USE THEREOF

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528209A (ja) 2003-07-31 2007-10-11 イミューノメディクス、インコーポレイテッド 抗ｃｄ１９抗体
JP2013535192A (ja) 2010-07-19 2013-09-12 インターナショナル−ドラッグ−デヴェロップメント−バイオテック Ａｄｃｃおよびｃｄｃ機能ならびに改善されたグリコシル化プロファイルを有する抗ｃｄ１９抗体
JP2018535657A (ja) 2015-10-02 2018-12-06 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 高親和性を有する抗ヒトｃｄｃ１９抗体

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