JP7064772B2 - 選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ） - Google Patents

選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ） Download PDF

Info

Publication number
JP7064772B2
JP7064772B2 JP2018557799A JP2018557799A JP7064772B2 JP 7064772 B2 JP7064772 B2 JP 7064772B2 JP 2018557799 A JP2018557799 A JP 2018557799A JP 2018557799 A JP2018557799 A JP 2018557799A JP 7064772 B2 JP7064772 B2 JP 7064772B2
Authority
JP
Japan
Prior art keywords
substituent
serd
present disclosure
boron atom
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018557799A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019514955A5 (enExample
JP2019514955A (ja
Inventor
ワン，ガンジ
リウ，ジアワン
ジェン，シロン
ジョン，チウ
グオ，シャンチュン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xavier University of Louisiana
Original Assignee
Xavier University of Louisiana
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xavier University of Louisiana filed Critical Xavier University of Louisiana
Publication of JP2019514955A publication Critical patent/JP2019514955A/ja
Publication of JP2019514955A5 publication Critical patent/JP2019514955A5/ja
Application granted granted Critical
Publication of JP7064772B2 publication Critical patent/JP7064772B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2018557799A 2016-05-06 2017-05-05 選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ） Active JP7064772B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662332541P 2016-05-06 2016-05-06
US62/332,541 2016-05-06
PCT/US2017/031297 WO2017192991A1 (en) 2016-05-06 2017-05-05 Selective estrogen receptor down-regulators (serds)

Publications (3)

Publication Number Publication Date
JP2019514955A JP2019514955A (ja) 2019-06-06
JP2019514955A5 JP2019514955A5 (enExample) 2020-06-18
JP7064772B2 true JP7064772B2 (ja) 2022-05-11

Family

ID=60203671

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018557799A Active JP7064772B2 (ja) 2016-05-06 2017-05-05 選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ）

Country Status (5)

Country Link
US (1) US20190233442A1 (enExample)
EP (1) EP3452486A4 (enExample)
JP (1) JP7064772B2 (enExample)
CN (1) CN109415388A (enExample)
WO (1) WO2017192991A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017182493A1 (en) 2016-04-20 2017-10-26 Astrazeneca Ab Indazole derivatives for use in down-regulation of the estrogen receptor for the treatment of cancer
US10149839B2 (en) 2016-07-25 2018-12-11 Astrazeneca Ab Chemical compounds
AU2017349797B2 (en) 2016-10-24 2020-05-21 Astrazeneca Ab 6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinoline derivatives useful in the treatment of cancer
UA125043C2 (uk) 2017-01-30 2021-12-29 Астразенека Аб Модулятори рецептора естрогену
IT201900004041A1 (it) * 2019-03-20 2020-09-20 Farmabios Spa Procedimento per la preparazione di un derivato del fulvestrant
WO2021213358A1 (zh) * 2020-04-21 2021-10-28 江苏先声药业有限公司 含硼化合物及其应用
WO2021214253A1 (en) 2020-04-24 2021-10-28 Astrazeneca Ab Dosage regimen for the treatment of cancer
MX2022013258A (es) 2020-04-24 2022-11-14 Astrazeneca Ab Formulaciones farmaceuticas.
IT202100008066A1 (it) 2021-03-31 2022-10-01 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI ACIDO B-[(7α,17β)-17-IDROSSI-7-[9-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFINIL]NONIL]ESTRA-1,3,5(10)-TRIEN-3-IL]-BORONICO E INTERMEDI DEL PROCESSO
IT202100012062A1 (it) * 2021-05-11 2022-11-11 Ind Chimica Srl PROCESSO PER LA PREPARAZIONE DI ACIDO B-[(7α,17β)-17-IDROSSI-7-[9-[(4,4,5,5,5-PENTAFLUOROPENTIL)SULFINIL]NONIL]ESTRA-1,3,5(10)-TRIEN-3-IL]-BORONICO E INTERMEDI DEL PROCESSO
CN113444134A (zh) * 2021-07-22 2021-09-28 中国药科大学 雌甾-1,3,5(10)-三烯类化合物其制备方法和医药用途
WO2023073413A1 (en) * 2021-10-29 2023-05-04 Industriale Chimica S.R.L. PROCESS FOR PREPARING β-[(7α,17β)-17-HYDROXY-7-[9-[(4,4,5,5,5-PENTAFLUROPENTYL)SULFINYL]NONYL]ESTRA-1,3,5(10)-TRIEN-3-YL]-BORONIC ACID AND PROCESS INTERMEDIATES

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520235A (ja) 1997-10-23 2001-10-30 アメリカン・ホーム・プロダクツ・コーポレイション エストラ−１，３，５（１０）−トリエン−７α−チオエーテル
WO2010107474A1 (en) 2009-03-16 2010-09-23 The Research Foundation Of State University Of New York Antiestrogens for breast cancer therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE527131C2 (sv) * 2004-02-13 2005-12-27 Innoventus Project Ab Steroider för cancerbehandling
EP3473630B1 (en) * 2014-07-02 2021-01-13 Xavier University Of Louisiana Boron-based prodrug strategy for increased bioavailability and lower-dosage requirements for drug molecules containing at least one phenol (or aromatic hydroxyl) group

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001520235A (ja) 1997-10-23 2001-10-30 アメリカン・ホーム・プロダクツ・コーポレイション エストラ−１，３，５（１０）−トリエン−７α−チオエーテル
WO2010107474A1 (en) 2009-03-16 2010-09-23 The Research Foundation Of State University Of New York Antiestrogens for breast cancer therapy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
International Journal of Cancer，2010年，Volume Date 2011, 128(4)，P.974-982
Journal of Medicinal Chemistry，2015年，58(8)，P.3522-3533

Also Published As

Publication number Publication date
EP3452486A1 (en) 2019-03-13
CN109415388A (zh) 2019-03-01
US20190233442A1 (en) 2019-08-01
WO2017192991A1 (en) 2017-11-09
EP3452486A4 (en) 2020-03-04
JP2019514955A (ja) 2019-06-06

Similar Documents

Publication Publication Date Title
JP7064772B2 (ja) 選択的エストロゲン受容体ダウンレギュレーター（ｓｅｒｄｓ）
JP7673041B2 (ja) 治療薬としての細胞毒素のペプチドコンジュゲート
JP2024023295A (ja) Ｓｈｐ２の活性を阻害するための化合物の製造方法
EP3802501A1 (en) Compounds as nuclear transport modulators and uses thereof
JP2016513737A5 (enExample)
JPWO2021007435A5 (enExample)
EP3101020B1 (en) Deuterated quinazolinone compound and pharmaceutical composition comprising same
JP2025111455A (ja) 抗増殖活性を有するフェノキシ（ヘテロ）アリールエーテル
EP3612539A1 (en) Phosphonium-ion tethered tetracycline drugs for treatment of cancer
JP7282036B2 (ja) 新規の芳香族化合物
CN113365641A (zh) 雌激素受体靶向拮抗剂
US20240140947A1 (en) Compound for the treatment of cancer
EP3864014B1 (en) Malonate salt of varlitinib
JP7208624B2 (ja) 新規化合物、炎症性疾患の予防及び／又は治療のための薬剤、又は、一酸化炭素送達物質
TWI535725B (zh) 用以治療發炎和／或腫瘤的新穎倍半萜類化合物之衍生物及包含此新穎倍半萜類化合物之衍生物的組合物
JP5083681B2 (ja) 新規抗癌剤
HK40095791A (en) Process of manufacture of a compound for inhibiting the activity of shp2
JP2017171624A (ja) 抗がん剤
WO2018193111A1 (en) Azithromycin derivatives containing a phosphonium ion as anticancer agents

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20200428

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200428

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210311

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210420

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210712

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210909

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211020

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20220322

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20220418

R150 Certificate of patent or registration of utility model

Ref document number: 7064772

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250