JP7095994B2 - ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 - Google Patents
ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 Download PDFInfo
- Publication number
- JP7095994B2 JP7095994B2 JP2017546102A JP2017546102A JP7095994B2 JP 7095994 B2 JP7095994 B2 JP 7095994B2 JP 2017546102 A JP2017546102 A JP 2017546102A JP 2017546102 A JP2017546102 A JP 2017546102A JP 7095994 B2 JP7095994 B2 JP 7095994B2
- Authority
- JP
- Japan
- Prior art keywords
- pyramidal
- expression
- retinal
- cells
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022082310A JP2022107042A (ja) | 2015-03-02 | 2022-05-19 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127194P | 2015-03-02 | 2015-03-02 | |
| US62/127,194 | 2015-03-02 | ||
| US201562134466P | 2015-03-17 | 2015-03-17 | |
| US62/134,466 | 2015-03-17 | ||
| PCT/US2016/020482 WO2016141078A1 (en) | 2015-03-02 | 2016-03-02 | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081106A Division JP2020122008A (ja) | 2015-03-02 | 2020-05-01 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
| JP2022082310A Division JP2022107042A (ja) | 2015-03-02 | 2022-05-19 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508519A JP2018508519A (ja) | 2018-03-29 |
| JP2018508519A5 JP2018508519A5 (OSRAM) | 2019-04-11 |
| JP7095994B2 true JP7095994B2 (ja) | 2022-07-05 |
Family
ID=56848956
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017546102A Active JP7095994B2 (ja) | 2015-03-02 | 2016-03-02 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
| JP2020081106A Pending JP2020122008A (ja) | 2015-03-02 | 2020-05-01 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
| JP2022082310A Withdrawn JP2022107042A (ja) | 2015-03-02 | 2022-05-19 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081106A Pending JP2020122008A (ja) | 2015-03-02 | 2020-05-01 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
| JP2022082310A Withdrawn JP2022107042A (ja) | 2015-03-02 | 2022-05-19 | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11021519B2 (OSRAM) |
| EP (1) | EP3265178A4 (OSRAM) |
| JP (3) | JP7095994B2 (OSRAM) |
| KR (1) | KR20170137730A (OSRAM) |
| CN (2) | CN114480502A (OSRAM) |
| AU (2) | AU2016226289B2 (OSRAM) |
| BR (1) | BR112017018846A2 (OSRAM) |
| CA (1) | CA2978068C (OSRAM) |
| EA (1) | EA201791939A1 (OSRAM) |
| HK (1) | HK1249067A1 (OSRAM) |
| IL (1) | IL254148B (OSRAM) |
| MX (1) | MX2017011041A (OSRAM) |
| MY (1) | MY187898A (OSRAM) |
| SG (1) | SG11201707063TA (OSRAM) |
| WO (1) | WO2016141078A1 (OSRAM) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| JP6072772B2 (ja) | 2011-04-22 | 2017-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 変異体キャプシドを有するアデノ関連ウイルスビリオンおよびその使用方法 |
| TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| WO2014194132A1 (en) | 2013-05-31 | 2014-12-04 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| AU2015231439B2 (en) | 2014-03-17 | 2019-11-14 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
| MY187898A (en) | 2015-03-02 | 2021-10-27 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| EP3277819B1 (en) | 2015-03-24 | 2021-03-03 | The Regents of The University of California | Adeno-associated virus variants and methods of use thereof |
| GB201508026D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Capsid |
| CN114606267A (zh) | 2015-09-28 | 2022-06-10 | 北卡罗来纳-查佩尔山大学 | 逃避抗体的病毒载体的方法和组合物 |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| AU2017286673B2 (en) * | 2016-06-16 | 2021-06-24 | Adverum Biotechnologies, Inc. | Treatment of AMD using AAV2 variant with aflibercept |
| MX2019001276A (es) * | 2016-07-29 | 2019-06-13 | Univ California | Viriones de virus adenoasociados con cápside variante y métodos para su uso. |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| CN110167494A (zh) * | 2017-01-03 | 2019-08-23 | 维特安公司 | 用于治疗视网膜脱离的方法和装置 |
| WO2018134168A1 (en) * | 2017-01-17 | 2018-07-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors |
| MX2019011040A (es) | 2017-03-17 | 2020-01-20 | Adverum Biotechnologies Inc | Composiciones y metodos para potenciar la expresion genica. |
| US20200121746A1 (en) * | 2017-06-30 | 2020-04-23 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsids and methods of use thereof |
| CA3059995A1 (en) | 2017-08-28 | 2019-03-07 | The Regents Of The University Of California | Adeno-associated virus capsid variants and methods of use thereof |
| DK3684423T5 (da) * | 2017-09-20 | 2024-08-26 | 4D Molecular Therapeutics Inc | Adeno-associerede virusvariantcapsider og fremgangsmåder til anvendelse deraf |
| KR102776626B1 (ko) * | 2017-10-16 | 2025-03-04 | 비게네론 게엠베하 | Aav 벡터 |
| KR102763312B1 (ko) * | 2017-10-20 | 2025-02-07 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 치료적으로 유효한 양의 재조합 aav9- 유도 벡터의 망막하 전달을 포함하는 대상체의 원추 광수용체 내 관심의 폴리뉴클레오티드를 발현하는 방법 |
| GB201800546D0 (en) * | 2018-01-12 | 2018-02-28 | Ucl Business Plc | Treatment |
| EP3774852A1 (en) | 2018-04-03 | 2021-02-17 | Stridebio, Inc. | Antibody-evading virus vectors |
| EA202092362A1 (ru) | 2018-04-03 | 2021-01-11 | Страйдбайо, Инк. | Вирусные векторы для нацеливания на ткани глаза |
| BR112020020266A2 (pt) | 2018-04-03 | 2021-01-19 | Stridebio, Inc. | Vetores de vírus com evasão de anticorpos |
| CA3106869A1 (en) * | 2018-07-20 | 2020-01-23 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Intraocular delivery of gene therapy expression vectors |
| CN111118016B (zh) | 2018-10-30 | 2022-04-15 | 上海朗昇生物科技有限公司 | 治疗视网膜色素变性疾病的基因治疗载体 |
| WO2020132578A1 (en) * | 2018-12-21 | 2020-06-25 | Chien Wade Wei De | Adeno-associated viruses and their uses for inner ear therapy |
| WO2020168111A1 (en) | 2019-02-15 | 2020-08-20 | Exhaura, Ltd. | Dual leucine zipper kinase inhibitors for gene therapy |
| EP3934698A1 (en) * | 2019-03-04 | 2022-01-12 | Adverum Biotechnologies, Inc. | Sequential intravitreal administration of aav gene therapy to contralateral eyes |
| BR112021018776A2 (pt) | 2019-03-21 | 2021-11-30 | Stridebio Inc | Vetores de vírus adenoassociado recombinante |
| TWI862583B (zh) * | 2019-04-26 | 2024-11-21 | 美商愛德維仁生物科技公司 | 用於玻璃體內遞送之變異體aav蛋白殼 |
| CN114787180A (zh) | 2019-10-17 | 2022-07-22 | 斯特里迪比奥公司 | 用于治疗c型尼曼-匹克病的腺相关病毒载体 |
| CA3157464A1 (en) * | 2019-10-31 | 2021-05-06 | Universitat Bern | Aav vector variants for ocular gene delivery |
| MX2022013411A (es) | 2020-04-27 | 2022-11-14 | 4D Molecular Therapeutics Inc | Genes gla con codones optimizados y usos de los mismos. |
| MX2022015048A (es) * | 2020-05-29 | 2023-03-08 | Univ California | Viriones de virus adenoasociados con variantes de capsides y metodos de uso de estos. |
| US12104163B2 (en) | 2020-08-19 | 2024-10-01 | Sarepta Therapeutics, Inc. | Adeno-associated virus vectors for treatment of Rett syndrome |
| US12385064B2 (en) * | 2021-03-26 | 2025-08-12 | Adverum Biotechnologies, Inc. | Intravitreal dosing for delivery of polynucleotides to retinal cones |
| JP2024519888A (ja) * | 2021-05-28 | 2024-05-21 | 上海瑞宏迪医薬有限公司 | カプシド変異を有する組換えアデノ随伴ウイルス及びその応用 |
| WO2022271984A1 (en) * | 2021-06-24 | 2022-12-29 | Applied Genetic Technologies Corporation | Methods for the treatment of achromatopsia and other cngb3 associated diseases |
| MX2024004217A (es) * | 2021-10-08 | 2024-06-26 | Dyno Therapeutics Inc | Variantes de cápside y métodos de uso de estas. |
| US20250101386A1 (en) * | 2021-12-28 | 2025-03-27 | Chengdu Origen Biotechnology Co., Ltd. | Modified aav capsid protein and use thereof |
| JP2025512534A (ja) * | 2022-04-15 | 2025-04-17 | ダイノ セラピューティクス, インク. | カプシドバリアント及びそれを使用する方法 |
| CN116970648A (zh) * | 2022-04-24 | 2023-10-31 | 上海朗昇生物科技有限公司 | 新型aav衣壳改造株及其用途 |
| EP4598941A2 (en) * | 2022-09-13 | 2025-08-13 | Dyno Therapeutics, Inc. | Capsid variants and methods of using the same |
| WO2024110770A1 (en) * | 2022-11-22 | 2024-05-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new promoter for retinal pigment epithelium (rpe) targeted gene therapy |
| CN119350454B (zh) * | 2024-12-27 | 2025-03-25 | 上海朗昇生物科技有限公司 | 衣壳重排型腺相关病毒载体及其用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014518614A (ja) | 2011-04-22 | 2014-08-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 変異体キャプシドを有するアデノ関連ウイルスビリオンおよびその使用方法 |
| WO2014186160A1 (en) | 2013-05-16 | 2014-11-20 | Applied Genetic Technologies Corporation | Promoters, expression cassettes, vectors, kits, and methods for the threatment of achromatopsia and other diseases |
Family Cites Families (191)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US46016A (en) * | 1865-01-24 | Improvement in coats with inner sleeves | ||
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US4874237A (en) | 1987-05-07 | 1989-10-17 | Lions Eye Inst. Of Western Australia | Electroretinogram apparatus |
| EP0441897A4 (en) | 1988-11-14 | 1992-06-24 | Us Health | Parvovirus capsids |
| FR2643252B1 (fr) | 1989-02-21 | 1991-06-07 | Technomed Int Sa | Appareil de destruction selective de cellules incluant les tissus mous et les os a l'interieur du corps d'un etre vivant par implosion de bulles de gaz |
| US5112946A (en) | 1989-07-06 | 1992-05-12 | Repligen Corporation | Modified pf4 compositions and methods of use |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| US6287815B1 (en) | 1989-09-14 | 2001-09-11 | Rijksuniversiteit Te Leiden | Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines |
| ATE159548T1 (de) | 1990-11-13 | 1997-11-15 | Immunex Corp | Bifunktionelle wählbare fusionsgene |
| US5383917A (en) | 1991-07-05 | 1995-01-24 | Jawahar M. Desai | Device and method for multi-phase radio-frequency ablation |
| GB9206016D0 (en) | 1992-03-19 | 1992-04-29 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JP3734262B2 (ja) | 1993-03-25 | 2006-01-11 | メルク エンド カンパニー インコーポレーテッド | 血管内皮細胞増殖因子阻害剤 |
| EP0804590A1 (en) | 1993-05-21 | 1997-11-05 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
| US5814618A (en) | 1993-06-14 | 1998-09-29 | Basf Aktiengesellschaft | Methods for regulating gene expression |
| CA2183667A1 (en) | 1994-02-22 | 1995-08-24 | Wayne A. Marasco | Nucleic acid delivery system, method of synthesis and uses thereof |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| FR2718150B1 (fr) | 1994-03-29 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
| US5639725A (en) | 1994-04-26 | 1997-06-17 | Children's Hospital Medical Center Corp. | Angiostatin protein |
| US5527533A (en) | 1994-10-27 | 1996-06-18 | Board Of Trustees Of The University Of Illinois | Method of retarding and ameliorating central nervous system and eye damage |
| US20020168342A1 (en) | 1994-11-03 | 2002-11-14 | Cell Genesys, Inc. | Novel adenoviral vectors, packaging cell lines, recombinant adenoviruses and methods |
| US6440425B1 (en) | 1995-05-01 | 2002-08-27 | Aventis Pasteur Limited | High molecular weight major outer membrane protein of moraxella |
| US6093570A (en) | 1995-06-07 | 2000-07-25 | The University Of North Carolina At Chapel Hill | Helper virus-free AAV production |
| US6040183A (en) | 1995-06-07 | 2000-03-21 | University Of North Carloina At Chapel Hill | Helper virus-free AAV production |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5641749A (en) | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
| US6096548A (en) | 1996-03-25 | 2000-08-01 | Maxygen, Inc. | Method for directing evolution of a virus |
| CA2251738A1 (en) | 1996-04-16 | 1997-10-23 | Immusol Incorporated | Targeted viral vectors |
| WO1998007435A1 (en) | 1996-08-20 | 1998-02-26 | The Regents Of The University Of California | Eye treatments using synthetic thyroid hormone compositions |
| AU738806B2 (en) | 1996-09-24 | 2001-09-27 | Merck & Co., Inc. | Gene therapy for inhibition of angiogenesis |
| FR2756297B1 (fr) | 1996-11-22 | 1999-01-08 | Centre Nat Rech Scient | Procede de production de virus recombinants |
| US6153436A (en) | 1997-01-10 | 2000-11-28 | The Board Of Trustees Of The University Of Arkansas | Method of gene delivery using wildtype adeno associated viral (AAV) vectors with insertions |
| AU728220B2 (en) | 1997-04-14 | 2001-01-04 | Cell Genesys, Inc. | Methods for increasing the efficiency of recombinant AAV product |
| AU7383298A (en) | 1997-05-13 | 1998-12-08 | Regents Of The University Of California, The | Novel antiangiogenic peptide agents and their therapeutic and diagnostic use |
| US6710036B2 (en) | 1997-07-25 | 2004-03-23 | Avigen, Inc. | Induction of immune response to antigens expressed by recombinant adeno-associated virus |
| US6458157B1 (en) | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
| AU9319198A (en) | 1997-09-19 | 1999-04-05 | Trustees Of The University Of Pennsylvania, The | Methods and vector constructs useful for production of recombinant aav |
| JPH11100327A (ja) | 1997-09-26 | 1999-04-13 | Toray Ind Inc | 網膜変性症治療剤 |
| AU9673998A (en) | 1997-10-01 | 1999-04-23 | G.D. Searle & Co. | Fusion proteins comprising an angiostatin moiety and their use in anti-tumor treatment |
| EP1690868A1 (en) | 1997-10-31 | 2006-08-16 | Maxygen, Inc. | Modification of virus tropism and host range by viral genome shuffling |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US6410300B1 (en) | 1998-01-12 | 2002-06-25 | The University Of North Carolina At Chapel Hill | Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV |
| WO1999036511A2 (en) | 1998-01-16 | 1999-07-22 | Chiron Corporation | Feline immunodeficiency virus gene therapy vectors |
| US6551795B1 (en) | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
| CA2322380C (en) | 1998-03-12 | 2008-10-14 | Genentech, Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
| DE19827457C1 (de) | 1998-06-19 | 2000-03-02 | Medigene Ag | Strukturprotein von AAV, seine Herstellung und Verwendung |
| US6593133B1 (en) | 1998-07-06 | 2003-07-15 | Nsgene A/S | Neurotrophic factors |
| EP1108049A2 (en) | 1998-08-28 | 2001-06-20 | Duke University | Adenoviruses deleted in the iva2, 100k and/or preterminal protein sequences |
| US6451594B1 (en) | 1998-09-11 | 2002-09-17 | The Regents Of The University Of California | Recombinant adenovirus for tissue specific expression in heart |
| WO2000015822A1 (en) | 1998-09-17 | 2000-03-23 | University Of Florida | Methods for treatment of degenerative retinal diseases |
| US20040234505A1 (en) | 1998-09-23 | 2004-11-25 | Stuart Naylor | Polynucleotide constructs and uses thereof |
| WO2000028004A1 (en) | 1998-11-10 | 2000-05-18 | The University Of North Carolina At Chapel Hill | Virus vectors and methods of making and administering the same |
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| WO2000054813A2 (en) | 1999-03-15 | 2000-09-21 | Chiron Corporation | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| US6498244B1 (en) | 1999-05-28 | 2002-12-24 | Cell Genesys, Inc. | Adeno-associated virus capsid immunologic determinants |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7306799B2 (en) | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
| US7314912B1 (en) | 1999-06-21 | 2008-01-01 | Medigene Aktiengesellschaft | AAv scleroprotein, production and use thereof |
| DE19933288A1 (de) | 1999-07-15 | 2001-01-18 | Medigene Ag | Strukturprotein von Adeno-assoziiertem Virus mit veränderter Antigenität, seine Herstellung und Verwendung |
| DE19933719A1 (de) | 1999-07-19 | 2001-01-25 | Medigene Ag | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
| US8232081B2 (en) | 1999-09-21 | 2012-07-31 | Basf Se | Methods and microorganisms for production of panto-compounds |
| AU2619301A (en) | 1999-10-25 | 2001-06-06 | Therus Corporation | Use of focused ultrasound for vascular sealing |
| US20070026394A1 (en) | 2000-02-11 | 2007-02-01 | Lawrence Blatt | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth using nucleic acid based technologies |
| US6855314B1 (en) | 2000-03-22 | 2005-02-15 | The United States Of America As Represented By The Department Of Health And Human Services | AAV5 vector for transducing brain cells and lung cells |
| NZ521952A (en) | 2000-04-17 | 2004-03-26 | Stuart Graham | Method and apparatus for electrophysiological assessment of visual function using a head-mounted stereo display |
| US6329181B1 (en) | 2000-08-07 | 2001-12-11 | Neurologix, Inc. | Helper functions for recombinant vector production |
| AU2002248297A1 (en) | 2001-01-05 | 2002-07-16 | Children's Hospital, Inc. | Aav2 vectors and methods |
| US7749492B2 (en) | 2001-01-05 | 2010-07-06 | Nationwide Children's Hospital, Inc. | AAV vectors and methods |
| AU2002236988A1 (en) | 2001-02-06 | 2002-08-19 | Novartis Ag | Photodynamic therapy of occult choroidal neovascularization linked to age-related macular degeneration |
| US20040102765A1 (en) | 2001-03-27 | 2004-05-27 | Karsten Koenig | Method for the minimal-to non-invase optical treatment of tissues of the eye and for diagnosis thereof and device for carrying out said method |
| CA2442670A1 (en) | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| JP2002363107A (ja) | 2001-06-04 | 2002-12-18 | Noriyuki Azuma | 色覚不全動物の色覚復元方法 |
| DK1412493T3 (da) | 2001-08-02 | 2012-01-09 | Inst Clayton De La Rech | Fremgangsmåder og sammensætninger der angår forbedrede lentiviral-vektor.-produktionsystemer |
| US7647184B2 (en) | 2001-08-27 | 2010-01-12 | Hanall Pharmaceuticals, Co. Ltd | High throughput directed evolution by rational mutagenesis |
| US20030129203A1 (en) | 2001-08-27 | 2003-07-10 | Nautilus Biotech S.A. | Mutant recombinant adeno-associated viruses |
| US6723551B2 (en) | 2001-11-09 | 2004-04-20 | The United States Of America As Represented By The Department Of Health And Human Services | Production of adeno-associated virus in insect cells |
| MX346493B (es) | 2001-11-13 | 2017-03-21 | Univ Pennsylvania | Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo. |
| US20050106558A1 (en) | 2001-12-21 | 2005-05-19 | Luca Perabo | Library of modified structural genes or capsid modified particles useful for the identification of viral clones with desired cell tropism |
| EP1490113A4 (en) | 2002-03-20 | 2007-05-02 | Univ Florida | RAAV VECTOR COMPOSITIONS AND METHOD FOR TREATING CHOROIDAL NEOVASCULARIZATION |
| WO2003089612A2 (en) | 2002-04-17 | 2003-10-30 | University Of Florida Research Foundation, Inc. | IMPROVED rAAV VECTORS |
| AU2003223775A1 (en) | 2002-04-30 | 2003-11-17 | Duke University | Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use |
| WO2003093436A2 (en) | 2002-04-30 | 2003-11-13 | University Of Florida | Treatment for phenylketonuria |
| US7254489B2 (en) | 2002-05-31 | 2007-08-07 | Microsoft Corporation | Systems, methods and apparatus for reconstructing phylogentic trees |
| US8304233B2 (en) | 2002-06-04 | 2012-11-06 | Poetic Genetics, Llc | Methods of unidirectional, site-specific integration into a genome, compositions and kits for practicing the same |
| WO2004020600A2 (en) | 2002-08-28 | 2004-03-11 | University Of Florida | Modified aav |
| GB0220467D0 (en) | 2002-09-03 | 2002-10-09 | Oxford Biomedica Ltd | Composition |
| WO2004079332A2 (en) | 2003-03-04 | 2004-09-16 | National Institute Of Advanced Industrial Science And Technology | Composition and method for increasing efficiency of introduction of target substance into cell |
| US20070172460A1 (en) | 2003-03-19 | 2007-07-26 | Jurgen Kleinschmidt | Random peptide library displayed on aav vectors |
| WO2004108922A2 (en) | 2003-04-25 | 2004-12-16 | The Trustees Of The University Of Pennsylvania | Use of aav comprising a capsid protein from aav7 or aav8 for the delivery of genes encoding apoprotein a or e genes to the liver |
| EP1486567A1 (en) | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
| WO2004112727A2 (en) | 2003-06-19 | 2004-12-29 | Avigen, Inc. | Aav virions with decreased immunoreactivity and uses therefor |
| EP1644038A2 (en) | 2003-06-23 | 2006-04-12 | A & G Pharmaceuticals, Inc. | Compositions and methods for restoring sensitivity of tumor cells to antitumor therapy and inducing apoptosis |
| US9441244B2 (en) | 2003-06-30 | 2016-09-13 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US9233131B2 (en) | 2003-06-30 | 2016-01-12 | The Regents Of The University Of California | Mutant adeno-associated virus virions and methods of use thereof |
| US20050148069A1 (en) | 2003-09-24 | 2005-07-07 | Gage Fred H. | IGF-1 instructs multipotent adult CNS neural stem cells to an oligodendroglial lineage |
| CN102199626B (zh) | 2003-09-30 | 2015-06-24 | 宾夕法尼亚大学托管会 | 腺伴随病毒(aav)进化支、序列、含有这些序列的载体及它们的应用 |
| WO2005072364A2 (en) | 2004-01-27 | 2005-08-11 | University Of Florida | A modified baculovirus expression system for production of pseudotyped raav vector |
| US7427396B2 (en) | 2004-06-03 | 2008-09-23 | Genzyme Corporation | AAV vectors for gene delivery to the lung |
| PL1802334T3 (pl) | 2004-10-21 | 2013-01-31 | Genentech Inc | Sposób leczenia wewnątrzgałkowych chorób neowaskularnych |
| SI1809750T1 (sl) | 2004-11-08 | 2012-08-31 | Chromagenics Bv | Izbira gostiteljskih celic, ki imajo visok nivo izraĹľanja proteina |
| EP1828390B1 (en) | 2004-12-15 | 2012-06-13 | The University Of North Carolina At Chapel Hill | Chimeric vectors |
| US20100172871A1 (en) | 2005-02-17 | 2010-07-08 | Flannery John G | Muller Cell Specific Gene Therapy |
| US7922670B2 (en) | 2005-02-24 | 2011-04-12 | Warren Jones | System and method for quantifying and mapping visual salience |
| EP2383346B1 (en) | 2005-04-07 | 2014-10-08 | The Trustees of the University of Pennsylvania | Modified AAVrh.64 capsids, compositions containing same and uses thereof |
| US20060234347A1 (en) | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
| AU2006304997B2 (en) | 2005-10-20 | 2012-03-01 | Uniqure Ip B.V. | Improved AAV vectors produced in insect cells |
| US20090191597A1 (en) | 2006-01-20 | 2009-07-30 | Asklepios Biopharmaceutical, Inc. | Enhanced production of infectious parvovirus vectors in insect cells |
| US7867484B2 (en) | 2006-01-27 | 2011-01-11 | University Of North Carolina At Chapel Hill | Heparin and heparan sulfate binding chimeric vectors |
| US20070190028A1 (en) | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
| US8118752B2 (en) | 2006-02-16 | 2012-02-21 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for mapping retinal function |
| US7384145B2 (en) | 2006-02-16 | 2008-06-10 | The Board Of Trustees Of The University Of Illinois | Mapping retinal function using corneal electrode array |
| US7588772B2 (en) | 2006-03-30 | 2009-09-15 | Board Of Trustees Of The Leland Stamford Junior University | AAV capsid library and AAV capsid proteins |
| US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
| EP3437473A1 (en) | 2006-05-04 | 2019-02-06 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| EP2012826B1 (en) | 2006-05-04 | 2016-04-13 | Fovea Pharmaceuticals | Combination comprising a vegf inhibitor and a serine protease for treating neovascular diseases |
| WO2007146953A2 (en) | 2006-06-12 | 2007-12-21 | Exegenics, Inc., D/B/A Opko Health, Inc. | Compositions and methods for sirna inhibition of angiogenesis |
| GB0612096D0 (en) | 2006-06-19 | 2006-07-26 | Greater Glasgow Nhs Board | Functional imaging of the retina |
| ES2785223T3 (es) | 2006-06-21 | 2020-10-06 | Uniqure Ip Bv | Células de insecto para la producción de vectores de AAV |
| US20100008170A1 (en) | 2006-06-27 | 2010-01-14 | Shinya Sato | Semiconductor tester and testing method of semiconductor memory |
| ES2385679T3 (es) | 2006-08-24 | 2012-07-30 | Virovek, Inc. | Expresión de células de insecto de genes con marcos de lectura abiertos superpuestos, métodos y composiciones de éstos |
| CN1966082B (zh) | 2006-11-03 | 2010-06-30 | 许瑞安 | 一种防治结直肠癌的基因药物及其制备方法和用途 |
| US8075137B2 (en) | 2007-02-16 | 2011-12-13 | Objectivision Limited | Stimulus method for multifocal visual evoked potential |
| US9725485B2 (en) | 2012-05-15 | 2017-08-08 | University Of Florida Research Foundation, Inc. | AAV vectors with high transduction efficiency and uses thereof for gene therapy |
| NZ593611A (en) | 2007-04-13 | 2012-06-29 | Catalyst Biosciences Inc | Modified factor vii polypeptides and uses thereof |
| EP1985708B1 (en) | 2007-04-27 | 2015-04-15 | Universität Rostock | Selective targeting of viruses to neural precursor cells |
| EP1995309A1 (en) | 2007-05-21 | 2008-11-26 | Vivalis | Recombinant protein production in avian EBx® cells |
| US10696983B2 (en) | 2007-05-30 | 2020-06-30 | The Trustees Of The University Of Pennsylvania | Method for transducing cells with primary cilia |
| US8540369B2 (en) | 2007-08-16 | 2013-09-24 | The Research Foundation Of State University Of New York | Led variable light source |
| US8518037B2 (en) | 2007-10-30 | 2013-08-27 | Boston Scientific Scimed, Inc. | Radiofrequency ablation device |
| WO2009073551A2 (en) | 2007-11-30 | 2009-06-11 | Scarab Genomics Llc | Lac expression system |
| AU2009215987B2 (en) | 2008-02-19 | 2015-01-22 | Uniqure Ip B.V. | Optimisation of expression of parvoviral rep and cap proteins in insect cells |
| JP2011512417A (ja) | 2008-02-20 | 2011-04-21 | ジェンザイム・コーポレーション | 血管形成の阻害 |
| US20100081707A1 (en) | 2008-02-21 | 2010-04-01 | Ali Robin R | Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea |
| ITFI20080081A1 (it) | 2008-04-18 | 2009-10-19 | Strumenti Oftalmici C S O S R | Procedimento e sistema per la registrazione di risposte elettrofunzionali erg, perg e vep multifocali in tempo reale |
| US8632764B2 (en) | 2008-04-30 | 2014-01-21 | University Of North Carolina At Chapel Hill | Directed evolution and in vivo panning of virus vectors |
| AU2009274482A1 (en) | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
| ES2330826B1 (es) | 2008-06-04 | 2010-07-26 | Proyecto De Biomedicina Cima, S.L. | Sistema para empaquetamiento de adenovirus de alta capacidad. |
| EP2297185A1 (en) | 2008-06-17 | 2011-03-23 | Amsterdam Molecular Therapeutics (AMT) B.V. | Parvoviral capsid with incorporated gly-ala repeat region |
| US9192685B2 (en) | 2008-10-07 | 2015-11-24 | Bracco Suisse S.A. | Targeting construct comprising anti-polymer antibody and contrast/therapeutic agents binding to the same |
| EP2396343B1 (en) | 2009-02-11 | 2017-05-17 | The University of North Carolina At Chapel Hill | Modified virus vectors and methods of making and using the same |
| CN102341406B (zh) | 2009-03-04 | 2016-06-08 | 德国癌症研究中心 | 组装活化蛋白(aap)及其用于制备基本上由vp3组成的细小病毒颗粒的应用 |
| US8679837B2 (en) | 2009-04-02 | 2014-03-25 | University Of Florida Research Foundation, Inc. | Inducible system for highly efficient production of recombinant Adeno-associated virus (rAAV) vectors |
| CN101532024A (zh) | 2009-04-30 | 2009-09-16 | 许瑞安 | 一种用于基因治疗的新型细胞特异性内含microRNA结合序列的基因HAAVmir |
| US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
| TWI466158B (zh) | 2009-07-03 | 2014-12-21 | Univ Lunghwa Sci & Technology | 電漿測量裝置、電漿系統及測量電漿特性之方法 |
| EP2287323A1 (en) | 2009-07-31 | 2011-02-23 | Association Institut de Myologie | Widespread gene delivery to the retina using systemic administration of AAV vectors |
| EP2292781A1 (en) | 2009-08-17 | 2011-03-09 | Genethon | Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions |
| WO2011034947A2 (en) | 2009-09-15 | 2011-03-24 | University Of Washington | Reagents and methods for modulating cone photoreceptor activity |
| US9169494B2 (en) | 2010-01-12 | 2015-10-27 | The University Of North Carolina At Chapel Hill | Restrictive inverted terminal repeats for viral vectors |
| EP2545165B1 (en) | 2010-03-11 | 2020-07-29 | uniQure IP B.V. | Mutated rep encoding sequences for use in aav production |
| WO2011117258A2 (en) | 2010-03-22 | 2011-09-29 | Association Institut De Myologie | Methods of increasing efficiency of vector penetration of target tissue |
| EP2553106A2 (en) | 2010-03-29 | 2013-02-06 | The Trustees Of The University Of Pennsylvania | Pharmacologically induced transgene ablation system |
| WO2011122950A1 (en) | 2010-04-01 | 2011-10-06 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Monomeric duplex aav vectors |
| US9102718B2 (en) | 2010-04-30 | 2015-08-11 | Lpath, Inc. | Anti-S1P antibody treatment of patients with ocular disease |
| CN201704771U (zh) | 2010-04-30 | 2011-01-12 | 陈福环 | 无水箱节水型抽水马桶 |
| WO2011140450A1 (en) | 2010-05-07 | 2011-11-10 | Medicinelodge, Inc Dba Imds Co-Innovation | Surgical rasp with radiofrequency ablation |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| US20110052678A1 (en) | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| DK2640743T3 (en) | 2010-11-16 | 2017-01-23 | Excelimmune Inc | PROCEDURES FOR THE PREPARATION OF RECOMBINANT PROTEINS |
| EP2661494B1 (en) | 2011-01-07 | 2019-06-12 | Applied Genetic Technologies Corporation | Promoters, expression cassettes and vectors for use treating achromatopsia and other diseases |
| EP3795581A3 (en) | 2011-08-24 | 2021-06-09 | The Board of Trustees of the Leland Stanford Junior University | New avv capsid proteins for nucleic acid transfer |
| WO2013063601A1 (en) | 2011-10-28 | 2013-05-02 | University Of Florida Research Foundation, Inc. | Chimeric promoter for cone photoreceptor targeted gene therapy |
| WO2013158309A2 (en) | 2012-04-18 | 2013-10-24 | The Board Of Trustees Of The Leland Stanford Junior University | Non-disruptive gene targeting |
| JP6385920B2 (ja) | 2012-05-09 | 2018-09-05 | オレゴン ヘルス アンド サイエンス ユニバーシティー | アデノ随伴ウイルスプラスミド及びベクター |
| TWI702955B (zh) | 2012-05-15 | 2020-09-01 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd) |
| US20150111275A1 (en) | 2012-06-11 | 2015-04-23 | Daniel V. Palanker | Optical regulation of gene expression in the retina |
| WO2014103957A1 (ja) | 2012-12-25 | 2014-07-03 | タカラバイオ株式会社 | Aav変異体 |
| EP3004339B1 (en) | 2013-05-29 | 2021-07-07 | Cellectis | New compact scaffold of cas9 in the type ii crispr system |
| WO2014194132A1 (en) | 2013-05-31 | 2014-12-04 | The Regents Of The University Of California | Adeno-associated virus variants and methods of use thereof |
| ES2716615T3 (es) * | 2013-06-28 | 2019-06-13 | Inst Nat Sante Rech Med | Métodos para expresar un polinucleótido de interés en la retina de un sujeto |
| US20150025939A1 (en) | 2013-07-18 | 2015-01-22 | Somnath Chatterjee | Company Centric Social Media Platfonn for Content Sharing aud Tracking |
| WO2015038958A1 (en) | 2013-09-13 | 2015-03-19 | California Institute Of Technology | Selective recovery |
| AU2014324717B2 (en) | 2013-09-26 | 2020-10-08 | University Of Florida Research Foundation, Inc. | Synthetic combinatorial AAV capsid library for targeted gene therapy |
| PL3459965T3 (pl) | 2013-10-11 | 2021-07-26 | Massachusetts Eye & Ear Infirmary | Sposoby przewidywania sekwencji wirusa-przodka i ich zastosowania |
| CN105636986B (zh) | 2013-10-18 | 2020-05-12 | 瑞泽恩制药公司 | 包含vegf拮抗剂和抗-ctla-4抗体的组合的方法和组合物 |
| EP3113787B1 (en) * | 2014-03-04 | 2019-12-04 | University of Florida Research Foundation, Inc. | Improved raav vectors and methods for transduction of photoreceptors and rpe cells |
| AU2015231439B2 (en) * | 2014-03-17 | 2019-11-14 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
| IL248102B (en) | 2014-05-02 | 2022-07-01 | Genzyme Corp | aav vectors for gene therapy of the central nervous system and retina |
| CA2951707A1 (en) | 2014-06-10 | 2015-12-17 | Massachusetts Institute Of Technology | Method for gene editing |
| MY187898A (en) | 2015-03-02 | 2021-10-27 | Adverum Biotechnologies Inc | Compositions and methods for intravitreal delivery of polynucleotides to retinal cones |
| EP3748007B1 (en) | 2015-03-06 | 2024-06-26 | Massachusetts Eye & Ear Infirmary | Gene augmentation therapies for inherited retinal degeneration caused by mutations in the prpf31 gene |
| WO2017023724A1 (en) | 2015-07-31 | 2017-02-09 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of aadc deficiency |
| GB2545763A (en) | 2015-12-23 | 2017-06-28 | Adverum Biotechnologies Inc | Mutant viral capsid libraries and related systems and methods |
| ES2908467T3 (es) | 2016-04-29 | 2022-04-29 | Adverum Biotechnologies Inc | Evasión de anticuerpos neutralizantes por un virus adenoasociado recombinante |
| US11364308B2 (en) | 2016-05-13 | 2022-06-21 | 4D Molecular Therapeutics Inc. | Adeno-associated virus variant capsids and methods of use thereof |
| AU2017286673B2 (en) | 2016-06-16 | 2021-06-24 | Adverum Biotechnologies, Inc. | Treatment of AMD using AAV2 variant with aflibercept |
| ES2916344T3 (es) | 2016-06-16 | 2022-06-30 | Adverum Biotechnologies Inc | Composiciones y métodos para reducir la neovascularización ocular |
| CA3040179A1 (en) | 2016-10-19 | 2018-04-26 | Adverum Biotechnologies, Inc. | Modified aav capsids and uses thereof |
| JP2020510424A (ja) | 2017-02-28 | 2020-04-09 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | 改変aavカプシドおよびその使用 |
| MX2019011040A (es) | 2017-03-17 | 2020-01-20 | Adverum Biotechnologies Inc | Composiciones y metodos para potenciar la expresion genica. |
-
2016
- 2016-03-02 MY MYPI2017703159A patent/MY187898A/en unknown
- 2016-03-02 WO PCT/US2016/020482 patent/WO2016141078A1/en not_active Ceased
- 2016-03-02 JP JP2017546102A patent/JP7095994B2/ja active Active
- 2016-03-02 AU AU2016226289A patent/AU2016226289B2/en active Active
- 2016-03-02 US US15/554,664 patent/US11021519B2/en active Active
- 2016-03-02 SG SG11201707063TA patent/SG11201707063TA/en unknown
- 2016-03-02 HK HK18108682.6A patent/HK1249067A1/zh unknown
- 2016-03-02 BR BR112017018846-5A patent/BR112017018846A2/pt not_active Application Discontinuation
- 2016-03-02 KR KR1020177027451A patent/KR20170137730A/ko not_active Ceased
- 2016-03-02 CN CN202210008919.XA patent/CN114480502A/zh active Pending
- 2016-03-02 EA EA201791939A patent/EA201791939A1/ru unknown
- 2016-03-02 IL IL254148A patent/IL254148B/en unknown
- 2016-03-02 EP EP16759427.4A patent/EP3265178A4/en active Pending
- 2016-03-02 CN CN201680013575.4A patent/CN107405507B/zh active Active
- 2016-03-02 CA CA2978068A patent/CA2978068C/en active Active
- 2016-03-02 MX MX2017011041A patent/MX2017011041A/es unknown
-
2020
- 2020-05-01 JP JP2020081106A patent/JP2020122008A/ja active Pending
-
2021
- 2021-05-05 US US17/308,785 patent/US20210388030A1/en not_active Abandoned
- 2021-07-27 AU AU2021209206A patent/AU2021209206A1/en not_active Abandoned
-
2022
- 2022-05-19 JP JP2022082310A patent/JP2022107042A/ja not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014518614A (ja) | 2011-04-22 | 2014-08-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 変異体キャプシドを有するアデノ関連ウイルスビリオンおよびその使用方法 |
| WO2014186160A1 (en) | 2013-05-16 | 2014-11-20 | Applied Genetic Technologies Corporation | Promoters, expression cassettes, vectors, kits, and methods for the threatment of achromatopsia and other diseases |
Non-Patent Citations (1)
| Title |
|---|
| Sci Transl Med,2013年,5(189),189ra76 |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201707063TA (en) | 2017-09-28 |
| BR112017018846A2 (pt) | 2018-07-31 |
| AU2021209206A1 (en) | 2021-08-19 |
| US11021519B2 (en) | 2021-06-01 |
| IL254148A0 (en) | 2017-10-31 |
| EP3265178A4 (en) | 2018-09-05 |
| EP3265178A1 (en) | 2018-01-10 |
| CN107405507A (zh) | 2017-11-28 |
| CN114480502A (zh) | 2022-05-13 |
| AU2016226289B2 (en) | 2021-04-29 |
| IL254148B (en) | 2022-09-01 |
| KR20170137730A (ko) | 2017-12-13 |
| JP2022107042A (ja) | 2022-07-20 |
| WO2016141078A1 (en) | 2016-09-09 |
| JP2020122008A (ja) | 2020-08-13 |
| EA201791939A1 (ru) | 2018-01-31 |
| CN107405507B (zh) | 2022-05-03 |
| JP2018508519A (ja) | 2018-03-29 |
| CA2978068C (en) | 2024-05-28 |
| AU2016226289A1 (en) | 2017-09-21 |
| US20180066022A1 (en) | 2018-03-08 |
| CA2978068A1 (en) | 2016-09-09 |
| US20210388030A1 (en) | 2021-12-16 |
| MX2017011041A (es) | 2018-03-02 |
| MY187898A (en) | 2021-10-27 |
| HK1249067A1 (zh) | 2018-10-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7095994B2 (ja) | ポリヌクレオチドを網膜錐体に硝子体内送達するための組成物及び方法 | |
| US12275959B2 (en) | Compositions and methods for enhanced gene expression in cone cells | |
| JP6827320B2 (ja) | LCA−8及び進行性RPを治療するための組換えAAV−Crumbsホモログ組成物及び方法 | |
| JP2021507723A (ja) | 視細胞における治療遺伝子の機能的発現を増強するための組成物および方法 | |
| JP2021520232A (ja) | 黄斑ジストロフィーを処置するための組成物及び方法 | |
| HK40049243A (en) | Compositions and methods for enhanced gene expression in cone cells | |
| JP2025500979A (ja) | 光受容体細胞のインビボリプログラミング | |
| HK1229816B (en) | Compositions and methods for enhanced gene expression in cone cells | |
| HK1229816A1 (en) | Compositions and methods for enhanced gene expression in cone cells | |
| NZ724403B2 (en) | Compositions and methods for enhanced gene expression in cone cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190301 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190301 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200205 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200501 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201104 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210204 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210802 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20211101 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220302 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220519 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20220602 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20220623 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7095994 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |