JP7240329B2 - 目的分子を産生するための遺伝的に最適化された微生物 - Google Patents
目的分子を産生するための遺伝的に最適化された微生物 Download PDFInfo
- Publication number
- JP7240329B2 JP7240329B2 JP2019561349A JP2019561349A JP7240329B2 JP 7240329 B2 JP7240329 B2 JP 7240329B2 JP 2019561349 A JP2019561349 A JP 2019561349A JP 2019561349 A JP2019561349 A JP 2019561349A JP 7240329 B2 JP7240329 B2 JP 7240329B2
- Authority
- JP
- Japan
- Prior art keywords
- gene
- microorganism
- genetically modified
- expression
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01049—Glucose-6-phosphate dehydrogenase (1.1.1.49)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01031—6-Phosphogluconolactonase (3.1.1.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01039—Ribulose-bisphosphate carboxylase (4.1.1.39)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01044—Phosphogluconate dehydrogenase (decarboxylating) (1.1.1.44)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01019—Phosphoribulokinase (2.7.1.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02003—Phosphoglycerate kinase (2.7.2.3)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022182031A JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1750694A FR3062394B1 (fr) | 2017-01-27 | 2017-01-27 | Microorganisme genetiquement optimise pour la production de molecules d'interet |
| FR1750694 | 2017-01-27 | ||
| PCT/EP2018/052005 WO2018138289A1 (fr) | 2017-01-27 | 2018-01-26 | Microorganisme génétiquement optimisé pour la production de molécules d'intérêt |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022182031A Division JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506723A JP2020506723A (ja) | 2020-03-05 |
| JP2020506723A5 JP2020506723A5 (https=) | 2021-02-12 |
| JP7240329B2 true JP7240329B2 (ja) | 2023-03-15 |
Family
ID=59070757
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561349A Active JP7240329B2 (ja) | 2017-01-27 | 2018-01-26 | 目的分子を産生するための遺伝的に最適化された微生物 |
| JP2022182031A Pending JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022182031A Pending JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200277592A1 (https=) |
| EP (1) | EP3574083A1 (https=) |
| JP (2) | JP7240329B2 (https=) |
| KR (1) | KR102643557B1 (https=) |
| CN (1) | CN110678541A (https=) |
| BR (1) | BR112019015458A2 (https=) |
| FR (1) | FR3062394B1 (https=) |
| WO (1) | WO2018138289A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109536398B (zh) * | 2013-02-22 | 2023-08-04 | 帝斯曼知识产权资产管理有限公司 | 用于产量增加的方法中的重组体微生物 |
| WO2017216136A1 (en) * | 2016-06-14 | 2017-12-21 | Dsm Ip Assets B.V. | Recombinant yeast cell |
| WO2020231137A1 (ko) * | 2019-05-10 | 2020-11-19 | 주식회사 씨앤큐어 | 암의 진단 및 치료용 dna 컨스트럭트 |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| CN112852664B (zh) * | 2021-01-14 | 2022-07-15 | 西华大学 | 一种酿酒酵母以及提高酿酒酵母产γ-氨基丁酸的方法 |
| CN112941061B (zh) * | 2021-03-19 | 2021-09-07 | 中国农业大学 | 一种Tk-Rubisco突变体、线性组装材料及其制备方法和应用 |
| CN114164237B (zh) * | 2021-11-04 | 2023-03-17 | 山东阜丰发酵有限公司 | 一种生产琥珀酸的方法 |
| CN114181879B (zh) * | 2021-12-09 | 2022-11-22 | 中国科学院深圳先进技术研究院 | 具有自养能力的底盘细胞及其构建方法和应用 |
| CN115851779B (zh) * | 2022-10-29 | 2024-03-26 | 昆明理工大学 | 一种葡萄糖-6-磷酸脱氢酶基因RkZWF1及其应用 |
| CN117210446A (zh) * | 2023-03-21 | 2023-12-12 | 北京蓝晶微生物科技有限公司 | 一种重建卡尔文循环提高异养微生物代谢产物产量的方法 |
| CN120384059B (zh) * | 2025-06-27 | 2025-09-26 | 南京大学 | 葡萄糖-6-磷酸脱氢酶突变体、生物材料、催化剂及应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002529079A (ja) | 1998-11-10 | 2002-09-10 | マキシジェン, インコーポレイテッド | 改変されたリブロース1,5−ビスホスフェートカルボキシラーゼ/オキシゲナーゼ |
| WO2009036095A1 (en) | 2007-09-10 | 2009-03-19 | Joule Biotechnologies, Inc. | Engineered light-harvesting organisms |
| WO2015177800A2 (en) | 2014-05-22 | 2015-11-26 | Yeda Research And Development Co. Ltd. | Recombinant microorganisms capable of carbon fixation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| FR3016371B1 (fr) * | 2014-01-16 | 2018-02-02 | Institut National De La Recherche Agronomique | Levures modifiees pour utiliser le dioxyde de carbone |
-
2017
- 2017-01-27 FR FR1750694A patent/FR3062394B1/fr active Active
-
2018
- 2018-01-26 WO PCT/EP2018/052005 patent/WO2018138289A1/fr not_active Ceased
- 2018-01-26 CN CN201880021659.1A patent/CN110678541A/zh active Pending
- 2018-01-26 EP EP18702647.1A patent/EP3574083A1/fr active Pending
- 2018-01-26 BR BR112019015458-2A patent/BR112019015458A2/pt active Search and Examination
- 2018-01-26 US US16/480,569 patent/US20200277592A1/en not_active Abandoned
- 2018-01-26 KR KR1020197024086A patent/KR102643557B1/ko active Active
- 2018-01-26 JP JP2019561349A patent/JP7240329B2/ja active Active
-
2022
- 2022-01-12 US US17/573,877 patent/US12018300B2/en active Active
- 2022-11-14 JP JP2022182031A patent/JP2023011947A/ja active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002529079A (ja) | 1998-11-10 | 2002-09-10 | マキシジェン, インコーポレイテッド | 改変されたリブロース1,5−ビスホスフェートカルボキシラーゼ/オキシゲナーゼ |
| WO2009036095A1 (en) | 2007-09-10 | 2009-03-19 | Joule Biotechnologies, Inc. | Engineered light-harvesting organisms |
| WO2015177800A2 (en) | 2014-05-22 | 2015-11-26 | Yeda Research And Development Co. Ltd. | Recombinant microorganisms capable of carbon fixation |
Non-Patent Citations (1)
| Title |
|---|
| Oliver Mueller-Cajar & Spencer M. Whitney,Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research,Photosynthesis Research,2008年,Vol. 98,667-675 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019015458A2 (pt) | 2020-03-31 |
| KR20190115447A (ko) | 2019-10-11 |
| FR3062394A1 (fr) | 2018-08-03 |
| WO2018138289A1 (fr) | 2018-08-02 |
| CN110678541A (zh) | 2020-01-10 |
| JP2023011947A (ja) | 2023-01-24 |
| EP3574083A1 (fr) | 2019-12-04 |
| KR102643557B1 (ko) | 2024-03-07 |
| US12018300B2 (en) | 2024-06-25 |
| US20220348897A1 (en) | 2022-11-03 |
| US20200277592A1 (en) | 2020-09-03 |
| JP2020506723A (ja) | 2020-03-05 |
| FR3062394B1 (fr) | 2021-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7240329B2 (ja) | 目的分子を産生するための遺伝的に最適化された微生物 | |
| US10961551B2 (en) | Process for producing at least one metabolite of interest by conversion of a pentose in a microorganism | |
| CN107828671B (zh) | 用于生产3-羟基丙酸的组合物和方法 | |
| KR101149566B1 (ko) | Nadph를 소비하는 생합성 경로에 최적화시킨 미생물 균주 | |
| Babaei et al. | Engineering oleaginous yeast as the host for fermentative succinic acid production from glucose | |
| JP2020506722A (ja) | 目的分子を産生するための遺伝的に最適化された微生物 | |
| US12378580B2 (en) | Co-production pathway for 3-HPA and acetyl-CoA derivatives from malonate semialdehyde | |
| DE112015003962B4 (de) | 3-Hydroxypropionsäure erzeugende rekombinante Hefe und Verfahren zum Herstellen von 3-Hydroxypropionsäure unter Nutzung derselben | |
| KR20120108538A (ko) | 말로닉 세미알데히드 환원 경로를 이용한 3-하이드록시프로피온산의 생산방법 | |
| WO2020060948A1 (en) | Production of cannabinoids in yeast using a fatty acid feedstock | |
| KR101674361B1 (ko) | 유기산 제조에서의 모나스쿠스의 용도 | |
| US20170183670A1 (en) | Strain and bioprocess engineering for high lipid production | |
| JP2013021940A (ja) | 遺伝子欠損酵母の製造方法 | |
| EP4330399A1 (en) | Genetically modified yeast cells and methods of use for increased lipid yield | |
| CN105861339A (zh) | 一株过表达gtp 环式水解酶基因的重组高山被孢霉、其构建方法及应用 | |
| Harth | Metabolic engineering of saccharomyces cerevisiae towards the biotransformation of D-galacturonic acid to L-galactonate | |
| CN120858175A (zh) | 用于生产d-阿洛酮糖的遗传修饰的微生物和发酵工艺 | |
| CA3045740A1 (en) | Improved glycerol free ethanol production |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200110 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201222 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20201222 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20211029 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20211116 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220124 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20220414 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20220712 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221114 |
|
| C60 | Trial request (containing other claim documents, opposition documents) |
Free format text: JAPANESE INTERMEDIATE CODE: C60 Effective date: 20221114 |
|
| C11 | Written invitation by the commissioner to file amendments |
Free format text: JAPANESE INTERMEDIATE CODE: C11 Effective date: 20221122 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20221212 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221223 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20221212 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20230104 |
|
| C21 | Notice of transfer of a case for reconsideration by examiners before appeal proceedings |
Free format text: JAPANESE INTERMEDIATE CODE: C21 Effective date: 20230110 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230207 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230303 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7240329 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |