JP2019530719A5 - - Google Patents
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- Publication number
- JP2019530719A5 JP2019530719A5 JP2019520040A JP2019520040A JP2019530719A5 JP 2019530719 A5 JP2019530719 A5 JP 2019530719A5 JP 2019520040 A JP2019520040 A JP 2019520040A JP 2019520040 A JP2019520040 A JP 2019520040A JP 2019530719 A5 JP2019530719 A5 JP 2019530719A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- wavelength
- measured
- temperature
- powder diffraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 36
- 230000005855 radiation Effects 0.000 claims description 34
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 25
- 239000013078 crystal Substances 0.000 claims description 17
- -1 (1R, 2R) -2-hydroxycyclohexylamino Chemical group 0.000 claims description 14
- ADZBMFGQQWPHMJ-RHSMWYFYSA-N 4-[[2-[[(1r,2r)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C3SC(N[C@H]4[C@@H](CCCC4)O)=NC3=CC=2)=C1 ADZBMFGQQWPHMJ-RHSMWYFYSA-N 0.000 claims description 12
- QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 150000003839 salts Chemical class 0.000 claims description 3
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 208000005017 glioblastoma Diseases 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- IHWOVMRZEIHNGY-SATBOSKTSA-N 4-[[2-[[(1R,2R)-2-hydroxycyclohexyl]amino]-1,3-benzothiazol-6-yl]oxy]-N-methylpyridine-2-carboxamide hydrochloride Chemical compound Cl.O[C@H]1[C@@H](CCCC1)NC=1SC2=C(N1)C=CC(=C2)OC2=CC(=NC=C2)C(=O)NC IHWOVMRZEIHNGY-SATBOSKTSA-N 0.000 claims 1
- 238000012986 modification Methods 0.000 description 7
- 230000004048 modification Effects 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408358P | 2016-10-14 | 2016-10-14 | |
| US62/408,358 | 2016-10-14 | ||
| PCT/IB2017/056379 WO2018069892A1 (en) | 2016-10-14 | 2017-10-13 | Crystalline forms of 4-(2-((1r,2r)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-n-methylpicolinamide |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019530719A JP2019530719A (ja) | 2019-10-24 |
| JP2019530719A5 true JP2019530719A5 (enExample) | 2020-11-19 |
| JP7068288B2 JP7068288B2 (ja) | 2022-05-16 |
Family
ID=60320932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019520040A Active JP7068288B2 (ja) | 2016-10-14 | 2017-10-13 | ４－（２－（（１ｒ，２ｒ）－２－ヒドロキシシクロヘキシルアミノ）ベンゾチアゾール－６－イルオキシ）－ｎ－メチルピコリンアミドの結晶形 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US10934273B2 (enExample) |
| EP (1) | EP3526217B1 (enExample) |
| JP (1) | JP7068288B2 (enExample) |
| KR (1) | KR20190064589A (enExample) |
| CN (1) | CN109843880B (enExample) |
| AU (1) | AU2017342239B2 (enExample) |
| BR (1) | BR112019006914A2 (enExample) |
| CA (1) | CA3039764A1 (enExample) |
| CL (1) | CL2019001008A1 (enExample) |
| ES (1) | ES2949414T3 (enExample) |
| IL (1) | IL265893A (enExample) |
| MX (1) | MX2019004345A (enExample) |
| RU (1) | RU2019114208A (enExample) |
| WO (1) | WO2018069892A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190080A1 (ar) | 2016-10-14 | 2019-04-11 | Bayer Pharma AG | مركبات مشتقة من 6-(1h-بيرازول-1-يل) بيريميدين-4- أمين مستبدل واستخداماتها |
| CA3162315A1 (en) * | 2019-12-20 | 2021-06-24 | Marinus Jacobus Verwijs | Crystalline hydrobromide salt of a ezh2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| PE20080359A1 (es) * | 2006-04-19 | 2008-06-06 | Novartis Ag | Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r |
| CA2834696C (en) * | 2011-05-05 | 2019-07-23 | Novartis Ag | Csf-1r inhibitors for treatment of brain tumors |
| WO2016100882A1 (en) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
-
2017
- 2017-10-13 AU AU2017342239A patent/AU2017342239B2/en not_active Ceased
- 2017-10-13 BR BR112019006914A patent/BR112019006914A2/pt not_active IP Right Cessation
- 2017-10-13 KR KR1020197010527A patent/KR20190064589A/ko not_active Ceased
- 2017-10-13 RU RU2019114208A patent/RU2019114208A/ru not_active Application Discontinuation
- 2017-10-13 JP JP2019520040A patent/JP7068288B2/ja active Active
- 2017-10-13 EP EP17797745.1A patent/EP3526217B1/en active Active
- 2017-10-13 ES ES17797745T patent/ES2949414T3/es active Active
- 2017-10-13 WO PCT/IB2017/056379 patent/WO2018069892A1/en not_active Ceased
- 2017-10-13 US US16/341,124 patent/US10934273B2/en active Active
- 2017-10-13 CA CA3039764A patent/CA3039764A1/en not_active Abandoned
- 2017-10-13 MX MX2019004345A patent/MX2019004345A/es unknown
- 2017-10-13 CN CN201780063254.XA patent/CN109843880B/zh active Active
-
2019
- 2019-04-07 IL IL265893A patent/IL265893A/en unknown
- 2019-04-12 CL CL2019001008A patent/CL2019001008A1/es unknown
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