JP7232204B2 - マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 - Google Patents

マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 Download PDF

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JP7232204B2
JP7232204B2 JP2019571960A JP2019571960A JP7232204B2 JP 7232204 B2 JP7232204 B2 JP 7232204B2 JP 2019571960 A JP2019571960 A JP 2019571960A JP 2019571960 A JP2019571960 A JP 2019571960A JP 7232204 B2 JP7232204 B2 JP 7232204B2
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ultrasound
microbubbles
frequency
radius
target tissue
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JP2020525168A (ja
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ピチオット， ラフィ デ
ハビエル グリンフェルド，
ヨアフ レヴィ，
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インサイテック・リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
JP2019571960A 2017-06-29 2018-06-29 マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化 Active JP7232204B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762526545P 2017-06-29 2017-06-29
US201762526550P 2017-06-29 2017-06-29
US201762526548P 2017-06-29 2017-06-29
US62/526,550 2017-06-29
US62/526,545 2017-06-29
US15/637,163 2017-06-29
US15/637,163 US11123575B2 (en) 2017-06-29 2017-06-29 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US62/526,548 2017-06-29
US201762597076P 2017-12-11 2017-12-11
US201762597073P 2017-12-11 2017-12-11
US62/597,076 2017-12-11
US62/597,073 2017-12-11
PCT/IB2018/000841 WO2019002947A1 (en) 2017-06-29 2018-06-29 ULTRASONIC FREQUENCY AND MICROBULLE SIZE OPTIMIZATION IN MICROBULLY ASSISTED ULTRASONIC TREATMENT

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JP2020525168A JP2020525168A (ja) 2020-08-27
JP2020525168A5 JP2020525168A5 (https=) 2021-07-26
JP7232204B2 true JP7232204B2 (ja) 2023-03-02

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JP2019571959A Pending JP2020525167A (ja) 2017-06-29 2018-06-29 キャビテーション強化型の標的化薬物送達および投与
JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画

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JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画

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EP (3) EP3645118B1 (https=)
JP (3) JP7232204B2 (https=)
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WO (3) WO2019002940A1 (https=)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy
US12527976B2 (en) 2020-06-18 2026-01-20 Histosonics, Inc. Histotripsy acoustic and patient coupling systems and methods
US12582848B2 (en) 2021-06-07 2026-03-24 The Regents Of The University Of Michigan Minimally invasive histotripsy systems and methods
US12599787B2 (en) 2021-06-07 2026-04-14 The Regents Of The University Of Michigan All-in-one ultrasound systems and methods including histotripsy

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123575B2 (en) 2017-06-29 2021-09-21 Insightec, Ltd. 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US20220161013A1 (en) * 2019-04-04 2022-05-26 Northwestern University Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
US11730452B2 (en) * 2019-04-09 2023-08-22 Insightec Ltd. Systems and methods for regulating microbubbles in ultrasound procedures
CN114144228B (zh) * 2019-07-25 2024-08-30 医视特有限公司 在超声治疗期间针对动态改变的介质的偏差校正
WO2021176275A1 (en) 2020-03-05 2021-09-10 Insightec, Ltd. Differential prediction of aberration corrections for ultrasound therapy
US20250263798A1 (en) 2021-07-01 2025-08-21 Insightec Ltd. Diagnostic and treatment monitoring based on blood-brain barrier disruption
CN113714070B (zh) * 2021-07-26 2022-05-24 中北大学 混合振膜结构宽频带电容式微机械超声换能器设计方法
WO2023180811A2 (en) * 2022-03-22 2023-09-28 Insightec Ltd. Monitoring tissue permeability during ultrasound procedures
WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
WO2024257021A1 (en) * 2023-06-13 2024-12-19 Insightec Ltd. Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof
KR102932441B1 (ko) * 2024-08-29 2026-02-27 주식회사 뉴머스 병리생리학적 상태에 기반한 음향공동화현상 발생 임계값 조절을 통한 뇌-혈관 장벽 제어 시스템 및 그 구동방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521275A (ja) 1998-12-03 2003-07-15 ボストン サイエンティフィック リミテッド 高能率局所薬物送達
US20080200845A1 (en) 2005-06-07 2008-08-21 Koninklijke Philips Electronics, N.V. Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids
US20110125080A1 (en) 2008-07-23 2011-05-26 Koninklijke Philips Electronics N.V. Ultrasound mediated drug delivery
US20110295105A1 (en) 2008-09-10 2011-12-01 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US20150258353A1 (en) 2012-10-12 2015-09-17 Koninklijke Philips N.V. Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focused ultrasound

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6309355B1 (en) * 1998-12-22 2001-10-30 The Regents Of The University Of Michigan Method and assembly for performing ultrasound surgery using cavitation
US7611462B2 (en) 2003-05-22 2009-11-03 Insightec-Image Guided Treatment Ltd. Acoustic beam forming in phased arrays including large numbers of transducer elements
JP4837663B2 (ja) * 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
TWI271202B (en) * 2004-11-12 2007-01-21 Ching-Hua Wang Formula for stimulating biological active substance entering skin or mucous membrane and the application of the same
CN100536783C (zh) * 2005-01-19 2009-09-09 微星科技股份有限公司 颅内压量测方法及系统
JP2006231304A (ja) * 2005-02-28 2006-09-07 Advance Alpha:Kk マイクロバブル発生方法およびマイクロバブル発生装置
JP4630127B2 (ja) * 2005-05-17 2011-02-09 株式会社日立製作所 超音波診断治療装置
US20070016039A1 (en) * 2005-06-21 2007-01-18 Insightec-Image Guided Treatment Ltd. Controlled, non-linear focused ultrasound treatment
JP4369907B2 (ja) * 2005-07-01 2009-11-25 株式会社日立製作所 音響化学治療装置
CN100386057C (zh) * 2005-10-31 2008-05-07 西安交通大学 基于包膜微泡的灌注成像与超声控制释放的系统和方法
US8548562B2 (en) * 2006-04-04 2013-10-01 John Trachtenberg System and method of guided treatment within malignant prostate tissue
EP2152351B1 (en) * 2007-05-07 2016-09-21 Guided Therapy Systems, L.L.C. Methods and systems for modulating medicants using acoustic energy
WO2009081339A1 (en) * 2007-12-21 2009-07-02 Koninklijke Philips Electronics, N.V. Systems and methods for tracking and guiding high intensity focused ultrasound beams
WO2011035312A1 (en) * 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
US9987505B2 (en) * 2008-08-20 2018-06-05 The Brigham And Women's Hospital, Inc. Method for modifying glomerular permeability and function with focused ultrasound
US20120116221A1 (en) * 2009-04-09 2012-05-10 The Trustees Of The University Of Pennsylvania Methods and systems for image-guided treatment of blood vessels
AU2010240501A1 (en) * 2009-04-23 2011-10-06 Yeda Research And Development Co. Ltd. Nasal flow device controller
CN102448497A (zh) * 2009-05-25 2012-05-09 默克专利有限公司 在癌症治疗中的西仑吉肽的持续给药
KR101200249B1 (ko) * 2009-10-05 2012-11-09 한국전기연구원 경피 약물 전달 장치
CN101698121B (zh) * 2009-10-23 2011-06-22 西安交通大学 促进药物透过血脑屏障的适型超声系统
US20120029396A1 (en) 2010-07-29 2012-02-02 Kobi Vortman Motion compensation for non-invasive treatment therapies
GB201115419D0 (en) * 2011-09-07 2011-10-19 Univ Leuven Kath Non-invasive in-situ radiation dosimetry
CN103842020B (zh) * 2011-10-05 2016-12-28 皇家飞利浦有限公司 用于超声介导的递送的化验
US20130331738A1 (en) * 2012-06-11 2013-12-12 Board Of Trustees University Of Arkansas Compositions and methods for potentiating sonothrombolysis
KR101991263B1 (ko) * 2012-06-27 2019-06-21 제주대학교 산학협력단 초음파의 열 효과를 가시화하는 스마트 조직 팬텀
US8927761B2 (en) * 2012-06-28 2015-01-06 Photocure Asa Form of hexyl-5-aminolevulinate hydrochloride and methods of using the same
US20150196638A1 (en) * 2012-07-08 2015-07-16 Sunnybrook Health Sciences Centre System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells
GB2505740A (en) * 2012-09-05 2014-03-12 Surf Technology As Instrument and method for ultrasound mediated drug delivery
JP6403689B2 (ja) * 2013-01-29 2018-10-10 インサイテック・リミテッド シミュレーションベース集束超音波治療計画
EP2964328B1 (en) 2013-03-06 2021-09-01 Insightec, Ltd. Frequency optimization in ultrasound treatment
CN103417249B (zh) * 2013-07-15 2015-06-03 南京航空航天大学 一种超声检测与治疗一体化的内窥镜
SI3049117T1 (sl) * 2013-09-27 2022-11-30 Exact Therapeutics As Dostava zdravil, posredovana z ultrazvokom
CN103520831A (zh) * 2013-10-14 2014-01-22 南京航空航天大学 药液超声治疗循环系统
CN104146730A (zh) * 2014-08-18 2014-11-19 中国人民解放军第三军医大学第二附属医院 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途
EP3234874B1 (en) * 2014-12-18 2025-04-02 Fresenius Medical Care Holdings, Inc. System and method of conducting in silico clinical trials
KR101657285B1 (ko) * 2015-05-13 2016-09-19 조선대학교산학협력단 초음파 치료 시뮬레이션시스템
US9934570B2 (en) 2015-10-09 2018-04-03 Insightec, Ltd. Systems and methods for registering images obtained using various imaging modalities and verifying image registration
US10475192B2 (en) 2016-06-10 2019-11-12 Insightec, Ltd. Motion tracking during non-invasive therapy

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003521275A (ja) 1998-12-03 2003-07-15 ボストン サイエンティフィック リミテッド 高能率局所薬物送達
US20080200845A1 (en) 2005-06-07 2008-08-21 Koninklijke Philips Electronics, N.V. Method and Apparatus for Ultrasound Drug Delivery and Thermal Therapy with Phase-Convertible Fluids
JP2008541975A (ja) 2005-06-07 2008-11-27 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超音波ドラッグデリバリーのための方法及び装置、並びに相可変流体による熱治療
US20110125080A1 (en) 2008-07-23 2011-05-26 Koninklijke Philips Electronics N.V. Ultrasound mediated drug delivery
JP2011529039A (ja) 2008-07-23 2011-12-01 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 超音波仲介による薬送達
US20110295105A1 (en) 2008-09-10 2011-12-01 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US20150258353A1 (en) 2012-10-12 2015-09-17 Koninklijke Philips N.V. Multi-foci sonications for hyperthermia treatments using magnetic resonance-guided focused ultrasound
JP2015531290A (ja) 2012-10-12 2015-11-02 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 磁気共鳴ガイドされた焦点式超音波を使用する加温療法処置のためのマルチ焦点超音波照射

Cited By (15)

* Cited by examiner, † Cited by third party
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US12491384B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11980778B2 (en) 2018-11-28 2024-05-14 Histosonics, Inc. Histotripsy systems and methods
US12599784B2 (en) 2018-11-28 2026-04-14 Histosonics, Inc. Histotripsy systems and methods
US12491382B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US12589261B2 (en) 2018-11-28 2026-03-31 Histosonics, Inc. Histotripsy systems and methods
US12420118B2 (en) 2018-11-28 2025-09-23 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12527976B2 (en) 2020-06-18 2026-01-20 Histosonics, Inc. Histotripsy acoustic and patient coupling systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12582848B2 (en) 2021-06-07 2026-03-24 The Regents Of The University Of Michigan Minimally invasive histotripsy systems and methods
US12599787B2 (en) 2021-06-07 2026-04-14 The Regents Of The University Of Michigan All-in-one ultrasound systems and methods including histotripsy
US12390665B1 (en) 2022-10-28 2025-08-19 Histosonics, Inc. Histotripsy systems and methods
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

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JP2020525168A (ja) 2020-08-27
CN110831665B (zh) 2022-03-04
JP2020525167A (ja) 2020-08-27
WO2019002947A8 (en) 2020-04-02
EP3645118C0 (en) 2023-11-29
EP3645118B1 (en) 2023-11-29
CN111032157A (zh) 2020-04-17
CN111132732A (zh) 2020-05-08
EP3645117A1 (en) 2020-05-06
EP3645116A1 (en) 2020-05-06
JP2020525169A (ja) 2020-08-27
CN111032157B (zh) 2023-04-21
EP3645117B1 (en) 2021-07-28
CN111132732B (zh) 2021-09-21
JP7289061B2 (ja) 2023-06-09
WO2019002947A1 (en) 2019-01-03
EP3645118A1 (en) 2020-05-06
EP3645116B1 (en) 2021-07-28
WO2019002940A1 (en) 2019-01-03
CN110831665A (zh) 2020-02-21
WO2019002943A1 (en) 2019-01-03

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