JP2020525167A5 - - Google Patents

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Publication number
JP2020525167A5
JP2020525167A5 JP2019571959A JP2019571959A JP2020525167A5 JP 2020525167 A5 JP2020525167 A5 JP 2020525167A5 JP 2019571959 A JP2019571959 A JP 2019571959A JP 2019571959 A JP2019571959 A JP 2019571959A JP 2020525167 A5 JP2020525167 A5 JP 2020525167A5
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JP
Japan
Prior art keywords
tissue
target volume
target
penetration
therapeutic agent
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JP2019571959A
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English (en)
Japanese (ja)
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JP2020525167A (ja
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Publication date
Priority claimed from US15/637,163 external-priority patent/US11123575B2/en
Application filed filed Critical
Priority claimed from PCT/IB2018/000811 external-priority patent/WO2019002940A1/en
Publication of JP2020525167A publication Critical patent/JP2020525167A/ja
Publication of JP2020525167A5 publication Critical patent/JP2020525167A5/ja
Pending legal-status Critical Current

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JP2019571959A 2017-06-29 2018-06-29 キャビテーション強化型の標的化薬物送達および投与 Pending JP2020525167A (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201762526550P 2017-06-29 2017-06-29
US201762526545P 2017-06-29 2017-06-29
US201762526548P 2017-06-29 2017-06-29
US62/526,550 2017-06-29
US62/526,545 2017-06-29
US15/637,163 2017-06-29
US15/637,163 US11123575B2 (en) 2017-06-29 2017-06-29 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
US62/526,548 2017-06-29
US201762597073P 2017-12-11 2017-12-11
US201762597076P 2017-12-11 2017-12-11
US62/597,076 2017-12-11
US62/597,073 2017-12-11
PCT/IB2018/000811 WO2019002940A1 (en) 2017-06-29 2018-06-29 TARGETED ADMINISTRATION AND DETERMINATION ENHANCED BY CAVITATION OF A MEDICAMENT

Publications (2)

Publication Number Publication Date
JP2020525167A JP2020525167A (ja) 2020-08-27
JP2020525167A5 true JP2020525167A5 (https=) 2022-07-26

Family

ID=63364094

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2019571960A Active JP7232204B2 (ja) 2017-06-29 2018-06-29 マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化
JP2019571959A Pending JP2020525167A (ja) 2017-06-29 2018-06-29 キャビテーション強化型の標的化薬物送達および投与
JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画

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JP2019571960A Active JP7232204B2 (ja) 2017-06-29 2018-06-29 マイクロバブル強化超音波処置における超音波周波数およびマイクロバブルサイズの最適化

Family Applications After (1)

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JP2019571961A Active JP7289061B2 (ja) 2017-06-29 2018-06-29 シミュレーションベースの薬物処置計画

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EP (3) EP3645118B1 (https=)
JP (3) JP7232204B2 (https=)
CN (3) CN111032157B (https=)
WO (3) WO2019002940A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123575B2 (en) 2017-06-29 2021-09-21 Insightec, Ltd. 3D conformal radiation therapy with reduced tissue stress and improved positional tolerance
CN113286552B (zh) 2018-11-28 2025-05-02 希斯托索尼克斯公司 组织摧毁术系统及方法
US20220161013A1 (en) * 2019-04-04 2022-05-26 Northwestern University Improved delivery of drug therapy to the cns by ultrasound-based opening of the blood-brain barrier
US11730452B2 (en) * 2019-04-09 2023-08-22 Insightec Ltd. Systems and methods for regulating microbubbles in ultrasound procedures
CN114144228B (zh) * 2019-07-25 2024-08-30 医视特有限公司 在超声治疗期间针对动态改变的介质的偏差校正
WO2021155026A1 (en) 2020-01-28 2021-08-05 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization
WO2021176275A1 (en) 2020-03-05 2021-09-10 Insightec, Ltd. Differential prediction of aberration corrections for ultrasound therapy
JP2023530477A (ja) 2020-06-18 2023-07-18 ヒストソニックス，インコーポレーテッド 組織破砕音響／患者結合システムおよび方法
EP4204084A4 (en) 2020-08-27 2024-10-09 The Regents Of The University Of Michigan ULTRASONIC TRANSDUCER WITH TRANSMIT-RECEIVE CAPABILITY FOR HISTOTRIPSY
EP4351718A4 (en) 2021-06-07 2025-03-26 The Regents of The University of Michigan MINIMALLY INVASIVE HISTOTRIPSY METHODS AND SYSTEMS
IL308943A (en) 2021-06-07 2024-01-01 Univ Michigan Regents All-inclusive ultrasound systems and methods that include histotripsy
US20250263798A1 (en) 2021-07-01 2025-08-21 Insightec Ltd. Diagnostic and treatment monitoring based on blood-brain barrier disruption
CN113714070B (zh) * 2021-07-26 2022-05-24 中北大学 混合振膜结构宽频带电容式微机械超声换能器设计方法
WO2023180811A2 (en) * 2022-03-22 2023-09-28 Insightec Ltd. Monitoring tissue permeability during ultrasound procedures
WO2024047580A1 (en) * 2022-08-31 2024-03-07 Insightec Ltd. Enforced tissue residency of payload molecules by acoustic disruption
AU2023366591A1 (en) 2022-10-28 2025-04-24 Histosonics, Inc. Histotripsy systems and methods
KR102626932B1 (ko) * 2023-01-03 2024-01-23 주식회사 뉴머스 환자 맞춤형 헬멧 및 이의 제조 방법
WO2024221001A2 (en) 2023-04-20 2024-10-24 Histosonics, Inc. Histotripsy systems and associated methods including user interfaces and workflows for treatment planning and therapy
WO2024257021A1 (en) * 2023-06-13 2024-12-19 Insightec Ltd. Tissue type-based blood-brain barrier opening and treatment parameter establishment systems thereof
KR102932441B1 (ko) * 2024-08-29 2026-02-27 주식회사 뉴머스 병리생리학적 상태에 기반한 음향공동화현상 발생 임계값 조절을 통한 뇌-혈관 장벽 제어 시스템 및 그 구동방법

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369039B1 (en) * 1998-06-30 2002-04-09 Scimed Life Sytems, Inc. High efficiency local drug delivery
US6309355B1 (en) * 1998-12-22 2001-10-30 The Regents Of The University Of Michigan Method and assembly for performing ultrasound surgery using cavitation
US7611462B2 (en) 2003-05-22 2009-11-03 Insightec-Image Guided Treatment Ltd. Acoustic beam forming in phased arrays including large numbers of transducer elements
JP4837663B2 (ja) * 2004-08-18 2011-12-14 ブラッコ・シュイス・ソシエテ・アノニム 造影画像化のためのガス充填微小胞組成物
TWI271202B (en) * 2004-11-12 2007-01-21 Ching-Hua Wang Formula for stimulating biological active substance entering skin or mucous membrane and the application of the same
CN100536783C (zh) * 2005-01-19 2009-09-09 微星科技股份有限公司 颅内压量测方法及系统
JP2006231304A (ja) * 2005-02-28 2006-09-07 Advance Alpha:Kk マイクロバブル発生方法およびマイクロバブル発生装置
JP4630127B2 (ja) * 2005-05-17 2011-02-09 株式会社日立製作所 超音波診断治療装置
CN101291705A (zh) * 2005-06-07 2008-10-22 皇家飞利浦电子股份有限公司 使用相可变流体的超声药物传输和热治疗的方法和装置
US20070016039A1 (en) * 2005-06-21 2007-01-18 Insightec-Image Guided Treatment Ltd. Controlled, non-linear focused ultrasound treatment
JP4369907B2 (ja) * 2005-07-01 2009-11-25 株式会社日立製作所 音響化学治療装置
CN100386057C (zh) * 2005-10-31 2008-05-07 西安交通大学 基于包膜微泡的灌注成像与超声控制释放的系统和方法
US8548562B2 (en) * 2006-04-04 2013-10-01 John Trachtenberg System and method of guided treatment within malignant prostate tissue
EP2152351B1 (en) * 2007-05-07 2016-09-21 Guided Therapy Systems, L.L.C. Methods and systems for modulating medicants using acoustic energy
WO2009081339A1 (en) * 2007-12-21 2009-07-02 Koninklijke Philips Electronics, N.V. Systems and methods for tracking and guiding high intensity focused ultrasound beams
WO2011035312A1 (en) * 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP5689416B2 (ja) * 2008-07-23 2015-03-25 コーニンクレッカ フィリップス エヌ ヴェ 超音波仲介による薬送達
US9987505B2 (en) * 2008-08-20 2018-06-05 The Brigham And Women's Hospital, Inc. Method for modifying glomerular permeability and function with focused ultrasound
WO2010030819A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
US20120116221A1 (en) * 2009-04-09 2012-05-10 The Trustees Of The University Of Pennsylvania Methods and systems for image-guided treatment of blood vessels
AU2010240501A1 (en) * 2009-04-23 2011-10-06 Yeda Research And Development Co. Ltd. Nasal flow device controller
CN102448497A (zh) * 2009-05-25 2012-05-09 默克专利有限公司 在癌症治疗中的西仑吉肽的持续给药
KR101200249B1 (ko) * 2009-10-05 2012-11-09 한국전기연구원 경피 약물 전달 장치
CN101698121B (zh) * 2009-10-23 2011-06-22 西安交通大学 促进药物透过血脑屏障的适型超声系统
US20120029396A1 (en) 2010-07-29 2012-02-02 Kobi Vortman Motion compensation for non-invasive treatment therapies
GB201115419D0 (en) * 2011-09-07 2011-10-19 Univ Leuven Kath Non-invasive in-situ radiation dosimetry
CN103842020B (zh) * 2011-10-05 2016-12-28 皇家飞利浦有限公司 用于超声介导的递送的化验
US20130331738A1 (en) * 2012-06-11 2013-12-12 Board Of Trustees University Of Arkansas Compositions and methods for potentiating sonothrombolysis
KR101991263B1 (ko) * 2012-06-27 2019-06-21 제주대학교 산학협력단 초음파의 열 효과를 가시화하는 스마트 조직 팬텀
US8927761B2 (en) * 2012-06-28 2015-01-06 Photocure Asa Form of hexyl-5-aminolevulinate hydrochloride and methods of using the same
US20150196638A1 (en) * 2012-07-08 2015-07-16 Sunnybrook Health Sciences Centre System and method for using ultrasound-stimulated microbubble exposures to induce ceramide accumulation in endothelial and tumor cells
GB2505740A (en) * 2012-09-05 2014-03-12 Surf Technology As Instrument and method for ultrasound mediated drug delivery
ES2732575T3 (es) * 2012-10-12 2019-11-25 Profound Medical Inc Sonicaciones de multifoco para tratamientos de hipertermia que usan ultrasonidos enfocados guiados por resonancia magnética
JP6403689B2 (ja) * 2013-01-29 2018-10-10 インサイテック・リミテッド シミュレーションベース集束超音波治療計画
EP2964328B1 (en) 2013-03-06 2021-09-01 Insightec, Ltd. Frequency optimization in ultrasound treatment
CN103417249B (zh) * 2013-07-15 2015-06-03 南京航空航天大学 一种超声检测与治疗一体化的内窥镜
SI3049117T1 (sl) * 2013-09-27 2022-11-30 Exact Therapeutics As Dostava zdravil, posredovana z ultrazvokom
CN103520831A (zh) * 2013-10-14 2014-01-22 南京航空航天大学 药液超声治疗循环系统
CN104146730A (zh) * 2014-08-18 2014-11-19 中国人民解放军第三军医大学第二附属医院 医用诊断超声波激励微泡调控双侧血脑屏障通透性的用途
EP3234874B1 (en) * 2014-12-18 2025-04-02 Fresenius Medical Care Holdings, Inc. System and method of conducting in silico clinical trials
KR101657285B1 (ko) * 2015-05-13 2016-09-19 조선대학교산학협력단 초음파 치료 시뮬레이션시스템
US9934570B2 (en) 2015-10-09 2018-04-03 Insightec, Ltd. Systems and methods for registering images obtained using various imaging modalities and verifying image registration
US10475192B2 (en) 2016-06-10 2019-11-12 Insightec, Ltd. Motion tracking during non-invasive therapy

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