DK3392276T3 - Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf - Google Patents
Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf Download PDFInfo
- Publication number
- DK3392276T3 DK3392276T3 DK16874885.3T DK16874885T DK3392276T3 DK 3392276 T3 DK3392276 T3 DK 3392276T3 DK 16874885 T DK16874885 T DK 16874885T DK 3392276 T3 DK3392276 T3 DK 3392276T3
- Authority
- DK
- Denmark
- Prior art keywords
- domain
- structural
- production
- molecule based
- heterodimer molecule
- Prior art date
Links
- 239000000833 heterodimer Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510938995.0A CN106883297B (zh) | 2015-12-16 | 2015-12-16 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| PCT/CN2016/110252 WO2017101828A1 (zh) | 2015-12-16 | 2016-12-16 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK3392276T3 true DK3392276T3 (da) | 2023-05-01 |
| DK3392276T5 DK3392276T5 (da) | 2024-09-23 |
Family
ID=59055700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16874885.3T DK3392276T5 (da) | 2015-12-16 | 2016-12-16 | Heterodimermolekyle baseret på strukturel CH3-domæne, og fremgangsmåde til fremstilling samt anvendelse deraf |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11168149B2 (da) |
| EP (2) | EP3392276B1 (da) |
| JP (3) | JP7103603B2 (da) |
| CN (3) | CN106883297B (da) |
| CA (1) | CA3007427C (da) |
| DK (1) | DK3392276T5 (da) |
| ES (1) | ES2944553T3 (da) |
| FI (1) | FI3392276T3 (da) |
| HK (1) | HK1253248A1 (da) |
| WO (1) | WO2017101828A1 (da) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106883297B (zh) * | 2015-12-16 | 2019-12-13 | 苏州康宁杰瑞生物科技有限公司 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| CA3035681A1 (en) | 2016-09-29 | 2018-04-05 | Beijing Hanmi Pharmaceutical Co., Ltd. | Heterodimeric immunoglobulin constructs and preparation methods thereof |
| PE20191080A1 (es) | 2016-11-18 | 2019-08-20 | Beijing Hanmi Pharmaceutical Co Ltd | Anticuerpo biespecifico heterodimerico estructural de anticuerpo natural anti-pd-1/anti-her2 y metodo para preparar el mismo |
| JP7282383B2 (ja) | 2017-06-14 | 2023-05-29 | ディンフー バイオターゲット カンパニー リミテッド | タンパク質性ヘテロ二量体及びその用途 |
| JP7097636B2 (ja) * | 2017-06-20 | 2022-07-08 | ナノマブ テクノロジー リミテッド | 抗Ｈｅｒ２ナノボディ及びそのコード序列と用途 |
| WO2019014912A1 (zh) * | 2017-07-21 | 2019-01-24 | 赵磊 | 一种异二聚体蛋白及其制备方法 |
| WO2019047885A1 (en) | 2017-09-07 | 2019-03-14 | Dingfu Biotarget Co., Ltd. | IMMUNOCONJUGATES COMPRISING ALPHA REGULATORY SIGNAL PROTEIN |
| JP2020535145A (ja) * | 2017-09-25 | 2020-12-03 | ディンフー バイオターゲット カンパニー リミテッド | 癌治療のための方法及び組成物 |
| WO2019057180A1 (en) * | 2017-09-25 | 2019-03-28 | Dingfu Biotarget Co., Ltd. | PROTEIN HETÉRODIMÈRE AND USE THEREOF |
| KR20200093639A (ko) | 2017-12-04 | 2020-08-05 | 북경한미약품 유한공사 | 천연 항체 구조-유사 헤테로다이머 형태의 항 pd-l1/항 cd47 이중특이성 항체 및 이의 제조 |
| WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| KR20200120927A (ko) * | 2018-02-11 | 2020-10-22 | 베이징 한미 파마슈티컬 컴퍼니 리미티드 | 항-pd-1/항-vegf 천연 항체 구조-유사 이형이량체형 이중특이성 항체 및 그의 제조 |
| CN108640997A (zh) * | 2018-05-22 | 2018-10-12 | 蔡毓旻 | 一种双特异性抗体 |
| CN113692416A (zh) * | 2019-03-25 | 2021-11-23 | 苏州丁孚靶点生物技术有限公司 | 蛋白质异二聚体及其用途 |
| CN113795516A (zh) * | 2019-03-28 | 2021-12-14 | Ab工作室有限公司 | 异多聚体蛋白质及其使用方法 |
| MX2021012872A (es) * | 2019-04-25 | 2021-11-17 | Hoffmann La Roche | Polipeptidos multiespecificos terapeuticos activados mediante intercambio de cadenas polipeptidicas. |
| CA3133898A1 (en) * | 2019-04-25 | 2020-10-29 | Ulrich Brinkmann | Activatable therapeutic multispecific polypeptides with extended half-life |
| CA3132275A1 (en) * | 2019-04-25 | 2020-10-29 | Ulrich Brinkmann | Generation of antibody-derived polypeptides by polypeptide chain exchange |
| JP7483865B2 (ja) | 2019-09-06 | 2024-05-15 | イーライ リリー アンド カンパニー | Ｔ細胞受容体の定常ドメインを含むタンパク質 |
| CN113121697B (zh) * | 2019-12-31 | 2023-06-09 | 周易 | Ch3结构域改造诱导形成的异源二聚体及其制备方法和应用 |
| CN113121696A (zh) * | 2019-12-31 | 2021-07-16 | 周易 | Fab改造诱导形成的双特异性抗体及其制备方法和用途 |
| CN115279796A (zh) * | 2020-01-23 | 2022-11-01 | 天演药业(瑞士)公司 | 具有Fc突变的异二聚蛋白质 |
| US20230279125A1 (en) * | 2020-08-05 | 2023-09-07 | Synthekine, Inc. | Il28ra binding molecules and methods of use |
| US12018085B2 (en) | 2020-08-05 | 2024-06-25 | Synthekine, Inc. | Interferon-gamma R2 (IFNGR2) binding molecules comprising single-domain antibodies and method of use thereof to treat autoimmune and inflammatory diseases |
| WO2022093857A1 (en) * | 2020-10-26 | 2022-05-05 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
| CN112977908B (zh) * | 2021-03-02 | 2022-12-02 | 康宁杰瑞(吉林)生物科技有限公司 | 灌装加塞机及其灌装的方法 |
| BR112023026966A2 (pt) * | 2021-07-02 | 2024-03-12 | Hoffmann La Roche | Métodos para tratar um indivíduo com melanoma, para alcançar uma resposta clínica, para tratar um indivíduo com linfoma não hodgkin, para tratar uma população de indivíduos com linfoma não hodgkin e para tratar um indivíduo com câncer colorretal metastático |
| EP4377351A1 (en) * | 2021-07-28 | 2024-06-05 | F. Hoffmann-La Roche AG | Methods and compositions for treating cancer |
| KR20240116743A (ko) * | 2021-11-09 | 2024-07-30 | 한양대학교 산학협력단 | Fc 변이체를 포함하는 이종이합체 및 이의 제조방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| HUE028536T2 (en) * | 2008-01-07 | 2016-12-28 | Amgen Inc | Method for producing antibody to FC heterodimer molecules using electrostatic control effects |
| ME02505B (me) * | 2009-12-29 | 2017-02-20 | Aptevo Res & Development Llc | Heterodimerni vezujući proteini i njihove upotrebe |
| RS59589B1 (sr) * | 2010-11-05 | 2019-12-31 | Zymeworks Inc | Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu |
| CN107840894A (zh) * | 2011-03-25 | 2018-03-27 | 格兰马克药品股份有限公司 | 异二聚体免疫球蛋白 |
| JP6326371B2 (ja) * | 2011-11-04 | 2018-05-16 | ザイムワークス，インコーポレイテッド | Ｆｃドメインにおける変異を有する安定なヘテロ二量体抗体デザイン |
| CN102558355B (zh) * | 2011-12-31 | 2015-02-25 | 苏州康宁杰瑞生物科技有限公司 | 基于电荷网络的异二聚体fc改造方法及异二聚体蛋白的制备方法 |
| AU2013249985B2 (en) * | 2012-04-20 | 2017-11-23 | Merus N.V. | Methods and means for the production of Ig-like molecules |
| JP6351572B2 (ja) * | 2012-05-10 | 2018-07-04 | ザイムワークス，インコーポレイテッド | Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物 |
| CN104640562A (zh) | 2012-07-13 | 2015-05-20 | 酵活有限公司 | 包含抗-cd3构建体的双特异性不对称异二聚体 |
| CN102851338A (zh) * | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| EA032681B1 (ru) * | 2012-11-27 | 2019-07-31 | Аджоу Юниверсити Индастри-Академик Кооперейшн Фаундейшн | ГЕТЕРОДИМЕР Fc ИММУНОГЛОБУЛИНА, СОДЕРЖАЩИЙ ВАРИАНТ ДОМЕНА CH3 ДЛЯ ОБРАЗОВАНИЯ АНТИТЕЛА ИЛИ ГИБРИДНОГО БЕЛКА С ГЕТЕРОМЕРНЫМ Fc С ВЫСОКОЙ ЭФФЕКТИВНОСТЬЮ, СПОСОБ ДЛЯ ЕГО ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ |
| CN106883297B (zh) * | 2015-12-16 | 2019-12-13 | 苏州康宁杰瑞生物科技有限公司 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| JP7282383B2 (ja) * | 2017-06-14 | 2023-05-29 | ディンフー バイオターゲット カンパニー リミテッド | タンパク質性ヘテロ二量体及びその用途 |
| WO2019047885A1 (en) * | 2017-09-07 | 2019-03-14 | Dingfu Biotarget Co., Ltd. | IMMUNOCONJUGATES COMPRISING ALPHA REGULATORY SIGNAL PROTEIN |
| JP2020535145A (ja) * | 2017-09-25 | 2020-12-03 | ディンフー バイオターゲット カンパニー リミテッド | 癌治療のための方法及び組成物 |
| WO2019057180A1 (en) * | 2017-09-25 | 2019-03-28 | Dingfu Biotarget Co., Ltd. | PROTEIN HETÉRODIMÈRE AND USE THEREOF |
-
2015
- 2015-12-16 CN CN201510938995.0A patent/CN106883297B/zh active Active
-
2016
- 2016-12-16 CA CA3007427A patent/CA3007427C/en active Active
- 2016-12-16 ES ES16874885T patent/ES2944553T3/es active Active
- 2016-12-16 EP EP16874885.3A patent/EP3392276B1/en active Active
- 2016-12-16 CN CN201680073286.3A patent/CN108473592B/zh active Active
- 2016-12-16 EP EP23162270.5A patent/EP4234584A3/en active Pending
- 2016-12-16 CN CN202210544074.6A patent/CN115057937A/zh active Pending
- 2016-12-16 US US16/062,405 patent/US11168149B2/en active Active
- 2016-12-16 JP JP2018531643A patent/JP7103603B2/ja active Active
- 2016-12-16 WO PCT/CN2016/110252 patent/WO2017101828A1/zh active Application Filing
- 2016-12-16 DK DK16874885.3T patent/DK3392276T5/da active
- 2016-12-16 FI FIEP16874885.3T patent/FI3392276T3/fi active
-
2018
- 2018-09-29 HK HK18112537.5A patent/HK1253248A1/zh unknown
-
2021
- 2021-10-07 US US17/496,240 patent/US20220017643A1/en active Pending
-
2022
- 2022-06-28 JP JP2022103464A patent/JP7444381B2/ja active Active
-
2024
- 2024-02-13 JP JP2024019083A patent/JP2024056829A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN115057937A (zh) | 2022-09-16 |
| WO2017101828A1 (zh) | 2017-06-22 |
| FI3392276T3 (fi) | 2023-05-05 |
| EP3392276A4 (en) | 2019-09-18 |
| JP2024056829A (ja) | 2024-04-23 |
| CN106883297B (zh) | 2019-12-13 |
| US11168149B2 (en) | 2021-11-09 |
| CN108473592A (zh) | 2018-08-31 |
| EP3392276B1 (en) | 2023-04-19 |
| JP2022130568A (ja) | 2022-09-06 |
| JP7103603B2 (ja) | 2022-07-20 |
| JP7444381B2 (ja) | 2024-03-06 |
| EP4234584A3 (en) | 2023-09-27 |
| US20220017643A1 (en) | 2022-01-20 |
| CN108473592B (zh) | 2022-05-03 |
| JP2019502701A (ja) | 2019-01-31 |
| CN106883297A (zh) | 2017-06-23 |
| HK1253248A1 (zh) | 2019-06-14 |
| EP3392276A1 (en) | 2018-10-24 |
| CA3007427A1 (en) | 2017-06-22 |
| ES2944553T3 (es) | 2023-06-22 |
| US20180362668A1 (en) | 2018-12-20 |
| DK3392276T5 (da) | 2024-09-23 |
| CA3007427C (en) | 2024-04-23 |
| EP4234584A2 (en) | 2023-08-30 |
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