JP7128519B2 - ペニシリンｇアシラーゼ - Google Patents

ペニシリンｇアシラーゼ Download PDF

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Publication number
JP7128519B2
JP7128519B2 JP2018557402A JP2018557402A JP7128519B2 JP 7128519 B2 JP7128519 B2 JP 7128519B2 JP 2018557402 A JP2018557402 A JP 2018557402A JP 2018557402 A JP2018557402 A JP 2018557402A JP 7128519 B2 JP7128519 B2 JP 7128519B2
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Prior art keywords
acylase
penicillin
insulin
engineered
phenylacetate
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Japanese (ja)
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JP2019514395A5 (cg-RX-API-DMAC7.html
JP2019514395A (ja
Inventor
ジョヴァナ ネイザー，
ヴェスナ ミッチェル，
デイビッド エルガート，
カトリーナ ダブリュー． レクサ，
ニッキ デラス，
ロバート ケビン オア，
オスカー アルビゾ，
ラヴィ デイビッド ガルシア，
ジュディ ヴィクトリア アントニオ ヴィドゥヤ，
コートニー ダイアン モフェット，
Original Assignee
コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018557402A 2016-05-05 2017-05-05 ペニシリンｇアシラーゼ Active JP7128519B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662332103P 2016-05-05 2016-05-05
US62/332,103 2016-05-05
PCT/US2017/031342 WO2017193022A1 (en) 2016-05-05 2017-05-05 Penicillin-g acylases

Publications (3)

Publication Number Publication Date
JP2019514395A JP2019514395A (ja) 2019-06-06
JP2019514395A5 JP2019514395A5 (cg-RX-API-DMAC7.html) 2020-04-16
JP7128519B2 true JP7128519B2 (ja) 2022-08-31

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Family Applications (1)

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JP2018557402A Active JP7128519B2 (ja) 2016-05-05 2017-05-05 ペニシリンｇアシラーゼ

Country Status (12)

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US (4) US10724025B2 (cg-RX-API-DMAC7.html)
EP (1) EP3452587B1 (cg-RX-API-DMAC7.html)
JP (1) JP7128519B2 (cg-RX-API-DMAC7.html)
KR (1) KR102382489B1 (cg-RX-API-DMAC7.html)
CN (1) CN109715793A (cg-RX-API-DMAC7.html)
AU (1) AU2017260355B2 (cg-RX-API-DMAC7.html)
CA (1) CA3021009A1 (cg-RX-API-DMAC7.html)
DK (1) DK3452587T3 (cg-RX-API-DMAC7.html)
IL (1) IL262550B (cg-RX-API-DMAC7.html)
MX (1) MX389364B (cg-RX-API-DMAC7.html)
SG (1) SG11201808957UA (cg-RX-API-DMAC7.html)
WO (1) WO2017193022A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102382489B1 (ko) 2016-05-05 2022-04-01 코덱시스, 인코포레이티드 페니실린 ｇ 아실라제
EP3645713A4 (en) 2017-06-27 2021-06-30 Codexis, Inc. PENICILLIN-G ACYLASES
CN114760980B (zh) * 2019-09-12 2024-10-18 科德克希思公司 针对10-乙酰基-3,7-二羟基吩噁嗪的过氧化物酶活性

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US20120270282A1 (en) 2008-11-10 2012-10-25 Codexis, Inc. Penicillin-g acylases

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Also Published As

Publication number Publication date
EP3452587B1 (en) 2021-09-08
EP3452587A4 (en) 2020-03-18
IL262550B (en) 2022-05-01
EP3452587A1 (en) 2019-03-13
SG11201808957UA (en) 2018-11-29
DK3452587T3 (da) 2021-10-11
US20170321202A1 (en) 2017-11-09
MX389364B (es) 2025-03-19
KR20180137025A (ko) 2018-12-26
AU2017260355A1 (en) 2018-11-01
MX2018013259A (es) 2019-04-22
NZ747064A (en) 2025-05-02
WO2017193022A1 (en) 2017-11-09
US11965192B2 (en) 2024-04-23
IL262550A (en) 2018-12-31
AU2017260355B2 (en) 2023-03-30
US11214786B2 (en) 2022-01-04
KR102382489B1 (ko) 2022-04-01
JP2019514395A (ja) 2019-06-06
US20220154164A1 (en) 2022-05-19
US20250034543A1 (en) 2025-01-30
CN109715793A (zh) 2019-05-03
US20200339972A1 (en) 2020-10-29
US10724025B2 (en) 2020-07-28
CA3021009A1 (en) 2017-11-09

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