JP7126520B2 - Ｌ－オルニチンフェニルアセテートを製造する方法 - Google Patents

Ｌ－オルニチンフェニルアセテートを製造する方法 Download PDF

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JP7126520B2
JP7126520B2 JP2019561997A JP2019561997A JP7126520B2 JP 7126520 B2 JP7126520 B2 JP 7126520B2 JP 2019561997 A JP2019561997 A JP 2019561997A JP 2019561997 A JP2019561997 A JP 2019561997A JP 7126520 B2 JP7126520 B2 JP 7126520B2
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ornithine
composition
reaction mixture
phenylacetate
solvent
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JP2020519624A (ja
JP2020519624A5 (https=
Inventor
ピルスル，ラディック
ウィンクラー，ゲオルク
デマーティン，フランク
エリツィン，ヴァシル
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オセラ セラピューティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/32—Phenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C07C227/42—Crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2019561997A 2017-05-11 2018-05-07 Ｌ－オルニチンフェニルアセテートを製造する方法 Active JP7126520B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762504911P 2017-05-11 2017-05-11
US62/504,911 2017-05-11
PCT/US2018/031405 WO2018208677A1 (en) 2017-05-11 2018-05-07 Processes of making l-ornithine phenylacetate

Publications (3)

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JP2020519624A JP2020519624A (ja) 2020-07-02
JP2020519624A5 JP2020519624A5 (https=) 2021-06-17
JP7126520B2 true JP7126520B2 (ja) 2022-08-26

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JP2019561997A Active JP7126520B2 (ja) 2017-05-11 2018-05-07 Ｌ－オルニチンフェニルアセテートを製造する方法

Country Status (10)

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US (1) US11066352B2 (https=)
EP (1) EP3621947A4 (https=)
JP (1) JP7126520B2 (https=)
KR (1) KR20200024145A (https=)
CN (1) CN110740988A (https=)
AU (1) AU2018266357B2 (https=)
CA (1) CA3063134A1 (https=)
IL (1) IL270413B (https=)
MX (1) MX389665B (https=)
WO (1) WO2018208677A1 (https=)

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* Cited by examiner, † Cited by third party
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HUE035921T2 (en) 2009-04-03 2018-05-28 Ocera Therapeutics Inc L-ornithine phenyl acetate and methods of making thereof
SG11202111509PA (en) * 2019-05-09 2021-11-29 Ocera Therapeutics Inc Methods of assessing and treating hepatic encephalopathy

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CA3063134A1 (en) 2018-11-15
JP2020519624A (ja) 2020-07-02
IL270413B (en) 2022-08-01
EP3621947A1 (en) 2020-03-18
AU2018266357A1 (en) 2019-11-14
US20200157033A1 (en) 2020-05-21
MX389665B (es) 2025-03-20
EP3621947A4 (en) 2021-03-10
IL270413A (https=) 2020-01-30
CN110740988A (zh) 2020-01-31
KR20200024145A (ko) 2020-03-06
US11066352B2 (en) 2021-07-20
WO2018208677A1 (en) 2018-11-15
AU2018266357B2 (en) 2022-12-08

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