JP7254792B2 - グルコース感受性アルブミン結合誘導体 - Google Patents

グルコース感受性アルブミン結合誘導体 Download PDF

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Publication number
JP7254792B2
JP7254792B2 JP2020525911A JP2020525911A JP7254792B2 JP 7254792 B2 JP7254792 B2 JP 7254792B2 JP 2020525911 A JP2020525911 A JP 2020525911A JP 2020525911 A JP2020525911 A JP 2020525911A JP 7254792 B2 JP7254792 B2 JP 7254792B2
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nhch
cooh
formula
linker
covalent bond
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JP2021502372A (ja
JP2021502372A5 (https=
Inventor
トーマス・クルーセ
ミケール・コフォード・ハンスン
マルティン・ヴェルナー・ボルクセニウス・ミュンツェル
ヘニング・トゥーヤスン
ペル・サウエルベルク
ヤコブ・エワルド・ラスムッセン
カルステン・ベーレンス
トマス・ホウ－イェンセン
ヴォイチェフ・バルシャネク
ズザナ・ドロブニャコヴァ
ラジスラフ・ドロズ
ミロスラフ・ハヴラーネク
ヴラジスラフ・コテク
ミラン・シュテングル
イヴァン・シュナイドル
ハナ・ヴァーニョヴァー
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Novo Nordisk AS
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Priority to JP2023051919A priority Critical patent/JP7622123B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/10—Methods of screening libraries by measuring physical properties, e.g. mass
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6827—Total protein determination, e.g. albumin in urine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020525911A 2017-11-09 2018-11-08 グルコース感受性アルブミン結合誘導体 Active JP7254792B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023051919A JP7622123B2 (ja) 2017-11-09 2023-03-28 ジボロン化合物および糖尿病関連ペプチドまたはタンパク質を含むジボロンコンジュゲートならびに１－ヒドロキシ－４－（トリフルオロメチル）－１，３－ジヒドロベンゾ［ｃ］［１，２］オキサボロール－６－カルボン酸
JP2025005534A JP2025061325A (ja) 2017-11-09 2025-01-15 グルコース感受性アルブミン結合誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17200734 2017-11-09
EP17200734.6 2017-11-09
EP18178294 2018-06-18
EP18178294.7 2018-06-18
PCT/EP2018/080650 WO2019092125A1 (en) 2017-11-09 2018-11-08 Glucose-sensitive albumin-binding derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023051919A Division JP7622123B2 (ja) 2017-11-09 2023-03-28 ジボロン化合物および糖尿病関連ペプチドまたはタンパク質を含むジボロンコンジュゲートならびに１－ヒドロキシ－４－（トリフルオロメチル）－１，３－ジヒドロベンゾ［ｃ］［１，２］オキサボロール－６－カルボン酸

Publications (3)

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JP2021502372A JP2021502372A (ja) 2021-01-28
JP2021502372A5 JP2021502372A5 (https=) 2021-11-18
JP7254792B2 true JP7254792B2 (ja) 2023-04-10

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JP2020525911A Active JP7254792B2 (ja) 2017-11-09 2018-11-08 グルコース感受性アルブミン結合誘導体
JP2023051919A Active JP7622123B2 (ja) 2017-11-09 2023-03-28 ジボロン化合物および糖尿病関連ペプチドまたはタンパク質を含むジボロンコンジュゲートならびに１－ヒドロキシ－４－（トリフルオロメチル）－１，３－ジヒドロベンゾ［ｃ］［１，２］オキサボロール－６－カルボン酸
JP2025005534A Pending JP2025061325A (ja) 2017-11-09 2025-01-15 グルコース感受性アルブミン結合誘導体

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JP2023051919A Active JP7622123B2 (ja) 2017-11-09 2023-03-28 ジボロン化合物および糖尿病関連ペプチドまたはタンパク質を含むジボロンコンジュゲートならびに１－ヒドロキシ－４－（トリフルオロメチル）－１，３－ジヒドロベンゾ［ｃ］［１，２］オキサボロール－６－カルボン酸
JP2025005534A Pending JP2025061325A (ja) 2017-11-09 2025-01-15 グルコース感受性アルブミン結合誘導体

Country Status (7)

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US (4) US11186595B2 (https=)
EP (2) EP4227313B1 (https=)
JP (3) JP7254792B2 (https=)
CN (2) CN111315751B (https=)
ES (2) ES3056386T3 (https=)
MA (2) MA71363A (https=)
WO (1) WO2019092125A1 (https=)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2025061325A (ja) * 2017-11-09 2025-04-10 ノヴォ ノルディスク アー／エス グルコース感受性アルブミン結合誘導体

Families Citing this family (12)

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WO2016179568A1 (en) 2015-05-06 2016-11-10 Protomer Technologies, Inc. Glucose responsive insulins
EP3946363A2 (en) * 2019-03-29 2022-02-09 Novo Nordisk A/S Glucose sensitive insulin derivatives
CN112174989B (zh) * 2019-07-02 2023-06-20 江西同和药业股份有限公司 一种克立硼罗的制备方法
JP7834341B2 (ja) * 2019-07-31 2026-03-24 シーエス ファーマシューティカルズ エルエルシー グルコース調節型立体配座スイッチを有するインスリン類似体
EP4126058A1 (en) * 2020-03-31 2023-02-08 Protomer Technologies Inc. Conjugates for selective responsiveness to vicinal diols
JP2024500284A (ja) * 2020-11-19 2024-01-09 プロトマー・テクノロジーズ・インコーポレイテッド 芳香族ホウ素含有化合物及びインスリン類似体
EP4255468A4 (en) * 2020-12-02 2024-06-05 The Regents of University of California INJECTABLE BIODEGRADABLE POLYMER COMPLEX FOR GLUCOSE-DEPENDENT INSULIN DELIVERY
WO2022235691A1 (en) * 2021-05-03 2022-11-10 The Trustees Of Indiana University Molecular design of glucose sensors in glucose-responsive insulin analogues
CN114478597B (zh) * 2021-12-29 2023-08-29 宁波大学 一种快速识别葡萄糖手性的试剂及其制备方法和应用
WO2023225534A1 (en) 2022-05-18 2023-11-23 Protomer Technologies Inc. Aromatic boron-containing compounds and related insulin analogs
AU2024251658A1 (en) * 2023-04-11 2025-09-18 Protomer Technologies, Inc. Compounds containing one or more diboronates and related insulin analogs
AU2024295902A1 (en) 2023-07-18 2026-01-15 Novo Nordisk A/S Pharmaceutical compositions of insulin derivatives

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JP2003535106A (ja) 2000-06-02 2003-11-25 ノボ ノルディスク アクティーゼルスカブ グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出
US20150320837A1 (en) 2012-12-12 2015-11-12 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment

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EP1453860A2 (en) 2001-12-02 2004-09-08 Novo Nordisk A/S Novel glucose-dependant insulins
US7317000B2 (en) 2001-12-02 2008-01-08 Novo Nordisk A/S Glucose-dependent insulins
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US20150320837A1 (en) 2012-12-12 2015-11-12 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
JP2025061325A (ja) * 2017-11-09 2025-04-10 ノヴォ ノルディスク アー／エス グルコース感受性アルブミン結合誘導体

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EP4227313C0 (en) 2025-10-22
US20220081451A1 (en) 2022-03-17
US11186595B2 (en) 2021-11-30
EP3707145A1 (en) 2020-09-16
JP2021502372A (ja) 2021-01-28
EP4227313A1 (en) 2023-08-16
CN117624207A (zh) 2024-03-01
MA50552A (fr) 2020-09-16
ES3056386T3 (en) 2026-02-20
CN111315751B (zh) 2023-12-12
US20230331745A1 (en) 2023-10-19
CN111315751A (zh) 2020-06-19
US20250122226A1 (en) 2025-04-17
US20200325160A1 (en) 2020-10-15
US11767332B2 (en) 2023-09-26
JP2023080126A (ja) 2023-06-08
EP4227313B1 (en) 2025-10-22
EP3707145B1 (en) 2023-06-21
US12227528B2 (en) 2025-02-18
ES2956032T3 (es) 2023-12-12
JP2025061325A (ja) 2025-04-10
EP3707145C0 (en) 2023-06-21
MA71363A (fr) 2025-04-30
JP7622123B2 (ja) 2025-01-27
WO2019092125A1 (en) 2019-05-16

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