IL270413B - Processes of making l-ornithine phenylacetate - Google Patents
Processes of making l-ornithine phenylacetateInfo
- Publication number
- IL270413B IL270413B IL270413A IL27041319A IL270413B IL 270413 B IL270413 B IL 270413B IL 270413 A IL270413 A IL 270413A IL 27041319 A IL27041319 A IL 27041319A IL 270413 B IL270413 B IL 270413B
- Authority
- IL
- Israel
- Prior art keywords
- ornithine
- reaction mixture
- composition
- phenylacetate
- solvent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 66
- 230000008569 process Effects 0.000 title claims description 61
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 title claims description 35
- 238000002360 preparation method Methods 0.000 title description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 67
- 239000000203 mixture Substances 0.000 claims description 66
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims description 64
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- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 22
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/32—Phenylacetic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US201762504911P | 2017-05-11 | 2017-05-11 | |
| PCT/US2018/031405 WO2018208677A1 (en) | 2017-05-11 | 2018-05-07 | Processes of making l-ornithine phenylacetate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL270413A IL270413A (https=) | 2020-01-30 |
| IL270413B true IL270413B (en) | 2022-08-01 |
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|---|---|---|---|
| IL270413A IL270413B (en) | 2017-05-11 | 2018-05-07 | Processes of making l-ornithine phenylacetate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11066352B2 (https=) |
| EP (1) | EP3621947A4 (https=) |
| JP (1) | JP7126520B2 (https=) |
| KR (1) | KR20200024145A (https=) |
| CN (1) | CN110740988A (https=) |
| AU (1) | AU2018266357B2 (https=) |
| CA (1) | CA3063134A1 (https=) |
| IL (1) | IL270413B (https=) |
| MX (1) | MX389665B (https=) |
| WO (1) | WO2018208677A1 (https=) |
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| CA2757373C (en) | 2009-04-03 | 2018-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| KR102852068B1 (ko) * | 2019-05-09 | 2025-08-28 | 오세라 테라퓨틱스, 아이엔씨. | 간성 뇌증의 평가 및 치료 방법 |
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| US20200157033A1 (en) | 2020-05-21 |
| EP3621947A4 (en) | 2021-03-10 |
| EP3621947A1 (en) | 2020-03-18 |
| AU2018266357B2 (en) | 2022-12-08 |
| US11066352B2 (en) | 2021-07-20 |
| KR20200024145A (ko) | 2020-03-06 |
| WO2018208677A1 (en) | 2018-11-15 |
| CA3063134A1 (en) | 2018-11-15 |
| AU2018266357A1 (en) | 2019-11-14 |
| CN110740988A (zh) | 2020-01-31 |
| JP2020519624A (ja) | 2020-07-02 |
| MX389665B (es) | 2025-03-20 |
| IL270413A (https=) | 2020-01-30 |
| JP7126520B2 (ja) | 2022-08-26 |
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