DK3392276T3 - Heterodimer molecule based on structural CH3 domain, and method for production and use thereof - Google Patents
Heterodimer molecule based on structural CH3 domain, and method for production and use thereof Download PDFInfo
- Publication number
- DK3392276T3 DK3392276T3 DK16874885.3T DK16874885T DK3392276T3 DK 3392276 T3 DK3392276 T3 DK 3392276T3 DK 16874885 T DK16874885 T DK 16874885T DK 3392276 T3 DK3392276 T3 DK 3392276T3
- Authority
- DK
- Denmark
- Prior art keywords
- domain
- structural
- production
- molecule based
- heterodimer molecule
- Prior art date
Links
- 239000000833 heterodimer Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510938995.0A CN106883297B (en) | 2015-12-16 | 2015-12-16 | CH3 domain-based heterodimer molecule, preparation method and application thereof |
| PCT/CN2016/110252 WO2017101828A1 (en) | 2015-12-16 | 2016-12-16 | Heterodimer molecule based on ch3 structural domain, and preparation method therefor and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3392276T3 true DK3392276T3 (en) | 2023-05-01 |
Family
ID=59055700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16874885.3T DK3392276T3 (en) | 2015-12-16 | 2016-12-16 | Heterodimer molecule based on structural CH3 domain, and method for production and use thereof |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US11168149B2 (en) |
| EP (2) | EP3392276B1 (en) |
| JP (2) | JP7103603B2 (en) |
| CN (3) | CN106883297B (en) |
| CA (1) | CA3007427A1 (en) |
| DK (1) | DK3392276T3 (en) |
| ES (1) | ES2944553T3 (en) |
| FI (1) | FI3392276T3 (en) |
| HK (1) | HK1253248A1 (en) |
| WO (1) | WO2017101828A1 (en) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019006074A2 (en) | 2016-09-29 | 2019-06-18 | Beijing Hanmi Pharmaceutical Co Ltd | heterodimer, method of producing the heterodimer, methods of producing a heterodimer, nucleic acid, vector or vector system, cell, pharmaceutical composition and method of treating or preventing a disease or disorder in a subject in need thereof |
| SG10201913260VA (en) | 2016-11-18 | 2020-03-30 | Beijing Hanmi Pharmaceutical Co Ltd | Anti-pd-1/anti-her2 natural antibody structural heterodimeric bispecific antibody and method of preparing the same |
| WO2018228442A1 (en) | 2017-06-14 | 2018-12-20 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
| WO2018233624A1 (en) * | 2017-06-20 | 2018-12-27 | 和迈生物科技有限公司 | Anti-her2 nanobody and coding sequence and use thereof |
| WO2019014912A1 (en) * | 2017-07-21 | 2019-01-24 | 赵磊 | Heterodimeric protein and preparation method thereof |
| CN111051350B (en) * | 2017-09-07 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Immunoconjugates comprising signal-modulating protein alpha |
| CN111094356B (en) * | 2017-09-25 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Protein heterodimer and application thereof |
| US11883503B2 (en) | 2017-09-25 | 2024-01-30 | Dingfu Biotarget Co., Ltd. | Methods and compositions for cancer treatment |
| WO2019109876A1 (en) * | 2017-12-04 | 2019-06-13 | 北京韩美药品有限公司 | Anti-pd-l1/anti-cd47 bispecific antibody with structure like natural antibody and in form of heterodimer and preparation thereof |
| WO2019153200A1 (en) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | Anti-pd-1/anti-her2 natural antibody structure-like bispecific antibody in heterodimeric form and preparation thereof |
| AU2019218433A1 (en) * | 2018-02-11 | 2020-09-03 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-PD-1/anti-VEGF natural antibody structure-like heterodimeric form bispecific antibody and preparation thereof |
| CN108640997A (en) * | 2018-05-22 | 2018-10-12 | 蔡毓旻 | A kind of bispecific antibody |
| CN113692416A (en) * | 2019-03-25 | 2021-11-23 | 苏州丁孚靶点生物技术有限公司 | Protein heterodimers and uses thereof |
| JP2022525275A (en) * | 2019-03-28 | 2022-05-12 | エービー ストゥーディオ インコーポレイテッド | Heteromultimer protein and its usage |
| AU2020261250A1 (en) * | 2019-04-25 | 2021-10-14 | F. Hoffmann-La Roche Ag | Generation of antibody-derived polypeptides by polypeptide chain exchange |
| MX2021012931A (en) * | 2019-04-25 | 2021-11-17 | Hoffmann La Roche | Activatable therapeutic multispecific polypeptides with extended half-life. |
| CA3132494A1 (en) * | 2019-04-25 | 2020-10-29 | Ulrich Brinkmann | Therapeutic multispecific polypeptides activated by polypeptide chain exchange |
| WO2021046072A1 (en) | 2019-09-06 | 2021-03-11 | Eli Lilly And Company | Proteins comprising t-cell receptor constant domains |
| CN113121697B (en) * | 2019-12-31 | 2023-06-09 | 周易 | CH3 domain modification induced heterodimer and preparation method and application thereof |
| CN113121696A (en) * | 2019-12-31 | 2021-07-16 | 周易 | Bispecific antibody formed by Fab modification induction and preparation method and application thereof |
| US20230295314A1 (en) * | 2020-08-05 | 2023-09-21 | Synthekine, Inc. | IL27RAlpha Binding Molecules and Methods of Use |
| WO2022093857A1 (en) * | 2020-10-26 | 2022-05-05 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
| CN112977908B (en) * | 2021-03-02 | 2022-12-02 | 康宁杰瑞(吉林)生物科技有限公司 | Filling and plugging machine and filling method thereof |
| TW202309078A (en) * | 2021-07-02 | 2023-03-01 | 美商建南德克公司 | Methods and compositions for treating cancer |
| CN117715936A (en) * | 2021-07-28 | 2024-03-15 | 豪夫迈·罗氏有限公司 | Methods and compositions for treating cancer |
| WO2023085779A1 (en) * | 2021-11-09 | 2023-05-19 | 한양대학교 산학협력단 | Heterodimer comprising fc mutant and method for preparing same |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ES2774337T3 (en) | 2008-01-07 | 2020-07-20 | Amgen Inc | Method for manufacturing heterodimeric Fc molecules of antibodies using electrostatic conduction effects |
| CN105693861A (en) | 2009-12-29 | 2016-06-22 | 新兴产品开发西雅图有限公司 | Heterodimer binding protein and application thereof |
| AU2011325833C1 (en) * | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| NZ608724A (en) * | 2011-03-25 | 2015-12-24 | Glenmark Pharmaceuticals Sa | Hetero-dimeric immunoglobulins |
| KR102052774B1 (en) * | 2011-11-04 | 2019-12-04 | 자임워크스 인코포레이티드 | Stable heterodimeric antibody design with mutations in the fc domain |
| CN102558355B (en) * | 2011-12-31 | 2015-02-25 | 苏州康宁杰瑞生物科技有限公司 | Heterodimeric FC (fragment crystallizable) modification method based on charge network and preparation method of heterodimeric proteins |
| EA035344B1 (en) | 2012-04-20 | 2020-05-29 | Мерюс Н.В. | Method for producing two antibodies from a single host cell |
| US20130336973A1 (en) * | 2012-05-10 | 2013-12-19 | Zymeworks Inc. | Heteromultimer Constructs of Immunoglobulin Heavy Chains with Mutations in the Fc Domain |
| US20140154253A1 (en) * | 2012-07-13 | 2014-06-05 | Zymeworks Inc. | Bispecific Asymmetric Heterodimers Comprising Anti-CD3 Constructs |
| CN102851338A (en) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | Method for preparing homodimer protein mixture by using charge repulsive interaction |
| KR101522954B1 (en) * | 2012-11-27 | 2015-05-27 | 아주대학교산학협력단 | CH3 domain mutant pairs for the high yield formation of heterodimeric Fc of antibody, method of production and use thereof |
| WO2018228442A1 (en) * | 2017-06-14 | 2018-12-20 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
| CN111051350B (en) * | 2017-09-07 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Immunoconjugates comprising signal-modulating protein alpha |
| US11883503B2 (en) * | 2017-09-25 | 2024-01-30 | Dingfu Biotarget Co., Ltd. | Methods and compositions for cancer treatment |
| CN111094356B (en) * | 2017-09-25 | 2022-11-01 | 苏州丁孚靶点生物技术有限公司 | Protein heterodimer and application thereof |
-
2015
- 2015-12-16 CN CN201510938995.0A patent/CN106883297B/en active Active
-
2016
- 2016-12-16 ES ES16874885T patent/ES2944553T3/en active Active
- 2016-12-16 DK DK16874885.3T patent/DK3392276T3/en active
- 2016-12-16 EP EP16874885.3A patent/EP3392276B1/en active Active
- 2016-12-16 WO PCT/CN2016/110252 patent/WO2017101828A1/en active Application Filing
- 2016-12-16 CN CN202210544074.6A patent/CN115057937A/en active Pending
- 2016-12-16 JP JP2018531643A patent/JP7103603B2/en active Active
- 2016-12-16 FI FIEP16874885.3T patent/FI3392276T3/en active
- 2016-12-16 CN CN201680073286.3A patent/CN108473592B/en active Active
- 2016-12-16 US US16/062,405 patent/US11168149B2/en active Active
- 2016-12-16 EP EP23162270.5A patent/EP4234584A3/en active Pending
- 2016-12-16 CA CA3007427A patent/CA3007427A1/en active Granted
-
2018
- 2018-09-29 HK HK18112537.5A patent/HK1253248A1/en unknown
-
2021
- 2021-10-07 US US17/496,240 patent/US20220017643A1/en active Pending
-
2022
- 2022-06-28 JP JP2022103464A patent/JP7444381B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4234584A2 (en) | 2023-08-30 |
| CN108473592B (en) | 2022-05-03 |
| CN106883297A (en) | 2017-06-23 |
| WO2017101828A1 (en) | 2017-06-22 |
| JP7444381B2 (en) | 2024-03-06 |
| EP3392276B1 (en) | 2023-04-19 |
| US11168149B2 (en) | 2021-11-09 |
| CN108473592A (en) | 2018-08-31 |
| US20180362668A1 (en) | 2018-12-20 |
| EP4234584A3 (en) | 2023-09-27 |
| HK1253248A1 (en) | 2019-06-14 |
| FI3392276T3 (en) | 2023-05-05 |
| JP2019502701A (en) | 2019-01-31 |
| US20220017643A1 (en) | 2022-01-20 |
| ES2944553T3 (en) | 2023-06-22 |
| CN115057937A (en) | 2022-09-16 |
| CN106883297B (en) | 2019-12-13 |
| JP2022130568A (en) | 2022-09-06 |
| JP7103603B2 (en) | 2022-07-20 |
| CA3007427A1 (en) | 2017-06-22 |
| EP3392276A4 (en) | 2019-09-18 |
| EP3392276A1 (en) | 2018-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3392276T3 (en) | Heterodimer molecule based on structural CH3 domain, and method for production and use thereof | |
| DOP2018000256A (en) | 3-OXO-2,6-DIFENIL-2,3-DIHIDROPIRIDAZIN-4-CARBOXAMIDS | |
| DK3538864T3 (en) | MICROTOME | |
| DK3138081T3 (en) | System and method for obtaining vehicle telematics data | |
| BR112016026939A2 (en) | apparatus and method. | |
| BR112017012364A2 (en) | fast pretreatment. | |
| DE102014017707A8 (en) | Coating method and corresponding coating system | |
| DK3113797T3 (en) | ANTIBODIES, USES AND METHODS | |
| DK3268555T3 (en) | Elongated composite profile and method for mounting the same | |
| DK3256546T3 (en) | depolymerization | |
| DK3265443T3 (en) | PYRROLIDINCARBOXAMIDE DERIVATIVES AND METHOD FOR PREPARING AND USING THE SAME | |
| DK3237691T3 (en) | VEHICLE SYSTEM AND METHOD | |
| DK3232555T3 (en) | PROCEDURE, DECORATION AND SYSTEM FOR DISTRIBUTED SUBMOLUARY MANAGEMENT | |
| FI20155419A (en) | METHOD FOR INCREASING THE FOAM STABILITY | |
| DK3589742T3 (en) | Method for detection | |
| BR112016018716A2 (en) | measuring apparatus. | |
| DK3411561T3 (en) | BOREHOLE COMPLETION SYSTEM | |
| FI20165587A (en) | Measuring method, measuring arrangement and measuring device | |
| DK3216791T3 (en) | POLYMORPHIC SUBSTANCE BASED ON YONKENAFIL HYDROCHLORIDE, PROCEDURE FOR MANUFACTURE THEREOF AND COMPOSITION AND USE THEREOF | |
| DK3237407T3 (en) | 3,5-DIAMINOPYRAZOLKINASE INHIBITORS | |
| DK3107554T3 (en) | ANTIBODIES FOR AFFECTING THE GENDER AND METHODS OF USING IT | |
| DK3131567T3 (en) | Method for preparing GNRH-containing gel | |
| DK3313453T3 (en) | METHOD FOR IMPROVING ARTHRITIS | |
| DK4093036T3 (en) | DATA GENERATING METHOD | |
| DK3108256T3 (en) | CANCER DETECTION METHOD |