JP2020506723A5 - - Google Patents
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- Publication number
- JP2020506723A5 JP2020506723A5 JP2019561349A JP2019561349A JP2020506723A5 JP 2020506723 A5 JP2020506723 A5 JP 2020506723A5 JP 2019561349 A JP2019561349 A JP 2019561349A JP 2019561349 A JP2019561349 A JP 2019561349A JP 2020506723 A5 JP2020506723 A5 JP 2020506723A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- microorganism
- molecule
- expression
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 31
- 108010080971 phosphoribulokinase Proteins 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- 108010003581 Ribulose-bisphosphate carboxylase Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 6
- 150000003505 terpenes Chemical class 0.000 claims 6
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 4
- 229930182558 Sterol Natural products 0.000 claims 3
- 235000001014 amino acid Nutrition 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims 3
- 229930195729 fatty acid Natural products 0.000 claims 3
- 239000000194 fatty acid Substances 0.000 claims 3
- 150000004665 fatty acids Chemical class 0.000 claims 3
- 229930003935 flavonoid Natural products 0.000 claims 3
- 150000002215 flavonoids Chemical class 0.000 claims 3
- 235000017173 flavonoids Nutrition 0.000 claims 3
- 150000007524 organic acids Chemical class 0.000 claims 3
- 235000005985 organic acids Nutrition 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- 150000003077 polyols Chemical class 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 150000003432 sterols Chemical class 0.000 claims 3
- 235000003702 sterols Nutrition 0.000 claims 3
- 235000007586 terpenes Nutrition 0.000 claims 3
- 235000013343 vitamin Nutrition 0.000 claims 3
- 229940088594 vitamin Drugs 0.000 claims 3
- 229930003231 vitamin Natural products 0.000 claims 3
- 239000011782 vitamin Substances 0.000 claims 3
- LXJXRIRHZLFYRP-VKHMYHEASA-L (R)-2-Hydroxy-3-(phosphonooxy)-propanal Natural products O=C[C@H](O)COP([O-])([O-])=O LXJXRIRHZLFYRP-VKHMYHEASA-L 0.000 claims 2
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims 2
- OSJPPGNTCRNQQC-UWTATZPHSA-N 3-phospho-D-glyceric acid Chemical compound OC(=O)[C@H](O)COP(O)(O)=O OSJPPGNTCRNQQC-UWTATZPHSA-N 0.000 claims 2
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims 2
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims 2
- LXJXRIRHZLFYRP-VKHMYHEASA-N D-glyceraldehyde 3-phosphate Chemical compound O=C[C@H](O)COP(O)(O)=O LXJXRIRHZLFYRP-VKHMYHEASA-N 0.000 claims 2
- 241000233866 Fungi Species 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 2
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 2
- 235000013922 glutamic acid Nutrition 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 2
- 238000012261 overproduction Methods 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 230000004108 pentose phosphate pathway Effects 0.000 claims 2
- 101150047627 pgk gene Proteins 0.000 claims 2
- 101150079312 pgk1 gene Proteins 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 241000228212 Aspergillus Species 0.000 claims 1
- FNZLKVNUWIIPSJ-UHNVWZDZSA-N D-ribulose 5-phosphate Chemical compound OCC(=O)[C@H](O)[C@H](O)COP(O)(O)=O FNZLKVNUWIIPSJ-UHNVWZDZSA-N 0.000 claims 1
- 101710088194 Dehydrogenase Proteins 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 101150050773 GSDA gene Proteins 0.000 claims 1
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 241000736262 Microbiota Species 0.000 claims 1
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 claims 1
- FNZLKVNUWIIPSJ-UHFFFAOYSA-N Rbl5P Natural products OCC(=O)C(O)C(O)COP(O)(O)=O FNZLKVNUWIIPSJ-UHFFFAOYSA-N 0.000 claims 1
- 101100174606 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TDH2 gene Proteins 0.000 claims 1
- 101100174613 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TDH3 gene Proteins 0.000 claims 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 claims 1
- 101150085516 ZWF1 gene Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000036983 biotransformation Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 101150091570 gapA gene Proteins 0.000 claims 1
- 238000012239 gene modification Methods 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000005017 genetic modification Effects 0.000 claims 1
- 235000013617 genetically modified food Nutrition 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 230000034659 glycolysis Effects 0.000 claims 1
- 101150095149 pgkA gene Proteins 0.000 claims 1
- -1 phospho Chemical class 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 101150063973 tdh1 gene Proteins 0.000 claims 1
- 101150078419 zwf gene Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022182031A JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1750694A FR3062394B1 (fr) | 2017-01-27 | 2017-01-27 | Microorganisme genetiquement optimise pour la production de molecules d'interet |
| FR1750694 | 2017-01-27 | ||
| PCT/EP2018/052005 WO2018138289A1 (fr) | 2017-01-27 | 2018-01-26 | Microorganisme génétiquement optimisé pour la production de molécules d'intérêt |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022182031A Division JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020506723A JP2020506723A (ja) | 2020-03-05 |
| JP2020506723A5 true JP2020506723A5 (https=) | 2021-02-12 |
| JP7240329B2 JP7240329B2 (ja) | 2023-03-15 |
Family
ID=59070757
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019561349A Active JP7240329B2 (ja) | 2017-01-27 | 2018-01-26 | 目的分子を産生するための遺伝的に最適化された微生物 |
| JP2022182031A Pending JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022182031A Pending JP2023011947A (ja) | 2017-01-27 | 2022-11-14 | 目的分子を産生するための遺伝的に最適化された微生物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200277592A1 (https=) |
| EP (1) | EP3574083A1 (https=) |
| JP (2) | JP7240329B2 (https=) |
| KR (1) | KR102643557B1 (https=) |
| CN (1) | CN110678541A (https=) |
| BR (1) | BR112019015458A2 (https=) |
| FR (1) | FR3062394B1 (https=) |
| WO (1) | WO2018138289A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE060246T2 (hu) * | 2013-02-22 | 2023-02-28 | Dsm Ip Assets Bv | Rekombináns mikroorganizmus, fokozott termékhozamú eljárásban történõ alkalmazásra |
| CN109312296B (zh) * | 2016-06-14 | 2023-05-05 | 帝斯曼知识产权资产管理有限公司 | 重组酵母细胞 |
| JP7789355B2 (ja) * | 2019-05-10 | 2025-12-22 | シーエヌキュア カンパニー リミテッド | 癌の診断および治療用ｄｎａコンストラクト |
| JP6917434B2 (ja) * | 2019-10-25 | 2021-08-11 | 長瀬産業株式会社 | 好気性菌の代謝酵素破壊株およびその培養法 |
| CN112852664B (zh) * | 2021-01-14 | 2022-07-15 | 西华大学 | 一种酿酒酵母以及提高酿酒酵母产γ-氨基丁酸的方法 |
| CN112941061B (zh) * | 2021-03-19 | 2021-09-07 | 中国农业大学 | 一种Tk-Rubisco突变体、线性组装材料及其制备方法和应用 |
| CN114164237B (zh) * | 2021-11-04 | 2023-03-17 | 山东阜丰发酵有限公司 | 一种生产琥珀酸的方法 |
| CN114181879B (zh) * | 2021-12-09 | 2022-11-22 | 中国科学院深圳先进技术研究院 | 具有自养能力的底盘细胞及其构建方法和应用 |
| CN115851779B (zh) * | 2022-10-29 | 2024-03-26 | 昆明理工大学 | 一种葡萄糖-6-磷酸脱氢酶基因RkZWF1及其应用 |
| CN117210446A (zh) * | 2023-03-21 | 2023-12-12 | 北京蓝晶微生物科技有限公司 | 一种重建卡尔文循环提高异养微生物代谢产物产量的方法 |
| CN120384059B (zh) * | 2025-06-27 | 2025-09-26 | 南京大学 | 葡萄糖-6-磷酸脱氢酶突变体、生物材料、催化剂及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9915191A (pt) | 1998-11-10 | 2001-12-11 | Maxygen Inc | Métodos para obter um polinucleotìdeo isolado epara produzir uma célula recombinante,protoplasto de célula vegetal, coleção deprotoplastos de célula vegetal, vegetal,polinucleotìdeo, biblioteca, um ou mais membros debiblioteca e célula recombinante alvo |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| US20090191599A1 (en) * | 2007-09-10 | 2009-07-30 | Joule Biotechnologies, Inc. | Engineered light-harvesting organisms |
| FR3016371B1 (fr) * | 2014-01-16 | 2018-02-02 | Institut National De La Recherche Agronomique | Levures modifiees pour utiliser le dioxyde de carbone |
| US10294482B2 (en) * | 2014-05-22 | 2019-05-21 | Yeda Research And Development Co. Ltd. | Recombinant microorganisms capable of carbon fixation |
-
2017
- 2017-01-27 FR FR1750694A patent/FR3062394B1/fr active Active
-
2018
- 2018-01-26 BR BR112019015458-2A patent/BR112019015458A2/pt active Search and Examination
- 2018-01-26 EP EP18702647.1A patent/EP3574083A1/fr active Pending
- 2018-01-26 KR KR1020197024086A patent/KR102643557B1/ko active Active
- 2018-01-26 WO PCT/EP2018/052005 patent/WO2018138289A1/fr not_active Ceased
- 2018-01-26 CN CN201880021659.1A patent/CN110678541A/zh active Pending
- 2018-01-26 US US16/480,569 patent/US20200277592A1/en not_active Abandoned
- 2018-01-26 JP JP2019561349A patent/JP7240329B2/ja active Active
-
2022
- 2022-01-12 US US17/573,877 patent/US12018300B2/en active Active
- 2022-11-14 JP JP2022182031A patent/JP2023011947A/ja active Pending
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