JP7137598B2 - 積層膜、積層膜を備える移植組織、および積層膜を製造する方法 - Google Patents
積層膜、積層膜を備える移植組織、および積層膜を製造する方法 Download PDFInfo
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Description
第3の態様において、内層厚を有する内層を提供することと、内層の一方の側に、第1の被覆層厚を有する第1の被覆層を提供することと、内層の他方の側に、第2の被覆層厚を有する第2の被覆層を提供することとを含む、移植組織のための積層膜を製造する方法が提供される。
第1の被覆層12は、内層11の一方の側を全体に被覆し得る。第2の被覆層13は、内層12の他方の側を全体に被覆し得る。
当業者は、いずれの材料が別の材料よりも低い摩擦であるかを判断する、多くの方法を認識するであろう。例えば、比較される材料は、平坦な表面を有するように形成されてよく、これらの表面の(それ自体または別の一般的な表面に対する)表面エネルギー、表面粗度、または静摩擦係数を、当業者によって確認され得るように測定してもよい。試験される材料の各々の平坦表面は、同じ処理(例えば電界紡糸、押し出し成形、フィルム成形、ディップ成形、回転成形、噴霧堆積、または蒸気堆積(換言すれば、蒸着)など)によって形成され得る。
第1の被覆層12および/または第2の被覆層13の弾性は、内層11の弾性より高いか、または等しくてよい。このような場合、積層膜10は、恒久的に変形する恐れなく、より小さい径方向の外形を有する収縮送達構成を可能にし得る。なぜなら、積層膜10を曲げる間に、内層11よりも大きく伸長される第1の被覆層12および/または第2の被覆層13は、内層11よりも良好に伸縮できるからである。
例えば、内層11はポリウレタン(PU)で構成されてよく、第1の被覆層12および第2の被覆層13の各々は、ポリテトラフルオロエチレン(PTFE)から構成されてよい。この場合、PUの内層11は、積層膜10に高い剛性をもたらし、その一方でPTFEの第1の被覆層12および第2の被覆層13は、低い摩擦を有する積層膜10の外表面となる。高い剛性は、積層膜10が確実に収縮送達構成から拡張展開構成へ移行するのを可能にして、その一方で低い摩擦面は、移動中の変形を軽減させ得る。
内層厚Xは4~8μmであってよく、第1の被覆層厚Yおよび第2の被覆層厚Zは1~3μmであってよい。別の実施形態において、内層厚Xは6~10μmであってよく、第1の被覆層厚Yおよび第2の被覆層厚Zは1~4μmであってよい。
細書で説明する任意の積層膜であってよい。積層膜31は、コア31が積層膜31を通過できる貫通穴を有し得る。積層膜33は、身体の内腔を通る流れを塞ぐよう構成される。
さらに、上記の積層膜は、コアおよび複数の可撓性剛毛を伴う閉塞形成装置に関して説明したが、本開示による積層体は、任意のタイプの閉塞形成装置にも適用可能である。
一実施形態において、積層膜は、収縮送達構成および拡張展開構成を有するように構成される。閉塞形成装置は閉塞形成コイルを備えてもよい。積層膜は、この閉塞形成コイルの少なくとも一部の周りに配設され得る。積層膜の少なくとも一部は、閉塞形成コイルにおける隣接した巻きの間に配設され得る。
さらに、上記の製造方法は、層の各々を形成するために電界紡糸処理を用いるが、様々な他の製造方法が使用され得る。例えば層は、電界紡糸、押し出し成形、フィルム成形、ディップ成形、回転成形、噴霧堆積、または蒸気堆積によって形成され得る。さらに、異なる層は異なる方法で形成され得る。例えば、内層はディップ成形または噴霧成形から形成され得る。第1の被覆層、および第2の被覆層の各々は、内層の上に電界紡糸で形成され得る。
施形態の基礎を形成するよう考慮される。
Claims (16)
- 移植組織のための積層膜の製造方法であって、
内層厚を有する内層を提供するステップと、
前記内層の一方の側に、第1の被覆層厚を有する第1の被覆層を提供するステップと、
前記内層の他方の側に、第2の被覆層厚を有する第2の被覆層を提供するステップと
を含み、
前記内層は、ポリウレタンとポリテトラフルオロエチレンとの複合材料を含むか、またはポリウレタンとポリテトラフルオロエチレンとの複合材料のみから構成され、前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方は、親水性材料を含むか、または親水性材料のみから構成される、積層膜の製造方法。 - 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方は、前記内層が作られる材料よりも低摩擦の材料から作られる、請求項1に記載の製造方法。
- 前記内層の剛性は、前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方の剛性よりも高い、請求項1または2に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方の弾性は、前記内層の弾性より高いか、または同じである、請求項1~3のいずれか一項に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方は、前記積層膜の外面層である、請求項1~4のいずれか一項に記載の製造方法。
- 前記内層、前記第1の被覆層、および前記第2の被覆層のうちの少なくとも1つは、電界紡糸、押し出し成形、フィルム成形、ディップ成形、回転成形、噴霧堆積、または蒸気堆積から作られる、請求項1~5のいずれか一項に記載の製造方法。
- 前記内層は、第1の被覆層および第2の被覆層のうちの少なくとも一方よりも高い弾性復元力、引裂き抵抗性、および透水性のうちの少なくとも1つを有する、請求項1~6のいずれか一項に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方は、前記内層よりも低い表面エネルギーを有する、請求項1~7のいずれか一項に記載の製造方法。
- 前記内層厚は4~8μmであり、前記第1の被覆層厚および前記第2の被覆層厚のうちの少なくとも一方は1~3μmである、請求項1~8のいずれか一項に記載の製造方法。
- 前記内層厚は6~10μmであり、前記第1の被覆層厚および前記第2の被覆層厚のうちの少なくとも一方は1~4μmである、請求項1~9のいずれか一項に記載の製造方法。
- 前記内層と前記第1の被覆層との間の結合層、および前記内層と前記第2の被覆層との間の結合層のうちの少なくとも一方を備える、請求項1~10のいずれか一項に記載の製造方法。
- 前記第1の被覆層厚および前記第2の被覆層厚のうちの少なくとも一方は、前記内層厚より小さい、請求項1~11のいずれか一項に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方は、前記内層の前記一方の側または前記他方の側をそれぞれ完全に被覆する、請求項1~12のいずれか一項に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層は共に、前記内層の全ての外表面を被覆する、請求項13に記載の製造方法。
- 前記内層の剛性は0.9~2.5GPa、または1.1~2.3GPa、または1.3~2.1GPaである、請求項1~14のいずれか一項に記載の製造方法。
- 前記第1の被覆層および前記第2の被覆層のうちの少なくとも一方の剛性は、0.1~0.75GPa、または0.25~0.65GPa、または0.4~0.55GPaである、請求項1~15のいずれか一項に記載の製造方法。
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JP7361950B2 (ja) * | 2020-05-22 | 2023-10-16 | クリアストリーム・テクノロジーズ・リミテッド | 塞栓デバイスおよびその製造方法 |
EP4161408A1 (en) * | 2020-06-04 | 2023-04-12 | Clearstream Technologies Limited | Flow restrictor for an embolization device |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000504594A (ja) | 1996-02-02 | 2000-04-18 | トランスバスキュラー インコーポレイテッド | 血管内の流れを遮断する方法及び装置 |
JP2004089718A (ja) | 1995-11-10 | 2004-03-25 | Endogad Research Pty Ltd | ガイドワイヤーを用いた腔内移植片の位置決めのためのカテーテル |
JP2008119022A (ja) | 2006-11-08 | 2008-05-29 | Olympus Corp | 医療器具およびその製造方法 |
JP2010500110A (ja) | 2006-08-07 | 2010-01-07 | ゴア エンタープライズ ホールディングス,インコーポレイティド | 膨張性成形バルーン |
WO2011158642A1 (ja) | 2010-06-16 | 2011-12-22 | テルモ株式会社 | 医療用具の製造方法 |
JP2013501857A (ja) | 2009-08-07 | 2013-01-17 | ゼウス インダストリアル プロダクツ インコーポレイテッド | 多層複合体 |
JP2014200291A (ja) | 2013-04-01 | 2014-10-27 | テルモ株式会社 | 潤滑コート剤および医療デバイス |
JP2015515358A (ja) | 2012-10-25 | 2015-05-28 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | ステントの位置移動を防止するための粘着性シリコーンコーティングを有するステント |
WO2016130674A1 (en) | 2015-02-10 | 2016-08-18 | Boston Scientific Scimed, Inc. | Vascular occlusion devices |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5333620A (en) * | 1991-10-30 | 1994-08-02 | C. R. Bard, Inc. | High performance plastic coated medical guidewire |
US5630844A (en) * | 1995-06-07 | 1997-05-20 | Novamed Medical Products Manufacturing, Inc. | Biocompatible hydrophobic laminate with thermoplastic elastomer layer |
US5585407A (en) | 1995-07-13 | 1996-12-17 | Minnesota Mining And Manufacturing Company | Water-based coatable compositions comprising reaction products of acrylic emulsion polymers with organoalkoxysilanes |
US7807211B2 (en) * | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
EP1149626B1 (de) | 2000-04-27 | 2005-07-20 | Sika Schweiz AG | Statisches Mischelement und Statikmischer sowie Verwendung derselben |
US20020084178A1 (en) | 2000-12-19 | 2002-07-04 | Nicast Corporation Ltd. | Method and apparatus for manufacturing polymer fiber shells via electrospinning |
US6960224B2 (en) * | 2003-01-22 | 2005-11-01 | Cardia, Inc. | Laminated sheets for use in a fully retrievable occlusion device |
US7790273B2 (en) * | 2006-05-24 | 2010-09-07 | Nellix, Inc. | Material for creating multi-layered films and methods for making the same |
US20110230810A1 (en) * | 2008-04-23 | 2011-09-22 | Raman Jaishankar | Implantable anti-adhesion three layer patch |
US9820746B2 (en) * | 2008-07-28 | 2017-11-21 | Incube Laboratories LLC | System and method for scaffolding anastomoses |
JP5658175B2 (ja) * | 2009-03-10 | 2015-01-21 | メドプリン リジェネラティブ メディカル テクノロジーズ カンパニーリミテッド | 人工硬膜及びその製造方法 |
US8388645B2 (en) * | 2009-12-21 | 2013-03-05 | Boston Scientific Scimed, Inc. | Intravascular filter restraining device |
DE102011012501A1 (de) * | 2011-02-25 | 2012-08-30 | Phenox Gmbh | Implantat mit Faservlies |
US20130204234A1 (en) * | 2011-08-12 | 2013-08-08 | Edward H. Cully | Systems for the reduction of leakage around medical devices at a treatment site |
US10342548B2 (en) * | 2012-01-13 | 2019-07-09 | W. L. Gore & Associates, Inc. | Occlusion devices and methods of their manufacture and use |
US9770352B2 (en) * | 2013-03-14 | 2017-09-26 | W. L. Gore & Associates, Inc. | Inflatable balloon and cover |
US10675039B2 (en) * | 2013-03-15 | 2020-06-09 | Embo Medical Limited | Embolisation systems |
BR112015022634B1 (pt) | 2013-03-15 | 2022-12-13 | Embo Medical Limited | Dispositivo de embolização de cerdas, sistema de carga e método para carga |
US10080640B2 (en) * | 2013-04-18 | 2018-09-25 | National University Corporation Yamagata University | Stent to be placed in bile duct |
TW201506445A (zh) | 2013-08-01 | 2015-02-16 | Hon Hai Prec Ind Co Ltd | 顯示系統及顯示系統的顯示方法 |
JP6595513B2 (ja) * | 2014-06-13 | 2019-10-23 | ニューラヴィ・リミテッド | 血管からの急性閉塞物の除去のための装置 |
WO2016030898A1 (en) * | 2014-08-27 | 2016-03-03 | Amnis Therapeutics Ltd. | Implantable devices comprising graft membranes |
CN110301955B (zh) | 2014-09-15 | 2022-07-26 | 恩波医疗有限公司 | 栓塞装置 |
GB201708025D0 (en) | 2017-05-18 | 2017-07-05 | Clearstream Tech Ltd | A laminate membrane, an implant comprising the laminate membrane and a method of manufacturing the same |
-
2017
- 2017-05-18 GB GBGB1708025.0A patent/GB201708025D0/en not_active Ceased
-
2018
- 2018-05-18 EP EP21197948.9A patent/EP3943022B1/en active Active
- 2018-05-18 EP EP18726136.7A patent/EP3576645A1/en active Pending
- 2018-05-18 JP JP2019563601A patent/JP6743313B2/ja active Active
- 2018-05-18 CN CN201911321427.0A patent/CN110840510B/zh active Active
- 2018-05-18 WO PCT/EP2018/063148 patent/WO2018211091A1/en unknown
- 2018-05-18 CN CN201880031300.2A patent/CN110621238B/zh active Active
- 2018-05-18 US US16/613,737 patent/US10952738B2/en active Active
- 2018-05-18 AU AU2018269863A patent/AU2018269863B2/en active Active
- 2018-05-18 NZ NZ773746A patent/NZ773746A/en unknown
-
2020
- 2020-04-16 AU AU2020202567A patent/AU2020202567B2/en active Active
- 2020-07-28 JP JP2020126929A patent/JP7137598B2/ja active Active
-
2021
- 2021-02-12 US US17/174,564 patent/US11602349B2/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004089718A (ja) | 1995-11-10 | 2004-03-25 | Endogad Research Pty Ltd | ガイドワイヤーを用いた腔内移植片の位置決めのためのカテーテル |
JP2000504594A (ja) | 1996-02-02 | 2000-04-18 | トランスバスキュラー インコーポレイテッド | 血管内の流れを遮断する方法及び装置 |
JP2010500110A (ja) | 2006-08-07 | 2010-01-07 | ゴア エンタープライズ ホールディングス,インコーポレイティド | 膨張性成形バルーン |
JP2008119022A (ja) | 2006-11-08 | 2008-05-29 | Olympus Corp | 医療器具およびその製造方法 |
JP2013501857A (ja) | 2009-08-07 | 2013-01-17 | ゼウス インダストリアル プロダクツ インコーポレイテッド | 多層複合体 |
WO2011158642A1 (ja) | 2010-06-16 | 2011-12-22 | テルモ株式会社 | 医療用具の製造方法 |
JP2015515358A (ja) | 2012-10-25 | 2015-05-28 | ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. | ステントの位置移動を防止するための粘着性シリコーンコーティングを有するステント |
JP2014200291A (ja) | 2013-04-01 | 2014-10-27 | テルモ株式会社 | 潤滑コート剤および医療デバイス |
WO2016130674A1 (en) | 2015-02-10 | 2016-08-18 | Boston Scientific Scimed, Inc. | Vascular occlusion devices |
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CN110621238B (zh) | 2020-10-16 |
US10952738B2 (en) | 2021-03-23 |
US11602349B2 (en) | 2023-03-14 |
EP3943022B1 (en) | 2024-03-27 |
WO2018211091A1 (en) | 2018-11-22 |
GB201708025D0 (en) | 2017-07-05 |
US20200078022A1 (en) | 2020-03-12 |
CN110840510B (zh) | 2022-10-14 |
CN110621238A (zh) | 2019-12-27 |
NZ758196A (en) | 2021-03-26 |
EP3943022A1 (en) | 2022-01-26 |
CN110840510A (zh) | 2020-02-28 |
AU2020202567A1 (en) | 2020-05-07 |
NZ773746A (en) | 2023-10-27 |
US20210161538A1 (en) | 2021-06-03 |
JP2020520280A (ja) | 2020-07-09 |
JP2020185415A (ja) | 2020-11-19 |
AU2018269863B2 (en) | 2020-03-12 |
EP3576645A1 (en) | 2019-12-11 |
JP6743313B2 (ja) | 2020-08-19 |
AU2018269863A1 (en) | 2019-10-31 |
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AU2020202567B2 (en) | 2021-03-11 |
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