JP7142639B2 - ２－シアノイミダゾール化合物の調製方法 - Google Patents

２－シアノイミダゾール化合物の調製方法 Download PDF

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JP7142639B2
JP7142639B2 JP2019545974A JP2019545974A JP7142639B2 JP 7142639 B2 JP7142639 B2 JP 7142639B2 JP 2019545974 A JP2019545974 A JP 2019545974A JP 2019545974 A JP2019545974 A JP 2019545974A JP 7142639 B2 JP7142639 B2 JP 7142639B2
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formula
group
reducing agent
compound
reacting
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JP2020508324A5 (cg-RX-API-DMAC7.html
JP2020508324A (ja
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ボーパル，メカ
ジャガディーシュ，スーラ
ゴピナザン ピライ，ビジュクマー
グラバニク，ミカエル
メイソン，ドローン
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アダマ・マクテシム・リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2019545974A 2017-02-23 2018-02-23 ２－シアノイミダゾール化合物の調製方法 Active JP7142639B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201731006545 2017-02-23
IN201731006545 2017-02-23
PCT/IL2018/050211 WO2018154582A1 (en) 2017-02-23 2018-02-23 Process for the preparation of 2-cyanoimidazole compounds

Publications (3)

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JP2020508324A JP2020508324A (ja) 2020-03-19
JP2020508324A5 JP2020508324A5 (cg-RX-API-DMAC7.html) 2021-04-01
JP7142639B2 true JP7142639B2 (ja) 2022-09-27

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JP2019545974A Active JP7142639B2 (ja) 2017-02-23 2018-02-23 ２－シアノイミダゾール化合物の調製方法

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US (1) US10968182B2 (cg-RX-API-DMAC7.html)
EP (1) EP3583094B1 (cg-RX-API-DMAC7.html)
JP (1) JP7142639B2 (cg-RX-API-DMAC7.html)
CN (1) CN110337434B (cg-RX-API-DMAC7.html)
AR (1) AR110997A1 (cg-RX-API-DMAC7.html)
BR (1) BR112019017556B1 (cg-RX-API-DMAC7.html)
ES (1) ES2890553T3 (cg-RX-API-DMAC7.html)
IL (1) IL268835B (cg-RX-API-DMAC7.html)
PL (1) PL3583094T3 (cg-RX-API-DMAC7.html)
PT (1) PT3583094T (cg-RX-API-DMAC7.html)
WO (1) WO2018154582A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10968182B2 (en) 2017-02-23 2021-04-06 Adama Makhteshim Ltd. Process for the preparation of 2-cyanoimidazole compounds
EP4162938A4 (en) * 2020-06-03 2024-06-26 Ishihara Sangyo Kaisha, Ltd. ANTIMICROBIAL AGENT FOR NON-HUMAN ANIMALS
CN115745893A (zh) * 2022-11-16 2023-03-07 西安近代化学研究所 一种合成2-氰基-5-芳基-1h-咪唑类化合物的方法
WO2025068799A1 (en) * 2023-09-29 2025-04-03 Cropnosys (India) Private Limited A process for the preparation of 4-chloro-5-(4-methylphenyl)-1h-imidazole-2-carbonitrile
WO2025068800A1 (en) * 2023-09-29 2025-04-03 Cropnosys (India) Private Limited A process for the preparation of 4-chloro-5-(4-methylphenyl)-1h-imidazole-2-carbonitrile
CN117800920A (zh) * 2023-12-05 2024-04-02 西安近代化学研究所 一种2-氰基-5-（对甲基苯基）咪唑的合成方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
CN102424671A (zh) 2011-11-04 2012-04-25 西安近代化学研究所 4-氯-2-氰基-1-二甲基氨基磺酰基-5-(4-甲基苯基)咪唑的合成方法
CN103936678A (zh) 2014-04-23 2014-07-23 西安近代化学研究所 一种4-氯-2-氰基-n,n-二甲基-5-(4-甲基苯基)-1h-咪唑-1-磺酰胺的合成方法
CN104292166A (zh) 2014-10-14 2015-01-21 西安近代化学研究所 4-氯-2-氰基-n,n-二甲基-5-对甲苯基咪唑-1-磺酰胺合成方法
WO2016024224A1 (en) 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited A process for the preparation of 4-fluoro-2-methylbenzonitrile

Family Cites Families (5)

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US4605521A (en) 1985-03-29 1986-08-12 Eastman Kodak Company Process for the preparation of organic nitriles from organic carboxylic acid primary amides
JP2879164B2 (ja) * 1990-06-28 1999-04-05 石原産業株式会社 置換２―シアノイミダゾール系化合物の製造方法
DE69513657T2 (de) 1994-09-08 2000-04-06 Ishihara Sangyo Kaisha Ltd. Verfahren zur Herstellung von 1-substituierten 2-Cyanoimidazolen
CN105130904B (zh) * 2015-08-24 2017-10-13 如东众意化工有限公司 一种2‑氰基‑4‑氯‑5‑（4‑甲基苯基）咪唑的合成方法
US10968182B2 (en) 2017-02-23 2021-04-06 Adama Makhteshim Ltd. Process for the preparation of 2-cyanoimidazole compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102424671A (zh) 2011-11-04 2012-04-25 西安近代化学研究所 4-氯-2-氰基-1-二甲基氨基磺酰基-5-(4-甲基苯基)咪唑的合成方法
CN103936678A (zh) 2014-04-23 2014-07-23 西安近代化学研究所 一种4-氯-2-氰基-n,n-二甲基-5-(4-甲基苯基)-1h-咪唑-1-磺酰胺的合成方法
WO2016024224A1 (en) 2014-08-11 2016-02-18 Sun Pharmaceutical Industries Limited A process for the preparation of 4-fluoro-2-methylbenzonitrile
CN104292166A (zh) 2014-10-14 2015-01-21 西安近代化学研究所 4-氯-2-氰基-n,n-二甲基-5-对甲苯基咪唑-1-磺酰胺合成方法

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Title
Kiasat, Ali Reza; Kazemi, Foad; Khosravian, Forogh.，Na2SO3/SOCl2, an efficient reagent for the dehydration of aldoximes to nitriles，Phosphorus, Sulfur and Silicon and the Related Elements，2003年，178(6)，1377-1383
O. S. SIZOVA ET AL.，PYRROLO[3,2-d]PYRIMIDINES. IV. SYNTHESIS AND ANTIBACTERIAL AND ANTITUMOR ACTIVITY OF 2,4,7-SUBSTITUTED PYRROLO[3,2-d]PYRIMIDINES，PHARMACEUTICAL CHEMISTRY JOURNAL，1982年，vol. 16, no. 11，834-838

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Publication number Publication date
EP3583094B1 (en) 2021-06-23
PT3583094T (pt) 2021-09-21
IL268835B (en) 2021-10-31
US20200071278A1 (en) 2020-03-05
AR110997A1 (es) 2019-05-22
WO2018154582A9 (en) 2018-11-01
EP3583094A1 (en) 2019-12-25
BR112019017556A2 (pt) 2020-04-07
BR112019017556B1 (pt) 2023-02-07
CN110337434B (zh) 2022-11-22
US10968182B2 (en) 2021-04-06
PL3583094T3 (pl) 2022-01-03
IL268835A (en) 2019-10-31
CN110337434A (zh) 2019-10-15
WO2018154582A1 (en) 2018-08-30
JP2020508324A (ja) 2020-03-19
ES2890553T3 (es) 2022-01-20

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