JP7189772B2 - 胃内滞留システムのための材料構造物 - Google Patents

胃内滞留システムのための材料構造物 Download PDF

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JP7189772B2
JP7189772B2 JP2018561622A JP2018561622A JP7189772B2 JP 7189772 B2 JP7189772 B2 JP 7189772B2 JP 2018561622 A JP2018561622 A JP 2018561622A JP 2018561622 A JP2018561622 A JP 2018561622A JP 7189772 B2 JP7189772 B2 JP 7189772B2
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drug
carrier polymer
polymer
segment
gastric retention
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JP2019521968A5 (OSRAM
JP2019521968A (ja
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ベリンガー アンドリュー
カナスティー ローズマリー
グラント タイラー
ビース ヌプラ
ディベネディクティス ロバート
ヤン チョン
ゼール スティーブン
クリアー ジョン
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リンドラ セラピューティクス, インコーポレイティド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/048Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
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    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
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    • A61P31/12Antivirals
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    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
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    • AHUMAN NECESSITIES
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    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • AHUMAN NECESSITIES
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602Type of release, e.g. controlled, sustained, slow
    • A61L2300/604Biodegradation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nursing (AREA)
  • Rheumatology (AREA)
JP2018561622A 2016-05-27 2017-05-26 胃内滞留システムのための材料構造物 Active JP7189772B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022193244A JP7615112B2 (ja) 2016-05-27 2022-12-02 胃内滞留システムのための材料構造物
JP2024231677A JP2025060940A (ja) 2016-05-27 2024-12-27 胃内滞留システムのための材料構造物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342798P 2016-05-27 2016-05-27
US62/342,798 2016-05-27
PCT/US2017/034856 WO2017205844A2 (en) 2016-05-27 2017-05-26 Materials architecture for gastric residence systems

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JP2022193244A Division JP7615112B2 (ja) 2016-05-27 2022-12-02 胃内滞留システムのための材料構造物

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JP2019521968A JP2019521968A (ja) 2019-08-08
JP2019521968A5 JP2019521968A5 (OSRAM) 2020-07-09
JP7189772B2 true JP7189772B2 (ja) 2022-12-14

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JP2018561622A Active JP7189772B2 (ja) 2016-05-27 2017-05-26 胃内滞留システムのための材料構造物
JP2022193244A Active JP7615112B2 (ja) 2016-05-27 2022-12-02 胃内滞留システムのための材料構造物
JP2024231677A Pending JP2025060940A (ja) 2016-05-27 2024-12-27 胃内滞留システムのための材料構造物

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JP2022193244A Active JP7615112B2 (ja) 2016-05-27 2022-12-02 胃内滞留システムのための材料構造物
JP2024231677A Pending JP2025060940A (ja) 2016-05-27 2024-12-27 胃内滞留システムのための材料構造物

Country Status (7)

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US (2) US12109305B2 (OSRAM)
EP (1) EP3463313A4 (OSRAM)
JP (3) JP7189772B2 (OSRAM)
CN (2) CN119925721A (OSRAM)
AU (1) AU2017268840B2 (OSRAM)
CA (1) CA3025650A1 (OSRAM)
WO (1) WO2017205844A2 (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
CN106573015B (zh) 2014-06-11 2021-11-26 麻省理工学院 肠溶弹性体
CN107592803B (zh) 2015-05-01 2021-01-22 麻省理工学院 可触发形状记忆感应装置
JP7085473B2 (ja) 2015-10-23 2022-06-16 リンドラ セラピューティクス, インコーポレイティド 治療薬の持続放出用の胃内滞留システム及びその使用方法
ES2963058T3 (es) 2015-12-08 2024-03-25 Lyndra Therapeutics Inc Configuraciones geométricas para sistemas de residencia gástrica
US12109305B2 (en) * 2016-05-27 2024-10-08 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
EP3518902A4 (en) 2016-09-30 2020-07-08 Lyndra, Inc. GASTRIC RESIDENCE SYSTEMS FOR LONG-TERM ADMINISTRATION OF ADAMANTANE CLASS MEDICINES
CN110891646B (zh) 2017-05-17 2023-07-04 麻省理工学院 具有高api载量的组件
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
US12023406B2 (en) 2017-06-09 2024-07-02 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films
CA3100710A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
EP3836866A4 (en) * 2018-08-15 2022-06-15 Lyndra Therapeutics, Inc. SYSTEMS FOR THE ENTERIC DELIVERY OF THERAPEUTIC AGENTS
WO2020117855A1 (en) * 2018-12-03 2020-06-11 Lyndra, Inc. Stomach simulating device
JP2022523121A (ja) 2019-02-01 2022-04-21 マサチューセッツ インスティテュート オブ テクノロジー 液体注入のためのシステムおよび方法
CN113966216A (zh) 2019-03-20 2022-01-21 林德拉治疗公司 用于胃滞留剂型的胶囊和胶囊衣层
EP4003012A1 (en) * 2019-07-29 2022-06-01 3M Innovative Properties Company Antimicrobial compositions and articles comprising the same
JP2022554375A (ja) * 2019-11-08 2022-12-28 リンドラ セラピューティクス, インコーポレイティド 胃内滞留システム用の高分子リンカー
CA3160665A1 (en) * 2019-11-08 2021-05-14 Lyndra Therapeutics, Inc. Gastric residence systems for administration of active agents
US11541216B2 (en) 2019-11-21 2023-01-03 Massachusetts Institute Of Technology Methods for manufacturing tissue interfacing components
CN111544592B (zh) * 2020-03-13 2022-05-03 中山大学附属第一医院 模式识别受体Dectin-1抑制剂对受体移植物的免疫保护及诱导免疫耐受的应用
US12472687B2 (en) 2020-07-20 2025-11-18 Peridot Print Llc Three-dimensional printing
US12144894B2 (en) 2020-07-29 2024-11-19 The Secant Group, Llc Shape-guided controlled release and retention with structures including crosslinked poly(glycerol sebacate)
AU2021391823A1 (en) 2020-12-03 2023-06-29 Battelle Memorial Institute Polymer nanoparticle and dna nanostructure compositions and methods for non-viral delivery
US11529310B2 (en) 2020-12-08 2022-12-20 Ruminant Biotech Corp Limited Devices and methods for delivery of substances to animals
AU2022210426A1 (en) * 2021-01-19 2023-08-24 Lyndra Therapeutics, Inc. Gastric residence systems for administration of risperidone
IL307454A (en) 2021-04-07 2023-12-01 Battelle Memorial Institute Technologies for rapid design, construction, testing, learning to identify and use non-viral vectors
CA3217611A1 (en) * 2021-05-05 2022-11-10 Nupura BHISE Gastric residence systems comprising buprenorphine and naloxone
WO2025042349A1 (en) * 2023-08-24 2025-02-27 Junion Therapeutics (Xiamen) Co., Ltd. A gastric residence article for oral administration
WO2025042350A1 (en) * 2023-08-24 2025-02-27 Junion Therapeutics (Xiamen) Co., Ltd. A gastric residence article for oral administration
WO2025072751A1 (en) 2023-09-29 2025-04-03 Battelle Memorial Institute Polymer nanoparticle compositions for in vivo expression of polypeptides
WO2025122954A1 (en) 2023-12-08 2025-06-12 Battelle Memorial Institute Use of dna origami nanostructures for molecular information based data storage systems
WO2025195482A1 (zh) * 2024-03-22 2025-09-25 厦门君德医药科技有限公司 一种胃滞留装置
CN120267955B (zh) * 2025-06-06 2025-09-19 浙江大学 一种自发电胃驻留电子胶囊及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015191920A1 (en) 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Residence structures and related methods

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1957564A (en) 1932-11-23 1934-05-08 Aubra T West Expanding capsule body
US3154461A (en) 1960-03-07 1964-10-27 Minnesota Mining & Mfg Matte-finish polymeric film and method of forming the same
US3531368A (en) 1966-01-07 1970-09-29 Toray Industries Synthetic filaments and the like
US3716614A (en) 1969-05-12 1973-02-13 Toray Industries Process of manufacturing collagen fiber-like synthetic superfine filament bundles
AU449029B2 (en) 1969-08-28 1974-04-17 Commonwealth Scientific And Industrial Research Organisation Device for administration to ruminants
JPS5512411B2 (OSRAM) 1974-03-12 1980-04-02
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
FI75816C (fi) 1981-02-06 1988-08-08 Ucb Sa Foerfarande foer framstaellning av terapeutiskt aktiv 2-/4-(difenylmetyl)-1-piperazinyl/-aettiksyror eller dess amid.
US4451260A (en) 1982-03-26 1984-05-29 Minnesota Mining And Manufacturing Company Sustained release oral medicinal delivery device
US4676507A (en) 1985-05-06 1987-06-30 Patterson Bruce D Puzzles forming platonic solids
US4735804A (en) 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
CA1273872A (en) 1985-05-10 1990-09-11 Larry J. Caldwell Drug delivery device which can be retained in the stomach for a controlled period of time
US4767627A (en) * 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4758436A (en) 1985-05-29 1988-07-19 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
EP0253554A3 (en) 1986-07-15 1988-07-20 Pfizer Inc. Controlled release drug-containing fibers
CA1314742C (en) 1986-12-12 1993-03-23 Hiromu Terada Optical fiber array
IL87710A (en) 1987-09-18 1992-06-21 Ciba Geigy Ag Covered floating retard form for controlled release in gastric juice
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
NZ228382A (en) 1989-03-17 1992-08-26 Carter Holt Harvey Plastic Pro Drug administering coil-like device for insertion in body cavity of animal
US5007790A (en) 1989-04-11 1991-04-16 Depomed Systems, Inc. Sustained-release oral drug dosage form
NZ234227A (en) 1989-06-30 1991-08-27 Smithkline Beecham Corp Delayed release dosage form
JPH03163011A (ja) 1989-08-31 1991-07-15 Yamanouchi Pharmaceut Co Ltd 胃内滞留デバイス
US5047464A (en) 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers
US5121329A (en) 1989-10-30 1992-06-09 Stratasys, Inc. Apparatus and method for creating three-dimensional objects
JP2648897B2 (ja) 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
US5939467A (en) 1992-06-26 1999-08-17 The Procter & Gamble Company Biodegradable polymeric compositions and products thereof
US5369142A (en) 1993-01-15 1994-11-29 The Ohio State University Water soluble polymers containing amino acid residues for dental restoratives
WO1995003558A1 (en) 1993-07-19 1995-02-02 Reflexite Corporation Retroreflective structure
DE4406424A1 (de) 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US6962579B2 (en) 1995-03-23 2005-11-08 Advanced Animal Technology Limited Substance delivery device
AU716398B2 (en) 1995-03-23 2000-02-24 Advanced Animal Technology Limited Substance delivery device including a retention apparatus
DE19539361A1 (de) * 1995-10-23 1997-04-24 Basf Ag Verfahren zur Herstellung von mehrschichtigen, festen Arzneiformen zur oralen oder rektalen Verabreichung
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
AU2521797A (en) 1996-04-12 1997-11-07 Japan Atomic Energy Research Institute Ph-sensitive polymers
US5762637A (en) 1996-08-27 1998-06-09 Scimed Life Systems, Inc. Insert molded catheter tip
US6120803A (en) 1997-08-11 2000-09-19 Alza Corporation Prolonged release active agent dosage form adapted for gastric retention
DE19850309A1 (de) 1998-10-30 2000-05-04 Lohmann Therapie Syst Lts Expandierbares gastroretensives Therapiesystem mit verlängerter Magenverweildauer
IL133196A0 (en) 1999-11-29 2001-03-19 Yissum Res Dev Co Gastroretentive controlled release pharmaceutical dosage forms
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
US7276252B2 (en) 2000-05-18 2007-10-02 Massachusetts Institute Of Technology Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
US20020022048A1 (en) 2000-05-26 2002-02-21 Bromberg Lev E. Composite wafer for controlled drug delivery
US6488962B1 (en) 2000-06-20 2002-12-03 Depomed, Inc. Tablet shapes to enhance gastric retention of swellable controlled-release oral dosage forms
US8158143B2 (en) 2000-07-14 2012-04-17 Helmholtz-Zentrum Geesthacht Zentrum Fuer Material- Und Kuestenforschung Gmbh Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect
US7803392B2 (en) 2000-12-27 2010-09-28 University Of Kentucky Research Foundation pH-Sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules
US6627206B2 (en) 2001-07-25 2003-09-30 Greg A. Lloyd Method and apparatus for treating obesity and for delivering time-released medicaments
US20040219186A1 (en) 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
IL160363A0 (en) 2001-08-16 2004-07-25 Oregon State Expandable gastric retention device
EP1503717A1 (en) 2002-01-23 2005-02-09 The UAB Research Foundation Glass-ionomer cements containing amino acids
WO2003089506A1 (en) 2002-04-22 2003-10-30 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
DE10224352A1 (de) 2002-06-01 2003-12-11 Mueller Schulte Detlef Thermosensitive Polymerträger mit veränderbarer physikalischer Struktur für die biochemische Analytik, Diagnostik und Therapie
GB0214013D0 (en) 2002-06-18 2002-07-31 Euro Celtique Sa Pharmaceutical product
AR040672A1 (es) 2002-07-25 2005-04-13 Glaxo Group Ltd Forma de dosificacion farmaceutica multicomponenete, cuerpo apropiado para ser utilizado en la misma y procedimiento para prepararla
AU2003282603A1 (en) 2002-10-11 2004-05-04 Depomed Development Ltd Gastro-retentive levodopa delivery form
US20060142794A1 (en) 2003-02-19 2006-06-29 Mnemoscience Gmbh Self-expanding device for the gastrointestinal or urogenital area
JP4497833B2 (ja) 2003-04-21 2010-07-07 富士フイルム株式会社 ポジ型平版印刷版原版
US7662864B2 (en) 2003-06-04 2010-02-16 Rutgers, The State University Of New Jersey Solution polymerization processes to prepare a polymer that degrades to release a physiologically active agent
WO2004110313A1 (de) 2003-06-13 2004-12-23 Mnemoscience Gmbh Stents
WO2004112755A1 (en) 2003-06-18 2004-12-29 John Michael Newton Controlled release devices with lumens
US20090259236A2 (en) 2003-07-28 2009-10-15 Baronova, Inc. Gastric retaining devices and methods
US8048169B2 (en) 2003-07-28 2011-11-01 Baronova, Inc. Pyloric valve obstructing devices and methods
US6825308B1 (en) 2003-10-29 2004-11-30 Council Of Scientific And Industrial Research Copolymers and preparation thereof
DE10350556A1 (de) 2003-10-29 2005-06-02 Clariant Gmbh Wasserbasierende Pigmentpräparationen
US20050201974A1 (en) 2003-12-09 2005-09-15 Spherics, Inc. Bioadhesive polymers with catechol functionality
WO2005065660A2 (en) 2003-12-31 2005-07-21 Alpharma, Inc. Ziprasidone formulations
US20080089933A1 (en) 2006-10-16 2008-04-17 Amir Alon Device and method for reducing calorie intake
PE20060003A1 (es) 2004-03-12 2006-03-01 Smithkline Beecham Plc Formulacion farmaceutica polimerica para moldear por inyeccion
WO2006033679A2 (en) 2004-05-25 2006-03-30 Chimeracore, Inc. Self-assembling nanoparticle drug delivery system
DE102004047076A1 (de) 2004-09-28 2006-04-06 Zimmer Ag Verfahren zur Herstellung von Polyestern
IL166183A0 (en) 2005-01-06 2006-01-15 Yissum Res Dev Co Novel diagnostic and imaging techniques of the gi tract
US20060182788A1 (en) 2005-01-27 2006-08-17 Parminder Singh Hydrophilic biocompatible adhesive formulations and uses
WO2006084164A2 (en) 2005-02-01 2006-08-10 Emisphere Technologies, Inc. Gastric retention and controlled release delivery system
US7785291B2 (en) 2005-03-01 2010-08-31 Tulip Medical Ltd. Bioerodible self-deployable intragastric implants
JP2006323082A (ja) 2005-05-18 2006-11-30 Canon Inc 現像剤補給容器
US8021384B2 (en) 2005-07-26 2011-09-20 Ram Weiss Extending intrabody capsule
JP4981671B2 (ja) 2005-08-05 2012-07-25 滋賀県 ポリマーブレンドを含んでなる液中物質捕集材料
US20070048383A1 (en) 2005-08-25 2007-03-01 Helmus Michael N Self-assembled endovascular structures
WO2007048223A2 (en) 2005-10-25 2007-05-03 Pharmascience Inc. A gastric retention drug delivery system
US8187633B2 (en) 2005-11-03 2012-05-29 Sun Pharma Advanced Research Company Limited Controlled release coated tablets having prolonged gastric retention
US7674396B2 (en) 2005-11-08 2010-03-09 Plensat Llc Method and system for treatment of eating disorders
CA2637655C (en) 2006-01-18 2017-06-27 Intec Pharma Ltd. Method and apparatus for forming delivery devices for oral intake of an agent
CA2642479C (en) 2006-02-15 2014-08-19 Intec Pharma Ltd. A gastro-retentive system for the delivery of macromolecules
EP1998684A4 (en) 2006-03-10 2014-09-17 Massachusetts Inst Technology CONJUGATES AND NANOSYSTEMS WITH TRIGGERED SELF ASSEMBLY
US7691151B2 (en) 2006-03-31 2010-04-06 Spiration, Inc. Articulable Anchor
US20070264307A1 (en) 2006-05-15 2007-11-15 Medtronic Vascular, Inc. Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices
EP1886665A1 (en) 2006-08-01 2008-02-13 Boehringer Ingelheim Pharma GmbH & Co. KG Gastro retentive delivery system
EP2068844A4 (en) 2006-09-04 2013-01-23 Panacea Biotec Ltd PROGRAMMABLE RELEASE TECHNIQUE BY FLOATING SYSTEM
US20080075766A1 (en) 2006-09-25 2008-03-27 Shun-Por Li Multi-core dosage form having transparent outer coating
US20100316712A1 (en) 2006-12-22 2010-12-16 Combinatorx, Incorporated Pharmaceutical compositions for treatment of parkinson's disease and related disorders
WO2008140651A2 (en) 2007-03-13 2008-11-20 Olson Arthur J Self-assembled polyhedra
WO2008111077A2 (en) 2007-03-13 2008-09-18 Technion Research & Development Foundation Ltd. Self-assembled polyhedral multimeric chemical structures
US20080249156A1 (en) 2007-04-09 2008-10-09 Palepu Nageswara R Combinations of statins and anti-obesity agent and glitazones
WO2008153611A2 (en) 2007-05-25 2008-12-18 Qlt Usa, Inc. Sustained delivery formulations of risperidone compounds
WO2008148083A1 (en) 2007-05-25 2008-12-04 Gorham Enterprises Llc Bariatric magnetic apparatus and method of manufacturing thereof
US8038659B2 (en) 2007-10-17 2011-10-18 The Invention Science Fund I, Llc Disintegrating digestive tract interaction system
US8637455B2 (en) 2007-10-22 2014-01-28 Affinergy, Llc Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces
US8974814B2 (en) * 2007-11-12 2015-03-10 California Institute Of Technology Layered drug delivery polymer monofilament fibers
EP2262367A4 (en) 2008-03-08 2011-04-20 Theraquest Biosciences Inc PHARMACEUTICAL ORAL COMPOSITIONS OF BUPRENORPHINE AND METHOD FOR THEIR USE
JP5607550B2 (ja) 2008-03-11 2014-10-15 ディポメド,インコーポレイティド 非オピオイド鎮痛剤及びオピオイド鎮痛剤の組合せを含む胃保持性持続放出剤形
US20130273135A1 (en) 2008-03-25 2013-10-17 University Of Utah Research Foundation Controlled Release Combination Biomaterials
DK2276473T3 (en) 2008-04-18 2017-01-09 Intec Pharma Ltd GASTRORETENTIV drug TO carbidopa / levodopa
WO2009132461A1 (en) 2008-04-28 2009-11-05 Electronic Dietary Foods Inc. Bezoar-forming units for weight control
US20100256342A1 (en) 2008-08-12 2010-10-07 Francis Raymond Salemme Protein nodes for controlled nanoscale assembly
KR20110042366A (ko) 2008-08-18 2011-04-26 팀 아카데미 오브 파마슈티컬 사이언스 위장체류 약물 전달 시스템, 제작 방법 및 그것들의 사용
WO2010035273A2 (en) 2008-09-29 2010-04-01 Intec Pharma Ltd. Novel gastroretentive delivery system
EP2331014B1 (en) 2008-10-10 2017-08-09 Reva Medical, Inc. Expandable slide and lock stent
WO2010064100A1 (en) 2008-12-04 2010-06-10 Intec Pharma Ltd. Baclofen gastroretentive drug delivery system
EP2373232A2 (en) 2008-12-27 2011-10-12 Chandra S. Duggirala Devices for treating obesity and methods of using those devices
US9845237B2 (en) 2009-02-26 2017-12-19 The Regents Of The University Of California Supramolecular approach for preparation of size controllable nanoparticles
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
CA2761769C (en) 2009-05-15 2018-06-05 Intersect Ent, Inc. Expandable devices and methods therefor
DE102009028076A1 (de) 2009-07-29 2011-02-03 Evonik Röhm Gmbh Beschichtungsmittel zum Tauchbeschichten von Kapselhälften
US20110052700A1 (en) 2009-08-31 2011-03-03 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of levosulpiride
WO2011032087A2 (en) * 2009-09-11 2011-03-17 Replication Medical Inc. Swellable polymeric device for dietary regulation
US20120321706A1 (en) 2009-10-19 2012-12-20 Intec Pharma Ltd. Novel gastroretentive dosage forms of poorly soluble drugs
US9421169B2 (en) 2009-11-20 2016-08-23 Covidien Lp Oral dosage forms for delivery of therapeutic agents
CN101711752B (zh) 2009-11-26 2011-09-21 中国科学院上海药物研究所 一种苯并异噁唑类衍生物的控释制剂及其制备方法
WO2011139796A2 (en) 2010-04-27 2011-11-10 The Johns Hopkins University Self-folding sub-centimeter structures
AU2011276170B2 (en) 2010-07-06 2016-03-10 Grunenthal Gmbh Novel gastro- retentive dosage forms comprising a GABA Analog and an opioid
WO2012018923A1 (en) 2010-08-05 2012-02-09 Taris Biomedical, Inc. Implantable drug delivery devices for genitourinary sites
US20120165793A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
US20120165792A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
US20120165794A1 (en) 2010-12-22 2012-06-28 Ethicon Endo-Surgery, Inc. Pill Catchers
CN103379902B (zh) 2011-02-04 2015-11-25 塔里斯生物医药公司 用于低溶解度药物的控制释放的可植入装置
WO2014014348A1 (en) 2012-07-16 2014-01-23 APET Holding B.V. Gastro-retentive drug delivery system
US20130017264A1 (en) 2011-07-15 2013-01-17 Piramal Life Sciences Limited Alginate tube drug delivery system and method therefor
EP2764557A4 (en) 2011-09-26 2016-04-27 Univ Northeastern CUSTOMIZABLE INTEGRATED SENSORS
US20150265536A1 (en) 2011-12-09 2015-09-24 Purdue Pharma L.P. Pharmaceutical dosage forms comprising poly(epsilon-caprolactone) and polyethylene oxide
US8979885B2 (en) 2012-02-24 2015-03-17 Elwha Llc Devices, systems, and methods to control stomach volume
US9307966B2 (en) 2012-08-15 2016-04-12 St. Jude Medical Puerto Rico Llc Vascular closure device anchor
IN2015DN01023A (OSRAM) 2012-08-16 2015-06-26 Teva Pharma
US10441760B2 (en) 2013-03-01 2019-10-15 The Johns Hopkins University Self-actuating chemomechanical devices for delivery and extended release of therapeutic agents in the gastrointestinal tract
CN103654903A (zh) 2013-11-27 2014-03-26 西安交通大学 一种用于人体消化道吻合的磁性可降解装置
ES2926480T3 (es) 2013-12-05 2022-10-26 Epitomee Medical Ltd Dispositivos y sistemas retentivos para la liberación in situ de principios activos farmacéuticos
US20170051099A1 (en) 2014-04-29 2017-02-23 The Brigham And Women's Hospital, Inc. Polymeric materials for bio-applications
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
RU2016151697A (ru) 2014-06-02 2018-07-10 Тева Фармасьютикал Индастриз Лтд. Расправляемая удерживаемая в желудке лекарственная форма
US20170266112A1 (en) 2014-06-11 2017-09-21 Massachusetts Institute Of Technology Residence structures and related methods
CN107592803B (zh) 2015-05-01 2021-01-22 麻省理工学院 可触发形状记忆感应装置
JP7085473B2 (ja) * 2015-10-23 2022-06-16 リンドラ セラピューティクス, インコーポレイティド 治療薬の持続放出用の胃内滞留システム及びその使用方法
EP3383365A1 (en) 2015-12-01 2018-10-10 Clexio Biosciences Ltd. Gastric retentive devices
CA3007165A1 (en) 2015-12-02 2017-06-08 Clexio Biosciences Ltd. Device for preparing gastroretentive dosage forms
ES2963058T3 (es) 2015-12-08 2024-03-25 Lyndra Therapeutics Inc Configuraciones geométricas para sistemas de residencia gástrica
EP3246050A1 (de) * 2016-05-17 2017-11-22 BSN medical GmbH Wund- oder hautauflage
US12109305B2 (en) 2016-05-27 2024-10-08 Lyndra Therapeutics, Inc. Materials architecture for gastric residence systems
EP3518902A4 (en) 2016-09-30 2020-07-08 Lyndra, Inc. GASTRIC RESIDENCE SYSTEMS FOR LONG-TERM ADMINISTRATION OF ADAMANTANE CLASS MEDICINES
WO2018089684A1 (en) 2016-11-09 2018-05-17 Massachusetts Institute Of Technology Triggerable hydrogel compositions and related methods
US10737079B2 (en) 2016-12-02 2020-08-11 Clexio Biosciences Ltd. Gastric residence system
US12023406B2 (en) 2017-06-09 2024-07-02 Lyndra Therapeutics, Inc. Gastric residence systems with release rate-modulating films
CN111511338B (zh) 2017-09-20 2022-11-29 林德拉治疗公司 胃驻留系统的封装
US11547839B2 (en) 2017-12-04 2023-01-10 Clexio Biosciences Ltd. Long acting gastric residence system
US11576860B2 (en) 2018-05-31 2023-02-14 Massachusetts Institute Of Technology Retrieval systems and related methods
WO2020102648A1 (en) 2018-11-15 2020-05-22 Massachusetts Institute Of Technology Millineedle systems for esophageal drug delivery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015191920A1 (en) 2014-06-11 2015-12-17 Massachusetts Institute Of Technology Residence structures and related methods

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