JP7068288B2 - ４－（２－（（１ｒ，２ｒ）－２－ヒドロキシシクロヘキシルアミノ）ベンゾチアゾール－６－イルオキシ）－ｎ－メチルピコリンアミドの結晶形 - Google Patents

４－（２－（（１ｒ，２ｒ）－２－ヒドロキシシクロヘキシルアミノ）ベンゾチアゾール－６－イルオキシ）－ｎ－メチルピコリンアミドの結晶形 Download PDF

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JP7068288B2
JP7068288B2 JP2019520040A JP2019520040A JP7068288B2 JP 7068288 B2 JP7068288 B2 JP 7068288B2 JP 2019520040 A JP2019520040 A JP 2019520040A JP 2019520040 A JP2019520040 A JP 2019520040A JP 7068288 B2 JP7068288 B2 JP 7068288B2
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pharmaceutical composition
hydroxycyclohexylamino
yloxy
benzothiazole
methylpicolinamide
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JP2019520040A
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Japanese (ja)
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JP2019530719A (ja
JP2019530719A5 (enExample
Inventor
グランドゥリ，アルノー
ムリダー ワイコール，リーラダー
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2019520040A 2016-10-14 2017-10-13 ４－（２－（（１ｒ，２ｒ）－２－ヒドロキシシクロヘキシルアミノ）ベンゾチアゾール－６－イルオキシ）－ｎ－メチルピコリンアミドの結晶形 Expired - Fee Related JP7068288B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662408358P 2016-10-14 2016-10-14
US62/408,358 2016-10-14
PCT/IB2017/056379 WO2018069892A1 (en) 2016-10-14 2017-10-13 Crystalline forms of 4-(2-((1r,2r)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-n-methylpicolinamide

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JP2019530719A JP2019530719A (ja) 2019-10-24
JP2019530719A5 JP2019530719A5 (enExample) 2020-11-19
JP7068288B2 true JP7068288B2 (ja) 2022-05-16

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JP2019520040A Expired - Fee Related JP7068288B2 (ja) 2016-10-14 2017-10-13 ４－（２－（（１ｒ，２ｒ）－２－ヒドロキシシクロヘキシルアミノ）ベンゾチアゾール－６－イルオキシ）－ｎ－メチルピコリンアミドの結晶形

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US (1) US10934273B2 (enExample)
EP (1) EP3526217B1 (enExample)
JP (1) JP7068288B2 (enExample)
KR (1) KR20190064589A (enExample)
CN (1) CN109843880B (enExample)
AU (1) AU2017342239B2 (enExample)
BR (1) BR112019006914A2 (enExample)
CA (1) CA3039764A1 (enExample)
CL (1) CL2019001008A1 (enExample)
ES (1) ES2949414T3 (enExample)
IL (1) IL265893A (enExample)
MX (1) MX2019004345A (enExample)
RU (1) RU2019114208A (enExample)
WO (1) WO2018069892A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190080A1 (ar) 2016-10-14 2019-04-11 Bayer Pharma AG مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها
KR20220130698A (ko) * 2019-12-20 2022-09-27 에피자임, 인코포레이티드 Ezh2 억제제의 결정질 하이드로브로마이드 염, 이의 제조 및 암의 치료에 유용한 약학적 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534410A (ja) 2006-04-19 2009-09-24 ノバルティス アクチエンゲゼルシャフト ６−ｏ−置換ベンゾオキサゾールおよびベンゾチアゾール化合物ならびにｃｓｆ−１ｒシグナル伝達を阻害する方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101432281B (zh) * 2006-04-19 2013-08-28 诺瓦提斯公司 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法
SI2704713T1 (sl) * 2011-05-05 2017-05-31 Novartis Ag CSF-1R inhibitorji za zdravljenje možganskih tumorjev
EP3233918A1 (en) * 2014-12-19 2017-10-25 Novartis AG Combination therapies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009534410A (ja) 2006-04-19 2009-09-24 ノバルティス アクチエンゲゼルシャフト ６−ｏ−置換ベンゾオキサゾールおよびベンゾチアゾール化合物ならびにｃｓｆ−１ｒシグナル伝達を阻害する方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Ｃ．Ｇ．ＷＥＲＭＵＴＨ編，最新 創薬化学 下巻，p.347-365，株式会社 テクノミック，1999年
高田則幸，PHARM STAGE，Vol.6, No.10，2007年，p.20-25

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Publication number Publication date
AU2017342239A1 (en) 2019-04-18
EP3526217A1 (en) 2019-08-21
ES2949414T3 (es) 2023-09-28
AU2017342239B2 (en) 2020-05-28
CA3039764A1 (en) 2018-04-19
WO2018069892A1 (en) 2018-04-19
JP2019530719A (ja) 2019-10-24
BR112019006914A2 (pt) 2019-07-02
CN109843880B (zh) 2023-12-01
KR20190064589A (ko) 2019-06-10
CL2019001008A1 (es) 2019-06-21
US10934273B2 (en) 2021-03-02
RU2019114208A (ru) 2020-11-16
IL265893A (en) 2019-06-30
EP3526217B1 (en) 2023-04-19
RU2019114208A3 (enExample) 2020-11-18
US20200190057A1 (en) 2020-06-18
MX2019004345A (es) 2019-07-01
CN109843880A (zh) 2019-06-04

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