JP7103603B2 - Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 - Google Patents

Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 Download PDF

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JP7103603B2
JP7103603B2 JP2018531643A JP2018531643A JP7103603B2 JP 7103603 B2 JP7103603 B2 JP 7103603B2 JP 2018531643 A JP2018531643 A JP 2018531643A JP 2018531643 A JP2018531643 A JP 2018531643A JP 7103603 B2 JP7103603 B2 JP 7103603B2
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JP2019502701A (ja
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霆 徐
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蘇州康寧傑瑞生物科技有限公司
江蘇康寧杰瑞生物制薬有限公司
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

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  • Molecular Biology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2018531643A 2015-12-16 2016-12-16 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 Active JP7103603B2 (ja)

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JP2022103464A JP7444381B2 (ja) 2015-12-16 2022-06-28 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途
JP2024019083A JP7788113B2 (ja) 2015-12-16 2024-02-13 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途

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CN201510938995.0 2015-12-16
CN201510938995.0A CN106883297B (zh) 2015-12-16 2015-12-16 基于ch3结构域的异二聚体分子、其制备方法及用途
PCT/CN2016/110252 WO2017101828A1 (zh) 2015-12-16 2016-12-16 基于ch3结构域的异二聚体分子、其制备方法及用途

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JP2022103464A Active JP7444381B2 (ja) 2015-12-16 2022-06-28 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途
JP2024019083A Active JP7788113B2 (ja) 2015-12-16 2024-02-13 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途

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JP2024019083A Active JP7788113B2 (ja) 2015-12-16 2024-02-13 Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途

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CN106883297A (zh) 2017-06-23
EP3392276B1 (en) 2023-04-19
WO2017101828A1 (zh) 2017-06-22
JP2019502701A (ja) 2019-01-31
DK3392276T5 (da) 2024-09-23
JP7788113B2 (ja) 2025-12-18
EP3392276A1 (en) 2018-10-24
US20180362668A1 (en) 2018-12-20
ES2944553T3 (es) 2023-06-22
EP3392276A4 (en) 2019-09-18
FI3392276T3 (fi) 2023-05-05
EP4234584B1 (en) 2025-07-16
US20250257150A1 (en) 2025-08-14
HK1253248A1 (zh) 2019-06-14
CN115057937A (zh) 2022-09-16
JP2024056829A (ja) 2024-04-23
JP7444381B2 (ja) 2024-03-06
DK3392276T3 (da) 2023-05-01
CN108473592B (zh) 2022-05-03
CA3007427C (en) 2024-04-23
CN115057937B (zh) 2025-07-18
EP4234584A3 (en) 2023-09-27
EP4234584A2 (en) 2023-08-30
CA3007427A1 (en) 2017-06-22
US11168149B2 (en) 2021-11-09
CN106883297B (zh) 2019-12-13
EP4234584C0 (en) 2025-07-16
US12281177B2 (en) 2025-04-22
CN108473592A (zh) 2018-08-31
CN120842427A (zh) 2025-10-28
JP2022130568A (ja) 2022-09-06
US20220017643A1 (en) 2022-01-20

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