JP2018502828A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018502828A5 JP2018502828A5 JP2017527368A JP2017527368A JP2018502828A5 JP 2018502828 A5 JP2018502828 A5 JP 2018502828A5 JP 2017527368 A JP2017527368 A JP 2017527368A JP 2017527368 A JP2017527368 A JP 2017527368A JP 2018502828 A5 JP2018502828 A5 JP 2018502828A5
- Authority
- JP
- Japan
- Prior art keywords
- mutations
- lung cancer
- aforementioned
- immune checkpoint
- synonymous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022129458A JP7550193B2 (ja) | 2014-11-21 | 2022-08-16 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
| JP2024107117A JP2024125234A (ja) | 2014-11-21 | 2024-07-03 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083088P | 2014-11-21 | 2014-11-21 | |
| US62/083,088 | 2014-11-21 | ||
| US201562132381P | 2015-03-12 | 2015-03-12 | |
| US62/132,381 | 2015-03-12 | ||
| PCT/US2015/062208 WO2016081947A2 (en) | 2014-11-21 | 2015-11-23 | Determinants of cancer response to immunotherapy by pd-1 blockade |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020135853A Division JP2020196732A (ja) | 2014-11-21 | 2020-08-11 | Pd−1遮断による免疫療法の癌奏効の決定因子 |
| JP2022129458A Division JP7550193B2 (ja) | 2014-11-21 | 2022-08-16 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502828A JP2018502828A (ja) | 2018-02-01 |
| JP2018502828A5 true JP2018502828A5 (https=) | 2022-09-01 |
| JP7173733B2 JP7173733B2 (ja) | 2022-11-16 |
Family
ID=56014697
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017527368A Active JP7173733B2 (ja) | 2014-11-21 | 2015-11-23 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
| JP2020135853A Withdrawn JP2020196732A (ja) | 2014-11-21 | 2020-08-11 | Pd−1遮断による免疫療法の癌奏効の決定因子 |
| JP2022129458A Active JP7550193B2 (ja) | 2014-11-21 | 2022-08-16 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
| JP2024107117A Pending JP2024125234A (ja) | 2014-11-21 | 2024-07-03 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020135853A Withdrawn JP2020196732A (ja) | 2014-11-21 | 2020-08-11 | Pd−1遮断による免疫療法の癌奏効の決定因子 |
| JP2022129458A Active JP7550193B2 (ja) | 2014-11-21 | 2022-08-16 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
| JP2024107117A Pending JP2024125234A (ja) | 2014-11-21 | 2024-07-03 | Pd-1遮断による免疫療法の癌奏効の決定因子 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20180291074A1 (https=) |
| EP (2) | EP4393546A3 (https=) |
| JP (4) | JP7173733B2 (https=) |
| CN (2) | CN107206064B (https=) |
| AU (3) | AU2015349644B2 (https=) |
| HK (1) | HK1244440A1 (https=) |
| MA (1) | MA40737A (https=) |
| WO (1) | WO2016081947A2 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| EP3212670B1 (en) | 2014-10-29 | 2020-12-23 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| IL260030B2 (en) | 2016-01-08 | 2025-12-01 | Nykode Therapeutics ASA | Therapeutic anticancer neoepitope vaccine |
| CA3015913A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods of treating cancer |
| JP6821693B2 (ja) * | 2016-02-29 | 2021-01-27 | ジェネンテック, インコーポレイテッド | がんのための治療方法及び診断方法 |
| WO2017151727A1 (en) * | 2016-03-01 | 2017-09-08 | North Carolina State University | Enhanced cancer immunotherapy by microneedle patch-assisted delivery |
| JP7147168B2 (ja) * | 2016-03-02 | 2022-10-05 | 東レ株式会社 | 免疫誘導剤 |
| EP3464360B1 (en) | 2016-05-27 | 2025-11-12 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
| WO2018003995A1 (ja) * | 2016-07-01 | 2018-01-04 | 国立大学法人東北大学 | 免疫チェックポイント阻害薬使用における免疫関連副作用の予測方法 |
| EP3500966B1 (en) * | 2016-08-25 | 2021-04-21 | Nantomics, LLC | Immunotherapy markers and uses therefor |
| CA3038712A1 (en) | 2016-10-06 | 2018-04-12 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| JP7295015B2 (ja) * | 2016-10-07 | 2023-06-20 | オムニセック インコーポレイテッド | 個別化治療を決定するための方法 |
| WO2018132753A1 (en) * | 2017-01-13 | 2018-07-19 | Nantbio, Inc. | Validation of neoepitope-based treatment |
| WO2018136664A1 (en) | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
| BR112019015797A2 (pt) | 2017-02-01 | 2020-03-17 | Modernatx, Inc. | Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação |
| CN110461342A (zh) * | 2017-02-06 | 2019-11-15 | 诺华股份有限公司 | 预测对免疫疗法的反应的方法 |
| EP3494235A1 (en) * | 2017-02-17 | 2019-06-12 | Stichting VUmc | Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets |
| US10859566B2 (en) * | 2017-03-20 | 2020-12-08 | Genocea Biosciences, Inc. | Treatment methods |
| EP3601355A1 (en) * | 2017-03-31 | 2020-02-05 | Bristol-Myers Squibb Company | Methods of treating tumor |
| GB201710815D0 (en) * | 2017-07-05 | 2017-08-16 | Francis Crick Inst Ltd | Method |
| JP7760242B2 (ja) | 2017-07-21 | 2025-10-27 | ジェネンテック, インコーポレイテッド | がんの治療法及び診断法 |
| JP7274454B2 (ja) * | 2017-07-28 | 2023-05-16 | ブリストル-マイヤーズ スクイブ カンパニー | チェックポイント阻害薬のための予測末梢血バイオマーカー |
| EP3681535A1 (en) * | 2017-09-13 | 2020-07-22 | Five Prime Therapeutics, Inc. | Combination anti-csf1r and anti-pd-1 antibody combination therapy for pancreatic cancer |
| WO2019055860A1 (en) * | 2017-09-15 | 2019-03-21 | The Texas A&M University System | METHODS FOR IMPROVING IMMUNOTHERAPY IN THE TREATMENT OF CANCER |
| CN117987553A (zh) | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
| CA3076918A1 (en) * | 2017-10-02 | 2019-04-11 | Curematch, Inc. | Method of prediction of tumor-derived neo-peptide antigenicity and/or immunogenicity using mutational signature patterns |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| WO2019075251A2 (en) * | 2017-10-12 | 2019-04-18 | Nantomics, Llc | CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS |
| CN111247169A (zh) * | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| WO2019090156A1 (en) | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| EP3710600B1 (en) * | 2017-11-17 | 2025-03-12 | GMDx Co Pty Ltd | Systems and methods for predicting the efficacy of cancer therapy |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| WO2019109086A1 (en) | 2017-12-01 | 2019-06-06 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
| US20210054465A1 (en) * | 2018-05-03 | 2021-02-25 | Roche Sequencing Solutions, Inc. | Surrogate marker and method for tumor mutation burden measurement |
| MX2020011684A (es) * | 2018-05-04 | 2020-12-10 | Merck Patent Gmbh | Inhibicion combinada de pd-1/pd-l1, tgfbeta y dna-pk para el tratamiento del cancer. |
| WO2020023420A2 (en) | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| WO2020021119A1 (en) | 2018-07-27 | 2020-01-30 | F. Hoffmann-La Roche Ag | Method of monitoring effectiveness of immunotherapy of cancer patients |
| WO2020045479A1 (ja) | 2018-08-29 | 2020-03-05 | 公益財団法人東京都医学総合研究所 | HGF-regulated tyrosine kinase substrate(HGS)を標的とした抗腫瘍剤 |
| CN121354685A (zh) | 2018-08-31 | 2026-01-16 | 夸登特健康公司 | 无细胞dna中的微卫星不稳定性检测 |
| JP7623281B2 (ja) | 2018-11-15 | 2025-01-28 | パーソナル ゲノム ダイアグノスティクス インコーポレイテッド | 免疫療法で治療されたがん患者の応答の予測を改善する方法 |
| US20200190598A1 (en) * | 2018-12-12 | 2020-06-18 | Medimmune, Llc | Blood-based tumor mutation burden predicts overall survival in nsclc |
| EP3982954A4 (en) | 2019-06-14 | 2024-01-03 | The Trustees of Columbia University in the City of New York | NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA |
| AU2020376937A1 (en) * | 2019-11-01 | 2022-06-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | HLA class I sequence divergence and cancer therapy |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| EP4143345A1 (en) * | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| AU2021285711A1 (en) * | 2020-06-01 | 2023-01-05 | Gmdx Co Pty Ltd | Methods of predicting cancer progression |
| CN112309502B (zh) * | 2020-10-14 | 2024-09-20 | 深圳市新合生物医疗科技有限公司 | 一种计算肿瘤新抗原负荷的方法及系统 |
| WO2022099004A1 (en) * | 2020-11-06 | 2022-05-12 | The General Hospital Corporation | Methods for characterizing biological samples |
| US20240238340A1 (en) * | 2021-05-03 | 2024-07-18 | Rutgers, The State University Of New Jersey | Immunotherapy for inflammatory bowel disease and/or cancer |
| CN113030475B (zh) * | 2021-05-25 | 2021-08-10 | 泛肽生物科技(浙江)有限公司 | 一种基于细胞线粒体质量评估的t细胞pd-1检测方法 |
| CN113355424B (zh) * | 2021-07-14 | 2022-03-25 | 江苏先声医学诊断有限公司 | Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| WO2024216165A1 (en) | 2023-04-12 | 2024-10-17 | Icahn School Of Medicine At Mount Sinai | Computational methods for selecting personalized neoantigen vaccines |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033497A1 (en) | 2002-08-13 | 2004-02-19 | Alarcon-Riquelme Marta E. | Polymorphisms of PD-1 |
| TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| AU2010319322A1 (en) * | 2009-11-13 | 2012-05-31 | Infinity Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| EA201690310A1 (ru) * | 2010-04-13 | 2016-12-30 | Селлдекс Терапьютикс Инк. | Антитела, связывающие cd27 человека, и их применение |
| EP2569633B1 (en) * | 2010-05-14 | 2016-02-10 | The General Hospital Corporation | Compositions and methods of identifying tumor specific neoantigens |
| WO2013130748A1 (en) * | 2012-02-29 | 2013-09-06 | The Regents Of The University Of Michigan | Prostate cancer markers and uses thereof |
| RU2737765C2 (ru) | 2012-05-04 | 2020-12-02 | Пфайзер Инк. | Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин |
| LT2901341T (lt) | 2012-09-28 | 2019-09-25 | The University Of Connecticut | Protekcinių vėžio epitopų identifikavimas, skirtas vėžio gydymui |
| EP3090066A4 (en) * | 2014-01-02 | 2017-08-30 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
| KR20230030022A (ko) * | 2014-11-13 | 2023-03-03 | 더 존스 홉킨스 유니버시티 | 관문 차단 및 미소부수체 불안정성 |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| CN117987553A (zh) * | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
-
2015
- 2015-11-22 MA MA040737A patent/MA40737A/fr unknown
- 2015-11-23 EP EP24157218.9A patent/EP4393546A3/en active Pending
- 2015-11-23 EP EP15861224.2A patent/EP3220950A4/en not_active Ceased
- 2015-11-23 HK HK18103939.8A patent/HK1244440A1/zh unknown
- 2015-11-23 CN CN201580073049.2A patent/CN107206064B/zh active Active
- 2015-11-23 CN CN202210026426.9A patent/CN114672559A/zh active Pending
- 2015-11-23 AU AU2015349644A patent/AU2015349644B2/en active Active
- 2015-11-23 US US15/528,385 patent/US20180291074A1/en not_active Abandoned
- 2015-11-23 WO PCT/US2015/062208 patent/WO2016081947A2/en not_active Ceased
- 2015-11-23 JP JP2017527368A patent/JP7173733B2/ja active Active
-
2019
- 2019-02-22 US US16/283,555 patent/US10993998B2/en active Active
-
2020
- 2020-08-11 JP JP2020135853A patent/JP2020196732A/ja not_active Withdrawn
-
2021
- 2021-03-15 US US17/202,173 patent/US12485162B2/en active Active
- 2021-08-09 AU AU2021215099A patent/AU2021215099A1/en not_active Abandoned
-
2022
- 2022-08-16 JP JP2022129458A patent/JP7550193B2/ja active Active
-
2024
- 2024-07-03 JP JP2024107117A patent/JP2024125234A/ja active Pending
- 2024-12-12 AU AU2024278364A patent/AU2024278364A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018502828A5 (https=) | ||
| Succony et al. | Adenocarcinoma spectrum lesions of the lung: Detection, pathology and treatment strategies | |
| Lee et al. | Identification of human complement factor B as a novel biomarker candidate for pancreatic ductal adenocarcinoma | |
| Liu et al. | Heterogeneity of PD-L1 expression among the different histological components and metastatic lymph nodes in patients with resected lung adenosquamous carcinoma | |
| Shah et al. | Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer | |
| Shay et al. | Bacteriome and mycobiome and bacteriome-mycobiome interactions in head and neck squamous cell carcinoma | |
| US20200109455A1 (en) | Systems and methods for predicting clinical responses to immunotherapies | |
| WO2021175746A1 (en) | Prediction of radiotherapy response for prostate cancer subject based on immune defense response genes | |
| WO2022069201A1 (en) | Prediction of an outcome of a bladder or kidney cancer subject | |
| Li et al. | Lung cancer-associated T cell repertoire as potential biomarker for early detection of stage I lung cancer | |
| Bogusz et al. | Genetic aberrations in small B-cell lymphomas and leukemias: molecular pathology, clinical relevance and therapeutic targets | |
| Abazari et al. | Estimation of survival rates in patients with lung cancer in west Azerbaijan, the northwest of Iran | |
| Li et al. | Prognostic model for risk stratification of de novo metastatic nasopharyngeal carcinoma patients treated with chemotherapy followed by locoregional radiotherapy | |
| CN105574365A (zh) | 高通量测序突变检测结果的统计学验证方法 | |
| CN111321225A (zh) | 一种基于lncRNA评分体系在预测肿瘤免疫治疗效果中的应用 | |
| Aoki et al. | Greater extent of blood‐tumor TCR repertoire overlap is associated with favorable clinical responses to PD‐1 blockade | |
| Li et al. | Features and efficacy of triple-targeted therapy for patients with EGFR-mutant non-small-cell lung cancer with acquired BRAF alterations who are resistant to epidermal growth factor receptor tyrosine kinase inhibitors | |
| Campo-Le-Brun et al. | Real-world efficacy of immune checkpoint inhibitors in microsatellite unstable/mismatch repair-deficient biliary tract cancer: An AGEO study | |
| Nawaz et al. | Association of the rs10757274 SNP with coronary artery disease in a small group of a Pakistani population | |
| Devarakonda et al. | Next-generation sequencing of lung cancers: lessons learned and future directions | |
| Kim et al. | Assessment of Anti-tumor Efficacy of Osimertinib in Non–Small Cell Lung Cancer Patients by Liquid Biopsy Using Bronchoalveolar Lavage Fluid, Plasma, or Pleural Effusion | |
| Inokuchi et al. | Cadherin 5 is a significant risk factor for hematogenous recurrence and a prognostic factor in locally advanced gastric cancer | |
| Sklodowski et al. | 59 Integrating deep proteomics profiling with survival analysis to identify novel biomarkers of response to PD-1 blockade in NSCLC patients | |
| Thursby et al. | Epigenetic Instability Based Metrics in Cell-Free DNA for Early Cancer Detection | |
| Chen et al. | 169p anlotinib plus chemotherapy as neoadjuvant treatment of high-risk, early-stage triple-negative breast cancer: A prospective, single-arm, single-center, phase ii clinical study |