JP7110203B2 - 腫瘍溶解性ウイルスおよび治療用分子 - Google Patents

腫瘍溶解性ウイルスおよび治療用分子 Download PDF

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JP7110203B2
JP7110203B2 JP2019535298A JP2019535298A JP7110203B2 JP 7110203 B2 JP7110203 B2 JP 7110203B2 JP 2019535298 A JP2019535298 A JP 2019535298A JP 2019535298 A JP2019535298 A JP 2019535298A JP 7110203 B2 JP7110203 B2 JP 7110203B2
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virus
oncolytic virus
oncolytic
cancer
tumor
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JP2020503040A (ja
JP2020503040A5 (enExample
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フィリップ、エルブ
ジョアン、フォロップ
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Transgene SA
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JP2019535298A 2016-12-28 2017-12-21 腫瘍溶解性ウイルスおよび治療用分子 Active JP7110203B2 (ja)

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EP16306831 2016-12-28
EP16306831.5 2016-12-28
PCT/EP2017/084022 WO2018122088A1 (en) 2016-12-28 2017-12-21 Oncolytic viruses and therapeutic molecules

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US (1) US20190330655A1 (enExample)
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KR (1) KR20190097240A (enExample)
CN (1) CN110168092A (enExample)
AU (1) AU2017387549B2 (enExample)
CA (1) CA3045228C (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102267837B1 (ko) * 2018-01-19 2021-06-22 코오롱생명과학 주식회사 재조합 백시니아 바이러스 및 이를 포함하는 약학 조성물
SG11202106898VA (en) * 2018-12-28 2021-07-29 Transgene Sa M2-defective poxvirus
CN110747174A (zh) * 2019-10-30 2020-02-04 青岛宁逸生物科技有限公司 一种用于肿瘤治疗的重组病毒
AU2021220188A1 (en) * 2020-02-11 2022-09-08 Cytonus Therapeutics, Inc. Rapid vaccine platform
WO2021211902A2 (en) * 2020-04-15 2021-10-21 Humane Genomics Artificial oncolytic viruses and related methods
CN116421734A (zh) * 2021-12-30 2023-07-14 深圳复诺健生物科技有限公司 适用于溶瘤病毒的冻干保护剂及其应用
CN115820721B (zh) * 2022-07-26 2024-03-22 贵州大学 提高贵州优质特色稻大白果糯分蘖和产量的方法和一种启动子核心序列及应用
CN120380015A (zh) 2022-08-18 2025-07-25 特兰斯吉恩公司 嵌合痘病毒
CN119015298B (zh) * 2024-06-14 2025-07-11 贵州医科大学 表观修饰核苷在治疗肿瘤中的应用
WO2026041811A1 (en) 2024-08-23 2026-02-26 Transgene Recombinant poxvirus and method for regulating the expression of toxic conditional gene products of said recombinant poxvirus in a producing cell

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009532053A (ja) 2006-04-07 2009-09-10 セルセントリック・リミテッド インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法
JP2011504104A (ja) 2007-11-19 2011-02-03 トランジェーヌ、ソシエテ、アノニム ポックスウイルス腫瘍細胞崩壊性ベクター
JP2013514779A (ja) 2009-12-18 2013-05-02 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 脱メチル化および細胞の再プログラミングを促進するためのシチジンデアミナーゼ関連薬剤の使用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US6222020B1 (en) 1987-01-07 2001-04-24 Imperial Cancer Research Technology Limited Antigens derived from the core protein of the human mammary epithelial mucin
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
FR2751343B1 (fr) 1996-07-16 1998-12-18 Transgene Sa Procede de conservation de virus recombinants infectieux, suspension aqueuse virale et utilisation comme medicament
CA2261989C (en) 1996-07-25 2008-09-30 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
EP0931158A1 (en) 1996-09-06 1999-07-28 The Trustees Of The University Of Pennsylvania An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase
EP1012276A2 (en) 1997-02-24 2000-06-28 Therion Biologics Corporation Recombinant pox virus for immunization against muc1 tumor-associated antigen
WO1998056415A1 (en) 1997-06-11 1998-12-17 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
CA2799545A1 (en) 2000-03-07 2001-09-13 Merck Sharp & Dohme Corp. Adenovirus formulations
NZ533302A (en) 2001-12-10 2005-11-25 Bavarian Nordic As Poxvirus containing formulations and process for preparing stable, poxvirus containing compositions containing a disaaccharide and a pharmaceutically acceptable polymer i.e. dextran or polyvinylpyrrolidon (PVP)
US20040009951A1 (en) * 2002-06-13 2004-01-15 Malim Michael H DNA deamination mediates innate immunity to (retro)viral infection
EP1528101A1 (en) 2003-11-03 2005-05-04 ProBioGen AG Immortalized avian cell lines for virus production
FR2884255B1 (fr) 2005-04-11 2010-11-05 Vivalis Utilisation de lignees de cellules souches aviaires ebx pour la production de vaccin contre la grippe
BRPI0618850A2 (pt) 2005-11-21 2011-09-13 Sanofi Pasteur Ltd formulações de estabilização para vìrus recombinantes
ES2611975T3 (es) 2006-06-20 2017-05-11 Transgene S.A. Procedimiento para producir poxvirus y composiciones de poxvirus
EP2029169A2 (en) 2006-06-20 2009-03-04 Transgene S.A. Recombinant viral vaccine
GB0705245D0 (en) 2007-03-19 2007-04-25 Stabilitech Ltd Stable biological products
EP1985305A1 (en) 2007-04-24 2008-10-29 Vivalis Duck embryonic derived stem cell lines for the production of viral vaccines
CA2676149C (en) 2007-05-14 2016-06-21 Bavarian Nordic A/S Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines
WO2008156655A2 (en) * 2007-06-15 2008-12-24 Genelux Corporation Vaccinia virus vectors encoding a sodium-dependent transporter protein for imaging and/or treatment of tumors
US8357531B2 (en) 2007-07-03 2013-01-22 Transgene S.A. Immortalized avian cell lines
KR101039235B1 (ko) * 2007-08-29 2011-06-07 메디포스트(주) 제대혈 유래 간엽줄기세포를 포함하는 인터루킨-8 또는지알오-알파 발현 세포가 관련된 질병의 진단, 예방 또는치료용 조성물
AU2008328258B2 (en) 2007-11-19 2013-09-26 Transgene Sa Poxviral oncolytic vectors
CN102257134B (zh) 2008-02-12 2014-03-05 赛诺菲巴斯德有限公司 使用离子交换和凝胶过滤色谱进行痘病毒纯化的方法
JP2012509678A (ja) 2008-11-27 2012-04-26 バヴァリアン・ノルディック・アクティーゼルスカブ 組換えウイルス発現のためのプロモーター
US8394385B2 (en) 2009-03-13 2013-03-12 Bavarian Nordic A/S Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell response against recombinant antigen in MVA vaccines
JP5684787B2 (ja) 2009-04-06 2015-03-18 大塚製薬株式会社 シチジンベースの抗新生物薬とシチジンデアミナーゼ阻害薬との組合せ、および癌の治療におけるその使用
ES2628580T3 (es) 2009-04-06 2017-08-03 Otsuka Pharmaceutical Co., Ltd. Combinación de decitabina con inhibidor de citidina deaminasa y uso del mismo en el tratamiento de cáncer el tratamiento de cáncer
KR20120026526A (ko) 2009-05-12 2012-03-19 트랜스진 에스.에이. 불멸화 조류 세포주 및 그의 용도
GB201006405D0 (en) 2010-04-16 2010-06-02 Isis Innovation Poxvirus expression system
WO2013022764A1 (en) 2011-08-05 2013-02-14 David Kirn Methods and compositions for production of vaccina virus
FI20115914L (fi) * 2011-09-16 2013-03-17 Oncos Therapeutics Ltd Muunnettu onkolyyttinen virus
BR112015009320A2 (pt) 2012-10-28 2017-10-17 Bavarian Nordic As promotor pr13.5 para respostas de células t e anticorpo robustas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009532053A (ja) 2006-04-07 2009-09-10 セルセントリック・リミテッド インヴィヴォでの核酸配列のエピジェネティック修飾用組成物および方法
JP2011504104A (ja) 2007-11-19 2011-02-03 トランジェーヌ、ソシエテ、アノニム ポックスウイルス腫瘍細胞崩壊性ベクター
JP2013514779A (ja) 2009-12-18 2013-05-02 ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ 脱メチル化および細胞の再プログラミングを促進するためのシチジンデアミナーゼ関連薬剤の使用

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Chen S et al.,APOBEC3A possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer,Int J Clin Exp Med,2015年,Vol. 8(7),pp. 10548-10557
Fend L et al.,Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor,OncoImmunology,2016年02月26日,Vol. 5(2):e1080414,pp. 1-11
P32320 (CDD_HUMAN),UniProtKB[online],1996年,URL: https://www.uniprot.org/uniprot/P32320#sequences,[retrieved on 10.12.2021]
Q06549 (CDD_YEAST),UniProtKB[online],1996年,URL: https://www.uniprot.org/uniprot/Q06549,[retrieved on 10.12.2021]
Wu P F et al.,APOBEC3B: a potential factor suppressing growth of human hepatocellular carcinoma cells,Anticancer Res,2015年,Vol. 35(3),pp. 1521-1528
Xu Y et al.,Effect of apolipoprotein B mRNA-editing catalytic polypeptide-like protein-3G in cervical cancer,Int. J. Clin. Exp. Pathol.,2015年,Vol. 8(10),pp. 12307-12312

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JP2020503040A (ja) 2020-01-30
CA3045228C (en) 2024-01-02
US20190330655A1 (en) 2019-10-31
CA3045228A1 (en) 2018-07-05
WO2018122088A1 (en) 2018-07-05
EP3562946A1 (en) 2019-11-06
DK3562946T3 (da) 2022-01-31
CN110168092A (zh) 2019-08-23
IL267639A (en) 2019-08-29
AU2017387549A1 (en) 2019-07-04
EP3562946B1 (en) 2021-11-24
ES2905478T3 (es) 2022-04-08
KR20190097240A (ko) 2019-08-20
AU2017387549B2 (en) 2023-07-06

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