JP7173733B2 - Ｐｄ－１遮断による免疫療法の癌奏効の決定因子 - Google Patents

Ｐｄ－１遮断による免疫療法の癌奏効の決定因子 Download PDF

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JP7173733B2
JP7173733B2 JP2017527368A JP2017527368A JP7173733B2 JP 7173733 B2 JP7173733 B2 JP 7173733B2 JP 2017527368 A JP2017527368 A JP 2017527368A JP 2017527368 A JP2017527368 A JP 2017527368A JP 7173733 B2 JP7173733 B2 JP 7173733B2
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ティモシー エイ． チャン
ナイヤー エイ． リズビ
マシュー ディー． ヘルマン
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メモリアル スローン ケタリング キャンサー センター
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JP2017527368A 2014-11-21 2015-11-23 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子 Active JP7173733B2 (ja)

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JP2022129458A JP7550193B2 (ja) 2014-11-21 2022-08-16 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子
JP2024107117A JP2024125234A (ja) 2014-11-21 2024-07-03 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子

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US201462083088P 2014-11-21 2014-11-21
US62/083,088 2014-11-21
US201562132381P 2015-03-12 2015-03-12
US62/132,381 2015-03-12
PCT/US2015/062208 WO2016081947A2 (en) 2014-11-21 2015-11-23 Determinants of cancer response to immunotherapy by pd-1 blockade

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JP2020135853A Division JP2020196732A (ja) 2014-11-21 2020-08-11 Ｐｄ−１遮断による免疫療法の癌奏効の決定因子
JP2022129458A Division JP7550193B2 (ja) 2014-11-21 2022-08-16 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子

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JP2018502828A JP2018502828A (ja) 2018-02-01
JP2018502828A5 JP2018502828A5 (https=) 2022-09-01
JP7173733B2 true JP7173733B2 (ja) 2022-11-16

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JP2017527368A Active JP7173733B2 (ja) 2014-11-21 2015-11-23 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子
JP2020135853A Withdrawn JP2020196732A (ja) 2014-11-21 2020-08-11 Ｐｄ−１遮断による免疫療法の癌奏効の決定因子
JP2022129458A Active JP7550193B2 (ja) 2014-11-21 2022-08-16 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子
JP2024107117A Pending JP2024125234A (ja) 2014-11-21 2024-07-03 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子

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JP2020135853A Withdrawn JP2020196732A (ja) 2014-11-21 2020-08-11 Ｐｄ−１遮断による免疫療法の癌奏効の決定因子
JP2022129458A Active JP7550193B2 (ja) 2014-11-21 2022-08-16 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子
JP2024107117A Pending JP2024125234A (ja) 2014-11-21 2024-07-03 Ｐｄ－１遮断による免疫療法の癌奏効の決定因子

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US (3) US20180291074A1 (https=)
EP (2) EP4393546A3 (https=)
JP (4) JP7173733B2 (https=)
CN (2) CN107206064B (https=)
AU (3) AU2015349644B2 (https=)
HK (1) HK1244440A1 (https=)
MA (1) MA40737A (https=)
WO (1) WO2016081947A2 (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
EP3212670B1 (en) 2014-10-29 2020-12-23 Five Prime Therapeutics, Inc. Combination therapy for cancer
MA40737A (fr) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
GB201516047D0 (en) 2015-09-10 2015-10-28 Cancer Rec Tech Ltd Method
ES2970865T3 (es) 2015-12-16 2024-05-31 Gritstone Bio Inc Identificación, fabricación y uso de neoantígenos
IL260030B2 (en) 2016-01-08 2025-12-01 Nykode Therapeutics ASA Therapeutic anticancer neoepitope vaccine
CA3015913A1 (en) 2016-02-29 2017-09-08 Foundation Medicine, Inc. Methods of treating cancer
JP6821693B2 (ja) * 2016-02-29 2021-01-27 ジェネンテック， インコーポレイテッド がんのための治療方法及び診断方法
WO2017151727A1 (en) * 2016-03-01 2017-09-08 North Carolina State University Enhanced cancer immunotherapy by microneedle patch-assisted delivery
JP7147168B2 (ja) * 2016-03-02 2022-10-05 東レ株式会社 免疫誘導剤
EP3464360B1 (en) 2016-05-27 2025-11-12 Agenus Inc. Anti-tim-3 antibodies and methods of use thereof
WO2018003995A1 (ja) * 2016-07-01 2018-01-04 国立大学法人東北大学 免疫チェックポイント阻害薬使用における免疫関連副作用の予測方法
EP3500966B1 (en) * 2016-08-25 2021-04-21 Nantomics, LLC Immunotherapy markers and uses therefor
CA3038712A1 (en) 2016-10-06 2018-04-12 Genentech, Inc. Therapeutic and diagnostic methods for cancer
JP7295015B2 (ja) * 2016-10-07 2023-06-20 オムニセック インコーポレイテッド 個別化治療を決定するための方法
WO2018132753A1 (en) * 2017-01-13 2018-07-19 Nantbio, Inc. Validation of neoepitope-based treatment
WO2018136664A1 (en) 2017-01-18 2018-07-26 Ichan School Of Medicine At Mount Sinai Neoantigens and uses thereof for treating cancer
BR112019015797A2 (pt) 2017-02-01 2020-03-17 Modernatx, Inc. Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação
CN110461342A (zh) * 2017-02-06 2019-11-15 诺华股份有限公司 预测对免疫疗法的反应的方法
EP3494235A1 (en) * 2017-02-17 2019-06-12 Stichting VUmc Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets
US10859566B2 (en) * 2017-03-20 2020-12-08 Genocea Biosciences, Inc. Treatment methods
EP3601355A1 (en) * 2017-03-31 2020-02-05 Bristol-Myers Squibb Company Methods of treating tumor
GB201710815D0 (en) * 2017-07-05 2017-08-16 Francis Crick Inst Ltd Method
JP7760242B2 (ja) 2017-07-21 2025-10-27 ジェネンテック， インコーポレイテッド がんの治療法及び診断法
JP7274454B2 (ja) * 2017-07-28 2023-05-16 ブリストル－マイヤーズ スクイブ カンパニー チェックポイント阻害薬のための予測末梢血バイオマーカー
EP3681535A1 (en) * 2017-09-13 2020-07-22 Five Prime Therapeutics, Inc. Combination anti-csf1r and anti-pd-1 antibody combination therapy for pancreatic cancer
WO2019055860A1 (en) * 2017-09-15 2019-03-21 The Texas A&M University System METHODS FOR IMPROVING IMMUNOTHERAPY IN THE TREATMENT OF CANCER
CN117987553A (zh) 2017-09-25 2024-05-07 纪念斯隆凯特琳癌症中心 肿瘤突变负荷和检查点免疫疗法
CA3076918A1 (en) * 2017-10-02 2019-04-11 Curematch, Inc. Method of prediction of tumor-derived neo-peptide antigenicity and/or immunogenicity using mutational signature patterns
EP4576103A3 (en) 2017-10-10 2025-08-27 Gritstone bio, Inc. Neoantigen identification using hotspots
WO2019075251A2 (en) * 2017-10-12 2019-04-18 Nantomics, Llc CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS
CN111247169A (zh) * 2017-10-15 2020-06-05 百时美施贵宝公司 治疗肿瘤的方法
WO2019090156A1 (en) 2017-11-03 2019-05-09 Guardant Health, Inc. Normalizing tumor mutation burden
EP3710600B1 (en) * 2017-11-17 2025-03-12 GMDx Co Pty Ltd Systems and methods for predicting the efficacy of cancer therapy
CN111630602A (zh) 2017-11-22 2020-09-04 磨石肿瘤生物技术公司 减少新抗原的接合表位呈递
WO2019109086A1 (en) 2017-12-01 2019-06-06 Illumina, Inc. Methods and systems for determining somatic mutation clonality
US20210054465A1 (en) * 2018-05-03 2021-02-25 Roche Sequencing Solutions, Inc. Surrogate marker and method for tumor mutation burden measurement
MX2020011684A (es) * 2018-05-04 2020-12-10 Merck Patent Gmbh Inhibicion combinada de pd-1/pd-l1, tgfbeta y dna-pk para el tratamiento del cancer.
WO2020023420A2 (en) 2018-07-23 2020-01-30 Guardant Health, Inc. Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage
WO2020021119A1 (en) 2018-07-27 2020-01-30 F. Hoffmann-La Roche Ag Method of monitoring effectiveness of immunotherapy of cancer patients
WO2020045479A1 (ja) 2018-08-29 2020-03-05 公益財団法人東京都医学総合研究所 ＨＧＦ－ｒｅｇｕｌａｔｅｄ ｔｙｒｏｓｉｎｅ ｋｉｎａｓｅ ｓｕｂｓｔｒａｔｅ（ＨＧＳ）を標的とした抗腫瘍剤
CN121354685A (zh) 2018-08-31 2026-01-16 夸登特健康公司 无细胞dna中的微卫星不稳定性检测
JP7623281B2 (ja) 2018-11-15 2025-01-28 パーソナル ゲノム ダイアグノスティクス インコーポレイテッド 免疫療法で治療されたがん患者の応答の予測を改善する方法
US20200190598A1 (en) * 2018-12-12 2020-06-18 Medimmune, Llc Blood-based tumor mutation burden predicts overall survival in nsclc
EP3982954A4 (en) 2019-06-14 2024-01-03 The Trustees of Columbia University in the City of New York NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA
AU2020376937A1 (en) * 2019-11-01 2022-06-09 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. HLA class I sequence divergence and cancer therapy
GB202003669D0 (en) * 2020-03-13 2020-04-29 Univ Oxford Innovation Ltd Method for identifying neo-antigens
EP4143345A1 (en) * 2020-04-28 2023-03-08 Genentech, Inc. Methods and compositions for non-small cell lung cancer immunotherapy
AU2021285711A1 (en) * 2020-06-01 2023-01-05 Gmdx Co Pty Ltd Methods of predicting cancer progression
CN112309502B (zh) * 2020-10-14 2024-09-20 深圳市新合生物医疗科技有限公司 一种计算肿瘤新抗原负荷的方法及系统
WO2022099004A1 (en) * 2020-11-06 2022-05-12 The General Hospital Corporation Methods for characterizing biological samples
US20240238340A1 (en) * 2021-05-03 2024-07-18 Rutgers, The State University Of New Jersey Immunotherapy for inflammatory bowel disease and/or cancer
CN113030475B (zh) * 2021-05-25 2021-08-10 泛肽生物科技(浙江)有限公司 一种基于细胞线粒体质量评估的t细胞pd-1检测方法
CN113355424B (zh) * 2021-07-14 2022-03-25 江苏先声医学诊断有限公司 Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用
WO2024216165A1 (en) 2023-04-12 2024-10-17 Icahn School Of Medicine At Mount Sinai Computational methods for selecting personalized neoantigen vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015533082A (ja) 2012-09-28 2015-11-19 ユニバーシティ オブ コネチカット 癌の治療のための腫瘍防御エピトープの同定

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033497A1 (en) 2002-08-13 2004-02-19 Alarcon-Riquelme Marta E. Polymorphisms of PD-1
TWI477602B (zh) 2006-02-09 2015-03-21 Educational Foundation Jichi Medical Univ Novel viral vector
AU2010319322A1 (en) * 2009-11-13 2012-05-31 Infinity Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
GB201004551D0 (en) * 2010-03-19 2010-05-05 Immatics Biotechnologies Gmbh NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer
EA201690310A1 (ru) * 2010-04-13 2016-12-30 Селлдекс Терапьютикс Инк. Антитела, связывающие cd27 человека, и их применение
EP2569633B1 (en) * 2010-05-14 2016-02-10 The General Hospital Corporation Compositions and methods of identifying tumor specific neoantigens
WO2013130748A1 (en) * 2012-02-29 2013-09-06 The Regents Of The University Of Michigan Prostate cancer markers and uses thereof
RU2737765C2 (ru) 2012-05-04 2020-12-02 Пфайзер Инк. Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин
EP3090066A4 (en) * 2014-01-02 2017-08-30 Memorial Sloan Kettering Cancer Center Determinants of cancer response to immunotherapy
KR20230030022A (ko) * 2014-11-13 2023-03-03 더 존스 홉킨스 유니버시티 관문 차단 및 미소부수체 불안정성
MA40737A (fr) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1
CN117987553A (zh) * 2017-09-25 2024-05-07 纪念斯隆凯特琳癌症中心 肿瘤突变负荷和检查点免疫疗法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015533082A (ja) 2012-09-28 2015-11-19 ユニバーシティ オブ コネチカット 癌の治療のための腫瘍防御エピトープの同定

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＭＥＤＩＣＩＮＥ ＡＮＤ ＢＩＯＴＥＣＨＮＯＬＯＧＹ，２０１０．０７．１７．，ＶＯＬ．２０１０，ＮＯ．１０２７５８，Ｐ．１－１２
ＯＮＣＯＩＭＭＵＮＯＬＯＧＹ，２０１４．０１．，ＶＯＬ．３，ｅ２７８１７，Ｐ．１－６
ＯＮＣＯＩＭＭＵＮＯＬＯＧＹ，２０１４．１１．０１．，ＶＯＬ．３，ＮＯ．１１，ｅ９６７１４７，Ｐ．１－５
ＴＨＥ ＮＥＷ ＥＮＧＬＡＮＤ ＪＯＵＲＮＡＬ ＯＦ ＭＥＤＩＣＩＮＥ，２０１４．１１．０９．，ＶＯＬ．３７１，Ｐ．２１８９－２１９９

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