JP7093791B2 - Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体 - Google Patents
Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体 Download PDFInfo
- Publication number
- JP7093791B2 JP7093791B2 JP2019563492A JP2019563492A JP7093791B2 JP 7093791 B2 JP7093791 B2 JP 7093791B2 JP 2019563492 A JP2019563492 A JP 2019563492A JP 2019563492 A JP2019563492 A JP 2019563492A JP 7093791 B2 JP7093791 B2 JP 7093791B2
- Authority
- JP
- Japan
- Prior art keywords
- thiophene
- pyrimidine
- ethylamino
- benzo
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2017/061987 | 2017-05-18 | ||
| EP2017061987 | 2017-05-18 | ||
| PCT/EP2018/062843 WO2018210987A1 (en) | 2017-05-18 | 2018-05-17 | Benzofurane and benzothiophene derivatives as pge2 receptor modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020520357A JP2020520357A (ja) | 2020-07-09 |
| JP2020520357A5 JP2020520357A5 (https=) | 2021-07-26 |
| JP7093791B2 true JP7093791B2 (ja) | 2022-06-30 |
Family
ID=62196583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563492A Expired - Fee Related JP7093791B2 (ja) | 2017-05-18 | 2018-05-17 | Ｐｇｅ２レセプター調節剤としてのベンゾフラン及びベンゾチオフェン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11325899B2 (https=) |
| EP (1) | EP3625227B1 (https=) |
| JP (1) | JP7093791B2 (https=) |
| KR (1) | KR102612649B1 (https=) |
| CN (1) | CN110621671A (https=) |
| AR (1) | AR111807A1 (https=) |
| CA (1) | CA3063632A1 (https=) |
| ES (1) | ES2929309T3 (https=) |
| TW (1) | TW201900179A (https=) |
| WO (1) | WO2018210987A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| PL3601233T3 (pl) | 2017-03-27 | 2025-01-07 | HYDRO-QUéBEC | Sole do zastosowania w kompozycjach elektrolitowych lub jako dodatki do elektrod |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| CN110621667A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 嘧啶衍生物 |
| PL3625228T3 (pl) | 2017-05-18 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Pochodne pirymidyny jako modulatory receptora pge2 |
| WO2021060281A1 (ja) * | 2019-09-24 | 2021-04-01 | Ａｇｃ株式会社 | プロスタグランジンｅ２レセプターｅｐ２／ｅｐ４デュアルアンタゴニスト |
| US20220048987A1 (en) * | 2020-08-13 | 2022-02-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method of treatment to prevent or reverse age-associated inflammation, cognitive decline, and neurodegeneration |
| US20230390303A1 (en) | 2020-11-13 | 2023-12-07 | Ono Pharmaceutical Co., Ltd. | Cancer treatment by combination of ep4 antagonist and immune checkpoint inhibitor |
| WO2022272062A1 (en) | 2021-06-24 | 2022-12-29 | Reservoir Neuroscience, Inc. | Ep2 antagonist compounds |
| CN114539193B (zh) * | 2022-01-20 | 2024-08-06 | 安徽普利药业有限公司 | 一种盐酸胺碘酮中间体的制备方法 |
| WO2024102968A1 (en) * | 2022-11-10 | 2024-05-16 | Tempest Therapeutics, Inc. | Uses of ep2/ep4 antagonist compounds for treating familial adenomatous polyposis (fap) |
| WO2025229177A1 (en) | 2024-05-02 | 2025-11-06 | Idorsia Pharmaceuticals Ltd | Crystalline forms of an n-substituted indole derivative |
Citations (2)
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| JP2008516974A (ja) | 2004-10-15 | 2008-05-22 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | プロスタグランジンｄ２受容体アンタゴニストとしての２，６−置換−４−一置換アミノ−ピリミジン |
| WO2009105220A1 (en) | 2008-02-19 | 2009-08-27 | Janssen Pharmaceutica N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
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| CN110621667A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 嘧啶衍生物 |
| EA201992676A1 (ru) | 2017-05-18 | 2020-05-06 | Идорсия Фармасьютиклз Лтд | Фенильные производные в качестве модуляторов pge2 рецепторов |
| PL3625228T3 (pl) | 2017-05-18 | 2021-12-20 | Idorsia Pharmaceuticals Ltd | Pochodne pirymidyny jako modulatory receptora pge2 |
| EP3625224B1 (en) | 2017-05-18 | 2021-08-04 | Idorsia Pharmaceuticals Ltd | N-substituted indole derivatives |
-
2018
- 2018-05-17 CN CN201880031813.3A patent/CN110621671A/zh active Pending
- 2018-05-17 ES ES18725497T patent/ES2929309T3/es active Active
- 2018-05-17 JP JP2019563492A patent/JP7093791B2/ja not_active Expired - Fee Related
- 2018-05-17 WO PCT/EP2018/062843 patent/WO2018210987A1/en not_active Ceased
- 2018-05-17 AR ARP180101312A patent/AR111807A1/es unknown
- 2018-05-17 CA CA3063632A patent/CA3063632A1/en active Pending
- 2018-05-17 US US16/614,211 patent/US11325899B2/en active Active
- 2018-05-17 EP EP18725497.4A patent/EP3625227B1/en active Active
- 2018-05-17 KR KR1020197037357A patent/KR102612649B1/ko active Active
- 2018-05-17 TW TW107116711A patent/TW201900179A/zh unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008516974A (ja) | 2004-10-15 | 2008-05-22 | アベンティス・ファーマスーティカルズ・インコーポレイテツド | プロスタグランジンｄ２受容体アンタゴニストとしての２，６−置換−４−一置換アミノ−ピリミジン |
| WO2009105220A1 (en) | 2008-02-19 | 2009-08-27 | Janssen Pharmaceutica N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3625227A1 (en) | 2020-03-25 |
| JP2020520357A (ja) | 2020-07-09 |
| US20210115031A1 (en) | 2021-04-22 |
| CA3063632A1 (en) | 2018-11-22 |
| KR20200007048A (ko) | 2020-01-21 |
| EP3625227B1 (en) | 2022-09-14 |
| AR111807A1 (es) | 2019-08-21 |
| WO2018210987A1 (en) | 2018-11-22 |
| KR102612649B1 (ko) | 2023-12-11 |
| ES2929309T3 (es) | 2022-11-28 |
| CN110621671A (zh) | 2019-12-27 |
| US11325899B2 (en) | 2022-05-10 |
| TW201900179A (zh) | 2019-01-01 |
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