CN111032157B - 基于模拟的药物治疗计划 - Google Patents

基于模拟的药物治疗计划 Download PDF

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Publication number
CN111032157B
CN111032157B CN201880056389.8A CN201880056389A CN111032157B CN 111032157 B CN111032157 B CN 111032157B CN 201880056389 A CN201880056389 A CN 201880056389A CN 111032157 B CN111032157 B CN 111032157B
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target
ultrasound
tissue
region
treatment
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CN111032157A (zh
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约阿夫·利维
R·德皮乔托
J·格林菲尔德
E·扎迪卡里奥
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Insightec Ltd
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Insightec Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0039—Ultrasound therapy using microbubbles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0082—Scanning transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0086—Beam steering
    • A61N2007/0095—Beam steering by modifying an excitation signal

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Surgical Instruments (AREA)
CN201880056389.8A 2017-06-29 2018-06-29 基于模拟的药物治疗计划 Active CN111032157B (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762526545P 2017-06-29 2017-06-29
US201762526550P 2017-06-29 2017-06-29
US201762526548P 2017-06-29 2017-06-29
US62/526,550 2017-06-29
US15/637,163 US11123575B2 (en) 2017-06-29 2017-06-29 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US62/526,545 2017-06-29
US15/637,163 2017-06-29
US62/526,548 2017-06-29
US201762597076P 2017-12-11 2017-12-11
US201762597073P 2017-12-11 2017-12-11
US62/597,076 2017-12-11
US62/597,073 2017-12-11
PCT/IB2018/000834 WO2019002943A1 (en) 2017-06-29 2018-06-29 SIMULATION-BASED TREATMENT PLANNING BASED ON SIMULATION

Publications (2)

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CN111032157A CN111032157A (zh) 2020-04-17
CN111032157B true CN111032157B (zh) 2023-04-21

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CN201880056389.8A Active CN111032157B (zh) 2017-06-29 2018-06-29 基于模拟的药物治疗计划
CN201880043567.3A Active CN110831665B (zh) 2017-06-29 2018-06-29 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
CN201880043399.8A Active CN111132732B (zh) 2017-06-29 2018-06-29 增强对靶组织的治疗同时限制对非靶组织的损伤的系统

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CN201880043567.3A Active CN110831665B (zh) 2017-06-29 2018-06-29 用于破坏靶组织以进行治疗以及评估靶组织破坏的系统
CN201880043399.8A Active CN111132732B (zh) 2017-06-29 2018-06-29 增强对靶组织的治疗同时限制对非靶组织的损伤的系统

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EP (3) EP3645117B1 (https=)
JP (3) JP7289061B2 (https=)
CN (3) CN111032157B (https=)
WO (3) WO2019002947A1 (https=)

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US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy
US12527976B2 (en) 2020-06-18 2026-01-20 Histosonics, Inc. Histotripsy acoustic and patient coupling systems and methods
US12582848B2 (en) 2021-06-07 2026-03-24 The Regents Of The University Of Michigan Minimally invasive histotripsy systems and methods
US12599787B2 (en) 2021-06-07 2026-04-14 The Regents Of The University Of Michigan All-in-one ultrasound systems and methods including histotripsy

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US12409345B2 (en) 2019-07-25 2025-09-09 Insightec Ltd. Aberration corrections for dynamically changing media during ultrasound therapy
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US20250263798A1 (en) 2021-07-01 2025-08-21 Insightec Ltd. Diagnostic and treatment monitoring based on blood-brain barrier disruption
CN113714070B (zh) * 2021-07-26 2022-05-24 中北大学 混合振膜结构宽频带电容式微机械超声换能器设计方法
WO2023180811A2 (en) * 2022-03-22 2023-09-28 Insightec Ltd. Monitoring tissue permeability during ultrasound procedures
WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
WO2024257021A1 (en) * 2023-06-13 2024-12-19 Insightec Ltd. Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof
KR102932441B1 (ko) * 2024-08-29 2026-02-27 주식회사 뉴머스 병리생리학적 상태에 기반한 음향공동화현상 발생 임계값 조절을 통한 뇌-혈관 장벽 제어 시스템 및 그 구동방법

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Cited By (15)

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Publication number Priority date Publication date Assignee Title
US12491384B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US11813484B2 (en) 2018-11-28 2023-11-14 Histosonics, Inc. Histotripsy systems and methods
US11980778B2 (en) 2018-11-28 2024-05-14 Histosonics, Inc. Histotripsy systems and methods
US12599784B2 (en) 2018-11-28 2026-04-14 Histosonics, Inc. Histotripsy systems and methods
US12491382B2 (en) 2018-11-28 2025-12-09 Histosonics, Inc. Histotripsy systems and methods
US12589261B2 (en) 2018-11-28 2026-03-31 Histosonics, Inc. Histotripsy systems and methods
US12420118B2 (en) 2018-11-28 2025-09-23 Histosonics, Inc. Histotripsy systems and methods
US11813485B2 (en) 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
US12527976B2 (en) 2020-06-18 2026-01-20 Histosonics, Inc. Histotripsy acoustic and patient coupling systems and methods
US12343568B2 (en) 2020-08-27 2025-07-01 The Regents Of The University Of Michigan Ultrasound transducer with transmit-receive capability for histotripsy
US12582848B2 (en) 2021-06-07 2026-03-24 The Regents Of The University Of Michigan Minimally invasive histotripsy systems and methods
US12599787B2 (en) 2021-06-07 2026-04-14 The Regents Of The University Of Michigan All-in-one ultrasound systems and methods including histotripsy
US12390665B1 (en) 2022-10-28 2025-08-19 Histosonics, Inc. Histotripsy systems and methods
US12318636B2 (en) 2022-10-28 2025-06-03 Histosonics, Inc. Histotripsy systems and methods
US12446905B2 (en) 2023-04-20 2025-10-21 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy

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EP3645116B1 (en) 2021-07-28
JP2020525168A (ja) 2020-08-27
EP3645116A1 (en) 2020-05-06
CN110831665A (zh) 2020-02-21
EP3645117A1 (en) 2020-05-06
JP2020525169A (ja) 2020-08-27
WO2019002947A8 (en) 2020-04-02
EP3645118B1 (en) 2023-11-29
CN111032157A (zh) 2020-04-17
EP3645117B1 (en) 2021-07-28
CN111132732A (zh) 2020-05-08
WO2019002947A1 (en) 2019-01-03
CN110831665B (zh) 2022-03-04
WO2019002940A1 (en) 2019-01-03
JP2020525167A (ja) 2020-08-27
EP3645118A1 (en) 2020-05-06
JP7232204B2 (ja) 2023-03-02
CN111132732B (zh) 2021-09-21
JP7289061B2 (ja) 2023-06-09
EP3645118C0 (en) 2023-11-29
WO2019002943A1 (en) 2019-01-03

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