JP2019502701A5 - - Google Patents
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- JP2019502701A5 JP2019502701A5 JP2018531643A JP2018531643A JP2019502701A5 JP 2019502701 A5 JP2019502701 A5 JP 2019502701A5 JP 2018531643 A JP2018531643 A JP 2018531643A JP 2018531643 A JP2018531643 A JP 2018531643A JP 2019502701 A5 JP2019502701 A5 JP 2019502701A5
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- Japan
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- 230000035772 mutation Effects 0.000 claims description 11
- 239000000833 heterodimer Substances 0.000 claims description 2
- 239000001608 potassium adipate Substances 0.000 claims 2
- 230000003993 interaction Effects 0.000 description 3
- 239000000710 homodimer Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022103464A JP7444381B2 (ja) | 2015-12-16 | 2022-06-28 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
| JP2024019083A JP7788113B2 (ja) | 2015-12-16 | 2024-02-13 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510938995.0 | 2015-12-16 | ||
| CN201510938995.0A CN106883297B (zh) | 2015-12-16 | 2015-12-16 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| PCT/CN2016/110252 WO2017101828A1 (zh) | 2015-12-16 | 2016-12-16 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103464A Division JP7444381B2 (ja) | 2015-12-16 | 2022-06-28 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019502701A JP2019502701A (ja) | 2019-01-31 |
| JP2019502701A5 true JP2019502701A5 (enExample) | 2020-02-06 |
| JP7103603B2 JP7103603B2 (ja) | 2022-07-20 |
Family
ID=59055700
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018531643A Active JP7103603B2 (ja) | 2015-12-16 | 2016-12-16 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
| JP2022103464A Active JP7444381B2 (ja) | 2015-12-16 | 2022-06-28 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
| JP2024019083A Active JP7788113B2 (ja) | 2015-12-16 | 2024-02-13 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022103464A Active JP7444381B2 (ja) | 2015-12-16 | 2022-06-28 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
| JP2024019083A Active JP7788113B2 (ja) | 2015-12-16 | 2024-02-13 | Ｃｈ３ドメインに基づくヘテロダイマー分子、その調製方法及び用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11168149B2 (enExample) |
| EP (2) | EP3392276B1 (enExample) |
| JP (3) | JP7103603B2 (enExample) |
| CN (4) | CN106883297B (enExample) |
| CA (1) | CA3007427C (enExample) |
| DK (1) | DK3392276T5 (enExample) |
| ES (1) | ES2944553T3 (enExample) |
| FI (1) | FI3392276T3 (enExample) |
| WO (1) | WO2017101828A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106883297B (zh) | 2015-12-16 | 2019-12-13 | 苏州康宁杰瑞生物科技有限公司 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| SG10201913263SA (en) | 2016-09-29 | 2020-03-30 | Beijing Hanmi Pharmaceutical Co Ltd | Heterodimeric immunoglobulin constructs and preparation methods thereof |
| WO2018090950A1 (zh) | 2016-11-18 | 2018-05-24 | 北京韩美药品有限公司 | 抗pd‐1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| WO2018228442A1 (en) * | 2017-06-14 | 2018-12-20 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
| WO2018233624A1 (zh) | 2017-06-20 | 2018-12-27 | 和迈生物科技有限公司 | 抗Her2纳米抗体及其编码序列和用途 |
| WO2019014912A1 (zh) * | 2017-07-21 | 2019-01-24 | 赵磊 | 一种异二聚体蛋白及其制备方法 |
| CN111315767B (zh) * | 2017-08-22 | 2025-03-18 | 萨纳生物有限责任公司 | 可溶性干扰素受体及其用途 |
| WO2019047885A1 (en) | 2017-09-07 | 2019-03-14 | Dingfu Biotarget Co., Ltd. | IMMUNOCONJUGATES COMPRISING ALPHA REGULATORY SIGNAL PROTEIN |
| JP7356726B2 (ja) * | 2017-09-25 | 2023-10-05 | ディンフー バイオターゲット カンパニー リミテッド | タンパク性ヘテロ二量体及びその使用 |
| US11883503B2 (en) | 2017-09-25 | 2024-01-30 | Dingfu Biotarget Co., Ltd. | Methods and compositions for cancer treatment |
| CA3084626A1 (en) | 2017-12-04 | 2019-06-13 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-pd-l1/anti-cd47 bispecific antibody with structure like natural antibody and in form of heterodimer and preparation thereof |
| WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| US11827697B2 (en) | 2018-02-11 | 2023-11-28 | Beijing Hanmi Pharmaceutical Co., Ltd. | Anti-PD-1/anti-VEGF natural antibody structure like heterodimeric form bispecific antibody and preparation thereof |
| CN108640997A (zh) * | 2018-05-22 | 2018-10-12 | 蔡毓旻 | 一种双特异性抗体 |
| US20220227827A1 (en) * | 2019-03-25 | 2022-07-21 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
| JP2022525275A (ja) * | 2019-03-28 | 2022-05-12 | エービー ストゥーディオ インコーポレイテッド | ヘテロ多量体タンパク質及びその使用法 |
| EP3959237A1 (en) * | 2019-04-25 | 2022-03-02 | F. Hoffmann-La Roche AG | Therapeutic multispecific polypeptides activated by polypeptide chain exchange |
| AU2020263910A1 (en) * | 2019-04-25 | 2021-10-21 | F. Hoffmann-La Roche Ag | Activatable therapeutic multispecific polypeptides with extended half-life |
| JP7812230B2 (ja) * | 2019-04-25 | 2026-02-09 | エフ． ホフマン－ラ ロシュ アーゲー | ポリペプチド鎖交換による抗体由来ポリペプチドの生成 |
| CA3149939A1 (en) | 2019-09-06 | 2021-03-11 | Stephen J. Demarest | Proteins comprising t-cell receptor constant domains |
| CN113121696A (zh) * | 2019-12-31 | 2021-07-16 | 周易 | Fab改造诱导形成的双特异性抗体及其制备方法和用途 |
| CN113121697B (zh) * | 2019-12-31 | 2023-06-09 | 周易 | Ch3结构域改造诱导形成的异源二聚体及其制备方法和应用 |
| TWI920054B (zh) * | 2020-01-23 | 2026-04-01 | 瑞士商天演藥業公司 | 具有Ｆｃ突變之異二聚蛋白質 |
| WO2022032005A2 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Il10rb binding molecules and methods of use |
| WO2022031890A1 (en) | 2020-08-05 | 2022-02-10 | Synthekine, Inc. | Ifngr2 binding molecules and methods of use |
| JP7743500B2 (ja) | 2020-08-05 | 2025-09-24 | シンセカイン インコーポレイテッド | Ｉｌ１０受容体結合性分子および使用方法 |
| US20230279125A1 (en) * | 2020-08-05 | 2023-09-07 | Synthekine, Inc. | Il28ra binding molecules and methods of use |
| US12122839B2 (en) | 2020-08-05 | 2024-10-22 | Synthekine, Inc. | IFNGR binding synthetic cytokines and methods of use |
| WO2022093857A1 (en) * | 2020-10-26 | 2022-05-05 | City Of Hope | Oncolytic virus compositions and methods for the treatment of cancer |
| CN112977908B (zh) * | 2021-03-02 | 2022-12-02 | 康宁杰瑞(吉林)生物科技有限公司 | 灌装加塞机及其灌装的方法 |
| KR20240028452A (ko) * | 2021-07-02 | 2024-03-05 | 제넨테크, 인크. | 암을 치료하기 위한 방법 및 조성물 |
| IL309120A (en) * | 2021-07-28 | 2024-02-01 | Hoffmann La Roche | Methods and compositions for the treatment of cancer |
| KR20240116743A (ko) * | 2021-11-09 | 2024-07-30 | 한양대학교 산학협력단 | Fc 변이체를 포함하는 이종이합체 및 이의 제조방법 |
| CN116948029A (zh) * | 2022-04-20 | 2023-10-27 | 南京融捷康生物科技有限公司 | 一种包含IgG类Fc区变体的抗体及其用途 |
| WO2025224084A1 (en) | 2024-04-22 | 2025-10-30 | Engimmune Therapeutics Ag | Proteins comprising t cell receptor constant domains |
| US20260109746A1 (en) | 2024-10-22 | 2026-04-23 | Gilead Sciences, Inc. | Cd4-targeted il-15 molecules and methods of use |
Family Cites Families (21)
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| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US7951917B1 (en) * | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| US20130089554A1 (en) * | 2009-12-29 | 2013-04-11 | Emergent Product Development Seattle, Llc | RON Binding Constructs and Methods of Use Thereof |
| CN103429620B (zh) | 2010-11-05 | 2018-03-06 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
| JP2014511836A (ja) | 2011-03-25 | 2014-05-19 | グレンマーク ファーマシューティカルズ， エセ．アー． | ヘテロ二量体免疫グロブリン |
| UA117901C2 (uk) * | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
| US9574010B2 (en) * | 2011-11-04 | 2017-02-21 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| CN102558355B (zh) * | 2011-12-31 | 2015-02-25 | 苏州康宁杰瑞生物科技有限公司 | 基于电荷网络的异二聚体fc改造方法及异二聚体蛋白的制备方法 |
| WO2013157953A1 (en) * | 2012-04-20 | 2013-10-24 | Merus B.V. | Methods and means for the production of ig-like molecules |
| JP6351572B2 (ja) * | 2012-05-10 | 2018-07-04 | ザイムワークス，インコーポレイテッド | Ｆｃドメインに突然変異を有する免疫グロブリン重鎖のヘテロ多量体構築物 |
| BR112015000798A2 (pt) | 2012-07-13 | 2017-06-27 | Zymeworks Inc | heterodímeros assimétricos biespecíficos compreendendo construtos anti-cd3 |
| CN102851338A (zh) | 2012-07-25 | 2013-01-02 | 苏州康宁杰瑞生物科技有限公司 | 利用电荷排斥作用制备同二聚体蛋白混合物的方法 |
| EA032681B1 (ru) * | 2012-11-27 | 2019-07-31 | Аджоу Юниверсити Индастри-Академик Кооперейшн Фаундейшн | ГЕТЕРОДИМЕР Fc ИММУНОГЛОБУЛИНА, СОДЕРЖАЩИЙ ВАРИАНТ ДОМЕНА CH3 ДЛЯ ОБРАЗОВАНИЯ АНТИТЕЛА ИЛИ ГИБРИДНОГО БЕЛКА С ГЕТЕРОМЕРНЫМ Fc С ВЫСОКОЙ ЭФФЕКТИВНОСТЬЮ, СПОСОБ ДЛЯ ЕГО ПОЛУЧЕНИЯ И ИСПОЛЬЗОВАНИЯ |
| MX385344B (es) * | 2012-11-28 | 2025-03-18 | Zymeworks Bc Inc | Pares de cadena pesada-cadena ligera de inmunoglobulina modificados genéticamente y usos de estos. |
| CN106883297B (zh) * | 2015-12-16 | 2019-12-13 | 苏州康宁杰瑞生物科技有限公司 | 基于ch3结构域的异二聚体分子、其制备方法及用途 |
| KR20180104148A (ko) * | 2016-02-05 | 2018-09-19 | 젠맵 에이/에스 | 개선된 내재화 특징을 갖는 다중특이적 항원-결합 분자 |
| WO2018228442A1 (en) * | 2017-06-14 | 2018-12-20 | Dingfu Biotarget Co., Ltd. | Proteinaceous heterodimer and use thereof |
| WO2019047885A1 (en) * | 2017-09-07 | 2019-03-14 | Dingfu Biotarget Co., Ltd. | IMMUNOCONJUGATES COMPRISING ALPHA REGULATORY SIGNAL PROTEIN |
| JP7356726B2 (ja) * | 2017-09-25 | 2023-10-05 | ディンフー バイオターゲット カンパニー リミテッド | タンパク性ヘテロ二量体及びその使用 |
| US11883503B2 (en) * | 2017-09-25 | 2024-01-30 | Dingfu Biotarget Co., Ltd. | Methods and compositions for cancer treatment |
-
2015
- 2015-12-16 CN CN201510938995.0A patent/CN106883297B/zh active Active
-
2016
- 2016-12-16 EP EP16874885.3A patent/EP3392276B1/en active Active
- 2016-12-16 FI FIEP16874885.3T patent/FI3392276T3/fi active
- 2016-12-16 WO PCT/CN2016/110252 patent/WO2017101828A1/zh not_active Ceased
- 2016-12-16 DK DK16874885.3T patent/DK3392276T5/da active
- 2016-12-16 EP EP23162270.5A patent/EP4234584B1/en active Active
- 2016-12-16 CN CN202210544074.6A patent/CN115057937B/zh active Active
- 2016-12-16 ES ES16874885T patent/ES2944553T3/es active Active
- 2016-12-16 JP JP2018531643A patent/JP7103603B2/ja active Active
- 2016-12-16 CN CN202511005700.4A patent/CN120842427A/zh active Pending
- 2016-12-16 US US16/062,405 patent/US11168149B2/en active Active
- 2016-12-16 CN CN201680073286.3A patent/CN108473592B/zh active Active
- 2016-12-16 CA CA3007427A patent/CA3007427C/en active Active
-
2021
- 2021-10-07 US US17/496,240 patent/US12281177B2/en active Active
-
2022
- 2022-06-28 JP JP2022103464A patent/JP7444381B2/ja active Active
-
2024
- 2024-02-13 JP JP2024019083A patent/JP7788113B2/ja active Active
-
2025
- 2025-03-19 US US19/084,362 patent/US20250257150A1/en active Pending
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