KR20190064589A - 4-(2-((1r,2r)-2-히드록시시클로헥실아미노)벤조티아졸-6-일옥시)-n-메틸피콜린아미드의 결정질 형태 - Google Patents
4-(2-((1r,2r)-2-히드록시시클로헥실아미노)벤조티아졸-6-일옥시)-n-메틸피콜린아미드의 결정질 형태 Download PDFInfo
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- KR20190064589A KR20190064589A KR1020197010527A KR20197010527A KR20190064589A KR 20190064589 A KR20190064589 A KR 20190064589A KR 1020197010527 A KR1020197010527 A KR 1020197010527A KR 20197010527 A KR20197010527 A KR 20197010527A KR 20190064589 A KR20190064589 A KR 20190064589A
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- benzothiazol
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Images
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Health & Medical Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
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| US62/408,358 | 2016-10-14 | ||
| PCT/IB2017/056379 WO2018069892A1 (en) | 2016-10-14 | 2017-10-13 | Crystalline forms of 4-(2-((1r,2r)-2-hydroxycyclohexylamino) benzothiazol-6-yloxy)-n-methylpicolinamide |
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| CA3162315A1 (en) * | 2019-12-20 | 2021-06-24 | Marinus Jacobus Verwijs | Crystalline hydrobromide salt of a ezh2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer |
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| CN101432281B (zh) * | 2006-04-19 | 2013-08-28 | 诺瓦提斯公司 | 6-0-取代的苯并*唑和苯并噻唑化合物以及抑制csf-1r信号传导的方法 |
| PE20080359A1 (es) * | 2006-04-19 | 2008-06-06 | Novartis Ag | Compuestos de benzoxazol y benzotiazol 6-0-sustituidos y metodos de inhibicion de la senalizacion de csf-1r |
| CA2834696C (en) * | 2011-05-05 | 2019-07-23 | Novartis Ag | Csf-1r inhibitors for treatment of brain tumors |
| WO2016100882A1 (en) * | 2014-12-19 | 2016-06-23 | Novartis Ag | Combination therapies |
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| CN109843880A (zh) | 2019-06-04 |
| EP3526217A1 (en) | 2019-08-21 |
| US20200190057A1 (en) | 2020-06-18 |
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| CN109843880B (zh) | 2023-12-01 |
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| EP3526217B1 (en) | 2023-04-19 |
| CL2019001008A1 (es) | 2019-06-21 |
| CA3039764A1 (en) | 2018-04-19 |
| AU2017342239B2 (en) | 2020-05-28 |
| JP7068288B2 (ja) | 2022-05-16 |
| BR112019006914A2 (pt) | 2019-07-02 |
| US10934273B2 (en) | 2021-03-02 |
| RU2019114208A (ru) | 2020-11-16 |
| ES2949414T3 (es) | 2023-09-28 |
| MX2019004345A (es) | 2019-07-01 |
| AU2017342239A1 (en) | 2019-04-18 |
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