JP7228586B2 - キナーゼ阻害剤としてのアミノイミダゾピリダジン - Google Patents

キナーゼ阻害剤としてのアミノイミダゾピリダジン Download PDF

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Publication number
JP7228586B2
JP7228586B2 JP2020524156A JP2020524156A JP7228586B2 JP 7228586 B2 JP7228586 B2 JP 7228586B2 JP 2020524156 A JP2020524156 A JP 2020524156A JP 2020524156 A JP2020524156 A JP 2020524156A JP 7228586 B2 JP7228586 B2 JP 7228586B2
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pyridazin
methyl
acetamidoimidazo
carboxamide
phenyl
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JP2020524156A
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Japanese (ja)
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JP2021501179A (ja
JP2021501179A5 (https=
Inventor
マイケル・イー・マーツマン
キャロリン・ダイアン・ジアーバ
ジェイソン・エム・ガーノン
エイミー・シー・ハート
グアンリン・ルオ
ジョン・イー・マコー
ウィリアム・ジェイ・ピッツ
ジャンリアン・シ
スティーブン・エイチ・スパーゲル
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2020524156A 2017-10-30 2018-10-29 キナーゼ阻害剤としてのアミノイミダゾピリダジン Active JP7228586B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762578607P 2017-10-30 2017-10-30
US62/578,607 2017-10-30
US201862626853P 2018-02-06 2018-02-06
US62/626,853 2018-02-06
PCT/US2018/057968 WO2019089442A1 (en) 2017-10-30 2018-10-29 Aminoimidazopyridines as kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2021501179A JP2021501179A (ja) 2021-01-14
JP2021501179A5 JP2021501179A5 (https=) 2021-12-09
JP7228586B2 true JP7228586B2 (ja) 2023-02-24

Family

ID=64332173

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020524156A Active JP7228586B2 (ja) 2017-10-30 2018-10-29 キナーゼ阻害剤としてのアミノイミダゾピリダジン

Country Status (23)

Country Link
US (1) US11440913B2 (https=)
EP (1) EP3704118B1 (https=)
JP (1) JP7228586B2 (https=)
KR (1) KR102662197B1 (https=)
CN (1) CN111566103B (https=)
AU (1) AU2018361249B2 (https=)
BR (1) BR112020007557A2 (https=)
CA (1) CA3080402A1 (https=)
CY (1) CY1124984T1 (https=)
DK (1) DK3704118T3 (https=)
ES (1) ES2905948T3 (https=)
HR (1) HRP20220297T1 (https=)
HU (1) HUE058292T2 (https=)
IL (1) IL274207B2 (https=)
LT (1) LT3704118T (https=)
MX (1) MX2020003706A (https=)
PL (1) PL3704118T3 (https=)
PT (1) PT3704118T (https=)
RS (1) RS62974B1 (https=)
SG (1) SG11202003824PA (https=)
SI (1) SI3704118T1 (https=)
SM (1) SMT202200087T1 (https=)
WO (1) WO2019089442A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA47460A (fr) 2017-02-13 2019-12-18 Bristol Myers Squibb Co Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase
CN112262139B (zh) 2018-01-26 2023-07-25 百时美施贵宝公司 作为激酶抑制剂的氨基吡咯并三嗪
AU2019339355A1 (en) 2018-09-13 2021-05-13 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
KR102906523B1 (ko) 2018-09-13 2025-12-30 브리스톨-마이어스 스큅 컴퍼니 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드
GB201905721D0 (en) 2019-04-24 2019-06-05 Univ Dundee Compounds
ES2969756T3 (es) * 2019-10-03 2024-05-22 Bristol Myers Squibb Co Indazol carboxamidas como inhibidores de cinasas
WO2021168521A1 (en) * 2020-02-27 2021-09-02 Anaxis Pharma Pty Ltd Inhibitors of necroptosis
CN114262322B (zh) * 2020-09-16 2026-01-06 中国科学院上海有机化学研究所 一类细胞程序性坏死抑制剂及其制备方法和用途
CN117120052A (zh) * 2020-10-13 2023-11-24 约翰斯·霍普金斯大学 取代的4-([1,2,4]三唑并[1,5-a]吡啶-6-基)噻吩-2-甲酰胺衍生物及其用途
AR123793A1 (es) 2020-10-19 2023-01-11 Bristol Myers Squibb Co Compuestos de triazolopiridinilo como inhibidores de quinasas
CN120530112A (zh) * 2022-12-30 2025-08-22 广州市联瑞制药有限公司 双环类化合物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2011507854A (ja) 2007-12-19 2011-03-10 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
JP2020507582A (ja) 2017-02-13 2020-03-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤としてのアミノトリアゾロピリジン

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JP5589003B2 (ja) * 2009-02-04 2014-09-10 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 脂質障害のような代謝疾患の処置のために有用な［１，３］オキサジン−２−オンの誘導体
EP2865671B1 (en) 2012-06-22 2017-11-01 Sumitomo Chemical Company, Ltd Fused heterocyclic compound
WO2014047024A1 (en) 2012-09-18 2014-03-27 Bristol-Myers Squibb Company Iap antagonists
WO2014081756A1 (en) 2012-11-20 2014-05-30 Biogen Idec Ma Inc. S1p and/or atx modulating agents
EP2970266B1 (en) 2013-03-15 2018-01-31 Epizyme, Inc. 1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as carm1 inhibitors and uses thereof
SG11201509351UA (en) 2013-06-10 2015-12-30 Bayer Pharma AG Novel compounds for the treatment of cancer
RU2017109122A (ru) 2014-08-21 2018-09-21 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Способы лечения с использованием гетероциклических амидов в качестве ингибиторов киназы
SG11201809693SA (en) 2016-05-05 2018-11-29 Lysosomal Therapeutics Inc SUBSTITUTED IMIDAZO[1,2-b]PYRIDAZINES, SUBSTITUTED IMIDAZO[1,5-b]PYRIDAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
WO2018017435A1 (en) 2016-07-22 2018-01-25 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of necrosis, composition and application thereof
CN112262139B (zh) 2018-01-26 2023-07-25 百时美施贵宝公司 作为激酶抑制剂的氨基吡咯并三嗪
AU2019339355A1 (en) 2018-09-13 2021-05-13 Bristol-Myers Squibb Company Indazole carboxamides as kinase inhibitors
KR102906523B1 (ko) 2018-09-13 2025-12-30 브리스톨-마이어스 스큅 컴퍼니 수용체-상호작용 단백질 키나제 1 (ripk1) 억제제로서의 1h-인다졸 카르복스아미드
EP3877371A4 (en) * 2018-11-07 2022-07-27 Dana-Farber Cancer Institute, Inc. IMIDAZOPYRIDINE DERIVATIVES AND AZA-IMIDAZOPYRIDINE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF

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JP2009530233A (ja) 2006-02-14 2009-08-27 ノバルティス アーゲー Ｐｉ−３キナーゼインヒビターおよびそれらの使用方法
JP2011507854A (ja) 2007-12-19 2011-03-10 アムジエン・インコーポレーテツド Ｐｉ３キナーゼの阻害薬
JP2020507582A (ja) 2017-02-13 2020-03-12 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ キナーゼ阻害剤としてのアミノトリアゾロピリジン

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HARRIS, Philip A. et al.，J.Med.Chem.，2017年，60，1247-1261

Also Published As

Publication number Publication date
HUE058292T2 (hu) 2022-07-28
CA3080402A1 (en) 2019-05-09
ES2905948T3 (es) 2022-04-12
RS62974B1 (sr) 2022-03-31
CY1124984T1 (el) 2023-01-05
CN111566103B (zh) 2023-06-23
LT3704118T (lt) 2022-02-25
SG11202003824PA (en) 2020-05-28
PL3704118T3 (pl) 2022-04-04
AU2018361249A1 (en) 2020-06-11
US20200277296A1 (en) 2020-09-03
PT3704118T (pt) 2022-02-14
MX2020003706A (es) 2020-07-22
KR20200078591A (ko) 2020-07-01
AU2018361249B2 (en) 2022-08-25
KR102662197B1 (ko) 2024-04-29
CN111566103A (zh) 2020-08-21
SI3704118T1 (sl) 2022-04-29
BR112020007557A2 (pt) 2020-09-24
HRP20220297T1 (hr) 2022-05-13
SMT202200087T1 (it) 2022-03-21
JP2021501179A (ja) 2021-01-14
WO2019089442A1 (en) 2019-05-09
EP3704118A1 (en) 2020-09-09
EP3704118B1 (en) 2022-01-12
IL274207B2 (en) 2023-04-01
US11440913B2 (en) 2022-09-13
WO2019089442A8 (en) 2019-06-27
DK3704118T3 (da) 2022-03-14
IL274207A (en) 2020-06-30
IL274207B (en) 2022-12-01

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