JP7101684B2 - 一価の抗プロペルジン抗体および抗体断片 - Google Patents

一価の抗プロペルジン抗体および抗体断片 Download PDF

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JP7101684B2
JP7101684B2 JP2019538396A JP2019538396A JP7101684B2 JP 7101684 B2 JP7101684 B2 JP 7101684B2 JP 2019538396 A JP2019538396 A JP 2019538396A JP 2019538396 A JP2019538396 A JP 2019538396A JP 7101684 B2 JP7101684 B2 JP 7101684B2
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antibody
antigen
binding fragment
seq
properdin
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JP2020507561A5 (enExample
JP2020507561A (ja
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エル． シェリダン，ダグラス
ピー． タンブリーニ，ポール
アン－タナラ マック，タネーシャ
シー． ヴィエトリ，ウォルター
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アレクシオン ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019538396A 2017-01-30 2018-01-30 一価の抗プロペルジン抗体および抗体断片 Active JP7101684B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022107980A JP2022153405A (ja) 2017-01-30 2022-07-04 一価の抗プロペルジン抗体および抗体断片
JP2024095141A JP2024116321A (ja) 2017-01-30 2024-06-12 一価の抗プロペルジン抗体および抗体断片

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762452187P 2017-01-30 2017-01-30
US62/452,187 2017-01-30
PCT/US2018/015985 WO2018140956A1 (en) 2017-01-30 2018-01-30 Monovalent anti-properdin antibodies and antibody fragments

Related Child Applications (1)

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JP2022107980A Division JP2022153405A (ja) 2017-01-30 2022-07-04 一価の抗プロペルジン抗体および抗体断片

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JP2020507561A JP2020507561A (ja) 2020-03-12
JP2020507561A5 JP2020507561A5 (enExample) 2021-03-04
JP7101684B2 true JP7101684B2 (ja) 2022-07-15

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JP2019538396A Active JP7101684B2 (ja) 2017-01-30 2018-01-30 一価の抗プロペルジン抗体および抗体断片
JP2022107980A Pending JP2022153405A (ja) 2017-01-30 2022-07-04 一価の抗プロペルジン抗体および抗体断片
JP2024095141A Pending JP2024116321A (ja) 2017-01-30 2024-06-12 一価の抗プロペルジン抗体および抗体断片

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JP2022107980A Pending JP2022153405A (ja) 2017-01-30 2022-07-04 一価の抗プロペルジン抗体および抗体断片
JP2024095141A Pending JP2024116321A (ja) 2017-01-30 2024-06-12 一価の抗プロペルジン抗体および抗体断片

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US (1) US11198725B2 (enExample)
EP (1) EP3573661A4 (enExample)
JP (3) JP7101684B2 (enExample)
KR (2) KR20230173731A (enExample)
CN (2) CN118184777A (enExample)
AU (2) AU2018212012B2 (enExample)
BR (1) BR112019014652A2 (enExample)
CA (1) CA3049806A1 (enExample)
CO (1) CO2019007686A2 (enExample)
IL (2) IL309890A (enExample)
MX (3) MX2019008827A (enExample)
WO (1) WO2018140956A1 (enExample)

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BR112019028269A2 (pt) 2017-07-11 2020-07-14 Alexion Pharmaceuticals, Inc. polipeptídeos que se ligam ao componente c5 do complemento ou à albumina sérica e suas proteínas de fusão
ES2974200T3 (es) * 2018-09-13 2024-06-26 Regeneron Pharma Rata nuligénica para el gen del factor H del complemento como modelo de glomerulopatía C3
WO2021140475A1 (en) * 2020-01-08 2021-07-15 Cadila Healthcare Limited Anti-properdin antibodies and preparation thereof
CN116437913A (zh) 2020-09-23 2023-07-14 艾其林医药公司 用于治疗补体介导的病症的药物化合物
WO2022089576A1 (zh) * 2020-10-30 2022-05-05 广州市妇女儿童医疗中心 用于抑制mhc-i和/或ii信号通路的试剂在治疗胆道闭锁中的应用
WO2023023227A1 (en) 2021-08-20 2023-02-23 Alexion Pharmaceuticals, Inc. Methods for treating sickle cell disease or beta thalassemia using complement alternative pathway inhibitors
US11981727B2 (en) 2021-08-31 2024-05-14 Novelmed Therapeutics, Inc Monospecific and bispecific antibodies and antigen binding fragments thereof
WO2024108529A1 (en) * 2022-11-25 2024-05-30 Linno Pharmaceuticals Inc. Properdin binding protein and use thereof
CA3264087A1 (en) * 2022-08-05 2024-02-08 Alexion Pharma Inc Pharmaceutical compositions based on fusion proteins and their methods of use
WO2024049951A1 (en) * 2022-08-31 2024-03-07 Alexion Pharmaceuticals, Inc. Dosage and administration of fusion polypeptides for treatment of sickle cell disease
KR20250112858A (ko) 2022-11-25 2025-07-24 리노 파마슈티컬스 아이엔씨. 프로퍼딘 결합 단백질 및 이의 용도
CN120399074A (zh) * 2023-06-02 2025-08-01 安徽金百奥生物科技有限公司 一种与人dr3胞外域高亲和力的纳米抗体

Citations (4)

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JP2008518636A (ja) 2004-11-03 2008-06-05 アムゲン・フレモント・インコーポレーテッド 抗プロペルジン抗体と、その作製方法および使用方法
JP2009514888A (ja) 2005-11-04 2009-04-09 ジェネンテック・インコーポレーテッド 眼疾患を処置するための補体経路の阻害剤の使用
JP2014522845A (ja) 2011-07-01 2014-09-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗プロペルジン抗体およびその使用
JP2015503909A (ja) 2011-12-21 2015-02-05 ノバルティス アーゲー Ｐ因子を標的とする抗体のための組成物および方法

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JP2009514888A (ja) 2005-11-04 2009-04-09 ジェネンテック・インコーポレーテッド 眼疾患を処置するための補体経路の阻害剤の使用
JP2014522845A (ja) 2011-07-01 2014-09-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 抗プロペルジン抗体およびその使用
JP2015503909A (ja) 2011-12-21 2015-02-05 ノバルティス アーゲー Ｐ因子を標的とする抗体のための組成物および方法

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Publication number Publication date
AU2018212012B2 (en) 2025-02-13
EP3573661A1 (en) 2019-12-04
CO2019007686A2 (es) 2019-07-31
WO2018140956A1 (en) 2018-08-02
KR20190111946A (ko) 2019-10-02
US20220162292A1 (en) 2022-05-26
US20190352381A1 (en) 2019-11-21
CA3049806A1 (en) 2018-08-02
KR20230173731A (ko) 2023-12-27
CN110831626B (zh) 2024-04-19
IL309890A (en) 2024-03-01
JP2022153405A (ja) 2022-10-12
CN118184777A (zh) 2024-06-14
JP2024116321A (ja) 2024-08-27
CN110831626A (zh) 2020-02-21
MX2023007840A (es) 2023-07-07
IL267898B1 (en) 2024-02-01
RU2019124873A (ru) 2021-03-01
IL267898A (en) 2019-09-26
MX2019008827A (es) 2019-09-26
MX2023004333A (es) 2023-05-04
BR112019014652A2 (pt) 2020-08-18
AU2018212012A1 (en) 2019-07-25
JP2020507561A (ja) 2020-03-12
EP3573661A4 (en) 2020-08-12
KR102613874B1 (ko) 2023-12-15
RU2019124873A3 (enExample) 2021-03-01
US11198725B2 (en) 2021-12-14
IL267898B2 (en) 2024-06-01
AU2025200709A1 (en) 2025-02-20

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