AU2015349644B2 - Determinants of cancer response to immunotherapy by PD-1 blockade - Google Patents
Determinants of cancer response to immunotherapy by PD-1 blockade Download PDFInfo
- Publication number
- AU2015349644B2 AU2015349644B2 AU2015349644A AU2015349644A AU2015349644B2 AU 2015349644 B2 AU2015349644 B2 AU 2015349644B2 AU 2015349644 A AU2015349644 A AU 2015349644A AU 2015349644 A AU2015349644 A AU 2015349644A AU 2015349644 B2 AU2015349644 B2 AU 2015349644B2
- Authority
- AU
- Australia
- Prior art keywords
- cancer
- immune checkpoint
- subject
- mutation
- mutations
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2021215099A AU2021215099A1 (en) | 2014-11-21 | 2021-08-09 | Determinants of cancer response to immunotherapy by PD-1 blockade |
| AU2024278364A AU2024278364A1 (en) | 2014-11-21 | 2024-12-12 | Determinants of cancer response to immunotherapy by PD-1 blockade |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462083088P | 2014-11-21 | 2014-11-21 | |
| US62/083,088 | 2014-11-21 | ||
| US201562132381P | 2015-03-12 | 2015-03-12 | |
| US62/132,381 | 2015-03-12 | ||
| PCT/US2015/062208 WO2016081947A2 (en) | 2014-11-21 | 2015-11-23 | Determinants of cancer response to immunotherapy by pd-1 blockade |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021215099A Division AU2021215099A1 (en) | 2014-11-21 | 2021-08-09 | Determinants of cancer response to immunotherapy by PD-1 blockade |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2015349644A1 AU2015349644A1 (en) | 2017-06-15 |
| AU2015349644B2 true AU2015349644B2 (en) | 2021-08-19 |
Family
ID=56014697
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2015349644A Active AU2015349644B2 (en) | 2014-11-21 | 2015-11-23 | Determinants of cancer response to immunotherapy by PD-1 blockade |
| AU2021215099A Abandoned AU2021215099A1 (en) | 2014-11-21 | 2021-08-09 | Determinants of cancer response to immunotherapy by PD-1 blockade |
| AU2024278364A Pending AU2024278364A1 (en) | 2014-11-21 | 2024-12-12 | Determinants of cancer response to immunotherapy by PD-1 blockade |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2021215099A Abandoned AU2021215099A1 (en) | 2014-11-21 | 2021-08-09 | Determinants of cancer response to immunotherapy by PD-1 blockade |
| AU2024278364A Pending AU2024278364A1 (en) | 2014-11-21 | 2024-12-12 | Determinants of cancer response to immunotherapy by PD-1 blockade |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20180291074A1 (https=) |
| EP (2) | EP4393546A3 (https=) |
| JP (4) | JP7173733B2 (https=) |
| CN (2) | CN107206064B (https=) |
| AU (3) | AU2015349644B2 (https=) |
| HK (1) | HK1244440A1 (https=) |
| MA (1) | MA40737A (https=) |
| WO (1) | WO2016081947A2 (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3255060A1 (en) | 2008-12-09 | 2017-12-13 | F. Hoffmann-La Roche AG | Anti-pd-l1 antibodies and their use to enhance t-cell function |
| SG10201804945WA (en) | 2013-12-12 | 2018-07-30 | Shanghai hengrui pharmaceutical co ltd | Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof |
| EP3212670B1 (en) | 2014-10-29 | 2020-12-23 | Five Prime Therapeutics, Inc. | Combination therapy for cancer |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| IL260030B2 (en) | 2016-01-08 | 2025-12-01 | Nykode Therapeutics ASA | Therapeutic anticancer neoepitope vaccine |
| CA3015913A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods of treating cancer |
| JP6821693B2 (ja) * | 2016-02-29 | 2021-01-27 | ジェネンテック, インコーポレイテッド | がんのための治療方法及び診断方法 |
| WO2017151727A1 (en) * | 2016-03-01 | 2017-09-08 | North Carolina State University | Enhanced cancer immunotherapy by microneedle patch-assisted delivery |
| JP7147168B2 (ja) * | 2016-03-02 | 2022-10-05 | 東レ株式会社 | 免疫誘導剤 |
| EP3464360B1 (en) | 2016-05-27 | 2025-11-12 | Agenus Inc. | Anti-tim-3 antibodies and methods of use thereof |
| WO2018003995A1 (ja) * | 2016-07-01 | 2018-01-04 | 国立大学法人東北大学 | 免疫チェックポイント阻害薬使用における免疫関連副作用の予測方法 |
| EP3500966B1 (en) * | 2016-08-25 | 2021-04-21 | Nantomics, LLC | Immunotherapy markers and uses therefor |
| CA3038712A1 (en) | 2016-10-06 | 2018-04-12 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
| JP7295015B2 (ja) * | 2016-10-07 | 2023-06-20 | オムニセック インコーポレイテッド | 個別化治療を決定するための方法 |
| WO2018132753A1 (en) * | 2017-01-13 | 2018-07-19 | Nantbio, Inc. | Validation of neoepitope-based treatment |
| WO2018136664A1 (en) | 2017-01-18 | 2018-07-26 | Ichan School Of Medicine At Mount Sinai | Neoantigens and uses thereof for treating cancer |
| BR112019015797A2 (pt) | 2017-02-01 | 2020-03-17 | Modernatx, Inc. | Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação |
| CN110461342A (zh) * | 2017-02-06 | 2019-11-15 | 诺华股份有限公司 | 预测对免疫疗法的反应的方法 |
| EP3494235A1 (en) * | 2017-02-17 | 2019-06-12 | Stichting VUmc | Swarm intelligence-enhanced diagnosis and therapy selection for cancer using tumor- educated platelets |
| US10859566B2 (en) * | 2017-03-20 | 2020-12-08 | Genocea Biosciences, Inc. | Treatment methods |
| EP3601355A1 (en) * | 2017-03-31 | 2020-02-05 | Bristol-Myers Squibb Company | Methods of treating tumor |
| GB201710815D0 (en) * | 2017-07-05 | 2017-08-16 | Francis Crick Inst Ltd | Method |
| JP7760242B2 (ja) | 2017-07-21 | 2025-10-27 | ジェネンテック, インコーポレイテッド | がんの治療法及び診断法 |
| JP7274454B2 (ja) * | 2017-07-28 | 2023-05-16 | ブリストル-マイヤーズ スクイブ カンパニー | チェックポイント阻害薬のための予測末梢血バイオマーカー |
| EP3681535A1 (en) * | 2017-09-13 | 2020-07-22 | Five Prime Therapeutics, Inc. | Combination anti-csf1r and anti-pd-1 antibody combination therapy for pancreatic cancer |
| WO2019055860A1 (en) * | 2017-09-15 | 2019-03-21 | The Texas A&M University System | METHODS FOR IMPROVING IMMUNOTHERAPY IN THE TREATMENT OF CANCER |
| CN117987553A (zh) | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
| CA3076918A1 (en) * | 2017-10-02 | 2019-04-11 | Curematch, Inc. | Method of prediction of tumor-derived neo-peptide antigenicity and/or immunogenicity using mutational signature patterns |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| WO2019075251A2 (en) * | 2017-10-12 | 2019-04-18 | Nantomics, Llc | CANCER SCORE FOR EVALUATION AND PREDICTION OF RESPONSE FROM BIOLOGICAL FLUIDS |
| CN111247169A (zh) * | 2017-10-15 | 2020-06-05 | 百时美施贵宝公司 | 治疗肿瘤的方法 |
| WO2019090156A1 (en) | 2017-11-03 | 2019-05-09 | Guardant Health, Inc. | Normalizing tumor mutation burden |
| EP3710600B1 (en) * | 2017-11-17 | 2025-03-12 | GMDx Co Pty Ltd | Systems and methods for predicting the efficacy of cancer therapy |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| WO2019109086A1 (en) | 2017-12-01 | 2019-06-06 | Illumina, Inc. | Methods and systems for determining somatic mutation clonality |
| US20210054465A1 (en) * | 2018-05-03 | 2021-02-25 | Roche Sequencing Solutions, Inc. | Surrogate marker and method for tumor mutation burden measurement |
| MX2020011684A (es) * | 2018-05-04 | 2020-12-10 | Merck Patent Gmbh | Inhibicion combinada de pd-1/pd-l1, tgfbeta y dna-pk para el tratamiento del cancer. |
| WO2020023420A2 (en) | 2018-07-23 | 2020-01-30 | Guardant Health, Inc. | Methods and systems for adjusting tumor mutational burden by tumor fraction and coverage |
| WO2020021119A1 (en) | 2018-07-27 | 2020-01-30 | F. Hoffmann-La Roche Ag | Method of monitoring effectiveness of immunotherapy of cancer patients |
| WO2020045479A1 (ja) | 2018-08-29 | 2020-03-05 | 公益財団法人東京都医学総合研究所 | HGF-regulated tyrosine kinase substrate(HGS)を標的とした抗腫瘍剤 |
| CN121354685A (zh) | 2018-08-31 | 2026-01-16 | 夸登特健康公司 | 无细胞dna中的微卫星不稳定性检测 |
| JP7623281B2 (ja) | 2018-11-15 | 2025-01-28 | パーソナル ゲノム ダイアグノスティクス インコーポレイテッド | 免疫療法で治療されたがん患者の応答の予測を改善する方法 |
| US20200190598A1 (en) * | 2018-12-12 | 2020-06-18 | Medimmune, Llc | Blood-based tumor mutation burden predicts overall survival in nsclc |
| EP3982954A4 (en) | 2019-06-14 | 2024-01-03 | The Trustees of Columbia University in the City of New York | NT5C2 INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA |
| AU2020376937A1 (en) * | 2019-11-01 | 2022-06-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | HLA class I sequence divergence and cancer therapy |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| EP4143345A1 (en) * | 2020-04-28 | 2023-03-08 | Genentech, Inc. | Methods and compositions for non-small cell lung cancer immunotherapy |
| AU2021285711A1 (en) * | 2020-06-01 | 2023-01-05 | Gmdx Co Pty Ltd | Methods of predicting cancer progression |
| CN112309502B (zh) * | 2020-10-14 | 2024-09-20 | 深圳市新合生物医疗科技有限公司 | 一种计算肿瘤新抗原负荷的方法及系统 |
| WO2022099004A1 (en) * | 2020-11-06 | 2022-05-12 | The General Hospital Corporation | Methods for characterizing biological samples |
| US20240238340A1 (en) * | 2021-05-03 | 2024-07-18 | Rutgers, The State University Of New Jersey | Immunotherapy for inflammatory bowel disease and/or cancer |
| CN113030475B (zh) * | 2021-05-25 | 2021-08-10 | 泛肽生物科技(浙江)有限公司 | 一种基于细胞线粒体质量评估的t细胞pd-1检测方法 |
| CN113355424B (zh) * | 2021-07-14 | 2022-03-25 | 江苏先声医学诊断有限公司 | Pcdh11x突变在预测非小细胞肺癌患者对免疫检查点抑制剂疗法敏感性中的应用 |
| WO2024216165A1 (en) | 2023-04-12 | 2024-10-17 | Icahn School Of Medicine At Mount Sinai | Computational methods for selecting personalized neoantigen vaccines |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014052707A2 (en) * | 2012-09-28 | 2014-04-03 | The University Of Connecticut | Identification of tumor-protective epitopes for the treatment of cancers |
| WO2015103037A2 (en) * | 2014-01-02 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040033497A1 (en) | 2002-08-13 | 2004-02-19 | Alarcon-Riquelme Marta E. | Polymorphisms of PD-1 |
| TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| AU2010319322A1 (en) * | 2009-11-13 | 2012-05-31 | Infinity Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer |
| GB201004551D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | NOvel immunotherapy against several tumors including gastrointestinal and gastric cancer |
| EA201690310A1 (ru) * | 2010-04-13 | 2016-12-30 | Селлдекс Терапьютикс Инк. | Антитела, связывающие cd27 человека, и их применение |
| EP2569633B1 (en) * | 2010-05-14 | 2016-02-10 | The General Hospital Corporation | Compositions and methods of identifying tumor specific neoantigens |
| WO2013130748A1 (en) * | 2012-02-29 | 2013-09-06 | The Regents Of The University Of Michigan | Prostate cancer markers and uses thereof |
| RU2737765C2 (ru) | 2012-05-04 | 2020-12-02 | Пфайзер Инк. | Простатоассоциированные антигены и иммунотерапевтические схемы на основе вакцин |
| KR20230030022A (ko) * | 2014-11-13 | 2023-03-03 | 더 존스 홉킨스 유니버시티 | 관문 차단 및 미소부수체 불안정성 |
| MA40737A (fr) | 2014-11-21 | 2017-07-04 | Memorial Sloan Kettering Cancer Center | Déterminants de la réponse d'un cancer à une immunothérapie par blocage de pd-1 |
| CN117987553A (zh) * | 2017-09-25 | 2024-05-07 | 纪念斯隆凯特琳癌症中心 | 肿瘤突变负荷和检查点免疫疗法 |
-
2015
- 2015-11-22 MA MA040737A patent/MA40737A/fr unknown
- 2015-11-23 EP EP24157218.9A patent/EP4393546A3/en active Pending
- 2015-11-23 EP EP15861224.2A patent/EP3220950A4/en not_active Ceased
- 2015-11-23 HK HK18103939.8A patent/HK1244440A1/zh unknown
- 2015-11-23 CN CN201580073049.2A patent/CN107206064B/zh active Active
- 2015-11-23 CN CN202210026426.9A patent/CN114672559A/zh active Pending
- 2015-11-23 AU AU2015349644A patent/AU2015349644B2/en active Active
- 2015-11-23 US US15/528,385 patent/US20180291074A1/en not_active Abandoned
- 2015-11-23 WO PCT/US2015/062208 patent/WO2016081947A2/en not_active Ceased
- 2015-11-23 JP JP2017527368A patent/JP7173733B2/ja active Active
-
2019
- 2019-02-22 US US16/283,555 patent/US10993998B2/en active Active
-
2020
- 2020-08-11 JP JP2020135853A patent/JP2020196732A/ja not_active Withdrawn
-
2021
- 2021-03-15 US US17/202,173 patent/US12485162B2/en active Active
- 2021-08-09 AU AU2021215099A patent/AU2021215099A1/en not_active Abandoned
-
2022
- 2022-08-16 JP JP2022129458A patent/JP7550193B2/ja active Active
-
2024
- 2024-07-03 JP JP2024107117A patent/JP2024125234A/ja active Pending
- 2024-12-12 AU AU2024278364A patent/AU2024278364A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014052707A2 (en) * | 2012-09-28 | 2014-04-03 | The University Of Connecticut | Identification of tumor-protective epitopes for the treatment of cancers |
| WO2015103037A2 (en) * | 2014-01-02 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
Non-Patent Citations (3)
| Title |
|---|
| BEI, R et al., "TAA Polyepitope DNA-based vaccines: a potential tool for cancer therapy.", J Biomed Biotechnol., vol. 2010, no. 102758, (2010-06-17), pages 1 - 12, URL: 10.1155/2010/102758 * |
| J. C. CASTLE ET AL, "Exploiting the Mutanome for Tumor Vaccination", CANCER RESEARCH, US, (2012-03-01), vol. 72, no. 5, doi:10.1158/0008-5472.CAN-11-3722, ISSN 0008-5472, pages 1081 - 1091 * |
| STEPHANE CHAMPIAT ET AL, "Exomics and immunogenics", ONCOIMMUNOLOGY, (2014-01-01), vol. 3, no. 1, doi:10.4161/onci.27817, page e27817 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180291074A1 (en) | 2018-10-11 |
| JP2023055625A (ja) | 2023-04-18 |
| CN114672559A (zh) | 2022-06-28 |
| MA40737A (fr) | 2017-07-04 |
| CN107206064A (zh) | 2017-09-26 |
| EP3220950A2 (en) | 2017-09-27 |
| AU2015349644A1 (en) | 2017-06-15 |
| JP7173733B2 (ja) | 2022-11-16 |
| JP2024125234A (ja) | 2024-09-13 |
| JP7550193B2 (ja) | 2024-09-19 |
| US12485162B2 (en) | 2025-12-02 |
| CA2968059A1 (en) | 2016-05-26 |
| AU2021215099A1 (en) | 2021-08-26 |
| US20200040049A1 (en) | 2020-02-06 |
| CN107206064B (zh) | 2021-12-21 |
| WO2016081947A3 (en) | 2016-07-07 |
| EP4393546A3 (en) | 2024-12-11 |
| JP2020196732A (ja) | 2020-12-10 |
| WO2016081947A4 (en) | 2016-09-09 |
| EP4393546A2 (en) | 2024-07-03 |
| US20210308241A1 (en) | 2021-10-07 |
| US10993998B2 (en) | 2021-05-04 |
| AU2024278364A1 (en) | 2025-02-13 |
| HK1244440A1 (zh) | 2018-08-10 |
| WO2016081947A2 (en) | 2016-05-26 |
| EP3220950A4 (en) | 2018-08-29 |
| JP2018502828A (ja) | 2018-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12485162B2 (en) | Determinants of cancer response to immunotherapy by pd-1 blockade | |
| RU2707530C2 (ru) | Детерминанты ответа раковой опухоли на иммунотерапию | |
| US11274342B2 (en) | Systems and methods for sequencing T cell receptors and uses thereof | |
| EP4226944A2 (en) | Tumor mutational load and checkpoint immunotherapy | |
| JP2020525030A (ja) | 癌の免疫療法への適合性を評価する方法 | |
| Hubbard et al. | Safety and activity of PolyPEPI1018 combined with maintenance therapy in metastatic colorectal cancer: an open-label, multicenter, phase Ib study | |
| US20190284640A1 (en) | Methods and Systems for Predicting Response to Immunotherapies for Treatment of Cancer | |
| WO2019008365A1 (en) | METHOD OF TREATING CANCER WITH A NEO-ANTIGEN INDEL PHASE | |
| CN115135386A (zh) | 用于治疗胶质母细胞瘤的方法 | |
| CA2968059C (en) | Determinants of cancer response to immunotherapy by pd-1 blockade | |
| HK40115175A (en) | Determinants of cancer response to immunotherapy by pd-1 blockade | |
| Pourmir | Membrane and soluble forms of the immune checkpoint TIM-3 in clear cell renal cell carcinoma: a promising biomarker for cancer immunotherapy | |
| Garrido-Barros et al. | Immune Checkpoint Blockade Response Biomarkers | |
| HK40098129A (en) | Tumor mutational load and checkpoint immunotherapy | |
| HK40032690A (en) | Tumor mutational load and checkpoint immunotherapy | |
| HK40015205A (en) | Systems and methods for sequencing t cell receptors and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |