JP7169195B2 - 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 - Google Patents

癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 Download PDF

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JP7169195B2
JP7169195B2 JP2018560520A JP2018560520A JP7169195B2 JP 7169195 B2 JP7169195 B2 JP 7169195B2 JP 2018560520 A JP2018560520 A JP 2018560520A JP 2018560520 A JP2018560520 A JP 2018560520A JP 7169195 B2 JP7169195 B2 JP 7169195B2
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riluzole
cancer
glutamate
agents
tumor
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JP2019516711A (ja
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ブラディミア・コリック
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Biohaven Pharmaceutical Holding Co Ltd
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018560520A 2016-05-20 2017-05-19 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用 Active JP7169195B2 (ja)

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JP2022173334A JP7493569B2 (ja) 2016-05-20 2022-10-28 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用

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US201662339433P 2016-05-20 2016-05-20
US62/339,433 2016-05-20
PCT/US2017/033688 WO2017201501A1 (en) 2016-05-20 2017-05-19 Use of riluzole, riluzole prodrugs or riluzole analogs with immunotherapies to treat cancers

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JP2022173334A Division JP7493569B2 (ja) 2016-05-20 2022-10-28 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用

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JP2019516711A JP2019516711A (ja) 2019-06-20
JP2019516711A5 JP2019516711A5 (https=) 2020-06-11
JP7169195B2 true JP7169195B2 (ja) 2022-11-10

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JP2018560520A Active JP7169195B2 (ja) 2016-05-20 2017-05-19 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用
JP2018560528A Active JP7224186B2 (ja) 2016-05-20 2017-05-19 癌を処置するためのグルタミン酸調節剤と免疫療法の併用
JP2022150358A Active JP7653398B2 (ja) 2016-05-20 2022-09-21 癌を処置するためのグルタミン酸調節剤と免疫療法の併用
JP2022173334A Active JP7493569B2 (ja) 2016-05-20 2022-10-28 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用

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JP2018560528A Active JP7224186B2 (ja) 2016-05-20 2017-05-19 癌を処置するためのグルタミン酸調節剤と免疫療法の併用
JP2022150358A Active JP7653398B2 (ja) 2016-05-20 2022-09-21 癌を処置するためのグルタミン酸調節剤と免疫療法の併用
JP2022173334A Active JP7493569B2 (ja) 2016-05-20 2022-10-28 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用

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US (4) US12383619B2 (https=)
EP (3) EP3458053B1 (https=)
JP (4) JP7169195B2 (https=)
KR (2) KR102369735B1 (https=)
CN (2) CN109890387B (https=)
AU (2) AU2017266951B2 (https=)
CA (1) CA3025019A1 (https=)
CY (1) CY1124999T1 (https=)
DK (2) DK4019019T3 (https=)
EA (1) EA201892587A1 (https=)
ES (3) ES2981830T3 (https=)
FI (1) FI4019019T3 (https=)
HR (2) HRP20240617T1 (https=)
HU (2) HUE058184T2 (https=)
IL (2) IL292302B2 (https=)
LT (2) LT3458053T (https=)
MX (2) MX2018013868A (https=)
PH (1) PH12018502409A1 (https=)
PL (2) PL4019019T3 (https=)
PT (2) PT4019019T (https=)
RS (2) RS62935B1 (https=)
SG (1) SG11201809669RA (https=)
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WO (2) WO2017201501A1 (https=)
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Cited By (1)

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JP2023012508A (ja) * 2016-05-20 2023-01-25 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド 癌を処置するためのリルゾール、リルゾールプロドラッグまたはリルゾール類似体と免疫療法との併用

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