SG11202001817PA - Novel anti-cd19 antibodies - Google Patents

Novel anti-cd19 antibodies

Info

Publication number
SG11202001817PA
SG11202001817PA SG11202001817PA SG11202001817PA SG11202001817PA SG 11202001817P A SG11202001817P A SG 11202001817PA SG 11202001817P A SG11202001817P A SG 11202001817PA SG 11202001817P A SG11202001817P A SG 11202001817PA SG 11202001817P A SG11202001817P A SG 11202001817PA
Authority
SG
Singapore
Prior art keywords
antibodies
novel anti
novel
Prior art date
Application number
SG11202001817PA
Inventor
Jing Li
Jieying Liu
Original Assignee
Wuxi Biologics Ireland Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wuxi Biologics Ireland Ltd filed Critical Wuxi Biologics Ireland Ltd
Publication of SG11202001817PA publication Critical patent/SG11202001817PA/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • A61K39/4611T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/464411Immunoglobulin superfamily
    • A61K39/464412CD19 or B4
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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SG11202001817PA 2017-09-21 2018-09-20 Novel anti-cd19 antibodies SG11202001817PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2017102631 2017-09-21
PCT/CN2018/106619 WO2019057100A1 (en) 2017-09-21 2018-09-20 Novel anti-cd19 antibodies

Publications (1)

Publication Number Publication Date
SG11202001817PA true SG11202001817PA (en) 2020-03-30

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US (1) US11497769B2 (en)
EP (1) EP3684820A4 (en)
JP (1) JP7295098B2 (en)
KR (1) KR20200055758A (en)
CN (2) CN115819588A (en)
AU (1) AU2018336520A1 (en)
BR (1) BR112020005402A2 (en)
CA (1) CA3074524A1 (en)
IL (1) IL273389A (en)
MX (1) MX2020003093A (en)
SG (1) SG11202001817PA (en)
TW (1) TWI812645B (en)
WO (1) WO2019057100A1 (en)

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CN110003334B (en) * 2019-04-12 2023-05-09 深圳普瑞金生物药业股份有限公司 Polypeptide, CD19 single domain antibody, preparation method thereof, nucleotide sequence and kit
JP2022550435A (en) 2019-10-04 2022-12-01 ウルトラジェニックス ファーマシューティカル インコーポレイテッド Methods for improved therapeutic use of recombinant AAV
CN110845617B (en) * 2019-12-05 2021-07-09 常州费洛斯药业科技有限公司 Fully human antibody or antibody fragment aiming at CD19, chimeric antigen receptor and application
CN110922482B (en) * 2019-12-25 2021-08-31 源道隆(苏州)医学科技有限公司 Polypeptide capable of binding CD19 and application thereof
BR112022021450A2 (en) * 2020-04-24 2022-12-27 Millennium Pharm Inc CD19 OR LEADING FRAGMENT, METHOD OF TREATMENT OF A CANCER, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID, VECTOR AND, ISOLATED CELL
CN111840571B (en) * 2020-08-03 2022-09-20 杭州皓阳生物技术有限公司 Antibody drug conjugate and application thereof
WO2022266075A1 (en) 2021-06-14 2022-12-22 Caribou Biosciences, Inc. Methods and materials for treating cancer using car constructs with an intracellular domain comprising a stap domain and a kinase domain or a stap domain and a phosphatase domain
CN117616048A (en) * 2021-07-09 2024-02-27 先声再明医药有限公司 CD19 antibodies and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080260731A1 (en) * 2002-03-01 2008-10-23 Bernett Matthew J Optimized antibodies that target cd19
EP2216342B1 (en) * 2003-07-31 2015-04-22 Immunomedics, Inc. Anti-CD19 antibodies
PL2383297T3 (en) * 2006-08-14 2013-06-28 Xencor Inc Optimized antibodies that target CD19
DK2066349T3 (en) * 2006-09-08 2012-07-09 Medimmune Llc HUMANIZED ANTI-CD19 ANTIBODIES AND USE THEREOF IN TREATMENT OF TUMORS, TRANSPLANTATION AND AUTOIMMUNE DISEASES
CL2007003622A1 (en) * 2006-12-13 2009-08-07 Medarex Inc Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method.
JP5727786B2 (en) 2007-10-19 2015-06-03 シアトル ジェネティクス,インコーポレーテッド CD19 binding substance and use thereof
CA2753158A1 (en) * 2009-02-23 2010-08-26 Glenmark Pharmaceuticals S.A. Humanized antibodies that bind to cd19 and their uses
EP2409993A1 (en) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC function with improved glycosylation profile
EP2409712A1 (en) * 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anti-CD19 antibody having ADCC and CDC functions and improved glycosylation profile
EP2524929A1 (en) * 2011-05-17 2012-11-21 Sanofi Use of anti-CD19 maytansinoid immunoconjugate antibody for the treatment of CD19+ B-cell malignancies syptoms
JPWO2014065402A1 (en) * 2012-10-26 2016-09-08 株式会社ペルセウスプロテオミクス Anti-human CD40 monoclonal antibody and use thereof
US9758575B2 (en) * 2015-04-06 2017-09-12 Yung Shin Pharmaceutical Industrial Co. Ltd. Antibodies which specifically bind to canine vascular endothelial growth factor and uses thereof
MY193249A (en) 2015-10-02 2022-09-28 Hoffmann La Roche Anti-human cd19 antibodies with high affinity
CN109476749A (en) 2016-06-30 2019-03-15 豪夫迈·罗氏有限公司 The adoptive T cell therapy of improvement
AU2019282836A1 (en) 2018-06-07 2021-01-07 Cullinan Oncology, Inc. Multi-specific binding proteins and methods of use thereof

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